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Oligodendroglioma

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131I accumulation in oligodendroglioma: before and after surgery.

Lingzhi Cao, Fanhui Yang, Suping Li, Jianping Xie,

Hell J Nucl Med (Hellenic journal of nuclear medicine)
[2020, :]

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Short-term outcomes associated with temozolomide vs. PCV chemotherapy for 1p/19q-codeleted WHO grade III anaplastic oligodendrogliomas: a national evaluation

Nayan Lamba, Malia McAvoy, Vasileios Kavouridis, TImothy Smith, Mehdi Touat, David Reardon, Julian Bryan Iorgulescu,

PURPOSE: The optimal chemotherapy regimen between temozolomide (TMZ) and procarbazine, lomustine, and vincristine (PCV) remains uncertain for newly-diagnosed anaplastic oligodendroglioma (AO). We therefore addressed this question using a national database. METHODS: Patients newly-diagnosed with 1p/19q-codeleted W.H.O. grade III AO between 2010-2016 were identified from the National Cancer Database. Predictors of ... Read more >>

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Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth.

N Leventoux, M Augustus, S Azar, S Riquier, J P Villemin, S Guelfi, L Falha, L Bauchet, C Gozé, W Ritchie, T Commes, H Duffau, V Rigau, J P Hugnot,

IDH1-mutated gliomas are slow-growing brain tumours which progress into high-grade gliomas. The early molecular events causing this progression are ill-defined. Previous studies revealed that 20% of these tumours already have transformation foci. These foci offer opportunities to better understand malignant progression. We used immunohistochemistry and high throughput RNA profiling to ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5504]

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Correlation between IDH, ATRX, and TERT promoter mutations in glioma.

Shigeo Ohba, Kiyonori Kuwahara, Seiji Yamada, Masato Abe, Yuichi Hirose,

According to the 2016 World Health Organization (WHO) classification of central nervous system tumors, diffuse astrocytic and oligodendroglial tumors are differentiated by the presence of isocitrate dehydrogenase 1 or 2 (IDH1/2) mutation and the combined loss of the short arm of chromosome 1 and the long arm of chromosome 19 ... Read more >>

Brain Tumor Pathol (Brain tumor pathology)
[2020, :]

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IDH1 Mutations Induce Organelle Defects Via Dysregulated Phospholipids

Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark Gilbert, Paras Prasad, Mioara Larion,

Summary Cytosolic IDH1 enzyme plays a key, but currently unexplored, role in lipid biosynthesis. Using Raman imaging microscopy, we identified heterogeneous lipid profiles in cellular organelles attributed uniquely to IDH1 mutations. Via organelle lipidomics, we found an increase in saturated and monounsaturated fatty acids in the endoplasmic reticulum of IDH1 ... Read more >>

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Pediatric low-grade glioma in the era of molecular diagnostics.

Scott Ryall, Uri Tabori, Cynthia Hawkins,

Low grade gliomas are the most frequent brain tumors in children and encompass a spectrum of histologic entities which are currently assigned World Health Organisation grades I and II. They differ substantially from their adult counterparts in both their underlying genetic alterations and in the infrequency with which they transform ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):30]

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Total copy number variation, somatic mutation burden, and histologic grade correlate with clinical outcome in oligodendroglioma.

Timothy E Richardson, Michael Williams, Kristyn Galbraith, Kanish Mirchia, Ashwani Kumar, Chao Xing, Jamie M Walker,

Clin. Neuropathol. (Clinical neuropathology)
[2020, :]

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Involvement of the Olfactory Apparatus by Gliomas.

X Wu, Y Li, C M Glastonbury, S Cha,

The olfactory bulbs and tracts are central nervous system white matter tracts maintained by central neuroglia. Although rare, gliomas can originate from and progress to involve the olfactory apparatus. Through a Health Insurance Portability and Accountability Act-compliant retrospective review of the institutional teaching files and brain MR imaging reports spanning ... Read more >>

AJNR Am J Neuroradiol (AJNR. American journal of neuroradiology)
[2020, :]

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Wild-Type IDH1 and Mutant IDH1 Opposingly Regulate Podoplanin Expression in Glioma.

Chao Sun, Liming Xiao, Yuanlin Zhao, Jiankuan Shi, Yuan Yuan, Yu Gu, Feng Zhang, Xing Gao, Ying Yang, Risheng Yang, Junhui Qin, Jin Zhang, Chao Wang, Yingmei Wang, Zhe Wang, Peizhen Hu, Ting Chang, Liang Wang, Gang Wang, Huangtao Chen, Zhuyi Li, Jing Ye,

Isocitrate dehydrogenase (IDH) mutations occur frequently in lower-grade gliomas, which result in genome-wide epigenetic alterations. The wild-type IDH1 is reported to participate in lipid biosynthesis and amino acid metabolism, but its role in tumorigenesis is still unclear. In this study, the expressions of IDH1 and podoplanin (Pdpn) were determined in ... Read more >>

Transl Oncol (Translational oncology)
[2020, 13(4):100758]

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Sox2-dependent maintenance of mouse oligodendroglioma involves the Sox2-mediated downregulation of Cdkn2b, Ebf1, Zfp423 and Hey2

Cristiana Barone, Mariachiara Buccarelli, Francesco Alessandrini, Miriam Pagin, Laura Rigoldi, Irene Sambruni, Rebecca Favaro, Sergio Ottolenghi, Roberto Pallini, Lucia Ricci-Vitiani, Paolo Malatesta, Silvia Nicolis,

Abstract Cancer stem cells (CSC) are essential for tumorigenesis. The transcription factor Sox2 is overexpressed in brain tumors. In gliomas, Sox2 is essential to maintain CSC. In mouse high-grade glioma pHGG, Sox2 deletion causes cell proliferation arrest and inability to reform tumors in vivo; 134 genes are significantly derepressed. To ... Read more >>

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Staged Laser Interstitial Thermal Therapy (LITT) Treatments to Left Insular Low-Grade Glioma.

Daniel M Hafez, Caroline Liekweg, Eric C Leuthardt,

BACKGROUND AND IMPORTANCE:Low-grade insular gliomas remain challenging tumors for aggressive resection because of the numerous functional and vascular structures surrounding them. Because of the potential morbidities associated with open surgical resection, less invasive techniques may confer a more optimal balance between cytoreduction and surgical complications. For this reason, we evaluated ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 86(3):E337-E342]

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A phase I trial of surgical resection with Gliadel Wafer placement followed by vaccination with dendritic cells pulsed with tumor lysate for patients with malignant glioma.

Jeremy D Rudnick, J Manuel Sarmiento, Benjamin Uy, Miriam Nuno, Christopher J Wheeler, Mia J Mazer, Hongqiang Wang, Jethro L Hu, Ray M Chu, Surasak Phuphanich, Keith L Black, John S Yu,

High grade gliomas are associated with poor prognosis and high mortality. Conventional treatments and management of high grade gliomas have shown little improvement in 5-year overall survival. This phase I trial evaluated the safety, immunogenicity, and potential synergy of surgical resection with Gliadel Wafer implantation, followed by autologous tumor lysate-pulsed ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, :]

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Tracking the Features of CIMP-positive Glioma: A Systematic Review and Meta-Analysis

Liang Zong, Huashi Xiao, Yingying Xu, He-chun Shen, Wanjun Liu, Siyuan Tan, Ping Chen, Guo Yu, Chuanli Ren, Liangdan Sun, Duonan Yu,

<title>Abstract</title> <p> Backgrounds Controversy surrounding CpG island methylator phenotype (CIMP) in glioma exists with regard to its prognostic value.Methods PubMed, EMBASE, and Cochrane Library databases were searched for studies describing molecular and clinicopathological features, and overall survival of gliomas stratified by CIMP status. Associations of CIMP with outcome ... Read more >>

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Gray Areas in the Gray Matter: IDH1/2 Mutations in Glioma.

Martin J van den Bent, Ingo K Mellinghoff, Ranjit S Bindra,

Since the first discovery of isocitrate dehydrogenase (IDH) mutations in cancer, considerable progress has been made in our understanding of their contribution to cancer development. For glioma, this has helped to identify two diagnostic groups of tumors (oligodendroglioma and astrocytoma IDHmt) with distinct clinical characteristics and that are now diagnosed ... Read more >>

Am Soc Clin Oncol Educ Book (American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting)
[2020, 40:1-8]

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[The role of SMARCE1 in the diagnosis of clear cell meningioma].

L Zhang, Z G Yao, F Lian, D Z Wang, Y P Chen, S S Cai, S Zhang, X F Wang,

Objective: To analyze the expression of SMARCE1 in clear cell meningioma (CCM), and evaluate the role of SMARCE1 in the differential diagnosis in morphologically similar diseases. Methods: Thirteen samples/11 cases of CCMs were collected from the First Affiliated Hospital of Fujian Medical University, Shandong Provincial Hospital, Xuanwu Hospital of Capital ... Read more >>

Zhonghua Bing Li Xue Za Zhi (Zhonghua bing li xue za zhi = Chinese journal of pathology)
[2020, 49(3):234-238]

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Avoiding New Biopsies by Identification of IDH1 and TERT Promoter Mutation in Nondiagnostic Biopsies From Glioma Patients.

Marc Barritault, Thiébaud Picart, Delphine Poncet, Tanguy Fenouil, Anne d'Hombres, Mathieu Gabut, Jacques Guyotat, Emmanuel Jouanneau, Roxana Ameli, Bastien Joubert, Nathalie Streichenberger, Alexandre Vasiljevic, Jérôme Honnorat, David Meyronet, François Ducray,

BACKGROUND:Biopsies in patients with a suspected glioma are occasionally nondiagnostic. OBJECTIVE:To explore the utility of molecular testing in this setting by determining whether IDH1 and TERT promoter (pTERT) mutations could be detected in nondiagnostic biopsies from glioma patients. METHODS:Using SNaPshot polymerase chain reaction, we retrospectively assessed IDH1 and pTERT mutation ... Read more >>

Neurosurgery (Neurosurgery)
[2020, :]

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Heme Oxygenase-1 and Carbon Monoxide Regulate Growth and Progression in Glioblastoma Cells.

Carlo Castruccio Castracani, Lucia Longhitano, Alfio Distefano, Michelino Di Rosa, Valeria Pittalà, Gabriella Lupo, Massimo Caruso, Daniela Corona, Daniele Tibullo, Giovanni Li Volti,

In human glioma tumours, heme oxygenase-1 (HO-1) is overexpressed when compared with normal brain tissues and during oligodendroglioma progression. However, the molecular mechanisms mediated by HO-1 to promote glioblastoma remain unknown. We therefore aimed at investigating the effect of HO-1 expression and its selective enzymatic inhibition in two different cell ... Read more >>

Mol. Neurobiol. (Molecular neurobiology)
[2020, :]

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HLA-E expression in diffuse glioma: relationship with clinicopathological features and patient survival.

Zhifeng Wu, Jingshan Liang, Zheng Wang, Aimin Li, Xing Fan, Tao Jiang,

BACKGROUND:Human leukocyte antigen-E (HLA-E) has been extensively investigated in various human cancers including glioma. However, the clinical significance of HLA-E expression in glioma patients has not been elucidated. The current study aimed to investigate the association of HLA-E expression with clinicopathological features and survival in patients with diffuse glioma. METHODS:A ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):59]

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Making heads or tails - the emergence of capicua (CIC) as an important multifunctional tumour suppressor.

Derek Wong, Stephen Yip,

Capicua, encoded by the gene CIC, is an evolutionarily conserved high-mobility group-box transcription factor downstream of the receptor tyrosine kinase and mitogen-activated protein kinase pathways. It was initially discovered and studied in Drosophila. Recurrent mutations in CIC were first identified in oligodendroglioma, a subtype of low-grade glioma. Subsequent studies have ... Read more >>

J. Pathol. (The Journal of pathology)
[2020, :]

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Predictors and early survival outcomes of maximal resection in WHO grade II 1p/19q-codeleted oligodendrogliomas.

Maya Harary, Vasileios K Kavouridis, Matthew Torre, Hasan A Zaidi, Ugonma N Chukwueke, David A Reardon, Timothy R Smith, J Bryan Iorgulescu,

BACKGROUND:Although surgery plays a crucial diagnostic role in World Health Organization (WHO) grade II 1p/19q-codeleted oligodendrogliomas, the role of maximal tumor surgical resection remains unclear, with early retrospective series limited by lack of molecular classification or appropriate control groups. METHODS:The characteristics, management, and overall survival (OS) of patients ≥20 years ... Read more >>

Neuro-oncology (Neuro-oncology)
[2020, 22(3):369-380]

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Imaging growth as a predictor of grade of malignancy and aggressiveness of IDH-mutant and 1p/19q-codeleted oligodendrogliomas in adults.

Alexandre Roux, Arnault Tauziede-Espariat, Marc Zanello, Sophie Peeters, Gilles Zah-Bi, Eduardo Parraga, Myriam Edjlali, Emmanuèle Lechapt, Natalia Shor, Luisa Bellu, Giulia Berzero, Didier Dormont, Edouard Dezamis, Fabrice Chretien, Catherine Oppenheim, Marc Sanson, Pascale Varlet, Laurent Capelle, Frédéric Dhermain, Johan Pallud,

BACKGROUND:We quantified the spontaneous imaging growth rate of oligodendrogliomas. We assessed whether: 1) it discriminates between grade II and grade III oligodendrogliomas; 2) grade III oligodendrogliomas with neoangiogenesis are associated with more fast growth rates (≥8 mm/year). METHODS:Retrospective bicentric cohort study (2010-2016) of adult patients harboring a newly diagnosed supratentorial ... Read more >>

Neuro-oncology (Neuro-oncology)
[2020, :]

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Bioinformatics Analysis of the Expression of ATP Binding Cassette Subfamily C Member 3 (ABCC3) in Human Glioma.

Zelin Sun, Xiaoyuan Qi, Yan Zhang,

Objective:To investigate the expression of the ABCC3 gene in human glioma and its correlation with the patient's prognosis. Methods:The cancer genome atlas (TCGA) database was used to analyze the differential expression of the ABCC3 gene in human glioma. The STRING database was used to construct the protein-protein interaction (PPI) network ... Read more >>

Open Med (Wars) (Open medicine (Warsaw, Poland))
[2020, 15:107-113]

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Extent of resection and molecular pathologic subtype are potent prognostic factors of adult WHO grade II glioma.

Jinhyun Choi, Se Hoon Kim, Sung Soo Ahn, Hye Jin Choi, Hong In Yoon, Jae Ho Cho, Tae Hoon Roh, Seok-Gu Kang, Jong Hee Chang, Chang-Ok Suh,

We evaluated prognostic factors of adult low-grade glioma (LGG) according to the new 2016 WHO classification. Records of 153 patients diagnosed with WHO grade II LGG between 2003 and 2015 were retrospectively reviewed. Based on the 2016 WHO classification, 80 patients (52.3%) had diffuse astrocytoma, IDH-mutant; 45 (29.4%) had oligodendroglioma, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2086]

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Spinal leptomeningeal oligodendrogliomatosis after resection of cerebral anaplastic oligodendoglioma with 1p19q Co-deletion - A case report.

Molina Jaque Felipe Andres, Ziad Fouzia, Raunio Sami,

Anaplastic Oligodendroglioma has a better prognosis in the presence of 1p19q co-deletion and IDH-1 mutation but spinal leptomeningeal dissemination of cerebral anaplastic oligodendroglioma is a rare occurrence. We describe the case of a 47 year old man with spinal leptomeningeal dissemination eight months after resection of an anaplastic cerebral oligodendroglioma presenting ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 73:314-316]

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Segmentation and Classification in Digital Pathology for Glioma Research: Challenges and Deep Learning Approaches.

Tahsin Kurc, Spyridon Bakas, Xuhua Ren, Aditya Bagari, Alexandre Momeni, Yue Huang, Lichi Zhang, Ashish Kumar, Marc Thibault, Qi Qi, Qian Wang, Avinash Kori, Olivier Gevaert, Yunlong Zhang, Dinggang Shen, Mahendra Khened, Xinghao Ding, Ganapathy Krishnamurthi, Jayashree Kalpathy-Cramer, James Davis, Tianhao Zhao, Rajarsi Gupta, Joel Saltz, Keyvan Farahani,

Biomedical imaging Is an important source of information in cancer research. Characterizations of cancer morphology at onset, progression, and in response to treatment provide complementary information to that gleaned from genomics and clinical data. Accurate extraction and classification of both visual and latent image features Is an increasingly complex challenge ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:27]

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