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Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster.

Heiko Meyer, Annika Buhr, Patrick Callaerts, Ronja Schiemann, Mariana F Wolfner, Steven J Marygold,

The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is associated with numerous human diseases. Here, we present a comprehensive list and classification of M13 family members in <i>Drosophila melanogaster</i>. Seven <i>Neprilysin</i> (<i>Nep</i>) ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Ovarian somatic Piwi regulates nurse cell proliferation and oocyte specification in Drosophila.

Lauren E Gonzalez, Gina Zhu, Haifan Lin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Piwi in the stem cell niche regulates nurse cell number and oocyte specification.

Gina Zhu, Lauren E Gonzalez, Haifan Lin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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fs(1)A13041 is a 5' UTR deletion of the essential gene small ovary in Drosophila.

Myles Hammond, Jillian G Gomez, Brian Oliver, Steve Kucera, Leif Benner,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Drosophila Plc21C is involved in calcium wave propagation during egg activation.

Qinan Hu, Adriana N Vélez-Avilés, Mariana F Wolfner,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats.

Firdaus Kausar, Muzafar Ahmad Rather, Showkeen Muzamil Bashir, Rana M Alsaffar, Showkat Ul Nabi, Sofi Imtiyaz Ali, Pankaj Goswami, Ansar Ahmad, Summya Rashid, Adil Farooq Wali,

<h4>Objectives</h4>The current study was designed to examine the therapeutic role of hydroalcoholic extract of <i>Cuscuta reflexa</i> Roxb (CRE) and <i>Peucedanum grande</i> C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats.<h4>Methods</h4>PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):94-104]

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Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models.

Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu, Rui Li,

<h4>Context</h4>Processing with vinegar could enhance the efficacy and reduce the toxicity of <i>Curcuma phaeocaulis</i> Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities.<h4>Objective</h4>This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity of <i>C. phaeocaulis</i> through zebrafish and rat models.<h4>Materials and methods</h4>Zebrafish embryos (AB and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):410-417]

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Creutzfeldt-Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues.

Collin C Luk, Candace K Mathiason, Christina D Orrù, Gerard H Jansen, Allison Thiele, Byron Caughey, Valerie L Sim,

Sporadic Creutzfeldt-Jakob Disease (sCJD) rarely affects women of childbearing age. There is currently no evidence of vertical transmission. Given the biosafety implications of performing Caesarean sections (C-section) in these patients, we used sensitive real-time quaking-induced conversion (RT-QuIC) assays to test for the infectious prion protein (PrP<sup>Sc</sup>) in products of gestation. ... Read more >>

Prion (Prion)
[2021, 15(1):107-111]

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Seeking synergies: understanding the evidence that links menstrual health and sexual and reproductive health and rights.

Lucy C Wilson, Kate H Rademacher, Julia Rosenbaum, Rebecca L Callahan, Geeta Nanda, Sarah Fry, Amelia C L Mackenzie,

Global efforts to improve menstrual health and sexual and reproductive health and rights (SRHR) are fundamentally intertwined and share similar goals for improving health and well-being and increasing gender equality. Historically, however, the two fields have operated independently and missed opportunities to build upon their biological and sociocultural linkages. Biological ... Read more >>

Sex Reprod Health Matters (Sexual and reproductive health matters)
[2021, 29(1):1882791]

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Evolution and diversification of the nuclear envelope.

Norma E Padilla-Mejia, Alexandr A Makarov, Lael D Barlow, Erin R Butterfield, Mark C Field,

Eukaryotic cells arose ~1.5 billion years ago, with the endomembrane system a central feature, facilitating evolution of intracellular compartments. Endomembranes include the nuclear envelope (NE) dividing the cytoplasm and nucleoplasm. The NE possesses universal features: a double lipid bilayer membrane, nuclear pore complexes (NPCs), and continuity with the endoplasmic reticulum, ... Read more >>

Nucleus (Nucleus (Austin, Tex.))
[2021, 12(1):21-41]

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Reproductive cycle and embryonic development of the ornamental shrimp Lysmata ankeri

Jhonatan Willians Pimentel Costa, Tayana Yngrid da Silva Brito, Jerônimo Costa Marques Neto, Fernando Araújo Abrunhosa, Carlos Murilo Tenório Maciel, Cristiana Ramalho Maciel,

In this study, the maturation of the ovarian portion of the ovotestes, the viability of mating, and the embryonic development were investigated for Lysmata ankeri, an ornamental species widely exploited by marine aquariums that presents protandric simultaneous hermaphroditism. Two types of pairs were formed: hermaphrodite × hermaphrodite (HH, n = 7 pairs) ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2021, 543:Not Available]

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Correction to: Are Heavy Metal Exposure and Trace Element Levels Related to Metabolic and Endocrine Problems in Polycystic Ovary Syndrome?

Demet Aydogan Kirmizi, Emre Baser, Vugar Ali Turksoy, Mustafa Kara, Ethem Serdar Yalvac, Ayse Yesim Gocmen,

Biol Trace Elem Res (Biological trace element research)
[2021, 199(9):3570]

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Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy.

Aisha Alsfouk,

Cyclin-dependent kinase 9 (CDK9) plays a vital role in transcription through regulation of short-lived anti-apoptotic genes required for cancer cell survival. Therefore, targeting CDK9 with small molecule inhibitors has emerged as a potential cancer therapy. This article reviews the most recent CDK9 patent literature (2012-2020) related to small molecule inhibitors ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):693-706]

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Correlation of Homeostatic Model Assessment-Insulin Resistance, Anti-Mullerian Hormone, and BMI in the Characterization of Polycystic Ovary Syndrome

Anupama Bahadur, Neha Verma, Rajlaxmi Mundhra, Latika Chawla, Megha Ajmani, Modalavalasa Swetha Sri, Shivaani Arora,

Objective: To evaluate the correlation of homeostatic model assessment-insulin resistance (HOMA-IR), anti-Mullerian hormone (AMH), and BMI and to compare their values across the different phenotypes in polycystic ovary syndrome (PCOS) women of the reproductive age group. Study design: A total of 307 PCOS-diagnosed women were included in the study and ... Read more >>

Cureus (Cureus)
[0, 13(6):]

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Resveratrol and Markers of Polycystic Ovary Syndrome: a Systematic Review of Animal and Clinical Studies.

Sara Shojaei-Zarghani, Maryam Rafraf,

Polycystic ovary syndrome (PCOS) is a common disorder affecting childbearing-age women, and is associated with reproductive and metabolic disturbances. The present study aimed to systematically review current animal studies and randomized placebo-controlled clinical trials (RCT) regarding the effects of resveratrol, a natural polyphenolic compound, on PCOS features. PubMed, Scopus, Web ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2021, :]

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Investigating the potential of clinical and biochemical markers to differentiate between functional hypothalamic amenorrhoea and polycystic ovarian syndrome: a retrospective observational study.

Sara Abou Sherif, Rebecca Newman, Sara Haboosh, Ahmed Al-Sharefi, Nikoleta Papanikolaou, Anastasia Dimakopoulou, Lisa J Webber, Ali Abbara, Stephen Franks, Waljit S Dhillo, Channa N Jayasena,

<h4>Objectives</h4>Functional hypothalamic amenorrhoea (FHA) is a common cause of amenorrhoea, but diagnosis can be challenging. The aim of this study was to investigate the clinical and biochemical features of FHA, compared to that of polycystic ovarian syndrome (PCOS) and assess the diagnostic performance of the different parameters for differentiating the ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2021, :]

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Lower sexual satisfaction in women with polycystic ovary syndrome and metabolic syndrome.

Małgorzata Kałużna, Agnieszka Nomejko, Aleksandra Słowińska, Katarzyna Wachowiak-Ochmańska, Katarzyna Pikosz, Katarzyna Ziemnicka, Marek Ruchala,

<h4>Background</h4>Polycystic ovary syndrome (PCOS) is a multi-symptom disorder linked with a range of metabolic and hormonal disturbances. Psychological and sexual aspects of PCOS also need to be considered.<h4>Objective of the study</h4>This study aimed to assess sexual satisfaction(SS) in PCOS patients and eumenorrheic controls (CON). The relationships between SS, depressive symptoms, ... Read more >>

Endocr Connect (Endocrine connections)
[2021, :]

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Changes in Proteomics of Endometrial Tissue During Secretion of Polycystic Ovary Syndrome May Affect Endometrial Receptivity

Jun Li, Xiaohua Jiang, Caihua Li, Huihui Che, Lin Ling, Zhaolian Wei,

Embryo implantation is a complex developmental process that requires coordinated interactions of embryo, endometrium and microenvirment of endometrium factors. Although impaired endometrial receptivity of patients of PCOS have been identified, our understanding of endometrial receptivity is limited. To understand impaired endometrial receptivity of patients of PCOS during luteal phases, a ... Read more >>

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Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.

Yingying Wang, Zhengyan Zeng, Shuhua Zhao, Li Tang, Jin Yan, Nianyu Li, Liping Zou, Xiaorong Fan, Chengcheng Xu, Jin Huang, Wei Xia, Changhong Zhu, Meng Rao,

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism and insulin resistance (IR); however, the pathogenesis of local ovarian IR in PCOS remains largely unclear. Humanin, a mitochondria-derived peptide, has been reported to be associated with IR. Our previous study confirmed ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(8):]

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Characteristics of surgically transposed ovaries on 18F-FDG PET/CT among patients with cancer.

Kwan Hyeong Jo, Soyoung Kim, Sang Hyun Hwang, Yong Hyu Jeong, Eun Ji Nam, Won Jun Kang,

<h4>Objective</h4>Fertility preservation in women with cancer is important for improving their quality of life. Successful ovarian transposition protects the ovary from radiation and preserves ovarian endocrine function and fertility. With the increasing use of <sup>18</sup>F-FDG PET/CT in gynecologic malignancies, the findings of transposed ovaries sometimes vary. This study aimed to ... Read more >>

Ann Nucl Med (Annals of nuclear medicine)
[2021, :]

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The relationship between presystolic wave and subclinical left ventricular dysfunction assessed by myocardial performance ındex in patients with polycystic ovary syndrome.

Faysal Saylik, Tayyar Akbulut,

<h4>Background</h4>Polycystic ovary syndrome (PCOS) patients have left ventricular dysfunction (LVD) in an earlier stage. Myocardial performance index (MPI) reflects both systolic and diastolic dysfunction. A presystolic wave (PSW) detected on late diastole has been found to be associated with LVD.<h4>Aims</h4>We sought to determine whether there is an association between PSW ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2021, :]

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Randomized double blind clinical trial evaluating the Ellagic acid effects on insulin resistance, oxidative stress and sex hormones levels in women with polycystic ovarian syndrome.

Mahnaz Kazemi, Fatemeh Lalooha, Mohammadreza Rashidi Nooshabadi, Fariba Dashti, Maria Kavianpour, Hossein Khadem Haghighian,

<h4>Objective</h4>The design of this study was due to the report of the antioxidant properties of Ellagic acid (EA) for its evaluation on the Insulin resistance (IR), oxidative stress and sex hormones levels in women with polycystic ovarian syndrome (PCOS).<h4>Methods</h4>In this randomized, double-blind, placebo-controlled clinical trial, 60 patients were recruited. Patients ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2021, 14(1):100]

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Association Between Menstrual Patterns and Adverse Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome Undergoing in Vitro Fertilization/Intracytoplasmic Sperm Injection Embryo Transfer Cycles with The Long-Acting Long-Term Follicular Phase: A Retrospective Analysis

Ting Yu, Di Wu, Yurong Cao, Jun Zhai,

<h4>Background: </h4> Menstrual patterns of patients with polycystic ovary syndrome (PCOS) is considered to be related to metabolism, but no study has analyzed the outcome of in vitro fertilization in patients with PCOS who have different menstrual patterns. This study aimed to observe the outcomes of in vitro fertilization in ... Read more >>

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LncRNA TMPO-AS1 suppresses the maturation of miR-335-5p to participate in polycystic ovary syndrome.

Fang Hou, Jie Li, Jie Peng, Zhenghua Teng, Jun Feng, Weiwei Xia,

<h4>Background</h4>TMPO-AS1 is a recently characterized oncogenic lncRNA in ovarian cancer. Its role in other ovary diseases is unknown. This study explored its role in polycystic ovary syndrome (PCOS).<h4>Methods</h4>Follicular fluid was extracted from both PCOS patients and controls. The levels of TMPO-AS1 and mature and premature miR-335-5p were analyzed by RT-qPCR. ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2021, 14(1):99]

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Polycystic Ovary Syndrome Phenotype Does Not Have Impact on Oocyte Morphology

Audrey Uk, Christine Decanter, Camille Grysole, Laura Keller, Hélène Béhal, Mauro Silva, Didier Dewailly, Geoffroy Robin, anne-laure barbotin,

<h4>Purpose: </h4> The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype. <h4>Methods: </h4> We performed a retrospective cohort study in the IVF unit at the Lille University ... Read more >>

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