Full Text Journal Articles about
Osteoclast

Advertisement

Find full text journal articles






The role of macrophages and osteoclasts in the progression of leukemia.

Kun Li, Runming Jin, Xiaoyan Wu,

<b>ABSTRACT</b>Bone marrow microenvironment provides critical regulatory signals for lineage differentiation and maintenance of HSC quiescence, and these signals also contribute to hematological myeloid malignancies. Macrophages exhibit high phenotypic heterogeneity under both physiological and pathological conditions and are mainly divided into proinflammatory M1 and anti-inflammatory M2 macrophages. Furthermore, osteoclasts are multinucleated ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):724-733]

Cited: 0 times

View full text PDF listing >>



3D Biofabricated In Vitro Models of Vascularized and Mineralized Bone Tissues.

Maria Vittoria Colombo, Simone Bersini, Chiara Arrigoni, Matteo Moretti,

This protocol describes a comprehensive practical guide for the biofabrication of 3D in vitro models of vascularized and mineralized bone Minitissues. These models give the possibility to study the contribution of physical and biochemical parameters on bone vascularization, as well as the osteoblast/osteoclast mediated matrix remodeling. Based on the specific ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2373:283-296]

Cited: 0 times

View full text PDF listing >>



Advertisement

B7–H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction

Younseo Oh, Robin Park, So Yeon Kim, Sung-ho Park, Sungsin Jo, Tae-Hwan Kim, Jong Dae Ji,

While their function, as immune checkpoint molecules, is well known, B7-family proteins also function as regulatory molecules in bone remodeling. B7–H3 is a receptor ligand of the B7 family that functions primarily as a negative immune checkpoint. While the regulatory function of B7–H3 in osteoblast differentiation has been established, its ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(11):]

Cited: 0 times

View full text PDF listing >>



The W9 peptide inhibits osteoclastogenesis and osteoclast activity by downregulating osteoclast autophagy and promoting osteoclast apoptosis.

Yuying Kou, Congshan Li, Panpan Yang, Dongfang Li, Xiong Lu, Hongrui Liu, Minqi Li,

The W9 peptide has been shown to act as a receptor activator for nuclear factor-κB ligand (RANKL) antagonist and tumor necrosis factor (TNF)-α antagonist, which can promote bone formation and inhibit bone resorption. Studies on the W9 peptide at the cellular level have mainly focused on osteoblasts, and little research ... Read more >>

J Mol Histol (Journal of molecular histology)
[2021, :]

Cited: 0 times

View full text PDF listing >>



OC_Finder: A deep learning-based software for osteoclast segmentation, counting, and classification

Xiao Wang, Mizuho Kittaka, Yilin He, Yiwei Zhang, Yasuyoshi Ueki, Daisuke Kihara,

Osteoclasts are multinucleated cells that exclusively resorb bone matrix proteins and minerals on the bone surface. They differentiate from monocyte/macrophage-lineage cells in the presence of osteoclastogenic cytokines such as the receptor activator of nuclear factor-κB ligand (RANKL) and are stained positive for tartrate-resistant acid phosphatase (TRAP). In vitro, osteoclast formation ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Mechanism of alveolar bone destruction in periodontitis — Periodontal bacteria and inflammation

Michihiko Usui, Satoru Onizuka, Tsuyoshi Sato, Shoichiro Kokabu, Wataru Ariyoshi, Keisuke Nakashima,

Periodontal disease is an inflammatory disease caused by periodontopathogenic bacteria, which eventually leads to bone tissue (alveolar bone) destruction as inflammation persists. Periodontal tissues have an immune system against the invasion of these bacteria, however, due to the persistent infection by periodontopathogenic bacteria, the host innate and acquired immunity is ... Read more >>

Jpn Dent Sci Rev (The Japanese dental science review)
[2021, 57:201-208]

Cited: 0 times

View full text PDF listing >>



AMP-activated protein kinase mediates lipopolysaccharide-induced proinflammatory responses and elevated bone resorption in differentiated osteoclasts.

Yu-Hsu Chen, Kuang-Kai Hsueh, Pei-Wen Chu, Shau-Kwaun Chen,

Systemic and intracellular metabolic states are critical factors affecting immune cell functions. The metabolic regulator AMP-activated protein kinase (AMPK) senses AMP levels and mediates cellular responses to energy-restrained conditions. The ubiquitously expressed AMPK participates in various biological functions in numerous cell types, including innate immune cell macrophages and osteoclasts, which ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2021, :]

Cited: 0 times

View full text PDF listing >>



SETD2-mediated epigenetic regulation of noncanonical Wnt5A during osteoclastogenesis.

Moonmoon Deb, Dipranjan Laha, Jyotirindra Maity, Hiranmoy Das,

To define the role of SETD2 in the WNT5a signaling in the context of osteoclastogenesis, we exploited two different models: in vitro osteoclast differentiation, and K/BxN serum-induced arthritis model. We found that SETD2 and WNT5a were upregulated during osteoclast differentiation and after induction of arthritis. Using gain- and loss-of-function approaches ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2021, 13(1):192]

Cited: 0 times

View full text PDF listing >>



Biomimetic polydopamine-laced hydroxyapatite collagen material orients osteoclast behavior to an anti-resorptive pattern without compromising osteoclasts' coupling to osteoblasts.

Lufei Wang, Tai-Hsien Wu, Xiangxiang Hu, Jie Liu, Di Wu, Patricia A Miguez, John Timothy Wright, Shaoping Zhang, Jen-Tsan Chi, Henry C Tseng, Ching-Chang Ko,

Polydopamine-assisted modification for bone substitute materials has recently shown great application potential in bone tissue engineering due to its excellent biocompatibility and adhesive properties. A scaffold material's impact on osteoclasts is equally as important as its impact on osteoblasts when considering tissue engineering for bone defect repair, as healthy bone ... Read more >>

Biomater Sci (Biomaterials science)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Bisphosphonate-enoxacin inhibit osteoclast formation and function by abrogating RANKL-induced JNK signalling pathways during osteoporosis treatment.

Qiang Xu, Ping Zhan, Xiaofeng Li, Fengbo Mo, Huaen Xu, Yuan Liu, Qi Lai, Bin Zhang, Min Dai, Xuqiang Liu,

Osteoporosis is an age-related disease characterized by low mineral density, compromised bone strength and increased risk of fragility fracture. Most agents for treating osteoporosis focus primarily on anti-resorption by inhibiting osteoclast activity. Bisphosphonate (BP) is a potent anti-resorptive agent that has been used clinically for decades and is proven to ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, :]

Cited: 0 times

View full text PDF listing >>



B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction.

Younseo Oh, Robin Park, So Yeon Kim, Sung-Ho Park, Sungsin Jo, Tae-Hwan Kim, Jong Dae Ji,

While their function, as immune checkpoint molecules, is well known, B7-family proteins also function as regulatory molecules in bone remodeling. B7-H3 is a receptor ligand of the B7 family that functions primarily as a negative immune checkpoint. While the regulatory function of B7-H3 in osteoblast differentiation has been established, its ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(11):971]

Cited: 0 times

View full text PDF listing >>



Effects of Bisphenol A and Its Alternatives, Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation

Hye-Min Kim, Seon-Min Lee, Jungil Choi, Nak-Kyun Soung, Jeong-Doo Heo,

Bisphenol A (BPA) is a typical environmental endocrine disruptor that exhibits estrogen-mimicking, hormone-like properties and can cause the collapse of bone homeostasis by an imbalance between osteoblasts and osteoclasts. Various BPA substitutes, structurally similar to BPA, have been used to manufacture ‘BPA-free’ products; however, the regulatory role of BPA alternatives ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(20):]

Cited: 0 times

View full text PDF listing >>



Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division.

Toshio Kukita, Hidenobu Hiura, Jiong-Yan Gu, Jing-Qi Zhang, Yukari Kyumoto-Nakamura, Norihisa Uehara, Sara Murata, Soichiro Sonoda, Takayoshi Yamaza, Ichiro Takahashi, Akiko Kukita,

Adrenomedullin (ADM), a member of the calcitonin family of peptides, is a potent vasodilator and was shown to have the ability to modulate bone metabolism. We have previously found a unique cell surface antigen (Kat1 antigen) expressed in rat osteoclasts, which is involved in the functional regulation of the calcitonin ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2021, 101(11):1449-1457]

Cited: 0 times

View full text PDF listing >>



SLC4A2 deficiency causes a new type of osteopetrosis.

Jing-Yi Xue, Giedre Grigelioniene, Zheng Wang, Gen Nishimura, Aritoshi Iida, Naomichi Matsumoto, Emma Tham, Noriko Miyake, Shiro Ikegawa, Long Guo,

Osteopetrosis is a group of rare inherited skeletal disorders characterized by a marked increase in bone density due to deficient bone resorption. Pathogenic variants in several genes involved in osteoclast differentiation and/or function have been reported to cause osteopetrosis. Solute carrier family 4 member 2 (SLC4A2, encoding anion exchanger 2) ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Anti-Osteoporotic Effect of Morroniside on Osteoblast and Osteoclast Differentiation In Vitro and Ovariectomized Mice In Vivo.

Chang Gun Lee, Jeonghyun Kim, Seung Hee Yun, Seokjin Hwang, Hyoju Jeon, Eunkuk Park, Seon-Yong Jeong,

Bone remodeling is a continuous process of bone synthesis and destruction that is regulated by osteoblasts and osteoclasts. Here, we investigated the anti-osteoporotic effects of morroniside in mouse preosteoblast MC3T3-E1 cells and mouse primary cultured osteoblasts and osteoclasts in vitro and ovariectomy (OVX)-induced mouse osteoporosis in vivo. Morroniside treatment enhanced ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(19):]

Cited: 0 times

View full text PDF listing >>



miR profile in pagetic osteoclasts: from large-scale sequencing to gene expression study.

Hoang Dong Nguyen, Martine Bisson, Michelle Scott, Gilles Boire, Luigi Bouchard, Sophie Roux,

Paget's disease of bone (PDB) is characterized by excessive and disorganized bone remodeling, in which bone-resorbing osteoclasts play a key role. We investigated microRNA (miR) expression in osteoclasts derived from the blood of 40 PDB patients and 30 healthy controls. By deep sequencing, a preliminary analysis identified differentially expressed miRs ... Read more >>

J Mol Med (Berl) (Journal of molecular medicine (Berlin, Germany))
[2021, :]

Cited: 0 times

View full text PDF listing >>



Toxic Effects of Indoxyl Sulfate on Osteoclastogenesis and Osteoblastogenesis

Jia-Fwu Shyu, Wen-Chih Liu, Cai-Mei Zheng, Te-Chao Fang, Yi-Chou Hou, Chiz-Tzung Chang, Ting-Ying Liao, Yin-Cheng Chen, Kuo-Cheng Lu,

Uremic toxins, such as indoxyl sulfate (IS) and kynurenine, accumulate in the blood in the event of kidney failure and contribute to further bone damage. To maintain the homeostasis of the skeletal system, bone remodeling is a persistent process of bone formation and bone resorption that depends on a dynamic ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(20):]

Cited: 0 times

View full text PDF listing >>



The miR-1906 mimic attenuates bone loss in osteoporosis by down-regulating the TLR4/MyD88/NF-κB pathway.

H Xie, L Cao, L Ye, G Shan, W Song,

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3-E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase ... Read more >>

Physiol Int (Physiology international)
[2021, 107(4):469-478]

Cited: 0 times

View full text PDF listing >>



Impacts of Hypoxia on Osteoclast Formation and Activity: Systematic Review.

Jen Kit Tan, Nur Shukriyah Mohamad Hazir, Ekram Alias,

Hypoxia is evident in several bone diseases which are characterized by excessive bone resorption by osteoclasts, the bone-resorbing cells. The effects of hypoxia on osteoclast formation and activities are widely studied but remain inconclusive. This systematic review discusses the studies reporting the effect of hypoxia on osteoclast differentiation and activity. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(18):]

Cited: 0 times

View full text PDF listing >>



Serum RANKL levels in Chinese patients with ankylosing spondylitis: a meta-analysis.

Feifei Ni, Yanchao Zhang, Yi Peng, Xiaoxiao Peng, Jianjun Li,

We aimed to determine the association between serum receptor activator of nuclear factor-kappa B ligand (sRANKL) levels and ankylosing spondylitis (AS) in Chinese patients. The PubMed, Cochrane Library, Embase, Chinese Biomedical Database, Web of Science, China National Knowledge Infrastructure, VIP, and Wan Fang databases were searched for studies conducted before ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2021, 16(1):615]

Cited: 0 times

View full text PDF listing >>



GPR120 Inhibits RANKL-Induced Osteoclast Formation and Resorption by Attenuating Reactive Oxygen Species Production in RAW264.7 Murine Macrophages.

Cynthia Sithole, Carla Pieterse, Kayla Howard, Abe Kasonga,

Osteoclasts are large, multinucleated cells that are responsible for the resorption of bone. Bone degenerative diseases, such as osteoporosis, are characterized by overactive osteoclasts. Receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) binding to its receptor on osteoclast precursors will trigger osteoclast formation and resorption. The production of reactive oxygen ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(19):]

Cited: 0 times

View full text PDF listing >>



Novel Preosteoclast Populations in Obesity-Associated Periodontal Disease.

K H Kwack, L Zhang, J Sohn, V Maglaras, R Thiyagarajan, K L Kirkwood,

Although there is a clear relationship between the degree of obesity and periodontal disease incidence, the mechanisms that underpin the links between these conditions are not completely understood. Understanding that myeloid-derived suppressor cells (MDSCs) are expanded during obesity and operate in a context-defined manner, we addressed the potential role of ... Read more >>

J Dent Res (Journal of dental research)
[2021, :220345211040729]

Cited: 0 times

View full text PDF listing >>



Osteoporosis therapies and their mechanisms of action (Review).

Beomchang Kim, Yong Jin Cho, Wonbong Lim,

Osteoporosis is a common disease that affects millions of patients worldwide and is most common in menopausal women. The main characteristics of osteoporosis are low bone density and increased risk of fractures due to deterioration of the bone architecture. Osteoporosis is a chronic disease that is difficult to treat; thus, ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2021, 22(6):1379]

Cited: 0 times

View full text PDF listing >>



Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity.

Jianbo He, Kai Chen, Tiancheng Deng, Jiewei Xie, Kunjing Zhong, Jinbo Yuan, Ziyi Wang, Zhifeng Xiao, Ronghe Gu, Delong Chen, Xiaojuan Li, Dingkun Lin, Jiake Xu,

The extravagant osteoclast formation and resorption is the main cause of osteoporosis. Inhibiting the hyperactive osteoclastic resorption is considered as an efficient treatment for osteoporosis. Rhaponticin (RH) is a small molecule that has been reported to possess anti-inflammatory, anti-allergic, anti-fibrotic, and anti-diabetic activities. However, the influence of RH on osteoclasts ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:645140]

Cited: 0 times

View full text PDF listing >>



Plasma Membrane Receptors Involved in the Binding and Response of Osteoclasts to Noncellular Components of the Bone.

Divakar S Karanth, Macey L Martin, Lexie S Holliday,

Osteoclasts differentiate from hematopoietic cells and resorb the bone in response to various signals, some of which are received directly from noncellular elements of the bone. In vitro, adherence to the bone triggers the reduction of cell-cell fusion events between osteoclasts and the activation of osteoclasts to form unusual dynamic ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(18):]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

1.0934 s