Full Text Journal Articles about
Paraneoplastic Autonomic Neuropathy

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Autonomic Peripheral Neuropathy.

Roy Freeman,

PURPOSE OF REVIEW:This article provides a summary of the autonomic neuropathies, including neuropathies associated with diabetes mellitus, neuropathies due to amyloid deposition, immune-mediated autonomic neuropathies (including those associated with a paraneoplastic syndrome), inherited autonomic neuropathies, and toxic autonomic neuropathies. The presenting features, diagnostic investigations, and natural history of these neuropathies ... Read more >>

Continuum (Minneap Minn) (Continuum (Minneapolis, Minn.))
[2020, 26(1):58-71]

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Diagnosis and Treatment of Hereditary Transthyretin Amyloidosis (hATTR) Polyneuropathy: Current Perspectives on Improving Patient Care.

Marco Luigetti, Angela Romano, Andrea Di Paolantonio, Giulia Bisogni, Mario Sabatelli,

Hereditary transthyretin amyloidosis (hATTR) with polyneuropathy (formerly known as Familial Amyloid Polyneuropathy) is a rare disease due to mutations in the gene encoding transthyretin (TTR) and characterized by multisystem extracellular deposition of amyloid, leading to dysfunction of different organs and tissues. hATTR amyloidosis represents a diagnostic challenge for neurologists considering ... Read more >>

Ther Clin Risk Manag (Therapeutics and clinical risk management)
[2020, 16:109-123]

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Peripheral neuropathy in hematologic malignancies - Past, present and future.

Tiffany Li, Hannah C Timmins, Hillard M Lazarus, Susanna B Park,

Neurotoxic treatments (including proteasome inhibitors, immunomodulatory drugs and vinca-alkaloids) are often used in the treatment of hematologic malignancy. Peripheral neuropathy can be part of a paraneoplastic syndrome accompanying the disease but more commonly is a consequence of treatment with neurotoxic therapies, and produces sensory, motor, autonomic nerve dysfunction or a ... Read more >>

Blood Rev. (Blood reviews)
[2020, :100653]

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An autoimmune-based, paraneoplastic neurologic syndrome following checkpoint inhibition and concurrent radiotherapy for merkel cell carcinoma: case report.

Alexander D Sherry, Michael Bezzerides, Mohamed H Khattab, Guozhen Luo, Kristin K Ancell, Austin N Kirschner,

PURPOSE:Merkel cell carcinoma is highly sensitive to both radiation and immunotherapy. Moreover, concurrent radioimmunotherapy may capitalize on anti-tumor immune activity and improve Merkel cell treatment response, although an enhanced immune system may cross-react with native tissues and lead to significant sequelae. METHODS:Here we present a case study of a patient with metastatic ... Read more >>

Strahlenther Onkol (Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al])
[2020, :]

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Paraneoplastic Diseases of the Central Nervous System.

Jonathan Galli, John Greenlee,

Paraneoplastic neurological syndromes are nonmetastatic complications of malignancy secondary to immune-mediated neuronal dysfunction or death. Pathogenesis may occur from cell surface binding of antineuronal antibodies leading to dysfunction of the target protein, or from antibodies binding against intracellular antigens which ultimately leads to cell death. There are several classical neurological ... Read more >>

F1000Res (F1000Research)
[2020, 9:]

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Limbic encephalitis associated with AMPA receptor and CRMP5 antibodies: A case report and literature review.

Yujuan Jia, Jie Wang, Lanping Xue, Yuli Hou,

AIMS:AMPA receptor (AMPAR) and CRMP5 antibodies are relatively uncommon in limbic encephalitis, and patients with both antibodies are rare. We recently treated such a patient, but the patient died after active treatment. To further understand this disease, we conducted a case report and literature review. DISCUSSIONS:To date, five encephalitis patients, ... Read more >>

Brain Behav (Brain and Behavior)
[2020, 10(3):e01528]

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Stiff Person Syndrome and Acetylcholine Receptor Ganglionic Neuronal Antibodies.

Jacobo Lester, Jimmy Cojab, Enrique Klériga,

The association between stiff person syndrome and paraneoplastic syndromes has been described, linking intracellular or extracellular antibodies. We describe the case of a 64-year-old woman with stiff person syndrome and positivity for acetylcholine receptor ganglionic neuronal antibodies, which can also be seen in muscular hyperexcitability conditions, as well as other ... Read more >>

Case Rep Neurol (Case reports in neurology)
[2020, 12(1):24-26]

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Phenotypic presentations of paraneoplastic neuropathies associated with MAP1B-IgG.

Jiraporn Jitprapaikulsan, C J Klein, Sean J Pittock, Avi Gadoth, Andrew McKeon, John R Mills, Divyanshu Dubey,

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(3):328-330]

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A Case of Paraneoplastic Neurological Syndrome Expressing Dual Antineuronal Antibodies: Anti-Hu and Recoverin.

Ho-Sung Ryu, Shin Yup Lee, Dong Ho Park, Jong-Mok Lee,

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(1):133-135]

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Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature.

Lisa M Cordes, Nicole N Davarpanah, Lauren B Reoma, Billel Gasmi, Martha Quezado, Omar I Khan, Avindra Nath, Andrea B Apolo,

We report a case of nivolumab-induced delayed-onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach. ... Read more >>

Clin Case Rep (Clinical case reports)
[2020, 8(1):24-32]

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Anti-SOX1 antibody-positive paraneoplastic neurological syndrome presenting with Lambert-Eaton myasthenic syndrome and small cell lung cancer: A case report.

Chunyang Li, Xiaolei Wang, Lihua Sun, Hui Deng, Yanqiu Han, Wenqi Zheng,

Paraneoplastic neurological syndromes (PNS) are rare disorders affecting any part of the central, peripheral or autonomic nervous system that occur in association with cancer. Among cancer patients, less than 1% overall develop PNS. Anti-SOX1 antibodies' positive paraneoplastic neurological disorders are rare and are usually associated with small cell lung cancer ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, 11(2):465-469]

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Brainstem dysfunction in critically ill patients.

Sarah Benghanem, Aurélien Mazeraud, Eric Azabou, Vibol Chhor, Cassia Righy Shinotsuka, Jan Claassen, Benjamin Rohaut, Tarek Sharshar,

The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. It controls the sleep-wake cycle and vital functions via the ascending reticular activating system and the autonomic nuclei, respectively. Brainstem dysfunction may lead to sensory and motor deficits, cranial ... Read more >>

Crit Care (Critical Care)
[2020, 24(1):5]

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Architecture of the Cutaneous Autonomic Nervous System.

Patrick Glatte, Sylvia J Buchmann, Mido Max Hijazi, Ben Min-Woo Illigens, Timo Siepmann,

The human skin is a highly specialized organ for receiving sensory information but also to preserve the body's homeostasis. These functions are mediated by cutaneous small nerve fibers which display a complex anatomical architecture and are commonly classified into cutaneous A-beta, A-delta and C-fibers based on their diameter, myelinization, and ... Read more >>

Front Neurol (Frontiers in Neurology)
[2019, 10:970]

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Seronegative autoimmune autonomic ganglionopathy from dual immune checkpoint inhibition in a patient with metastatic melanoma.

Catherine A Gao, Urs M Weber, Aldo J Peixoto, Sarah A Weiss,

BACKGROUND:Immune checkpoint inhibitors have improved clinical outcomes including survival in several malignancies but have also been associated with a range of immune-related adverse events (irAEs). Neurological irAEs are rare compared to the more typical skin, gastrointestinal, and endocrine toxicities, and are often underrecognized and challenging to diagnose. Here, we report ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2019, 7(1):262]

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Anti-Hu Antibody-Associated Adie's Pupil and Paraneoplastic Sensorimotor Polyneuropathy Caused by Primary Mediastinal Small Cell Carcinoma.

Lei Zhang, Si Luo, Hui Jin, Xueman Lv, Jiajun Chen,

We report a woman with unilateral Adie's pupil associated with peripheral sensorimotor polyneuropathy, elevated anti-Hu antibody, and primary mediastinal small cell carcinoma (SCC). To our knowledge, this is the first report of Adie's pupil in a patient with mediastinal SCC. Although rare, Adie's pupil and sensorimotor polyneuropathy may be the ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:1236]

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Peripheral nerve disease secondary to systemic conditions in children.

Jo M Wilmshurst, Robert A Ouvrier, Monique M Ryan,

This review is an overview of systemic conditions that can be associated with peripheral nervous system dysfunction. Children may present with neuropathic symptoms for which, unless considered, a causative systemic condition may not be recognized. Similarly, some systemic conditions may be complicated by comorbid peripheral neuropathies, surveillance for which is ... Read more >>

Ther Adv Neurol Disord (Therapeutic advances in neurological disorders)
[2019, 12:1756286419866367]

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The clinical significance of atypical indirect immunofluorescence patterns on primate cerebellum in paraneoplastic antibody screening.

Joris Godelaine, Xavier Bossuyt, Koen Poesen,

PurposeScreening for paraneoplastic antibodies is often performed by means of indirect immunofluorescence on primate cerebellar slices. However, atypical immunofluorescence patterns, i.e. patterns that are not specifically related to paraneoplastic antibodies, are often reported. The clinical significance of these patterns is not clear. Therefore, the purpose of this study was to ... Read more >>

Auto Immun Highlights (Autoimmunity Highlights)
[2019, 10(1):]

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18 F-Fluorodeoxyglucose positron-emission tomography for the investigation of malignancy in patients with suspected paraneoplastic neurologic syndromes and negative or indeterminate conventional imaging: a retrospective analysis of the Ontario PET Access Program, with systematic review and meta-analysis.

C Harlos, U Metser, R Poon, P MacCrostie, W Mason,

Objective:Paraneoplastic neurologic syndrome (pns) is a rare condition indirectly caused by an underlying malignancy. In many cases, the malignancy is occult at the time of the pns diagnosis, and the optimal diagnostic modality to detect the underlying tumour is unclear. In the present study, we aimed to assess the utility ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2019, 26(4):e458-e465]

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Secondary Parkinson disease caused by breast cancer during pregnancy: A case report.

Lei Li,

BACKGROUND:Paraneoplastic neurological syndrome manifesting as secondary Parkinson disease caused by breast cancer is extremely rare. CASE SUMMARY:We report a 39-year-old primipara of 31 gestational weeks, who presented with worsening tremors, facial stiffness and speech disfluencies, and decreased limb strength. Thorough physical examinations and auxiliary tests suggested secondary Parkinson's disease, but ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2019, 7(23):4052-4056]

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Cerebellar cortical degeneration associated with feline leukemia virus infection and cerebellar lymphoma in a young cat.

Alejandra Parra Pardo, Marcelo A Gómez, Carlos M González,

Background:Cerebellar cortical degeneration (CCD) is the premature death of cerebellar neurons of heterogeneous etiology that is uncommonly observed as a neurological complication of certain neoplasia. Case Description:Here, we report an 8-month-old male domestic cat with altered consciousness, symmetric ataxia, hypermetric gait, vertical positional nystagmus, mydriasis, strabismus, intention tremor of the ... Read more >>

Open Vet J (Open veterinary journal)
[2019, 9(3):246-252]

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Autoimmune autonomic neuropathies and ganglionopathies: epidemiology, pathophysiology, and therapeutic advances.

Elisabeth P Golden, Steven Vernino,

Autonomic disorders can be the result of autoimmunity. The classic, well-characterized example is autoimmune autonomic ganglionopathy (AAG), in which antibodies against the ganglionic nicotinic acetylcholine receptor impair autonomic transmission, causing autonomic failure, which responds to immunotherapy. However, a number of other autoimmune disorders cause autonomic failure through a variety of ... Read more >>

Clin. Auton. Res. (Clinical autonomic research : official journal of the Clinical Autonomic Research Society)
[2019, 29(3):277-288]

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A Rare Case of Acute Transverse Myelitis (ATM) and Acute Motor and Sensory Axonal Neuropathy (AMSAN) Overlap.

Zarmina Javed, Waseem T Malik, Omair Ul Haq Lodhi,

Concomitant acute transverse myelitis (ATM) and Guillain-Barre syndrome (GBS) is described as GBS and ATM overlap. Its presentation varies greatly, thus making the diagnosis difficult. Overlap syndrome is more commonly associated with acute motor axonal neuropathy (AMAN) subtype of GBS. However, we present a case of a middle-aged gentleman with ... Read more >>

Cureus (Cureus)
[2019, 11(8):e5426]

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Lambert-Eaton Myasthenic Syndrome Secondary to Nivolumab and Ipilimumab in a Patient with Small-Cell Lung Cancer.

Kavita Agrawal, Nirav Agrawal,

We present a case of a 59-year-old male with a confirmed diagnosis of small-cell lung cancer (SCLC). He had progressive disease even after four cycles of cisplatin and etoposide chemotherapy and 21 cycles of radiation. He was therefore started on immunotherapy with nivolumab every 2 weeks and ipilimumab every 6 ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2019, 2019:5353202]

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CMT2A Harboring Mitofusin 2 Mutation with Optic Nerve Atrophy and Normal Visual Acuity.

Silvana Guerriero, Francesco D'Oria, Giacomo Rossetti, Rosa Anna Favale, Stefano Zoccolella, Giovanni Alessio, Vittoria Petruzzella,

Charcot-Marie-Tooth (CMT) constitutes a group of heterogeneous hereditary motor and sensor neuropathies. Mutations in mitofusin-2 (MFN2) cause CMT type 2A by altering mitochondrial fusion and trafficking along with the axonal microtubule system. In literature patients presenting with CMT2A are reported as having a subacute onset of optic atrophy associated with ... Read more >>

Int Med Case Rep J (International medical case reports journal)
[2020, 13:41-45]

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Antibody Negative Autoimmune Encephalitis- Does it Differ from Definite One?

Sunil Pradhan, Animesh Das, Ananya Das, Madhura Mulmuley,

Context:Autoimmune encephalitis (AE) is an emerging cause of non-infective encephalitis, presentations of which vary widely. Traditionally the diagnosis of AE is based on detection of antibodies in a patient with clinical picture suggestive of AE. Aim:To evaluate the clinical characteristics and response to immunotherapy in patients with antibody negative autoimmune ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2019, 22(4):401-408]

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