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Osteoporosis

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Is there an association between peptic ulcer disease and osteoporosis: a systematic review and cumulative analysis.

Shankun Zhao, Lingzhi Ding, Qiang Xie, Jingsheng Zhang, Suqing Yang, Weifang Xu, Jianhong Yang, Yan Xu, Changjun Zheng,

<b>Background:</b>Mounting studies have emerged indicating that patients with peptic ulcer disease (PUD) are at a high risk of developing osteoporosis, but the evidence has not been previously synthesized. The present study aims to examine whether patients with PUD have a significantly higher prevalence of osteoporosis than the healthy normal subjects.<br><br><b>Methods:</b>Four ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(1):9-16]

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Total-Body PET Imaging of Musculoskeletal Disorders.

Abhijit J Chaudhari, William Y Raynor, Ali Gholamrezanezhad, Thomas J Werner, Chamith S Rajapakse, Abass Alavi,

Imaging of musculoskeletal disorders, including arthritis, infection, osteoporosis, sarcopenia, and malignancies, is often limited when using conventional modalities such as radiography, computed tomography (CT), and MR imaging. As a result of recent advances in Positron Emission Tomography (PET) instrumentation, total-body PET/CT offers a longer axial field-of-view, higher geometric sensitivity, and ... Read more >>

PET Clin (PET clinics)
[2021, 16(1):99-117]

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Cardiovascular disease is a risk factor for osteoporosis: a case-control study in Chinese women

Hao Chai, Jirong Ge, Li Li, Jianyang Li, Yunjin Ye,

Abstract Background: Osteoporosis and cardiovascular disease (CVD) are age-related diseases. According to some studies, patients with CVD have a higher risk of bone loss. This retrospective study intended to reveal the correlation between osteoporosis and CVD in Chinese women. Although epidemiological evidence has provided evidence of the relationship between the ... Read more >>

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Pelvic Fragility Fractures: An Opportunity to Improve the Undertreatment of Osteoporosis.

Christian T Smith, David W Barton, Amit S Piple, Jonathan J Carmouche,

<b>Background: </b>Osteoporosis is often undiagnosed until patients experience fragility fractures. Pelvic fractures are common but underappreciated sentinel fractures. Screening patients with a pelvic fracture for osteoporosis may provide an opportunity to initiate appropriate treatments such as anti-osteoporosis therapy to prevent additional fractures.<br><br><b>Methods: </b>This retrospective cohort review examined the management of ... Read more >>

J Bone Joint Surg Am (The Journal of bone and joint surgery. American volume)
[2020, :]

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Meta-analysis Reveals Genetic Correlates of Osteoporosis Pathogenesis.

Laith K Hasan, Jihad Aljabban, Michael Rohr, Mohamed Mukhtar, Nikhil Adapa, Rahaf Salim, Nabeal Aljabban, Saad Syed, Sharjeel Syed, Maryam Panahiazar, Dexter Hadley, Wael Jarjour,

<b>Objective:</b>Osteoporosis is a growing health care burden. By identifying osteoporosis promoting genetic variations, we can spotlight targets for new pharmacologic therapies that will improve patient outcomes. In this meta-analysis, we analyzed mesenchymal stem cell biomarkers in patients with osteoporosis.<br><br><b>Methods:</b>We employed our Search Tag Analyze Resource (STARGEO) platform to conduct a ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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Gene Expression and RNA Splicing Imputation Identifies Novel Candidate Genes Associated with Osteoporosis.

Yong Liu, Hui Shen, Jonathan Greenbaum, Anqi Liu, Kuan-Jui Su, Li-Shu Zhang, Lei Zhang, Qing Tian, Hong-Gang Hu, Jin-Sheng He, Hong-Wen Deng,

CONTEXT:Though genome-wide association studies (GWASs) have identified hundreds of genetic variants associated with osteoporosis related traits, such as bone mineral density (BMD) and fracture, it remains a challenge to interpret their biological functions and underlying biological mechanisms. OBJECTIVE:Integrate diverse expression quantitative trait loci and splicing quantitative trait loci data with ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(12):]

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Cost-effectiveness of Screening for Osteoporosis in Older Men With a History of Falls.

Kouta Ito,

<b>Importance:</b>Falls and osteoporosis share the potential clinical end point of fractures among older patients. To date, few fall prevention guidelines incorporate screening for osteoporosis to reduce fall-related fractures.<br><br><b>Objective:</b>To assess the cost-effectiveness of screening for osteoporosis using dual-energy x-ray absorptiometry (DXA) followed by osteoporosis treatment in older men with a history ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(12):e2027584]

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Comorbidities Associated With Chronic Obstructive Pulmonary Disease.

Vipin Villgran, Ayla Gordon, Khalid Malik, Tariq Cheema,

Chronic obstructive pulmonary disease or COPD is characterized by airflow obstruction, causing respiratory symptoms. There are treatments available for COPD; however, COPD has significant extrapulmonary effects, including well-recognized ones as cardiovascular disease and often underdiagnosed ones as osteoporosis. It is imperative to be aware of these comorbidities to optimize COPD ... Read more >>

Crit Care Nurs Q (Critical care nursing quarterly)
[2021, 44(1):103-112]

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Evaluation of relationship between SPON1 gene and genetic susceptibility of postmenopausal osteoporosis.

Wenlong Ma, Ke Chen, Wenqing Xiao, Hongtao Tang, Shaohui Wang, Kunzheng Wang,

Purpose: Postmenopausal osteoporosis (PMOP) is one of systemic bone degenerative diseases characterised by decreased bone mineral density (BMD). Previous studies suggest that the SPON1 gene may be associated with BMD and play an important role in the occurrence and development of PMOP. In this study, we aimed to investigate the ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):818-823]

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Bone Health and Osteoporosis Prevention and Treatment.

Marcus MuÑoz, Kathleen Robinson, Amal Shibli-Rahhal,

Postmenopausal osteoporosis is a common condition and is associated with increased risk of fracture, including hip and vertebral fractures that in turn can have devastating consequences on morbidity and mortality. In this article, we review the pathogenesis and diagnostic approach to postmenopausal osteoporosis. We review available nonpharmacologic and pharmacologic therapies ... Read more >>

Clin Obstet Gynecol (Clinical obstetrics and gynecology)
[2020, 63(4):770-787]

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Real-world bone turnover marker use: impact on treatment decisions and fracture.

N E Lane, K Saag, T J O'Neill, M Manion, R Shah, U Klause, R Eastell,

The use of bone turnover marker (BTM) testing for patients with osteoporosis in the USA has not been well characterized. This retrospective US-based real-world data study found BTM testing has some association with treatment decision-making and lower fracture risk in patients with presumed osteoporosis, supporting its use in clinical practice. ... Read more >>

Osteoporos Int (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA)
[2020, :]

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Hepatic osteodystrophy in cirrhosis due to alcohol-related liver disease.

Flávio Pereira, Richard Azevedo, Marisa Linhares, João Pinto, Cátia Leitão, Ana Caldeira, José Tristan, Eduardo Pereira, Rui Sousa, António Banhudo,

<b>Introduction: </b>Hepatic osteodystrophy, including osteoporosis, is an abnormal bone metabolism related with chronic liver diseases. Osteoporosis is associated with an increased risk of bone fractures, with a significant impact on morbidity, mortality and healthcare costs. Nevertheless, bone disorders tend to be undervalued in cirrhosis due to alcohol-related liver disease (ALD ... Read more >>

Rev Esp Enferm Dig (Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva)
[2020, :]

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Ginsenoside Rg3 Attenuates Aluminum-Induced Osteoporosis Through Regulation of Oxidative Stress and Bone Metabolism in Rats.

Miao Song, Fubo Jia, Zheng Cao, Haiyang Zhang, Menglin Liu, Li Gao,

Aluminum (Al)-induced bone metabolism disorder is a primary cause of osteoporosis. Ginsenoside Rg3 (Rg3) has demonstrated therapeutic properties in the treatment of osteoporosis. The present study aimed to identify potential bone protection mechanisms of Rg3 against Al-induced osteoporosis in rats. In this study, forty healthy male Sprague-Dawley rats were randomly ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2020, 198(2):557-566]

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Overview of Skeletal Repair (Fracture Healing and Its Assessment).

Elise F Morgan, Anthony De Giacomo, Louis C Gerstenfeld,

The study of postnatal skeletal repair is of immense clinical interest. Optimal repair of skeletal tissue is necessary in all varieties of elective and reparative orthopedic surgical treatments. However, the repair of fractures is unique in this context in that fractures are one of the most common traumas that humans ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2230:17-37]

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Hysterectomies are associated with an increased risk of osteoporosis and bone fracture: A population-based cohort study.

Ying-Ting Yeh, Pei-Chen Li, Kun-Chi Wu, Yu-Cih Yang, Weishan Chen, Hei-Tung Yip, Jen-Hung Wang, Shinn-Zong Lin, Dah-Ching Ding,

<b>Aim:</b>This study investigated the risk of osteoporosis or bone fractures (vertebrae, hip and others) in hysterectomized women in Taiwan.<br><br><b>Materials and methods:</b>This is a retrospective population-based cohort study from 2000 to 2013. Women aged ≥30 years who underwent hysterectomy between 2000 and 2012 were included in this study. The comparison group ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0243037]

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RANKL-Based Osteoclastogenic Assay from Murine Bone Marrow Cells.

Zhenqiang Yao, Lianping Xing, Brendan F Boyce,

The osteoclast is the unique type of cell that resorbs bone in vivo and it is required for normal skeletal development and postnatal homeostasis. Osteoclast deficiency impairs skeletal development during embryogenesis and results in osteopetrosis and impaired tooth eruption. In contrast, excessive osteoclast formation in adults results in bone loss ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2230:457-465]

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High-Intensity Physical Activity with High Serum Vitamin D Levels is Associated with a Low Prevalence of Osteopenia and Osteoporosis: A Population-Based Study.

C Min, D M Yoo, J H Wee, H-J Lee, H G Choi,

We found that combination of high-intensity PA and high 25(OH)D levels was associated with low prevalence of osteoporosis/osteopenia. In addition, the prevalence of osteoporosis was lower in the low PA with high 25(OH)D levels than in the moderate or high PA with low 25(OH)D levels. INTRODUCTION:The aim of this study ... Read more >>

Osteoporos Int (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA)
[2020, :]

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Optimizing DXA to Assess Skeletal Health: Key Concepts for Clinicians.

Kurt A Kennel, Jad G Sfeir, Matthew T Drake,

CONTEXT:The diagnosis of osteoporosis and assessment of fracture risk prior to a sentinel fracture was transformed by the widespread clinical use of dual-energy X-ray absorptiometry (DXA) for the assessment of bone mineral density (BMD). EVIDENCE ACQUISITION:This review is based on a collection of primary and review literature gathered from a ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(12):]

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Osteoporosis and the risk of Parkinson's disease: A nationwide propensity score-matched longitudinal follow-up study.

Shih-Hao Feng, Ya-Ping Huang, Kuo-Cheng Yeh, Shin-Liang Pan,

CONTEXT:Osteoporosis and Parkinson's (PD) disease often co-occur, and even patients with early-stage PD may have reduced bone-mineral density levels. This may imply that osteoporosis is associated with a higher risk of PD. OBJECTIVES:To determine whether patients with osteoporosis are at a higher risk of subsequently developing PD. DESIGN, SETTING:A retrospective ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, :]

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Generation and Characterization of Mouse Models for Skeletal Disease.

Gabrielle E Foxa, Ye Liu, Lisa M Turner, Alexander G Robling, Tao Yang, Bart O Williams,

Our laboratories have used genetically engineered mouse models (GEMMs) to assess genetic contributions to skeletal diseases such as osteoporosis and osteoarthritis. Studies on the genetic contributions to OA are often done by assessing how GEMMs respond to surgical methods that induce symptoms modeling OA. Here, we will describe protocols outlining ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2221:165-191]

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Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies.

Jun Long Liao, Qiang Qin, Yong Sheng Zhou, Ru Ping Ma, He Chao Zhou, Mao Rong Gu, Yun Ping Feng, Bo Yuan Wang, Ling Yang,

OBJECTIVE:This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women. MATERIALS AND METHODS:The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and odds ratio (OR) with 95% ... Read more >>

Genes Nutr (Genes & nutrition)
[2020, 15(1):20]

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Clinical Study of Correlation Between Osteoporosis and Osteoarthritis of Knee Joint Using Gold Nanomaterial Contrast Agent.

Dan Li, Yunpeng Wan, Yongjin Sun, Xing Wu,

The relationship between osteoporosis (OP) and knee osteoarthritis (OA) was studied using gold nanomaterial (GNP) contrast agent from the imaging and clinical perspectives. Patients were divided into the OA and OP comorbidity group (experimental), OA group (positive control), and OP group (negative control) and evaluated using the Lysholm knee joint ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2020, 20(12):7761-7768]

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Genetic variability in noncoding RNAs: involvement of miRNAs and long noncoding RNAs in osteoporosis pathogenesis.

Simona Fittipaldi, Virginia Veronica Visconti, Umberto Tarantino, Giuseppe Novelli, Annalisa Botta,

The pathogenesis of osteoporosis is multifactorial and is the consequence of genetic, hormonal and lifestyle factors. Epigenetics, including noncoding RNA (ncRNA) deregulation, represents a link between susceptibility to develop the disease and environmental influences. The majority of studies investigated the expression of ncRNAs in osteoporosis patients; however, very little information is available on ... Read more >>

Epigenomics (Epigenomics)
[2020, :]

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Genetic Variation in VKORC1 and Risk for Osteoporosis.

Jin He, Hua Xie, Chengyuan Yan, Yawen Sun, Zhonghua Xu, Xing Zhang,

BACKGROUND AND AIMS:The vitamin K epoxide reductase complex subunit 1 (VKORC1) plays an important role in bone development and bone metabolism by influencing the vitamin K cycle. The aim of this study was to investigate the association between VKORC1 gene polymorphisms and bone mineral density and the risk of osteoporosis. ... Read more >>

Arch Med Res (Archives of medical research)
[2020, :]

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Contribution of elevation and residential proximity to the coast in explaining geographic variations in hip fracture incidence. A Norwegian Epidemiologic Osteoporosis Studies (NOREPOS) study.

C Dahl, C Madsen, T K Omsland, A-J Søgaard, G S Tell, K Holvik, H E Meyer,

A higher risk of hip fracture was found in areas of Norway at higher elevation and farther from the coast. However, the previously seen county variations could not be explained by these geographical factors. INTRODUCTION:Norway is an elongated country extending north of the Arctic Circle with substantial coast-inland variation in ... Read more >>

Osteoporos Int (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA)
[2020, :]

Cited: 0 times

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