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Osteoporosis

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Construction of a 5-feature gene model by support vector machine for classifying osteoporosis samples.

Minwei Hu, Ling Zou, Jiong Lu, Zeyu Yang, Yinan Chen, Yaozeng Xu, Changhui Sun,

Osteoporosis is a progressive bone disease in the elderly and lacks an effective classification method of patients. This study constructed a gene signature for an accurate prediction and classification of osteoporosis patients. Three gene expression datasets of osteoporosis samples were acquired from the Gene Expression Omnibus database with pre-set criteria. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6821-6830]

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Inhibitory effect of Astragalus Membranaceus on osteoporosis in SAMP6 mice by regulating vitaminD/FGF23/Klotho signaling pathway.

Yihui Chai, Xiang Pu, Yongzhen Wu, Xingzhong Tian, Qian Li, Fanyong Zeng, Jing Wang, Jie Gao, Huaqian Gong, Yunzhi Chen,

Spontaneous senile osteoporosis severely threatens the health of the senior population which has emerged as a severe issue for society. A SAMP6 mouse model was utilized to estimate the impact of intragastrically administered Astragalus Membranaceus (AR) on spontaneous senile osteoporosis. Bone mineral density (BMD) and bone microstructure were measured using ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4464-4474]

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Trelagliptin stimulates osteoblastic differentiation by increasing runt-related transcription factor 2 (RUNX2): a therapeutic implication in osteoporosis.

Haiyu Shao, Renzheng Wu, Li Cao, Haifeng Gu, Fang Chai,

Osteoporosis, an aging-associated bone metabolic disease, is affecting millions of people worldwide. The deregulated process of osteoblastic differentiation has been linked with the progression of osteoporosis. Trelagliptin is a long-acting inhibitor of DPP-4 used for the management of type 2 diabetes mellitus. However, it is unknown whether Trelagliptin possesses a ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):960-968]

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Long non-coding RNA XIST promotes osteoporosis by inhibiting the differentiation of bone marrow mesenchymal stem cell by sponging miR-29b-3p that suppresses nicotinamide N-methyltransferase.

Jiang Yu, Min Xiao, Guohai Ren,

Bone formation is important in the development of osteoporosis (OP). X-inactive specific transcript (XIST), a lncRNA, is involved in this process; however, mode of its action is not known. We compared the serum levels of XIST and miR-29b-3p among the patients with and without OP. In rat bone marrow mesenchymal ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6057-6069]

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LncRNA ROR/miR-145-5p axis modulates the osteoblasts proliferation and apoptosis in osteoporosis.

Yin Fu, Xiaoyang Hu, Yanyu Gao, Kai Li, Qiang Fu, Qingpeng Liu, Dan Liu, Zhijia Zhang, Jiutao Qiao,

Osteoporosis (OP) is a systemic bone metabolic disease. Promotion of osteoblast proliferation and inhibition of cell apoptosis may be helpful for the prevention and clinical treatment of OP. In the current study, we focused on the expression changes and clinical values of lncRNA ROR and miR-145-5p in OP clinical serum ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):7714-7723]

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Circular RNA_0062582 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via regulation of microRNA-145/CBFB axis.

Feng Li, Hao Wu, Guoyou Zou, Dingwei Cang, Yixin Shen,

Osteoporosis poses a threat to human health worldwide. To date, there have been few studies regarding targeted treatment of osteoporosis. We aimed to identify the possible molecular mechanism of circular RNA (circ)_0062582 in osteogenic differentiation, and the interactions among circ_0062582, microRNA-145 (miR-145) and core-binding factor subunit β (CBFB). The proliferation ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1952-1963]

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Physiological testosterone replacement effects on male aged rats with orchiectomy-induced osteoporosis in advanced stage: a tomographic and biomechanical pilot study.

Vinícius de Paiva Gonçalves, Adriana Alicia Cabrera-Ortega, Jhonatan de Souza Carvalho, Dania Ramadan, Luís Carlos Spolidorio,

<b>Aim:</b> This study aimed to evaluate the effect of physiological testosterone replacement on male aged rats with orchiectomy-induced osteoporosis in advanced stage.<b>Methods:</b> Thirty male rats (<i>Rattus norvegicus albinus</i>, Holtzman lineage) were randomly distributed into 3 groups (<i>n</i> = 10): 1-sham, 2-orchiectomy (OCX), 3-OCX + testosterone replacement (OCX + T). On day 0, a sham or orchiectomy ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2021, 24(1):139-147]

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Circular RNA circ_0000020 promotes osteogenic differentiation to reduce osteoporosis via sponging microRNA miR-142-5p to up-regulate Bone Morphogenetic Protein BMP2.

Rongkui Zhou, Shichang Miao, Jun Xu, Liping Sun, Yaofei Chen,

This study was designed to study functions of Circ_0000020 during osteogenic differentiation. First, we used RT-qPCR to detect the expression of Circ_0000020, miR-142-5p and osteogenesis-related genes, whereas western blot analysis detected the expression of osteogenesis markers after the osteogenic differentiation of primary BMSCs isolated from rats. Alkaline phosphatase (ALP) activity and alizarin ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3824-3836]

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The association between pre-transfusion hemoglobin levels and thalassemia complications.

Wasuwit Wanchaitanawong, Adisak Tantiworawit, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada, Piangrawee Niprapan, Kanda Fanhchaksai, Pimlak Charoenkwan,

<h4>Objectives</h4>To evaluate any association between pre-transfusion hemoglobin (Hb) levels and thalassemia complications and to identify the Hb cutoff values to predict thalassemia complications.<h4>Methods</h4>We performed a cross-sectional study in thalassemia patients who attended the Adult Hematology Clinic of the tertiary care University Hospital from October 2017 to October 2018. A point-biserial ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):1-8]

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Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells.

Xiaochen Wang, Yaochuan Mi, Wei He, Xiaona Hu, Shuo Yang, Lu Zhao, Yanyang Zhang, Binhong Wen,

Diabetic osteoporosis (DOP) is a chronic complication of diabetes in the skeletal system. High level of miR-340-5p may be harmful to the bone formation. In this study, the DOP model of rats was successfully established via streptozotocin (STZ) and ovariectomy (OVX) treatment. It was manifested by reduced body weight, insulin ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1126-1137]

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Ficus deltoidea promotes bone formation in streptozotocin-induced diabetic rats.

Nurdiana Samsulrizal, Yong-Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal'ain Azmi, Noor Syaffinaz NoorMohamad Zin, Mahdi Ebrahimi,

<h4>Context</h4>Diabetes mellitus increases the risk of bone diseases including osteoporosis and osteoarthritis. We have previously demonstrated that <i>Ficus deltoidea</i> Jack (Moraceae) is capable of reducing hyperglycaemia. However, whether <i>F. deltoidea</i> could protect against diabetic osteoporosis remains to be determined.<h4>Objective</h4>The study examines the effect of <i>F. deltoidea</i> on bone histomorphometric parameters, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):66-73]

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The interaction of miR-181a-5p and sirtuin 1 regulated human bone marrow mesenchymal stem cells differentiation and apoptosis.

Haitao Zhu, Hua Chen, DeGang Ding, Shui Wang, XiaoFeng Dai, YuLong Zhu,

Osteoporosis (OP) characterizes a decrease in bone density and bone mass which leads to brittle fractures and serious damages to individuals. In recent years, various researches have proved that miRNAs act pivotally in the onset of bone-related diseases. In our research, we probed into the impact of miR-181a-5P on viability, ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1426-1435]

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Circular RNA Circ_0005564 promotes osteogenic differentiation of bone marrow mesenchymal cells in osteoporosis.

Zitao Liu, Qiyu Liu, Shanchuang Chen, Haitao Su, Tao Jiang,

Circular RNA <b>(C</b>ircRNA) plays a potential role in bone formation. We aimed to study the circRNAs expression profiles and their functions in osteogenic differentiation of human bone marrow stromal cells (BMSCs). Firstly, we established osteogenic differentiation of BMSCs displaying increased mRNA expression of osteogenic differentiation marker (RUNX2, OPN, and OCN), ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4911-4923]

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Novel positive allosteric modulators of A2B adenosine receptor acting as bone mineralisation promoters.

Elisabetta Barresi, Chiara Giacomelli, Laura Marchetti, Emma Baglini, Silvia Salerno, Giovanni Greco, Federico Da Settimo, Claudia Martini, Maria Letizia Trincavelli, Sabrina Taliani,

Small-molecules acting as positive allosteric modulators (PAMs) of the A<sub>2B</sub> adenosine receptor (A<sub>2B</sub> AR) could potentially represent a novel therapeutic strategy for pathological conditions characterised by altered bone homeostasis, including osteoporosis. We investigated a library of compounds (<b>4</b>-<b>13</b>) exhibiting different degrees of chemical similarity with three indole derivatives (<b>1</b>-<b>3</b>), which ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):286-294]

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The miR-1906 mimic attenuates bone loss in osteoporosis by down-regulating the TLR4/MyD88/NF-κB pathway.

H Xie, L Cao, L Ye, G Shan, W Song,

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3-E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase ... Read more >>

Physiol Int (Physiology international)
[2021, 107(4):469-478]

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Non-random relations in drug use expressed as patterns comprising prescription and over-the-counter drugs in multimorbid elderly patients in primary care: Data of the exploratory analysis of the multicentre, observational cohort study MultiCare.

Caroline Krüger, Ingmar Schäfer, Hendrik van den Bussche, Michael Baehr, Horst Bickel, Angela Fuchs, Jochen Gensichen, Wolfgang Maier, Steffi G Riedel-Heller, Hans-Helmut König, Anne Dahlhaus, Gerhard Schön, Siegfried Weyerer, Birgitt Wiese, Wolfgang von Renteln-Kruse, Claudia Langebrake, Martin Scherer,

<h4>Background</h4>The elderly population deals with multimorbidity (three chronic conditions) and increasinged drug use with age. A comprehensive characterisation of the medication - including prescription and over-the-counter (OTC) drugs - of elderly patients in primary care is still insufficient.<h4>Objectives</h4>This study aims to characterise the medication (prescription and OTC) of multimorbid elderly ... Read more >>

Eur J Gen Pract (The European journal of general practice)
[2021, 27(1):119-129]

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The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis.

Nader Salari, Hooman Ghasemi, Loghman Mohammadi, Mohammad Hasan Behzadi, Elham Rabieenia, Shamarina Shohaimi, Masoud Mohammadi,

Osteoporosis affects all sections of society, including families with people affected by osteoporosis, government agencies and medical institutes in various fields. For example, it involves the patient and his/her family members, and government agencies in terms of the cost of treatment and medical care. Providing a comprehensive picture of the ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2021, 16(1):609]

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IL1R2 polymorphisms and their interaction are associated with osteoporosis susceptibility in the Chinese Han population.

Kai Rong, Zhiquan Liang, Wenyuan Xiang, Zhan Wang, Fengli Wen, Laijin Lu,

Interleukin 1 (IL-1) inhibitory receptor type 2 (IL1R2) serves as a negative regulator of IL-1 signalling and is involved in the pathogenesis of osteoporosis. This study aimed to determine the correlation between IL1R2 polymorphism and osteoporosis susceptibility in the Chinese Han population. We recruited 594 osteoporosis patients and 599 healthy controls. Six ... Read more >>

Int J Immunogenet (International journal of immunogenetics)
[2021, :]

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Development and in vivo evaluation of intranasal formulations of parathyroid hormone (1-34).

Dan Wang, Yimeng Du, Wenpeng Zhang, Xiaolu Han, Hui Zhang, Zengming Wang, Nan Liu, Meng Li, Xiang Gao, Xiaomei Zhuang, Jing Gao, Aiping Zheng,

For efficient intranasal transport of parathyroid hormone (1-34) [PTH(1-34)], there is a great medical need to investigate permeation enhancers for intranasal formulations. In this study, the development of PTH(1-34) intranasal formulations was conducted. Based on conformation and chemical stability studies, the most preferable aqueous environment was determined to be 0.008 M ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):487-498]

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Complication Trends and Costs of Surgical Management in 11,086 Osteoporotic Patients Receiving Lumbar Fusion.

Shane Shahrestani, Xiao T Chen, Alexander M Ballatori, Andy Ton, Joshua Bakhsheshian, Raymond J Hah, Jeffrey C Wang, Zorica Buser,

<h4>Study design</h4>Retrospective cohort study.<h4>Objective</h4>The aim of this study was to compare different aspects of fusion surgery in patients with osteoporosis with regard to graft subtype and surgical approach.<h4>Summary of background data</h4>Osteoporosis and chronic lower back pain are common in elderly populations and significantly increase the risk of compression fractures within ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2021, 46(21):1478-1484]

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Circular RNA Hsa_circ_0006766 targets microRNA miR-4739 to regulate osteogenic differentiation of human bone marrow mesenchymal stem cells.

Zhaodi Guo, Manlin Xie, Yanfang Zou, Qianxin Liang, Fubin Liu, Jing Su, Zhiliang He, Xiuping Cai, Zhixiang Chen, Qing Zhao, Kewei Zhao,

Circular RNAs (circRNAs) are emerging as important regulators in bone metabolism, which is mediated by microRNA (miRNA) sponges. However, it is not clear how circRNA regulates osteogenic differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs).Therefore, based on the previous circRNA chip results, hsa_circ_0006766, which is differentially expressed in the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5679-5687]

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Q-Dixon and GRAPPATINI T2 Mapping Parameters: A Whole Spinal Assessment of the Relationship Between Osteoporosis and Intervertebral Disc Degeneration.

Xiangwen Li, Yuxue Xie, Rong Lu, Yuyang Zhang, Qing Li, Tobias Kober, Tom Hilbert, Hongyue Tao, Shuang Chen,

The relationship between osteoporosis and intervertebral disc (IVD) degeneration remains controversial. Novel quantitative Dixon (Q-Dixon) and GRAPPATINI T2 mapping techniques have shown potential for evaluating the biochemical components of the spine. To investigate the correlation of osteoporosis with IVD degeneration in postmenopausal women. Prospective. A total of 105 postmenopausal females ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2021, :]

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Polycytosine RNA-Binding Protein 1 Regulates Osteoblast Function via a Ferroptosis Pathway in Type 2 Diabetic Osteoporosis

Hongdong Ma, yueming Jiang, Haitian Li, Maowei Yang,

In recent years, type 2 diabetic osteoporosis has become a research hotspot for the complications of diabetes, but the specific mechanism of its occurrence and development remain unknown. Ferroptosis caused by iron overload is considered to be one of the important cause of type 2 diabetic osteoporosis. Polycytosine RNA-binding protein ... Read more >>

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Role of diet in osteoporosis incidence: Umbrella review of meta-analyses of prospective observational studies.

Weili Feng, Xiaoping Wang, Daoqiang Huang, Anqi Lu,

An umbrella review and meta-analysis were conducted to summarize evidence for the association between dietary factors and the incidence of osteoporosis in adults. Only systematic reviews or meta-analyses were eligible for this study. Two researchers independently performed reading, data extraction, and quality evaluation of the included literature. The outcomes included ... Read more >>

Crit Rev Food Sci Nutr (Critical reviews in food science and nutrition)
[2021, :1-10]

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Bisphosphonate-enoxacin inhibit osteoclast formation and function by abrogating RANKL-induced JNK signalling pathways during osteoporosis treatment.

Qiang Xu, Ping Zhan, Xiaofeng Li, Fengbo Mo, Huaen Xu, Yuan Liu, Qi Lai, Bin Zhang, Min Dai, Xuqiang Liu,

Osteoporosis is an age-related disease characterized by low mineral density, compromised bone strength and increased risk of fragility fracture. Most agents for treating osteoporosis focus primarily on anti-resorption by inhibiting osteoclast activity. Bisphosphonate (BP) is a potent anti-resorptive agent that has been used clinically for decades and is proven to ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, :]

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