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Organ Preservation

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Machine perfusion organ preservation: Highlights from the American Transplant Congress 2021.

Juliana Pavan-Guimaraes, Ali Zarrinpar, Thiago Beduschi, Carl Atkinson, Paulo N Martins,

The American Transplant Congress 2021 was a virtual meeting and occurred between June 4 and June 9 through an online platform. We highlighted abstracts discussing machine perfusion preservation, a hot topic that may become the gold standard of organ preservation in the future. A total of 33 abstracts on organ ... Read more >>

Artif Organs (Artificial organs)
[2021, :]

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Advances in Kidney Preservation Techniques and Their Application in Clinical Practice.

Sarah A Hosgood, Rachel J Brown, Michael L Nicholson,

The use of cold preservation solutions to rapidly flush and cool the kidney followed by static cold storage in ice has been the standard kidney preservation technique for the last 50 y. Nonetheless, changing donor demographics that include organs from extended criteria donors and donation after circulatory death donors have ... Read more >>

Transplantation (Transplantation)
[2021, 105(11):e202-e214]

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Innovations in Heart Transplantation: A Review.

Amanda C Coniglio, Chetan B Patel, Michelle Kittleson, Kelly Schlendorf, Jacob N Schroder, Adam D DeVore,

Advanced heart failure affects tens of thousands of people in the United States alone with high morbidity and mortality. Cardiac transplantation offers the best treatment strategy but has been historically limited by donor availability. Recently, there have been significant advances in organ allocation, donor-recipient matching, organ preservation and expansion of ... Read more >>

J Card Fail (Journal of cardiac failure)
[2021, :]

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The effect of different soft-tissue management techniques for alveolar ridge preservation: a randomized controlled clinical trial

Colline Papace, Christopher Büsch, Oliver Ristow, Martin Keweloh, Jürgen Hoffmann, Christian Mertens,

<h4>Purpose</h4> For alveolar ridge preservation, various treatment protocols have been described. While most studies focus on the effect of the bone graft material, the aim of this study was to analyze the influence of different soft-tissue management techniques on the soft and hard tissue. <h4>Methods</h4> A total of 20 maxillary ... Read more >>

Int J Implant Dent (International journal of implant dentistry)
[2021, 7:]

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Effect of Body Refrigeration Time on Cornea Donor Tissue.

Wuqaas M Munir, Clayton H Brown, Saleha Z Munir, Caroline K Hoover,

<h4>Purpose</h4>To determine how early body refrigeration affects corneal donor transplant suitability and endothelial cell density.<h4>Methods</h4>Donor information was obtained from the CorneaGen Eye Bank including demographics, time of death to preservation, and body refrigeration status, for donors between 2012 and 2016. The death to preservation interval was classified into 3 categories: ... Read more >>

Cornea (Cornea)
[2021, 40(12):1590-1593]

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Feasibility of Organ Preservation With Short Course Radiation Therapy as Part of Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer During the COVID-19 Pandemic

R.R. Sarkar, A.J. Wu, M. Reyngold, J.J. Cuaron, M. Zinovoy, C. Hajj, E. Pappou, N. Segal, R. Yaeger, I.H. Wei, M. Widmar, M. Weiser, P. Paty, A. Cercek, J.J. Smith, L. Saltz, J. Garcia-Aguilar, C.H. Crane, P.B. Romesser,

<h4>Purpose/Objective(s)</h4> While long course chemoradiation therapy has been studied as part of a watch-and-wait (WW) strategy for patients with locally advanced rectal cancer, it is unclear whether short-course radiation therapy (SCRT) will be associated with similar rates of organ preservation. We hypothesized that a WW strategy to facilitate organ preservation ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 111(3):e73-e74]

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Hypothermic oxygenated machine perfusion for extended criteria donor allografts-Preliminary experience with extended organ preservation times in the setting of organ reallocation.

Sandra Pavicevic, Deniz Uluk, Sophie Reichelt, Panagiotis Fikatas, Brigitta Globke, Nathanael Raschzok, Moritz Schmelzle, Robert Öllinger, Wenzel Schöning, Dennis Eurich, Johann Pratschke, Georg Lurje,

<h4>Background</h4>In times of critical organ shortage, poor organ pool utilization and increased use of extended-criteria donor (ECD) allografts remain a major problem. Hypothermic oxygenated machine perfusion (HOPE) has emerged as a promising and feasible strategy in ECD liver transplantation (LT). However, potential safety limits regarding the duration of perfusion are ... Read more >>

Artif Organs (Artificial organs)
[2021, :]

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Organ Preservation in Patients with Rectal Cancer Treated with Total Neoadjuvant Therapy.

Rosa M Jimenez-Rodriguez, Felipe Quezada-Diaz, Irbaz Hameed, Aleksandr Kalabin, Sujata Patil, J Joshua Smith, Julio Garcia-Aguilar,

<h4>Background</h4>Retrospective studies suggest that watch-and-wait is a safe alternative to total mesorectal excision in selected patients with a clinical complete response after chemoradiotherapy.<h4>Objective</h4>This study aimed to determine the proportion of patients with rectal cancer who may benefit from watch-and-wait.<h4>Design</h4>This study is a retrospective analysis of data from prospectively maintained databases.<h4>Setting</h4>This ... Read more >>

Dis Colon Rectum (Diseases of the colon and rectum)
[2021, 64(12):1463-1470]

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Feasibility of Organ Preservation With Short Course Radiation Therapy as Part of Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer During the COVID-19 Pandemic.

R R Sarkar, A J Wu, M Reyngold, J J Cuaron, M Zinovoy, C Hajj, E Pappou, N Segal, R Yaeger, I H Wei, M Widmar, M Weiser, P Paty, A Cercek, J J Smith, L Saltz, J Garcia-Aguilar, C H Crane, P B Romesser,

<h4>Purpose/objective(s)</h4>While long course chemoradiation therapy has been studied as part of a watch-and-wait (WW) strategy for patients with locally advanced rectal cancer, it is unclear whether short-course radiation therapy (SCRT) will be associated with similar rates of organ preservation. We hypothesized that a WW strategy to facilitate organ preservation with ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 111(3S):e73-e74]

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Organ Preservation With Definitive Chemoradiotherapy for T4 Laryngeal Squamous Cell Carcinoma.

J Hara, A J Rosenberg, A Pearson, Z Gooi, B J Baird, E A Blair, N Agrawal, E E Vokes, D J Haraf, A Juloori,

<h4>Purpose/objective(s)</h4>Randomized trials established chemoradiotherapy as standard treatment for locoregionally advanced laryngeal cancer, but T4 patients were largely excluded from RTOG 91-11. The standard of care for T4 patients includes upfront surgical resection. Our institution has experience with organ preservation for this population. The purpose of this study was to report ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 111(3S):e363]

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Mitochondrial respiratory chain and Krebs cycle enzyme function in human donor livers subjected to end-ischaemic hypothermic machine perfusion.

Hamid Abudhaise, Jan-Willem Taanman, Peter DeMuylder, Barry Fuller, Brian R Davidson,

<h4>Introduction</h4>Marginal human donor livers are highly susceptible to ischaemia reperfusion injury and mitochondrial dysfunction. Oxygenation during hypothermic machine perfusion (HMP) was proposed to protect the mitochondria but the mechanism is unclear. Additionally, the distribution and uptake of perfusate oxygen during HMP are unknown. This study aimed to examine the feasibility ... Read more >>

PLoS One (PloS one)
[2021, 16(10):e0257783]

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Long-term Therapeutic and Functional Outcomes With Organ Preservation for T4 Larynx and Hypopharynx Cancers.

A Rybkin, A Eita, J J Kang, M Fiasconaro, Z Zhang, K Zakeri, Y Yu, L Chen, D Gelblum, C J Tsai, N Riaz, S M McBride, E Sherman, L Dunn, A Ho, M Cohen, J Cracchiolo, D G Pfister, R J Wong, N Y Lee,

<h4>Purpose/objective(s)</h4>Stage T4 larynx and hypopharynx cancers were poorly represented in the original organ preservation trials, so concerns over reduced outcomes with nonoperative management have led to a preference for surgery. For patients who refuse surgery or are not surgical candidates, there is little data to guide decision making and counseling. ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 111(3S):e365-e366]

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Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer.

Stefano Filippo Zorzi, Maria Silvia Lazio, Giacomo Pietrobon, Francesco Chu, Valeria Zurlo, Debora Bibiano, Luigi De Benedetto, Augusto Cattaneo, Rita De Berardinis, Chiara Mossinelli, Daniela Alterio, Maria Cossu Rocca, Sara Gandini, Oreste Gallo, Susanna Chiocca, Marta Tagliabue, Mohssen Ansarin,

<h4>Purpose</h4>Advanced-stage laryngeal cancer is a challenging disease that needs multimodal treatment. Medical and surgical organ-preservation strategies have been developing in the last decades to spare these functions while granting cancer cure. The current work presents the experience of a tertiary-care center in conservative surgery for advanced-stage laryngeal cancer.<h4>Materials and methods</h4>We ... Read more >>

Am J Otolaryngol (American journal of otolaryngology)
[2021, 43(1):103272]

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Long-term normothermic machine preservation of human livers: What is needed to succeed?

Bianca Lascaris, Adam M Thorne, Ton Lisman, Maarten W N Nijsten, Robert J Porte, Vincent E de Meijer,

While short-term machine perfusion (≤24 h) allows for resuscitation and viability assessment of high-risk donor livers, the donor organ shortage might be further remedied by long-term perfusion machines. Extended preservation of injured donor livers may allow reconditioning, repair and regeneration. This review summarizes the necessary requirements and challenges for long-term ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2021, :]

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Current state of fertility preservation for adolescent and young adult patients with gynecological cancer.

Tatsuru Ohara, Shiho Kuji, Tomo Takenaga, Haruka Imai, Hiraku Endo, Ryo Kanamori, Jun Takeuchi, Yuko Nagasawa, Noriyuki Yokomichi, Haruhiro Kondo, Imari Deura, Akiko Tozawa, Nao Suzuki,

Although the incidence of the various gynecological cancers has been increasing in recent years, long-term survival is now possible for many patients thanks to advances in multimodality treatment. When treating gynecological cancer in adolescent and young adult (AYA) patients who desire future pregnancy, it is necessary to preserve the reproductive ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, :]

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ASO Visual Abstract: Adoption of Organ Preservation and Surgeon Variability for Patients with Rectal Cancer Does Not Correlate with Worse Survival.

Jin K Kim, Hannah Thompson, Rosa M Jimenez-Rodriguez, Fan Wu, Francisco Sanchez-Vega, Garrett M Nash, Jose G Guillem, Philip B Paty, Iris H Wei, Emmanouil P Pappou, Maria Widmar, Martin R Weiser, J Joshua Smith, Julio Garcia-Aguilar,

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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Adoption of Organ Preservation and Surgeon Variability for Patients with Rectal Cancer Does Not Correlate with Worse Survival.

Jin K Kim, Hannah Thompson, Rosa M Jimenez-Rodriguez, Fan Wu, Francisco Sanchez-Vega, Garrett M Nash, Jose G Guillem, Philip B Paty, Iris H Wei, Emmanouil P Pappou, Maria Widmar, Martin R Weiser, J Joshua Smith, Julio Garcia-Aguilar,

<h4>Background and objectives</h4>Watch-and-wait is variably adopted by surgeons and the impact of this on outcomes is unknown. We compared the disease-free survival and organ preservation rates of locally advanced rectal cancer patients treated by expert colorectal surgeons at a comprehensive cancer center.<h4>Methods</h4>This study included retrospective data on patients diagnosed with ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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The 14th European Colorectal Congress (#ECCStGallen), 29 November-2 December 2020, St. Gallen, Switzerland.

M Adamina, J Lange, G Pozza, F Ris, V Delaune, ,

Tech Coloproctol (Techniques in coloproctology)
[2021, 25(12):1337-1344]

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Tanshinone IIA attenuates renal injury during hypothermic preservation via the MEK/ERK1/2/GSK-3β pathway.

Linhao Xu, Yizhou Xu, Zhoujing Zhu, Huiquan Gu, Chaofeng Chen, Jian Chen,

<h4>Background</h4>Oxidative stress-induced injury during hypothermic preservation is a universal problem that delays graft function and decrease the success of organ transplantation. Tanshinone IIA (Tan IIA) was reported to exhibit a variety of biochemical activities, including protection against oxidative stress. Therefore, the specific molecular pathway by which Tan IIA protects renal ... Read more >>

BMC Complement Med Ther (BMC complementary medicine and therapies)
[2021, 21(1):257]

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Effect of Long Cold Ischemia Time of Kidneys from Aged Donors on Prognosis of Kidney Transplantation.

Lian Liu, Ke Cheng, Jufang Huang,

With the increasing incidence of end-stage renal disease (ESRD), patients' life span and life quality are significantly reduced. Kidney transplantation has gradually become the ideal method for treating ESRD, and the shortage of organ sources has become the main problem. In recent years, China has successfully realized the transformation of ... Read more >>

Ann Transplant (Annals of transplantation)
[2021, 26:e928735]

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Comment on "Salvage Surgery with Organ Preservation for Patients with Local Regrowth After Watch and Wait: Is It Still Possible?''.

Bülent Cavit Yüksel, Frenki Vila,

Dis Colon Rectum (Diseases of the colon and rectum)
[2021, :]

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Isochoric supercooled preservation and revival of human cardiac microtissues.

Matthew J Powell-Palm, Verena Charwat, Berenice Charrez, Brian Siemons, Kevin E Healy, Boris Rubinsky,

Low-temperature biopreservation and 3D tissue engineering present two differing routes towards eventual on-demand access to transplantable biologics, but recent advances in both fields present critical new opportunities for crossover between them. In this work, we demonstrate sub-zero centigrade preservation and revival of autonomously beating three-dimensional human induced pluripotent stem cell ... Read more >>

Commun Biol (Communications biology)
[2021, 4(1):1118]

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A New Hope for a New Year.

Robert S Brown,

Happy New Year! Time flies, paradoxically it seems even faster the older we all get. It seems just yesterday that I was writing the editorial to begin my tenure as Editor-in-Chief. Now, one year later, so much has changed, politically, in public health and society, all of which continue to ... Read more >>

Liver Transpl (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2021, :]

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A cohort study on factors impairing semen quality in transgender women.

I De Nie, J Asseler, A Meißner, I Ac Voorn-De Warem, E H Kostelijk, M Den Heijer, J Huirne, N M Van Mello,

<h4>Background</h4>Transgender women (birth-assigned males, female gender identity) can choose to cryopreserve semen prior to their medical transition, to retain the possibility to parent genetically related offspring later in life. Our previous retrospective study showed that semen quality in transgender women is decreased compared to the general population. The etiology of ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

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Organ preservation in the multimodality approach to locally advanced oesophageal cancer: festina lente.

J C Bolger, J V Reynolds,

Br J Surg (The British journal of surgery)
[2021, 108(10):1142-1144]

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