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Estrogens still represent an attractive therapeutic approach for Alzheimer's disease.

Elena Tamagno, Michela Guglielmotto,

Neural Regen Res (Neural regeneration research)
[2022, 17(1):93-94]

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Prevalence and risk analysis of mobile colistin resistance and extended-spectrum β-lactamase genes carriage in pet dogs and their owners: a population based cross-sectional study.

Lei Lei, Yongqiang Wang, Junjia He, Chang Cai, Qingzhi Liu, Dawei Yang, Zhiyu Zou, Lingyu Shi, Jianqin Jia, Yang Wang, Timothy R Walsh, Jianzhong Shen, Yougang Zhong,

Mobile colistin resistance gene <i>mcr-1</i> and extended-spectrum <i>β</i>-lactamase gene <i>bla</i> <sub>CTX-M</sub> are highly prevalent in human - and pet-derived bacteria. Isolation of identical strains of <i>mcr-1</i>-positive <i>Escherichia coli</i> (MCRPEC) or <i>bla</i> <sub>CTX-M</sub>-positive <i>E. coli</i> (CTX-MPEC) from pets and humans highlighted the potential for co-colonization of antibiotic-resistant bacteria which can be ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):242-251]

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The miR-1906 mimic attenuates bone loss in osteoporosis by down-regulating the TLR4/MyD88/NF-κB pathway.

H Xie, L Cao, L Ye, G Shan, W Song,

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3-E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase ... Read more >>

Physiol Int (Physiology international)
[2021, 107(4):469-478]

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Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells.

Xiaochen Wang, Yaochuan Mi, Wei He, Xiaona Hu, Shuo Yang, Lu Zhao, Yanyang Zhang, Binhong Wen,

Diabetic osteoporosis (DOP) is a chronic complication of diabetes in the skeletal system. High level of miR-340-5p may be harmful to the bone formation. In this study, the DOP model of rats was successfully established via streptozotocin (STZ) and ovariectomy (OVX) treatment. It was manifested by reduced body weight, insulin ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1126-1137]

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The effect of splash block on the need for analgesia in dogs subjected to video-assisted ovariectomy.

Vincenzo Cicirelli, Giovanni M Lacalandra, Giulio G Aiudi,

<h4>Objectives</h4>The present study aimed to demonstrate the efficacy of splash block using lidocaine to provide additional analgesia during ovariectomy in bitches. To identify an acute intraoperative nociceptive response, three clinical parameters were used: increased blood pressure, heart rate and respiratory rate.<h4>Material and methods</h4>Forty healthy bitches were randomly assigned to receive ... Read more >>

Vet Med Sci (Veterinary medicine and science)
[2021, :]

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6-hydroxydopamine and ovariectomy has no effect on heart rate variability parameters of females.

Tomás de la Rosa, Viviam Sanabria Calvo, Valeria Cassia Gonçalves, Débora Amado Scerni, Fúlvio Alexandre Scorza,

<h4>Objectives</h4>In addition to the classic motor symptoms of Parkinson's disease (PD), patients also present with non-motor symptoms, such as autonomic dysfunction, which is present in almost 90% of patients with PD, affecting the quality of life and mortality. Regarding sex differences in prevalence and presentation, there is increasing concern about ... Read more >>

Clinics (Sao Paulo) (Clinics (Sao Paulo, Brazil))
[2021, 76:e3175]

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Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer

Elizabeth Wellberg, Karen Corleto, Allyson Checkley, Sonali Jindal, Ginger Johnson, Janine Higgins, Sarina Obeid, Steven Anderson, Ann Thor, Pepper Schedin, Paul MacLean, Erin Giles,

<h4>ABSTRACT</h4> Obesity and adult weight gain are linked to increased breast cancer risk and poorer clinical outcomes in postmenopausal women, particularly for hormone-dependent tumors. Menopause is a time when significant weight gain occurs in many women, and clinical and preclinical studies have identified menopause (or ovariectomy) as a period of ... Read more >>

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Trends in the Use of Minimally Invasive Adnexal Surgery in the United States.

Shayan Dioun, Yongmei Huang, Alexander Melamed, Allison Gockley, Caryn M St Clair, June Y Hou, Ana I Tergas, Fady Khoury-Collado, Dawn L Hershman, Jason D Wright,

<h4>Objective</h4>To examine the utilization of minimally invasive adnexal surgery, including ovarian cystectomy and oophorectomy, among women with benign gynecologic diseases and compare the associated morbidity and mortality of minimally invasive and open surgery.<h4>Methods</h4>Women with benign ovarian pathology who underwent an ovarian cystectomy or oophorectomy from 2016 through 2018 in the ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2021, :]

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Effects of early estradiol valerate administration on bone turnover markers in surgically induced menopausal women.

Jarika Vatrasresth, Ammarin Suwan, Krasean Panyakhamlerd,

<h4>Background</h4>Compared with a natural process, surgically induced menopausal women have a higher bone loss rate. This study aims to evaluate early treatment with estradiol valerate on bone turnover markers after surgically induced menopause.<h4>Methods</h4>This prospective study included 41 pre and perimenopausal women who underwent hysterectomy with oophorectomy for benign gynecologic conditions. ... Read more >>

BMC Womens Health (BMC women's health)
[2021, 21(1):363]

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Ovariectomy Causes Degeneration of Perivascular Adipose Tissue.

Tomomi Nakamura, Kento Miyamoto, Hirona Kugo, Keita Sutoh, Keisuke Kiriyama, Tatsuya Moriyama, Nobuhiro Zaima,

Women are more resistant than men to the development of vascular diseases. However, menopause is a factor leading to deterioration of female vascular integrity, and it is reported that the risk of vascular diseases such as atherosclerosis and abdominal aortic aneurysm is increased in postmenopausal women. Although it is suggested ... Read more >>

J Oleo Sci (Journal of oleo science)
[2021, :]

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A Comparison of Times Taken for the Placement of the First Portal and Complication Rates between the Veress Needle Technique and the Modified Hasson Technique in Canine Ovariectomy Laparoscopic Surgery

Amanda Bianchi, Francesco Collivignarelli, Massimo Vignoli, Lorenzo Scaletta, Amedeo Cuomo, Ilaria Falerno, Andrea Paolini, Roberto Tamburro,

<h4>Simple Summary</h4> Laparoscopy is routinely used in veterinary medicine for both diagnostic and operative procedures. Laparoscopy requires the creation of a pneumoperitoneum to increase the working space, and the placement of portals to allow the insertion of instruments into the abdominal cavity. Instrument insertion is associated with most of the ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2021, 11(10):]

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Rapamycin Alleviates Cancellous Bone Loss and Cortical Bone Porosity In Ovariectomized Mice But Not Overall Biomechanical Performance

Ruoyao Li, Junhao Liu, Zhiping Huang, Xiuhua Wu, Qingan Zhu,

<h4>Background: </h4> Recent studies have shown that rapamycin (Rapa) rescues cancellous bone loss of osteoporosis models, but its effects on cortical bone and the biomechanical properties remain uncertain. This study was aimed to determine whether rapamycin improve the quality of long bones in ovariectomy (OVX)-induced osteoporosis. <h4>Methods: </h4>: Thirty female ... Read more >>

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Tributyltin protects against ovariectomy-induced trabecular bone loss in C57BL/6J mice with an attenuated effect in high fat fed mice.

Rachel Freid, Amira I Hussein, Jennifer J Schlezinger,

Risk factors for poor bone quality include estrogen loss at menopause, a high fat diet and exposures to drugs/chemicals that activate peroxisome proliferator activated receptor gamma (PPARγ). We previously reported that the PPARγ and retinoid X receptor dual ligand, tributyltin (TBT), repressed periosteal bone formation but enhanced trabecular bone formation ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2021, 431:115736]

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piRNA-36741 regulates BMP2 mediated osteoblast differentiation via METTL3 controlled m6A modification.

Jianmin Liu, Ming Chen, Longyang Ma, Xingbo Dang, Gongliang Du,

The osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is essential for bone formation, and its imbalance can lead to bone diseases such as osteoporosis. It is reported that PIWI-interacting RNA-36741 (piR-36741) is up-regulated during the osteogenic differentiation, but its role in regulating osteogenic differentiation remains unclear. Here, the ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(undefined):]

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Combined laparoscopic ovariectomy and laparoscopic-assisted gastropexy utilizing a 2-port technique in 10 dogs.

Andrew C Radford, Nicole C Bonaventura, Justin B Ganjei,

A case series was selected retrospectively to evaluate the technique, outcome, and short-term complications associated with a combined laparoscopic ovariectomy (Lap OVX) and laparoscopic-assisted gastropexy (LAG) using a 2-port technique, and to compare it with previously published combined laparoscopic techniques for Lap OVX and LAG in dogs. Medical records of ... Read more >>

Can Vet J (The Canadian veterinary journal = La revue veterinaire canadienne)
[2021, 62(10):1111-1116]

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Ovariectomy reduces vasocontractile responses of rat middle cerebral arteries after focal cerebral ischemia.

Mimmi Rehnström, Hilda Ahnstedt, Diana N Krause, Marie Louise Edvinsson, Kristian Agmund Haanes, Lars Edvinsson,

<h4>Abstract</h4>Effects of sex hormones on stroke outcome is not fully understood. A deleterious consequence of cerebral ischemia is upregulation of vasoconstrictor receptors in cerebral arteries that exacerbate stroke injury. Here, we tested the hypothesis that female sex hormones alter vasocontractile responses after experimental stroke in vivo or following organ culture ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2021, :]

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A ruptured cornual pregnancy successfully managed in a patient with a history of oophorectomy and salpingectomy: A rare case report

Marah Mansour, Amr Hamza, AlHomam AlMarzook, Ilda moafak kanbour, Tamim Alsuliman, Bashar kurdi,

Abstract Cornual pregnancy is a rare condition that accounts for approximately 2–4% of ectopic pregnancies worldwide. Herein, we report an unstable case of a 32‐year‐old woman with a history of oophorectomy and salpingectomy who was admitted for a ruptured cornual pregnancy in the left cornu, which was successfully managed by ... Read more >>

Clin Case Rep (Clinical case reports)
[2021, 9(10):]

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Lumbar Disk Degeneration in Female Patients with and without Ovariectomy: A Case-Control Study.

Yachao Zhao, Haidong Wang, Zhaohui Li, Zhiwei Wang, Yachong Huo, Sidong Yang, Wenyuan Ding,

<h4>Objective</h4>We sought to provide clinical evidence of the potential influence of ovariectomy (OVX) on intervertebral disk degeneration.<h4>Methods</h4>We retrospectively reviewed patients with a history of OVX who visited our hospital for lower back pain. In addition, 60 age-matched patients without OVX were randomly selected as control subjects. Next, the following demographic ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 156:68-75]

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Comparison of the incidence of intra-operative haemorrhage from ovarian vessels during ovariectomy and ovariohysterectomy of dogs and cats performed by inexperienced surgeons using surgeon's and constrictor knots.

E Belluzzi, M A Santos, A Jifcovici, G Redolfi, F Di Virgilio, A Deneuche, A L Bongartz, J A Caraty,

<h4>Aims</h4>To compare the incidence of intra-operative haemorrhage from ovarian vessels during ovariectomy (OV) and ovariohysterectomy (OVH) in dogs and cats performed by inexperienced surgeons using surgeon's and constrictor knots to ligate the ovarian pedicles.<h4>Methods</h4>All client-owned female dogs (n=51) and cats (n=102) that presented for OV or OVH at two referral ... Read more >>

N Z Vet J (New Zealand veterinary journal)
[2021, :1-13]

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Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies.

Eleftherios G Kaklamanos, Miltiadis A Makrygiannakis, Athanasios E Athanasiou,

<h4>Background</h4>The long-term use of contraceptive methods that contain estrogens, progestogens or combinations of the above among women aged 15 to 49 years is extensive. Both estrogens and progestogens affect bone metabolism.<h4>Objective</h4>To systematically investigate and appraise the quality of the available evidence from animal studies regarding the impact of exogenous administration ... Read more >>

PLoS One (PloS one)
[2021, 16(9):e0257778]

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Expression Profile Analysis of Long Non-coding RNA in OVX Models-Derived BMSCs for Postmenopausal Osteoporosis by RNA Sequencing and Bioinformatics.

Huijie Gu, Zhongyue Huang, Kaifeng Zhou, Guangnan Chen, Chong Bian, Jun Xu, Xiaofan Yin,

Osteoporosis (OP) has the characteristics of a systematically impaired bone mass, strength, and microstructure. Long non-coding RNAs (lncRNAs) are longer than 200 nt, and their functions in osteoporosis is yet not completely understood. We first harvested the bone marrow mesenchymal stem cells (BMSCs) from ovariectomy (OVX) and sham mice. Then, ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:719851]

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Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.

Zhuo Feng, Changyuan Wang, Yue, Jin, Qiang Meng, Jingjing Wu, Huijun Sun,

<h4>Context</h4>The effect of kaempferol, a regulator of oestrogen receptors, on atherosclerosis (AS) and the underlying mechanism is elusive.<h4>Objective</h4>To explore the effect and mechanism of kaempferol on AS.<h4>Methods and materials</h4><i>In vivo</i>, C57BL/6 and apolipoprotein E (APOE)<sup>-/-</sup> mice were randomly categorized into six groups (C57BL/6: control, ovariectomy (OVX), high-fat diet (HFD); APOE<sup>-/-</sup>: ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1106-1116]

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Dietary syringic acid reduces fat mass in an ovariectomy-induced mouse model of obesity.

Teruyoshi Tanaka, Kazuko Iwamoto, Maki Wada, Erika Yano, Toshiyuki Suzuki, Nobuhisa Kawaguchi, Norifumi Shirasaka, Tatsuya Moriyama, Yoshimi Homma,

<h4>Objective</h4>Postmenopausal women are at increased risk of metabolic diseases such as obesity and diabetes. Therefore, the chemoprevention of postmenopausal changes in health via dietary supplements is important. Syringic acid (SA) is a phenolic compound present in the fruit of the assai palm, Euterpe oleracea, and in the mycelium of the ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2021, :]

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Predominance of Heart Failure With Preserved Ejection Fraction in Postmenopausal Women: Intra- and Extra-Cardiomyocyte Maladaptive Alterations Scaffolded by Estrogen Deficiency.

Adebayo Oluwafemi Adekunle, Gabriel Komla Adzika, Richard Mprah, Marie Louise Ndzie Noah, Joseph Adu-Amankwaah, Ruqayya Rizvi, Nazma Akhter, Hong Sun,

Heart failure (HF) remains a public health concern as it is associated with high morbidity and death rates. In particular, heart failure with preserved ejection fraction (HFpEF) represents the dominant (>50%) form of HF and mostly occurring among postmenopausal women. Hence, the initiation and progression of the left ventricular diastolic ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:685996]

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Estradiol valerate enhances cardiac function via the Nrf2 signaling pathway to protect against oxidative stress by the Nrf2 signaling pathway in an ovariectomized rat model.

Xin Qian, Jiao Wang, Minghui Cai, Haijuan Sun, Han Xu, Haixia Wen, Hui Zhu,

<h4>Background</h4>The increased risk of cardiovascular disease (CVD) in postmenopausal women and ovariectomized patients suggests that estrogen has a protective effect on cardiac function. Oxidative stress is the main cause of CVD, and the cellular defensive Nrf2 antioxidant pathway plays a protective role in various pathologies. However, the regulation of Nrf2 ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2021, :]

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