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OncomiRs miR-106a and miR-17 negatively regulate the nucleoside-derived drug transporter hCNT1.

Clara Boces-Pascual, Aida Mata-Ventosa, Mireia Martín-Satué, Loreto Boix, Meritxell Gironella, Marçal Pastor-Anglada, Sandra Pérez-Torras,

High-affinity uptake of natural nucleosides as well as nucleoside derivatives used in anticancer therapies is mediated by human concentrative nucleoside transporters (hCNTs). hCNT1, the hCNT family member that specifically transports pyrimidines, is also a transceptor involved in tumor progression. In particular, oncogenesis appears to be associated with hCNT1 downregulation in ... Read more >>

Cell Mol Life Sci (Cellular and molecular life sciences : CMLS)
[2021, :]

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Author Correction: miR-93 functions as an oncomiR for the downregulation of PDCD4 in gastric carcinoma.

Hongwei Liang, Feng Wang, Danping Chu, Weijie Zhang, Zhicong Liao, Zheng Fu, Xin Yan, Hao Zhu, Wen Guo, Yujing Zhang, Wenxian Guan, Xi Chen,

Sci Rep (Scientific reports)
[2021, 11(1):18601]

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Therapeutic potential of chemically modified, synthetic, triplex peptide nucleic acid-based oncomiR inhibitors for cancer therapy.

Karishma Dhuri, Ravinder Reddy Gaddam, Ajit Vikram, Frank J Slack, Raman Bahal,

MicroRNA-155 (miR-155) is overexpressed in various types of lymphomas and leukemias, suggesting that targeting miR-155 could be a potential platform for the development of precision medicine. Here we tested the anti-cancer activity of novel, chemically modified, triplex peptide nucleic acid (PNA)-based antimiRs compared to the current state-of-the-art conventional full length ... Read more >>

Cancer Res (Cancer research)
[2021, :]

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MicroRNAs and Heat Shock Proteins in Breast Cancer Biology.

Mehmet Taha Yildiz, Lütfi Tutar, Nazlı Irmak Giritlioğlu, Banu Bayram, Yusuf Tutar,

Breast cancer has five major immune types; luminal A, luminal B, HER2, Basal-like, and normal-like. Cells produce a family of protein called heat shock proteins (Hsps) in response to exposure to thermal and other proteotoxic stresses play essential roles in cancer metabolism and this large family shows a diverse set ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2257:293-310]

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MicroRNA Expression Profiles and Breast Cancer Chemotherapy.

Matthew G Davey, Aoife J Lowery, Nicola Miller, Michael J Kerin,

Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the treatment paradigm to include prescription of chemotherapeutical agents, radiotherapies, targeted ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(19):]

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Bile reflux and hypopharyngeal cancer (Review).

Dimitra P Vageli, Sotirios G Doukas, Panagiotis G Doukas, Benjamin L Judson,

Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been considered a risk factor in the development of hypopharyngeal cancer. Bile acids are frequently present in the gastroesophageal refluxate and their effect has been associated with inflammatory and neoplastic changes in the upper aerodigestive tract. Recent <i>in vitro</i> and <i>in vivo</i> studies ... Read more >>

Oncol Rep (Oncology reports)
[2021, 46(5):]

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MicroRNA-17-5p inhibits thyroid cancer progression by suppressing Early growth response 2 (EGR2).

Xiang Geng, YangYang Sun, JinJin Fu, Liang Cao, Yuan Li,

miR-17-5p has been proved that play important roles in many kinds of tumors progression. This study aimed at explore the function and mechanism of miR-17-5p in thyroid cancer (TC). RT-qPCR was used to detect miR-17-5p and Early growth response 2 (EGR2) expression in TC tissues and cells. CCK8 and colony ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2713-2722]

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An in silico integrative analysis of hepatocellular carcinoma omics databases shows the dual regulatory role of microRNAs either as tumor suppressors or as oncomirs

Mahmoud Tolba, Bangli Soliman, Abdul Jabbar, HebaT'Allah Nasser, Mahmoud Elhefnawi,

MicroRNAs are well known as short RNAs bases, 22 nucleotides, binding directly to 3'untranslated region (3'UTR) of the messenger RNA to repress their functions. Recently, microRNAs have been widely used as a therapeutic approach for various types of Cancer. MicroRNA is categorized into tumor suppressor and oncomirs. Tumor suppressor microRNAs ... Read more >>

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Molecular Mechanisms of PD-1 and PD-L1 Activity on a Pan-Cancer Basis: A Bioinformatic Exploratory Study.

Siddarth Kannan, Geraldine Martina O'Connor, Emyr Yosef Bakker,

Immune checkpoint blockade targeting PD-1 (PDCD1)/PD-L1 (CD274) is increasingly used for multiple cancers. However, efficacy and adverse-related events vary significantly. This bioinformatic study interrogated molecular differences pertaining to PDCD1/CD274 and their correlated genes on a pan-cancer basis to identify differences between cancer types. Patient RNA-seq data from fifteen cancer types ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(11):]

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Emerging roles of miRNAs in the development of pancreatic cancer.

Mohadeseh Fathi, Soudeh Ghafouri-Fard, Atefe Abak, Mohammad Taheri,

Pancreatic cancer is a fatal cancer which is expected to exceed breast cancer as the third foremost source of cancer mortality by 2025. This cancer has been associated with several somatic genetic aberrations including mutations in the KRAS, CDKN2A/p16, TP53, and SMAD4. In addition, epigenetic alterations have been shown to ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, 141:111914]

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The Landscape of Regulatory Noncoding RNAs in Ewing's Sarcoma.

Connor Barrett, Anuj Budhiraja, Vijay Parashar, Mona Batish,

Ewing's sarcoma (ES) is a pediatric sarcoma caused by a chromosomal translocation. Unlike in most cancers, the genomes of ES patients are very stable. The translocation product of the EWS-FLI1 fusion is most often the predominant genetic driver of oncogenesis, and it is pertinent to explore the role of epigenetic ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(8):]

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miRNAs Involved in Esophageal Carcinogenesis and miRNA-Related Therapeutic Perspectives in Esophageal Carcinoma.

Giovanni Zarrilli, Francesca Galuppini, Valentina Angerilli, Giada Munari, Marianna Sabbadin, Vanni Lazzarin, Lorenzo Nicolè, Rachele Biancotti, Matteo Fassan,

MicroRNAs (miRNAs) are small non-coding RNAs that play a pivotal role in many aspects of cell biology, including cancer development. Within esophageal cancer, miRNAs have been proved to be involved in all phases of carcinogenesis, from initiation to metastatic spread. Several miRNAs have been found to be dysregulated in esophageal ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(7):]

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Clinical Applications of MicroRNAs in Acute Myeloid Leukemia: A Mini-Review.

Bhavana Bhatnagar, Ramiro Garzon,

MicroRNAs (miRs) are short non-coding RNAs, typically 18-25 nucleotides in length, that are critically important, through their direct effects on target mRNAs, in a variety of cellular processes including cell differentiation, proliferation and survival. Dysregulated miR expression has been identified in numerous cancer types including acute myeloid leukemia (AML). From ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:679022]

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Liquid Biopsy-Based Exo-oncomiRNAs Can Predict Prostate Cancer Aggressiveness.

Xavier Ruiz-Plazas, Antonio Altuna-Coy, Marta Alves-Santiago, José Vila-Barja, Joan Francesc García-Fontgivell, Salomé Martínez-González, José Segarra-Tomás, Matilde R Chacón,

Liquid biopsy-based biomarkers, including microRNAs packaged within extracellular vesicles, are promising tools for patient management. The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is related to PCa progression and is found in the semen of patients with PCa. TWEAK can induce the transfer of exo-oncomiRNAs from tumor cells ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(2):]

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MicroRNA as an Important Target for Anticancer Drug Development.

Zhiwen Fu, Liu Wang, Shijun Li, Fen Chen, Kathy Ka-Wai Au-Yeung, Chen Shi,

Cancer has become the second greatest cause of death worldwide. Although there are several different classes of anticancer drugs that are available in clinic, some tough issues like side-effects and low efficacy still need to dissolve. Therefore, there remains an urgent need to discover and develop more effective anticancer drugs. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:736323]

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Magic and mystery of microRNA-32.

Z L Zeng, Qingyun Zhu, Zhibo Zhao, Xuyu Zu, Jianghua Liu,

MicroRNAs (miRNAs) are a group of endogenous, small (∼22 nts in length) noncoding RNA molecules that function specifically by base pairing with the mRNA of genes and regulate gene expression at the post-transcriptional level. Alterations in miR-32 expression have been found in numerous diseases and shown to play a vital ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, 25(18):8588-8601]

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MicroRNAs: The Link between the Metabolic Syndrome and Oncogenesis.

Adriana Fodor, Andrada Luciana Lazar, Cristina Buchman, Brandusa Tiperciuc, Olga Hilda Orasan, Angela Cozma,

Metabolic syndrome (MetS) represents a cluster of disorders that increase the risk of a plethora of conditions, in particular type two diabetes, cardiovascular diseases, and certain types of cancers. MetS is a complex entity characterized by a chronic inflammatory state that implies dysregulations of adipokins and proinflammatory cytokins together with ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(12):]

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Aberrant Expression of microRNA Clusters in Head and Neck Cancer Development and Progression: Current and Future Translational Impacts.

Li-Jie Li, Wei-Min Chang, Michael Hsiao,

MicroRNAs are small non-coding RNAs known to negative regulate endogenous genes. Some microRNAs have high sequence conservation and localize as clusters in the genome. Their coordination is regulated by simple genetic and epigenetic events mechanism. In cells, single microRNAs can regulate multiple genes and microRNA clusters contain multiple microRNAs. MicroRNAs ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2021, 14(3):]

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Emerging Evidence of the Functional Impact of the miR379/miR656 Cluster (C14MC) in Breast Cancer.

Elan C McCarthy, Róisín M Dwyer,

Many microRNAs exist in clusters that share comparable sequence homology and may target genes in a common pathway. The miR-379/miR-656 (C14MC) cluster is imprinted in the DLK1-Dio3 region of 14q32.3 and contains 42 miRNAs. It plays a functional role in numerous biological pathways including vascular remodeling and early development. With ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(7):]

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Expression, regulation, and function of exosome-derived miRNAs in cancer progression and therapy.

Bowen Li, Yu Cao, Mingjun Sun, Hui Feng,

Exosomes are a novel class of intercellular signal modulators that contain a wide range of molecules and deliver information between cells and tissues. MicroRNAs (miRNAs), a type of regulatory non-coding RNA, are often incorporated into exosomes as signaling molecules. In this review, we discuss the expression of exosomal miRNAs from ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21916]

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The role of microRNA-21 in the onset and progression of cancer.

Ashutosh Singh, Ashutosh Kumar Singh, Rajanish Giri, Dhruv Kumar, Rohit Sharma, Martin Valis, Kamil Kuca, Neha Garg,

MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the expression of genes. Aberrant expression of miRNA is reported in various types of cancer. Since the first report of oncomiR-21 involvement in the glioma, its upregulation was reported in multiple cancers and was allied with high oncogenic property. In addition to the ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2021, :]

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microRNA Levels in Cervical Cancer Samples and Relationship with Lesion Grade and HPV Infection.

Carolina R Hoelzle, Solène Arnoult, Cinthya R M Borém, Mariana Ottone, Kênia C S F de Magalhães, Istéfani L da Silva, Renata T Simões,

<h4>Background</h4>miR-21, miR-214, and miR-let-7a are three validated and well-known miRNAs. miR-21 is described as an "oncomir," while miR-214 and miR-let-7a are described mainly as tumor suppressors. The role of these miRNAs remains unclear in cervical cancer, an important malignancy among women worldwide and responsible for many deaths every year.<h4>Objective</h4>The objective ... Read more >>

Microrna (MicroRNA (Shariqah, United Arab Emirates))
[2021, :]

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Dicer-to-Argonaute switch controls biogenesis of oncogenic miRNA

Winchester, van Bijsterveldt, Dhawan, Wigfield, Triantafyllidis, Haider, McIntyre, T.C. Humphrey, A.L. Harris, F.M. Buffa,

miRNAs are post-transcriptional regulators of gene expression, controlling biological processes from development to pathogenesis. We asked whether the reshaped functional miRNA landscape in cancers is driven by altered transcription of its precursors, or altered biogenesis and maturation of miRNAs. Integrated analysis of genomic and transcriptomic data in 9,111 samples across ... Read more >>

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Role of miR-24 in Multiple Endocrine Neoplasia Type 1: A Potential Target for Molecular Therapy.

Francesca Marini, Maria Luisa Brandi,

Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant inherited multiple cancer syndrome of neuroendocrine tissues. Tumors are caused by an inherited germinal heterozygote inactivating mutation of the <i>MEN1</i> tumor suppressor gene, followed by a somatic loss of heterozygosity (LOH) of the <i>MEN1</i> gene in target neuroendocrine cells, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(14):]

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Preclinical Imaging Evaluation of MiRNAs Delivery and Effects in Breast Cancer Mouse Models: A Systematic Review

Francesca Maria Orlandella, Luigi Auletta, Adelaide Greco, Antonella Zannetti, Giuliana Salvatore,

<h4>Background: </h4> miRNAs have been defined as a tumor suppressor or oncogene (oncomiR) in several human cancers. We have conducted a systematic review highlighting and specifically focusing in the advancements in preclinical molecular imaging to study in vivo the delivery and the therapeutic efficacy of miRNAs in mouse models of ... Read more >>

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