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Oral Hypoglycemic Agent Toxicity

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Thrombotic microangiopathy and liver toxicity due to a combination therapy of leflunomide and methotrexate: a case report.

Rainer Ullrich Pliquett, Christoph Lübbert, Christoph Schäfer, Matthias Girndt,

BACKGROUND:Treatment of active rheumatoid arthritis may necessitate a methotrexate mono- or combination therapy. As in the present case, novel side effects may occur, when escalating therapy. CASE PRESENTATION:A 63-year-old Caucasian female patient with rheumatoid arthritis on methotrexate for 8 years and on leflunomide for 6 years was admitted for weakness, edema, ascites, ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2020, 14(1):26]

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The recent use of Swietenia mahagoni (L.) Jacq. as antidiabetes type 2 phytomedicine: A systematic review.

Sukardiman, Martha Ervina,

Background:Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic drugs provide of both properties. Among antidiabetes plants, mahogany seed (Swietenia macrophylla) has been used ... Read more >>

Heliyon (Heliyon)
[2020, 6(3):e03536]

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Efficacy and Safety of Basal Insulin-Based Treatment Versus Twice-Daily Premixed Insulin After Short-Term Intensive Insulin Therapy in Patients with Type 2 Diabetes Mellitus in China: Study Protocol for a Randomized Controlled Trial (BEYOND V).

Jing Liu, Xia Jiang, Binhua Xu, Guoping Wang, Nan Cui, Xia Zhang, Jingcheng Liu, Yiming Mu, Lixin Guo,

INTRODUCTION:Many Chinese patients who are uncontrolled by oral antidiabetic drugs (OADs) receive short-term intensive insulin therapy (IIT) in hospital to rapidly relieve glucose-associated toxicity and to preserve/improve β-cell function. However, evidence for optimizing insulin algorithms for maintenance treatment after IIT is lacking. This study will compare the efficacy and safety ... Read more >>

Adv Ther (Advances in therapy)
[2020, :]

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Antidiabetic Activity of Extracts of Terminalia brownii Fresen. Stem Bark in Mice.

Niguse Meles Alema, Gomathi Periasamy, Gereziher Gebremedhin Sibhat, Gebretsadkan Hintsa Tekulu, Mebrahtom Gebrelibanos Hiben,

Background:Diabetes mellitus is a chronic metabolic disorder that imposes a huge health and economic burden on societies. Because the currently available medications have many drawbacks, it is important to search for alternative therapies. Medicinal plants used in traditional medicines are ideal candidates. Hence, this study was undertaken to investigate the antidiabetic ... Read more >>

J Exp Pharmacol (Journal of experimental pharmacology)
[2020, 12:61-71]

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Hypoglycemic and hepatoprotective effect of Rhizophora mucronata and Avicennia marina against streptozotocin-induced diabetes in male rats.

Obidallah Hamdan Ali Al-Jaghthmi, Isam ELDin Mohamed ELAmin Abu Zeid,

Objectives:Aqueous extracts of Rhizophora mucronata and Avicennia marina leaves were investigated for their hepatoprotective potential in diabetic rats.Materials and methods:One hundred twenty male albino rats were randomly assigned to eight equal groups (n = 15). The first group (control) comprised normal healthy rats, while the second to fifth groups were ... Read more >>

J Adv Vet Anim Res (Journal of Advanced Veterinary and Animal Research)
[2020, 7(1):177-185]

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An overview on medicinal perspective of thiazolidine-2,4-dione: A remarkable scaffold in the treatment of type 2 diabetes.

Garima Bansal, Punniyakoti Veeraveedu Thanikachalam, Rahul K Maurya, Pooja Chawla, Srinivasan Ramamurthy,

Diabetes or diabetes mellitus is a complex or polygenic disorder, which is characterized by increased levels of glucose (hyperglycemia) and deficiency in insulin secretion or resistance to insulin over an elongated period in the liver and peripheral tissues. Thiazolidine-2,4-dione (TZD) is a privileged scaffold and an outstanding heterocyclic moiety in ... Read more >>

J Adv Res (Journal of advanced research)
[2020, 23:163-205]

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Potential Effect of Hydroxychloroquine in Diabetes Mellitus: A Systematic Review on Preclinical and Clinical Trial Studies.

Dawit Zewdu Wondafrash, Tsion Zewdu Desalegn, Ebrahim M Yimer, Arega Gashaw Tsige, Betelhem Anteneh Adamu, Kaleab Alemayehu Zewdie,

Background:Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia. It affects millions of people globally. In spite of many antidiabetic drugs that are available, an adequate level of control remains challenging. Hydroxychloroquine is an immunomodulatory drug that has been used for the treatment of malaria and autoimmune diseases. ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2020, 2020:5214751]

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Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases.

Jose A Fernández-Albarral, Rosa de Hoz, Ana I Ramírez, Inés López-Cuenca, Elena Salobrar-García, María D Pinazo-Durán, José M Ramírez, Juan J Salazar,

Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1408-1416]

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Exploration of hypoglycemic effect of an extract from leaves of a plant from Tunisian pharmacopeia: Artemisia campestris (Asteraceae).

Amel Belgacem, Neyla Ben Gdara, Ikram Khemiri, Lotfi Bitri,

Background and objectives:A lot of research has been directed towards medicinal plants which are considered as a source of multiple phytotherapic substances endowed with hypoglycemic activities that could be used to treat diabetes and its complications. Our study was carried out in Wistar rats to investigate the hypoglycemic effect of ... Read more >>

Afr Health Sci (African health sciences)
[2019, 19(4):2846-2853]

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Testosterone Replacement Therapy and the Risk of Hypoglycemia.

Analía Verónica Yamaguchi, Pablo René Costanzo, Verónica Andrea Peuchot, Pablo Knoblovits,

We report the case of a 45-year-old man with a history of Klinefelter syndrome undergoing testosterone replacement therapy, and with type 2 diabetes treated with metformin with poor metabolic control. When vildagliptin was added to his treatment, he presented hypoglycemia after the testosterone injection. We highlight this not widely reported ... Read more >>

Case Rep Endocrinol (Case reports in endocrinology)
[2019, 2019:9616125]

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Comparative Study of Crude and Wine-Processing Corni Fructus on Chemical Composition and Antidiabetic Effects.

Huailong Bi, Dou Niu, Chen Guo, Jia Li, Xue Chen, Yuan Zhang, Shaojun Wang, Jiqing Bai, Xing Li, Jiefang Kang,

Wine processing is a specialized technology which involves sautéing crude herbal medicine using Chinese rice wine. Herein, we identified the changes in chemical profiles and antidiabetic effects of Corni Fructus (CF) after wine processing in high-fat diet (HFD) streptozotocin- (STZ-) induced diabetic mice. A novel high-efficiency method for simultaneously quantifying ... Read more >>

Evid Based Complement Alternat Med (Evidence-based Complementary and Alternative Medicine : eCAM)
[2019, 2019:3986964]

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A rare case of purulent meningitis caused by Capnocytophaga canimorsus in the Czech Republic - case report and review of the literature.

Petr Prasil, Lenka Ryskova, Stanislav Plisek, Pavel Bostik,

BACKGROUND:Invasive infections caused by Capnocytophaga canimorsus are rare. Immunocompromised patients, who report being bitten by or having a close contact with an animal, represent a high-risk group for this infection. There are only few dozens of infections by this bacteria manifesting as purulent meningitis reported worldwide. The reported case is ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):100]

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Potential Antidiabetic Activity of Extracts and Isolated Compound from Adenosma bracteosum (Bonati).

Ngoc Hong Nguyen, Quang Thang Pham, Thi Ngoc Han Luong, Hoang Khai Le, Van Giau Vo,

Adenosma bracteosum Bonati. (A. bracteosum) has been used in traditional and modern medicine in Vietnam for curing hepatitis. In this study, ethanol and aqueous extracts of A. bracteosum were evaluated for their α-glucosidase inhibitory activities and anti-hyperglycemic effects on glucose loaded hyperglycemic and streptozotocin (STZ) induced diabetic mice. The α-glucosidase ... Read more >>

Biomolecules (Biomolecules)
[2020, 10(2):]

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Successful kidney transplantation from an expanded criteria donor with long-term extracorporeal membrane oxygenation treatment: A case report.

Hye Won Seo, Sua Lee, Hwa Young Lee, Sun Cheol Park, Byung Ha Chung, Chul Woo Yang, Tae Hyun Ban,

BACKGROUND:Due to a shortage of donor kidneys, many centers have utilized graft kidneys from brain-dead donors with expanded criteria. Kidney transplantation (KT) from donors on extracorporeal membrane oxygenation (ECMO) has been identified as a successful way of expanding donor pools. However, there are currently no guidelines or recommendations that guarantee ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2020, 8(3):540-545]

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The Pharmacological Effects and Health Benefits of Platycodon grandiflorus-A Medicine Food Homology Species.

Ming-Yue Ji, Agula Bo, Min Yang, Jin-Fan Xu, Lin-Lin Jiang, Bao-Chang Zhou, Min-Hui Li,

Platycodon grandiflorus is a widely used edible, traditional Chinese medicinal herb. It is rich in saponins, flavonoids, phenolic acids, and other compounds. It contains a large number of fatty acids such as linoleic acid (up to 63.24%), a variety of amino acids, vitamins, and multiple essential trace elements. P. grandiflorus ... Read more >>

Foods (Foods (Basel, Switzerland))
[2020, 9(2):]

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Inverse Association between Metformin and Amiodarone-Associated Extracardiac Adverse Events.

Sayoko Kinoshita, Kouichi Hosomi, Satoshi Yokoyama, Mitsutaka Takada,

Background: The association between metformin and amiodarone-induced adverse events was examined using spontaneous adverse event database. Additionally, the association between other antidiabetic drugs and amiodarone-induced adverse events were also examined. Methods: A total of 6,153,696 reports from the first quarter of 2004 through the fourth quarter of 2015 were downloaded ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(3):302-309]

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Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy.

Lingling Yang, Feng Chen, Cheng Gao, Jiabao Chen, Junyan Li, Siyan Liu, Yuanyuan Zhang, Zhouyu Wang, Shan Qian,

Overexpression of protein tyrosine phosphatase 1B (PTP1B) induces insulin resistance in various basic and clinical research. In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported. However, C10a has some pharmacological defects and cytotoxicity. Herein, a structure-based drug design approach was used ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):152-164]

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Fournier´s Gangrene Under Sodium-Glucose Cotransporter 2 Inhibitor Therapy as a Life-Threatening Adverse Event: A Case Report and Review of the Literature.

Severin Rodler, Thomas Weig, Christa Finkenzeller, Christian Stief, Michael Staehler,

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a relatively new class of oral antidiabetic drugs. The US FDA has recently published a new warning about the safety of SGLT2 inhibitor administration in type 2 diabetes mellitus patients. There is an emerging evidence of an increased risk for developing Fournier´s gangrene (FG; ... Read more >>

Cureus (Cureus)
[2019, 11(9):e5778]

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Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia.

Marco Ciacciarelli, Gianluca Caruso, Marco Rengo, Piero Maceroni, Carmen Misurale, Eleonora D'Armiento, Alessandro Polidoro, Cristina Napoli, Alberto Lombardini, Umberto Ceratti, Ruben Manuel Luciano Colunga Biancatelli, Leonardo Calvosa, Romina Milanese, Sonia Ferri, Teresa Massaro, Andrea Lorusso, Veronica Sorrentino, Vincenzo Petrozza, Luigi Iuliano,

Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old ... Read more >>

Case Rep Endocrinol (Case reports in endocrinology)
[2020, 2020:4239679]

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Identification and Isolation of Active Compounds from Astragalus membranaceus that Improve Insulin Secretion by Regulating Pancreatic β-Cell Metabolism.

Dahae Lee, Da Hye Lee, Sungyoul Choi, Jin Su Lee, Dae Sik Jang, Ki Sung Kang,

In type 2 diabetes (T2D), insufficient secretion of insulin from the pancreatic β-cells contributes to high blood glucose levels, associated with metabolic dysregulation. Interest in natural products to complement or replace existing antidiabetic medications has increased. In this study, we examined the effect of Astragalus membranaceus extract (ASME) and its ... Read more >>

Biomolecules (Biomolecules)
[2019, 9(10):]

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Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity.

Salinee Jantrapirom, Wutigri Nimlamool, Nipon Chattipakorn, Siriporn Chattipakorn, Piya Temviriyanukul, Woorawee Inthachat, Piyarat Govitrapong, Saranyapin Potikanond,

Neuronal insulin resistance is a significant feature of Alzheimer's disease (AD). Accumulated evidence has revealed the possible neuroprotective mechanisms of antidiabetic drugs in AD. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog and an antidiabetic agent, has a benefit in improving a peripheral insulin resistance. However, the neuronal effect of liraglutide on ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(5):]

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Glucose and lipid lowering effects of Enhydra fluctuans extract in cadmium treated normal and type-2 diabetic model rats.

Mohammad Nazmul Hasan, Farah Sabrin, Begum Rokeya, Md Shahinul Haque Khan, Mahtab Uddin Ahmed, Abel Matondo, Md Morsaline Billah, Salima Akter,

BACKGROUND:Recent epidemiological and experimental studies suggest that cadmium and diabetes-related hyperglycemia may act synergistically to worsen metabolic regulation. The present study aims to evaluate the potential effects of Enhydra fluctuans extract in diabetes and dyslipidemia in cadmium (CdCl2) induced- normal and type 2 diabetic model rats. METHOD:Forty-eight Long-Evans rats were ... Read more >>

BMC Complement Altern Med (BMC complementary and alternative medicine)
[2019, 19(1):278]

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Antidiabetic and Hypolipidemic Effects of 5,7-Dimethoxyflavone in Streptozotocin-Induced Diabetic Rats.

Yongli Xie, Yawei Zhang, Xiaoqing Su,

BACKGROUND The flavones are considered as competent antidiabetic molecules due to their strong antioxidant activities and higher in vivo stability. The present study evaluated the antidiabetic and hypolipidemic effects of 5,7-dimethoxyflavone in streptozotocin (STZ)-induced diabetic rat models. MATERIAL AND METHODS The antidiabetic potential of 5,7-dimethoxyflavone was evaluated in streptozotocin-induced diabetic ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2019, 25:9893-9901]

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Design, synthesis and biological activity evaluation of a new class of 2,4-thiazolidinedione compounds as insulin enhancers.

Zou Huiying, Chen Guangying, Zhou Shiyang,

Diabetes mellitus (DM) is a global disease with a high incidence of type 2 diabetes. Current studies have shown that insulin enhancers play an important role in the treatment of type 2 diabetes and have great importance in the improvement of type 2 diabetes. In this research, Rosiglitazone was taken ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2019, 34(1):981-989]

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Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats.

Gustavo Roberto Villas Boas, João Marcos Rodrigues Lemos, Matheus William de Oliveira, Rafael Claudino Dos Santos, Ana Paula Stefanello da Silveira, Flávia Barbieri Bacha, Caren Naomi Aguero Ito, Ediane Bortolotte Cornelius, Fernanda Brioli Lima, Andrea Marisa Sachilarid Rodrigues, Nathália Belmal Costa, Felipe Francisco Bittencourt, Fernando Freitas de Lima, Marina Meirelles Paes, Priscila Gubert, Silvia Aparecida Oesterreich,

BACKGROUND:Diabetes mellitus is one of the most common todays public health problems. According to a survey by the World Health Organization, this metabolic disorder has reached global epidemic proportions, with a worldwide prevalence of 8.5% in the adult population. OBJECTIVES:The present study aimed to investigate the hypoglycemic effect of aqueous ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0227105]

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