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Obstructive Sleep Apnea

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Injury and Apoptosis in the Palatopharyngeal Muscle in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome.

Jiaqi Dong, Xun Niu, Xiong Chen,

BACKGROUND This study aimed to elucidate the possible activity of the mitochondrial-mediated apoptotic pathway (MMAP) in obstructive sleep apnea-hypopnea syndrome (OSAHS). MATERIAL AND METHODS A control group, a mild OSAHS group, a moderate OSAHS group, and a severe OSAHS group were included. Masson staining, hematoxylin and eosin staining, and terminal ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e919501]

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Intrathecal Morphine and Pulmonary Complications after Arthroplasty in Patients with Obstructive Sleep Apnea: A Retrospective Cohort Study.

Johnny W Bai, Mandeep Singh, Anthony Short, Didem Bozak, Frances Chung, Vincent W S Chan, Anuj Bhatia, Anahi Perlas,

BACKGROUND:Intrathecal morphine is commonly and effectively used for analgesia after joint arthroplasty, but has been associated with delayed respiratory depression. Patients with obstructive sleep apnea may be at higher risk of postoperative pulmonary complications. However, data is limited regarding the safety of intrathecal morphine in this population undergoing arthroplasty. METHODS:This ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):702-712]

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Primary Aldosteronism and Obstructive Sleep Apnea: Casual Association or Pathophysiological Link?

Alessio Pecori, Fabrizio Buffolo, Jacopo Pieroni, Vittorio Forestiero, Elisa Sconfienza, Franco Veglio, Paolo Mulatero, Silvia Monticone,

The coexistence of aldosterone oversecretion and obstructive sleep apnea is frequently observed, especially in patients with resistant hypertension, obesity, and metabolic syndrome. Since aldosterone excess and sleep apnea are both independently associated with an increased risk of cardiovascular disease, to investigate whether their coexistence might be attributed to common predisposing ... Read more >>

Horm. Metab. Res. (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme)
[2020, :]

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Excessive Daytime Sleepiness and Safety Performance: Comparing Proactive and Reactive Approaches.

Vahid Gharibi, Hamidreza Mokarami, Rosanna Cousins, Mehdi Jahangiri, Davood Eskandari,

BACKGROUND:Sleep disorders and excessive daytime sleepiness negatively affect employees' safety performance. OBJECTIVE:To investigate the relationship between excessive daytime sleepiness with obstructive sleep apnea and safety performance at an oil construction company in Iran. METHODS:661 employees consented to participate in this study. Excessive daytime sleepiness was measured with the STOP-BANG questionnaire ... Read more >>

Int J Occup Environ Med (The international journal of occupational and environmental medicine)
[2020, 11(2):95-107]

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The Utility of Early Tongue Reduction Surgery for Macroglossia in Beckwith-Wiedemann Syndrome.

Jennifer L Cohen, Christopher M Cielo, Jonida Kupa, Kelly A Duffy, Evan R Hathaway, Jennifer M Kalish, Jesse A Taylor,

BACKGROUND:Macroglossia, a cardinal feature of the (epi)genetic disorder Beckwith-Wiedemann syndrome, is associated with obstructive sleep apnea, speech and/or feeding difficulties, and dental or jaw malalignment. These sequelae may be treated and/or prevented with tongue reduction surgery; the authors sought to determine whether certain Beckwith-Wiedemann syndrome patients may benefit from early ... Read more >>

Plast. Reconstr. Surg. (Plastic and reconstructive surgery)
[2020, 145(4):803e-813e]

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Non-contact diagnosis of obstructive sleep apnea using impulse-radio ultra-wideband radar.

Sun Kang, Dong-Kyu Kim, Yonggu Lee, Young-Hyo Lim, Hyun-Kyung Park, Sung Ho Cho, Seok Hyun Cho,

While full-night polysomnography is the gold standard for the diagnosis of obstructive sleep apnea, its limitations include a high cost and first-night effects. This study developed an algorithm for the detection of respiratory events based on impulse-radio ultra-wideband radar and verified its feasibility for the diagnosis of obstructive sleep apnea. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5261]

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Multi-perspective clustering of obstructive sleep apnea towards precision therapeutic decision including craniofacial intervention.

Su-Jung Kim, Waleed Maqbul Alnakhli, Ali Saeed Alfaraj, Kyung-A Kim, Sung-Wan Kim, Stanley Yung-Chuan Liu,

PURPOSE:Previous studies focusing on phenotyping obstructive sleep apnea (OSA) have outlined its heterogeneity in clinical symptoms, comorbidities, and polysomnographic features. However, the role of anatomical or pathophysiological causality including craniofacial skeletal deformity has not been studied. We aimed to identify and characterize phenotypes of OSA based on multi-perspective clustering by ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2020, :]

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Polysomnographic risk factors for vigilance-related cognitive decline and obstructive sleep apnea.

Karen McCloy, Brett Duce, Vinayak Swarnkar, Craig Hukins, Udantha Abeyratne,

PURPOSE:Cognitive decline (CD) and obstructive sleep apnea (OSA) are often comorbid. Some modifiable risk factors (RF) for CD are also associated with OSA. Diagnostic polysomnography (PSG) measures these RF and may identify at risk patients prior to the onset of CD. We aim to determine whether there are severe RF ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2020, :]

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The efficacy of different treatment approaches for pediatric OSAHS patients with mandibular rethognathia: a study protocol for a multicenter randomized controlled trial

Yuehua Liu, Yuanyuan Li, Jiali Wu, Jinghan Guo, Liming Yu, Jing Wang, Xiaoyan Li, Shuhua Xu, Min Zhu, Jinqiu Feng,

<title>Abstract</title> <p> <bold>Background</bold>: Pediatric obstructive sleep apnea/hypopnea syndrome (OSAHS) is a multifactorial syndrome caused by many risk factors, such as craniofacial anomalies, adenotonsillar hypertrophy, obesity and airway inflammation. Although new treatment patterns have been recently proposed, treatment methods for children have continued to be particularly challenging and controversial. ... Read more >>

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Transoral Robotic Surgery versus Plasma Ablation for Tongue Base Reduction in Obstructive Sleep Apnea: Meta-analysis.

Joshua A Lee, Young Jae Byun, Shaun A Nguyen, Eric J Lentsch, M Boyd Gillespie,

OBJECTIVES:To compare the effectiveness of transoral robotic surgery (TORS) versus plasma ablation (PA) in tongue base reduction surgery for obstructive sleep apnea (OSA). DATA SOURCES:PubMed, Scopus, Cochrane Library, OVID. REVIEW METHODS:Keywords searched included OSA, tongue base surgery, TORS, and coblation. Outcomes included pre- to postoperative apnea-hypopnea index, Epworth Sleepiness Scale ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2020, :194599820913533]

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Forkhead Box P3 Methylation and Expression in Men with Obstructive Sleep Apnea.

David Sanz-Rubio, Arianne Sanz, Luis Varona, Rosa Bolea, Marta Forner, Ana V Gil, Pablo Cubero, Marta Marin-Oto, Inmaculada Martin-Burriel, Jose M Marin,

BACKGROUND:Epigenetic changes in obstructive sleep apnea (OSA) have been proposed as a mechanism for end-organ vulnerability. In children with OSA, Forkhead Box P3 (FOXP3) DNA methylation were associated with inflammatory biomarkers; however, the methylation pattern and its effect in the expression of this gene have not been tested in adults ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(6):]

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Obstructive Sleep Apnea-Hypopnea Syndrome and Keratoconus: An Epiphenomenon Related to Sleep Position?

Damien Gatinel, Virgilio Galvis, Alejandro Tello, Camilo A Niño, Juán J Rey, Paul A Camacho, Sergio E Serrano,

Cornea (Cornea)
[2020, 39(4):e11]

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Prospective Association of Obstructive Sleep Apnea Risk Factors With Heart Failure and its Subtypes in Postmenopausal Women: The Women's Health Initiative.

Patrick Koo, Umama Gorsi, JoAnn E Manson, Matthew A Allison, Michael J LaMonte, Mary B Roberts, Aladdin Shadyab, Charles B Eaton,

STUDY OBJECTIVES:The relationship between obstructive sleep apnea (OSA) and heart failure (HF) incidence in postmenopausal women has been understudied given the limited representation of women in heart failure studies. We investigated the relationship between OSA risk factors and HF and its subtypes in postmenopausal women. METHODS:We performed a prospective analysis ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2020, :]

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Obstructive sleep apnea and neurocognitive impairment in children with congenital heart disease.

Daniel Combs, Jamie O Edgin, Scott Klewer, Brent J Barber, Wayne J Morgan, Chiu-Hsieh Hsu, Ivo Abraham, Sairam Parthasarathy,

BACKGROUND:Children with congenital heart disease (CHD) have an increased risk of neurocognitive impairment. No prior studies have evaluated the role of obstructive sleep apnea (OSA), which is associated with neurocognitive impairment in children without CHD. RESEARCH QUESTION:Is OSA is associated with neurocognitive impairment in children with CHD? STUDY DESIGN AND ... Read more >>

Chest (Chest)
[2020, :]

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Does ischemia-modified albumin level predict severity of obstructive sleep apnea?

Mustafa Düger, Ekrem Cengiz Seyhan, Mehmet Zeki Günlüoğlu, Mustafa Bolatkale, Mehmet Akif Özgül, Demet Turan, Efsun Uğur, Gözde Ülfer,

OBJECTIVE AND AIM:Ischemia-modified albumin (IMA) is a newly recognized marker of chronic inflammation used to evaluate oxidative stress status in patients with various diseases. We explored the possible relationship between IMA levels and obstructive sleep apnea (OSA). METHODS:In this retrospective study, 169 of 216 sequential patients being evaluated for suspicion ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2020, :]

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Treatment of Obstructive Sleep Apnea in Children: Handling the Unknown with Precision.

David Gozal, Hui-Leng Tan, Leila Kheirandish-Gozal,

Treatment approaches to pediatric obstructive sleep apnea (OSA) have remarkably evolved over the last two decades. From an a priori assumption that surgical removal of enlarged upper airway lymphadenoid tissues (T&A) was curative in the vast majority of patients as the recommended first-line treatment for pediatric OSA, residual respiratory abnormalities ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

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Environmental Factors as Modulators of the Relationship between Obstructive Sleep Apnea and Lesions in the Circulatory System.

Dominika Urbanik, Helena Martynowicz, Grzegorz Mazur, Rafał Poręba, Paweł Gać,

Obstructive sleep apnea (OSA) is a growing social problem, particularly in well-developed countries. It has been demonstrated that obstructive sleep apnea is a significant risk factor for cardiovascular diseases, including arterial hypertension, ischemic heart disease, heart failure, rhythm/conduction disturbances, as well as cerebral stroke. The pathophysiology of these diseases is ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

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Sleep disturbances and residual neuromuscular blockade: future research possibilities.

M Medina, S Tufik, M L Andersen,

Anaesthesia (Anaesthesia)
[2020, 75(4):552]

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Severe Obstructive Sleep Apnea Associated With Higher Risk of Mortality in Stage III and IV Lung Cancer.

Hung-Yu Huang, Shih-Wei Lin, Li-Pang Chuang, Chih-Liang Wang, Ming-Hui Sun, Hsueh-Yu Li, Chee-Jen Chang, Shu-Chen Chang, Cheng-Ta Yang, Ning-Hung Chen,

STUDY OBJECTIVES:Obstructive sleep apnea (OSA) has been associated with increased cancer incidence and mortality. The aim of this study was to investigate cancer-related mortality, overall survival and progression free survival in patients with suspected OSA and lung cancer. METHODS:This was a case series analysis of lung cancer from a sleep ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2020, :]

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Arrhythmias and sleep apnea: physiopathologic link and clinical implications.

Stefania Angela Di Fusco, Carlo Pignalberi, Luca Santini, Furio Colivicchi, Massimo Santini,

Available evidence suggests a pathogenetic role of sleep breathing disorders in both atrial and ventricular arrhythmias with non-negligible clinical implications. Scientific literature has reported convincing findings on the link between sleep breathing disorders and arrhythmias. The coexistence of these conditions should be appropriately managed because OSA treatment may reduce arrhythmia ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2020, :]

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Severe Obstructive Sleep Apnea Associated With Higher Risk of Mortality in Stage III and IV Lung Cancer.

Hung-Yu Huang, Lin Shih-Wei, Li-Pang Chuang, Chih-Liang Wang, Ming-Hui Sun, Hsueh-Yu Li, Chee-Jen Chang, Shu-Chen Chang, Cheng-Ta Yang, Ning-Hung Chen,

STUDY OBJECTIVES:Obstructive sleep apnea (OSA) has been associated with increased cancer incidence and mortality. The aim of this study was to investigate cancer-related mortality, overall survival and progression free survival in patients with suspected OSA and lung cancer. METHODS:This was a case series analysis of lung cancer from a sleep ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2020, :]

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Association of the serum irisin level with obstructive sleep apnea: a body mass index- and physical activity-matched study.

Weijun Huang, Yupu Liu, Huajun Xu, Huaming Zhu, Jian Guan, Hongliang Yi, Jianyin Zou,

Obesity is strongly correlated with the pathogenesis of obstructive sleep apnea (OSA); myokines may play important roles in this condition. We performed a body mass index- (BMI) and physical activity- (PA) matched study to explore the relationship between the irisin level and OSA. Ninety-six consecutive participants were recruited. After matching ... Read more >>

Endocr. J. (Endocrine journal)
[2020, :]

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Sleep Disordered Breathing in Hypertrophic Cardiomyopathy-Current State and Future Directions.

Shreyas Venkataraman, Shahid Karim, Aiswarya Rajendran, C Anwar A Chahal, Virend K Somers,

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and sleep disordered breathing (SDB) is a treatable risk factor that has been seen to occur concurrently, and is known to propagate mortality and morbidity in a number of cardiovascular disease states including heart failure, and indeed hypertrophic cardiomyopathy. In this ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

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Respiratory safety of lemborexant in healthy adult and elderly subjects with mild obstructive sleep apnea: A randomized, double-blind, placebo-controlled, crossover study.

Jocelyn Y Cheng, Gleb Filippov, Margaret Moline, Gary K Zammit, Mohammad Bsharat, Nancy Hall,

Lemborexant is a dual orexin receptor antagonist indicated for the treatment of adult and elderly individuals with insomnia. Some current pharmacologic treatments for insomnia cause respiratory depression, a serious safety concern, particularly for individuals with obstructive sleep apnea (OSA). This phase 1, randomized, double-blind, placebo-controlled, two-period crossover study examined respiratory ... Read more >>

J Sleep Res (Journal of sleep research)
[2020, :e13021]

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Sleep apnea diagnosis in children using software-generated apnea-hypopnea index (AHI) derived from data recorded with a single photoplethysmogram sensor (PPG) : Results from the Childhood Adenotonsillectomy Study (CHAT) based on cardiopulmonary coupling analysis.

Hugi Hilmisson, Stephen Berman, Solveig Magnusdottir,

OBJECTIVE:Sleep quality is vital for healthy development in children. Sleep disorders are prevalent and negatively affect sleep quality. Early identification and appropriate intervention can improve children's health and quality of life. The current reference standard, polysomnography (PSG) has limitations regarding availability, cost, and access and may not replicate normal sleep ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2020, :]

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