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Wild Caught Nematode Identification and Early Embryo Development: An accessible undergraduate research experience.

Haley Attix, Alex George, Henali Panchal, Angel Cortez, Martin Cho, Kathy Zarilla, Eric Hastie,

Ample evidence suggests that participation in undergraduate research in community college is critical for stimulating interest and retention in STEM careers. Guided skill development and practice in a collaborative lab setting allows students to be competitive when applying to future research opportunities. The goals of this undergraduate research experience (URE) ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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DMSO reduces the cytotoxicity of anticancer ruthenium complex KP1019 in yeast.

Jonathan Davis, Anne Cetto, Mary Campbell, Seth Scoggins, Laura Stultz, Pamela Hanson,

Low solubility in aqueous solutions is a significant limitation of the otherwise promising anticancer ruthenium complex KP1019. In laboratory studies, this challenge is often overcome by using DMSO to help drive the drug into solution. Since DMSO was previously shown to alter the bioactivity of platinum-based chemotherapeutics, here we examine ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Recombination and biased segregation of mitochondrial genomes during crossing and meiosis of different Schizosaccharomyces pombe strains.

Stephan Kamrad, María Rodríguez-López, Shoumit Dey, Mimoza Hoti, Henry Wallace, Markus Ralser, Jürg Bähler,

During meiosis, tethering of parental mitochondria to opposite cell poles inhibits the mixing of mitochondria with different genomes and ensures uniparental inheritance in thestandard laboratory strain of fission yeast. We here investigate mitochondrial inheritance in crosses between natural isolates using tetrad dissection and next-generation sequencing. We find that colonies grown ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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The C. elegans pseudogene sspt-16 (F55A3.7) is required to safeguard germ cells against reprogramming.

Andreas Ofenbauer, Clara Maria Kraus, Baris Tursun,

We recently identified FAcilitates Chromatin Transcription (FACT) as a reprogramming barrier of transcription factor (TF) mediated conversion of germ cells into neurons in <i>C. elegans</i>. FACT is a conserved heterodimer consisting of SPT16 and SSRP1 in mammals. Duplication events during evolution in <i>C. elegans</i> generated two SSRP1 homologs named HMG-3 ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Repetitive mild traumatic brain injury causes synergistic effects on mortality.

Ashley M Willes, Tori R Krcmarik, Alexander E Daughtry, Douglas J Brusich,

Repetitive mild TBI (rmTBI) events are common in the U.S. However, rmTBI is challenging to study and this contributes to a poor understanding of mechanistic bases for disease following these injuries. We used fruit flies (<i>D. melanogaster</i>) and a modified version of the high-impact trauma (HIT) method of TBI to ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Pharyngeal pumping phenotypes of common fluorescently-tagged C. elegans strains.

Rosemary Bauer, Andy Golden,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Caenorhabditis elegans strain sensitivity to sodium arsenite exposure is varied based on age and outcome measured.

Kathleen Hershberger, Tess Leuthner, Tanner Waters, Joel Meyer,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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Pregnancy outcomes of COVID-19 positive pregnant women at the Cantonal Hospital Zenica, Bosnia and Herzegovina.

Jasmin Hodžić, Bedrana Muračević, Hana Štimjanin, Rasim Iriškić, Muamera Husika,

Aim To investigate clinical presentation of COVID-19 infection in pregnancy, its course during pregnancy, effects on pregnancy outcomes for both mothers and newborns as well as the potential for vertical transmission. Methods This retrospective observational study included all identifi ed COVID-19-positive pregnant women admitted to the Cantonal Hospital in Zenica ... Read more >>

Med Glas (Zenica) (Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina)
[2022, 19(1):]

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Stroke recovery enhancing therapies: lessons from recent clinical trials.

Andreas Rogalewski, Wolf-Rüdiger Schäbitz,

Poststroke recovery processes include restoration or compensation of function, respectively functions initially lost or new functions acquired after an injury. Therapeutic interventions can enhance these processes and/or reduce processes impeding regeneration. Numerous experimental studies suggest great opportunities for such treatments, but the results from recent large clinical trials using neuromodulators ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):717-720]

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Challenges in developing therapeutic strategies for mild neonatal encephalopathy.

Alice McDouall, Guido Wassink, Laura Bennet, Alistair J Gunn, Joanne O Davidson,

There is increasing evidence that infants with mild neonatal encephalopathy (NE) have significant risks of mortality, brain injury and adverse neurodevelopmental outcomes. In the era of therapeutic hypothermia, infants need to be diagnosed within 6 hours of birth, corresponding with the window of opportunity for treatment of moderate to severe ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):277-282]

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Immediate Effect of Ankle Mobilization on Range of Motion, Dynamic Knee Valgus, and Knee Pain in Women With Patellofemoral Pain and Ankle Dorsiflexion Restriction: A Randomized Controlled Trial With 48-Hour Follow-Up.

Bruno Augusto Lima Coelho, Helena Larissa das Neves Rodrigues, Gabriel Peixoto Leão Almeida, Sílvia Maria Amado João,

<h4>Context</h4>Restriction in ankle dorsiflexion range of motion (ROM) has been previously associated with excessive dynamic knee valgus. This, in turn, has been correlated with knee pain in women with patellofemoral pain.<h4>Objectives</h4>To investigate the immediate effect of 3 ankle mobilization techniques on dorsiflexion ROM, dynamic knee valgus, knee pain, and patient ... Read more >>

J Sport Rehabil (Journal of sport rehabilitation)
[2021, 30(5):697-706]

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Efficacy of Meditation-Based Interventions on Post-Traumatic Stress Disorder (PTSD) Among Veterans: A Narrative Review.

Taj Haider, Chia-Liang Dai, Manoj Sharma,

<h4>Background</h4>Decades of research have documented post-traumatic stress disorder (PTSD) symptoms in war veterans. Current treatment options for PTSD are unappealing as they either require re-exposure to the traumatic event or medications that are greatly impacted by comorbidities. Meditation-based interventions are a promising alternative. However, there is a dearth of research ... Read more >>

Adv Mind Body Med (Advances in mind-body medicine)
[2021, 35(1):16-24]

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A randomized, active-controlled, multicentre clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated or complicated urinary tract infection.

Ying Li, Yousheng Yin, Xiaomei Peng, Hongguang Zheng, Fajun Fu, Zhenxiang Liu, Xiongfei Wu, Xiaoyan Wu, Song Zheng, Nan Chen, Leye He, Laicheng Ren, Zhaohui Ni, Detian Li, Peiyu Liang, Xiaoju Lv, Yingyuan Zhang,

<h4>Purpose</h4>To evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated urinary tract infection (UTI) or complicated UTI.<h4>Methods</h4>In this randomized, active-controlled clinical trial, the patients with acute uncomplicated UTI were randomized to receive sitafloxacin 100-mg once-daily (qd) or levofloxacin 500-mg qd orally for 3-5 days. ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):217-226]

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Economic Evaluation of Total Laboratory Automation in the Clinical Laboratory of a Tertiary Care Hospital.

KyungYi Kim, Sang-Guk Lee, Tae Hyun Kim, Sang Gyu Lee,

<h4>Background</h4>Total laboratory automation (TLA) is an innovation in laboratory technology; however, the high up-front costs restrict its widespread adoption. To examine whether the capital investment for TLA is worthwhile, we analyzed its clinical- and cost-effectiveness for the expected payback period.<h4>Methods</h4>Clinical chemistry tests and immunoassays performed in the clinical laboratory of ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(1):89-95]

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Therapeutic Antibodies: An Overview.

Gunnar Houen,

Polyclonal immunoglobulin (Ig) preparations have been used for several decades for treatment of primary and secondary immunodeficiencies and for treatment of some infections and intoxications. This has demonstrated the importance of Igs, also called antibodies (Abs) for prevention and elimination of infections. Moreover, elucidation of the structure and functions of ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2313:1-25]

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Cognitive Behavioral Therapy for Patients with Trigeminal Neuralgia: A Feasibility Study.

H Clare Daniel, Jolyon Ji Poole, Helene Klein, Cleo Huang, Joanna M Zakrzewska,

<h4>Aims</h4>To test the feasibility and acceptability of a customized six-session cognitive behavioral therapy (CBT) group intervention for adults with recurrent trigeminal neuralgia (TN).<h4>Methods</h4>Fifteen participants with TN were recruited from a specialist facial pain unit in London, United Kingdom. The effects of the group intervention were evaluated using validated self-report measures, ... Read more >>

J Oral Facial Pain Headache (Journal of oral & facial pain and headache)
[2021, 35(1):30-34]

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Walnut intake, cognitive outcomes and risk factors: a systematic review and meta-analysis.

Danielle Cahoon, Shruti P Shertukde, Esther E Avendano, Jirayu Tanprasertsuk, Tammy M Scott, Elizabeth J Johnson, Mei Chung, Nanguneri Nirmala,

<h4>Background</h4>Walnuts contain nutrients that are associated with improved cognitive health. To our knowledge, no review has systematically examined the effects of walnuts on cognitive function and risk for cognitive decline.<h4>Objective</h4>To conduct a systematic review and meta-analysis evaluating the effects of walnut intake on cognition-related outcomes and risk-factors for cognitive decline ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):971-997]

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Arthrocentesis of the Temporomandibular Joint: Systematic Review and Clinical Implications of Research Findings.

Luca Guarda-Nardini, Andrè Mariz De Almeida, Daniele Manfredini,

<h4>Aims</h4>To review randomized clinical trials on arthrocentesis for managing temporomandibular disorders (TMD) and to discuss the clinical implications.<h4>Methods</h4>On March 10, 2019, a systematic search of relevant articles published over the last 20 years was performed in PubMed, as well as in Scopus, the authors' personal libraries, and the reference lists ... Read more >>

J Oral Facial Pain Headache (Journal of oral & facial pain and headache)
[2021, 35(1):17-29]

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Thoracic sympathectomy for the treatment of primary axillary hyperhidrosis: systematic review and proportional meta-analysis.

Gilmar Felisberto, Antônio José Maria Cataneo, Daniele Cristina Cataneo,

<h4>Introduction</h4>Primary hyperhidrosis is a disorder that involves excessive sweat production, which has a negative impact on the quality of life.<h4>Objective</h4>To evaluate the effectiveness and safety of video-assisted thoracoscopic sympathectomy (VATS) for treating primary axillary hyperhidrosis (PAH) and determine which level of ganglion resection offers the best outcome.<h4>Method</h4>This was a systematic ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1216-1226]

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Ethnic differences in acute promyelocytic leukaemia between New Zealand Polynesian and European patients.

Chris Varghese, Valery Yizhuo Liu, Tracey Immanuel, Nicole Chien, Taryn Green, George Chan, Edward Theakston, Maggie Kalev-Zylinska,

Ethnic differences in haematologic malignancies remain poorly elucidated, hence research in this area is important. This was a retrospective study into potential ethnic disparity in the presentation and outcomes of acute promyelocytic leukaemia (APL) between New Zealand (NZ) Polynesian and European patients. Data were analysed for patients treated at Auckland ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):215-224]

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Post-residency medical education fellowships: a scoping review.

Mariel L Cataldi, Margot Kelly-Hedrick, Julie Nanavati, Margaret S Chisolm, Walsh Anne L,

The authors conducted a scoping review to investigate the structure, content, and potential impact of post-residency medical education fellowships. The authors searched eight databases to identify English-language articles describing longitudinal, post-residency medical fellowships that both focused on medical education and described the structure and content of the curriculum. The authors ... Read more >>

Med Educ Online (Medical education online)
[2021, 26(1):1920084]

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Effectiveness of multimodal nutrition interventions during pregnancy to achieve 2009 Institute of Medicine gestational weight gain guidelines: a systematic review and meta-analysis.

Andrew R Beauchesne, Kelly Copeland Cara, Jiawen Chen, Qisi Yao, Laura Paige Penkert, Wenfang Yang, Mei Chung,

<h4>Background</h4>In 2009, the Institute of Medicine (IOM) published a revision to its 1990 recommendations on gestational weight gain (GWG). The objective of this review is to update a previous systematic review and meta-analysis to evaluate the effectiveness of nutrition interventions in achieving recommended GWG.<h4>Methods</h4>We conducted updated literature searches in MEDLINE<sup>®</sup> ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1179-1197]

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A cost-effectiveness analysis of the prophylaxis versus on-demand regimens in severe hemophilia A patients under 12 years old in southern Iran.

Zohreh Zahedi, Mehran Karimi, Khosro Keshavarz, Sezaneh Haghpanah, Ramin Ravangard,

<h4>Objective</h4>This study aimed to compare the cost-effectiveness of these two regimens in hemophilia A patients, under-12-years-old in southern Iran.<h4>Methods</h4>A cost-effectiveness study comparing prophylaxis versus on-demand was conducted on 34 hemophilia patients (24 and 10 patients were on the prophylaxis and on-demand regimens respectively) in 2017. The Markov model was used ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):240-248]

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A five-year retrospective study of treatment outcomes using the L-asparaginase-based regimen as a first-line chemotherapy protocol for patients diagnosed with extranodal NK/T-cell lymphoma, nasal-type, in Thailand.

Pongthep Vittayawacharin, Archrob Khuhapinant,

<h4>Objective</h4>To assess clinical outcomes of newly diagnosed extranodal NK/T-cell lymphoma nasal-type (ENKTL) patients treated with L-asparaginase-containing chemotherapy as first-line chemotherapy.<h4>Materials and methods</h4>We retrospectively reviewed data of new ENKTL patients in Siriraj Hospital, Thailand during 2012-2016.<h4>Results</h4>Among 27 patients, 16 were men and 11 were women, and their median age was 52 ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):75-82]

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Comparison of outcomes of peritoneal dialysis between patients after failed kidney transplant and transplant-naïve patients: a meta-analysis of observational studies.

Xiaohua Meng, Weifei Wu, Shuang Xu, Zhiqun Cheng,

<h4>Purpose</h4>The influence of prior failed kidney transplants on outcomes of peritoneal dialysis (PD) is unclear. Thus, we conducted a systematic review and meta-analysis to compare the outcomes of patients initiating PD after a failed kidney transplant with those initiating PD without a prior history of kidney transplantation.<h4>Methods</h4>We searched PubMed, Embase, ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):698-708]

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