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Increased expression of pgph-1, T23F2.4, and cyp-14A5 in C. elegans dpy-7 mutants and by high salt.

Gabrielle Scolaro, Kelsey Bridges, Shayla Curry, Stephanie Jacobson, Marissa LoPresti, Katina Pappas, Nicolas Ramirez, Lindsay Savigne, Sarah Sherman, Katherine Upshaw, Erin Walsh, Keith Choe,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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Distal radial approach versus conventional radial approach: a comparative study of feasibility and safety.

Rania Hammami, Fatma Zouari, Mohamed Aymen Ben Abdessalem, Awatef Sassi, Tarek Ellouze, Amine Bahloul, Souad Mallek, Faten Triki, Abdallah Mahdhaoui, Gouider Jeridi, Leila Abid, Selma Charfeddine, Samir Kammoun, Jihen Jdidi,

The distal radial approach (DRA) is suggested to have benefits over the conventional radial approach (CRA) in terms of local complications and comfort of both patient and operator. Therefore, we aimed to compare the feasibility and safety of DRA and CRA in a real life population. We conducted a prospective, ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2021, 16(1):1830600]

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Efficacy and safety of the metformin-mazindol anorectic combination in rat.

Federico Argüelles-Tello, José Eduardo Roa-Coria, Ángel Zúñiga-Romero, Juan Carlos Huerta-Cruz, Geovanna Nalley Quiñonez-Bastidas, Francisco Javier Flores-Murrieta, Héctor Isaac Rocha-González, Juan Gerardo Reyes-García,

The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry ... Read more >>

Acta Pharm (Acta pharmaceutica (Zagreb, Croatia))
[2021, 71(2):279-291]

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Surgical Treatment of Type 2 Diabetes Mellitus in Youth.

Anna Zenno, Evan P Nadler,

Bariatric surgery is currently the most effective weight loss treatment of severe obesity and its associated comorbidities and is being increasingly used to treat children and adolescents with severe obesity, including those with Type 2 Diabetes (T2D). This review focuses on the conventional management of T2D in children and adolescents, ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, 1307:321-330]

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Novel approaches to sarcopenic obesity and weight management before and after kidney transplantation.

Ekamol Tantisattamo, Kamyar Kalantar-Zadeh, Fabian Halleck, Wiebke Duettmann, Marcel Naik, Klemens Budde,

PURPOSE OF REVIEW:Although a widely recognized and complex pathophysiological condition, sarcopenic obesity remains less appreciated and may elude diagnosis and workup in both kidney transplant waitlisted candidates and kidney transplant recipients. The lack of consensus definition, and practical diagnostic tools for evaluating waitlisted candidates and transplant recipients are barriers to ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2021, 30(1):14-26]

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Effects of GLP-1 and Its Analogs on Gastric Physiology in Diabetes Mellitus and Obesity.

Daniel B Maselli, Michael Camilleri,

The processing of proglucagon in intestinal L cells results in the formation of glucagon, GLP-1, and GLP-2. The GLP-1 molecule becomes active through the effect of proconvertase 1, and it is inactivated by dipeptidyl peptidase IV (DPP-IV), so that the half-life of endogenous GLP-1 is 2-3 min. GLP-1 stimulates insulin secretion ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, 1307:171-192]

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Identifying Novel Predictors of State Legislative Action to Address Obesity.

Abigail Arons, Jennifer Pomeranz, Rita Hamad,

OBJECTIVE:There is wide variation in the number and types of obesity policies enacted across states, and prior studies suggest that partisan factors may not fully explain this variation. In this exploratory analysis, we examined the association of a broad array of state-level factors with the number and types of obesity ... Read more >>

J Public Health Manag Pract (Journal of public health management and practice : JPHMP)
[2021, 27(1):E9-E18]

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Laparoscopic Vertical Sleeve Gastrectomy as a Treatment Option for Adults with Diabetes Mellitus.

Timothy R Koch, Timothy R Shope,

Obesity is a major factor in the worldwide rise in the prevalence of type 2 diabetes mellitus. The obesity "epidemic" will require novel, effective interventions to permit both the prevention and treatment of diabetes caused by obesity. Laparoscopic vertical sleeve gastrectomy is a newer bariatric surgical procedure with a lower ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, 1307:299-320]

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Blastomere removal affects homeostatic control leading to obesity in male mice.

Magdalena Kotlarska, Dawid Winiarczyk, Wiesława Florek, Marta Ziętek, Jolanta Pęczkowicz-Szyszka, Adrian Mateusz Stankiewicz, Rafał Radosław Starzyński, Roberta Arena, Gaspare Drago, Silvestre Sampino, Jacek Andrzej Modlinski,

Preimplantation embryos are particularly vulnerable to environmental perturbations, including those related to assisted reproductive technologies. Invasive embryo manipulations, such as blastomere biopsy, are applied worldwide in clinical settings for preimplantation genetic testing. Mouse models have previously shown that blastomere biopsy may be associated with altered phenotypes in adult offspring. The ... Read more >>

Reproduction (Reproduction (Cambridge, England))
[2021, 161(1):61-72]

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Pulmonary Manifestations of Endocrine and Metabolic Diseases in Children.

Alexander A Broomfield, Raja Padidela, Stuart Wilkinson,

Advances in technology, methodology, and deep phenotyping are increasingly driving the understanding of the pathologic basis of disease. Improvements in patient identification and treatment are impacting survival. This is true in endocrinology and inborn errors of metabolism, where disease-modifying therapies are developing. Inherent to this evolution is the increasing awareness ... Read more >>

Pediatr Clin North Am (Pediatric clinics of North America)
[2021, 68(1):81-102]

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Motor Skills of Children and Adolescents With Obesity and Severe Obesity-A CIRCUIT Study.

Anna-Luisa Häcker, Jean-Luc Bigras, Mélanie Henderson, Tracie A Barnett, Marie-Eve Mathieu,

Häcker, A-L, Bigras, J-L, Henderson, M, Barnett, TA, and Mathieu, M-E. Motor skills of children and adolescents with obesity and severe obesity-a CIRCUIT study. J Strength Cond Res 34(12): 3577-3586, 2020-During childhood, excessive weight is negatively associated with the development of motor skills, with overweight children or children with obesity ... Read more >>

J Strength Cond Res (Journal of strength and conditioning research)
[2020, 34(12):3577-3586]

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The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia's population: an evidence-based meta-analysis.

Chenyao Xie, Wenxi Hua, Yuening Zhao, Jingwen Rui, Jiarong Feng, Yanjie Chen, Yu Liu, Jingjing Liu, Xiaoqin Yang, Xiaojing Xu,

Whether the Adrenoceptor Beta 3 (ADRB3) gene rs4994 polymorphism could affect the individual risk of childhood and adolescent overweight/obesity remains controversial. This meta-analysis was performed to estimate the prevalence of this polymorphism in overweight/obesity, and test the potential association by summarizing existing evidence. Comprehensive literature search in PubMed, Web of ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):77-86]

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New index of abdominal obesity, a body shape index, is BMI-independently associated with systemic arterial stiffness in real-world Japanese population.

Daiji Nagayama, Yasuhiro Watanabe, Takashi Yamaguchi, Mitsuya Maruyama, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno,

OBJECTIVE:To clarify that the new index of abdominal obesity, a body shape index (ABSI), is associated with obesity-related metabolic disorders and arterial stiffness. MATERIALS:We analyzed the cross-sectional data from 62,514 Japanese subjects (mean age 44.4 years, mean body mass index (BMI) 22.2 kg/m2) without a past history of cardiovascular disease, stroke, or ... Read more >>

Int J Clin Pharmacol Ther (International journal of clinical pharmacology and therapeutics)
[2020, 58(12):709-717]

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Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity.

Chaomin Li, Jing Li, Fang He, Kun Li, Xu Li, Yan Zhang,

Objective Matrix Gla protein (MGP) is a potent calcification inhibitor. Mgp-/- mice display increased proportion of brown adipose tissue. However, whether MGP is involved in fat metabolism remains unclear. This study aims to investigate the involvement. Methods Expression of adipocyte differentiation markers was examined by RT-qPCR. Adipocyte formation was assessed ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):68-76]

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Use of Anthropometry Versus Ultrasound for the Assessment of Body Fat and Comorbidities in Children With Obesity.

Nehal El-Koofy, Hend Soliman, Mennat-Allah Elbarbary, Al Shimaa El Garhy, Maha Sheba, Hanan Fouad,

OBJECTIVES:We aimed to examine the association between abdominal fat measured by ultrasound and anthropometric indices in children with obesity, and those with normal weight. We also examined the association between anthropometry and fat measures in the prediction of comorbidities in children with obesity. METHODS:Forty children with body mass index of ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2020, 71(6):782-788]

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Long term hypoxia during gestation alters perirenal adipose tissue gene expression in the lamb.

Dean A Myers, Krista Singleton, Kim Hyatt, Kanchan M Kaushal, Charles A Ducsay,

We previously reported that following long-term hypoxia (LTH), the ovine foetus exhibits enhanced expression of brown/beige adipose genes. This study was designed to determine if these changes are preserved after birth. Pregnant ewes were divided among three groups, 1) Control, sea level, 2) LTH, high altitude (3,820 m, LTH-HA) from ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):223-233]

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Socioeconomic Status and Childhood Obesity: a Review of Literature from the Past Decade to Inform Intervention Research.

Christian E Vazquez, Catherine Cubbin,

PURPOSE OF REVIEW:This is a review of the patterns, conceptualization, and suggested mechanisms underlying the relationship of socioeconomic status (SES) to obesity in childhood and the implications of these data for interventions going forward. RECENT FINDINGS:Adiposity and SES are negatively associated in high-income countries and positively associated in medium to ... Read more >>

Curr Obes Rep (Current obesity reports)
[2020, 9(4):562-570]

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Integrative analyses of biomarkers and pathways for adipose tissue after bariatric surgery.

Yingshan Liu, Jing Jin, Yanshan Chen, Chuna Chen, Zhenguo Chen, Lingling Xu,

We explored potential biomarkers and molecular mechanisms regarding multiple benefits after bariatric surgery. Differentially expressed genes (DEGs) for subcutaneous adipose tissue (AT) after bariatric surgery were identified by analyzing two expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, PPI network, and gene-microRNAs and gene-TFs networks were interrogated to identify ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):384-400]

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Impact of obesity on COVID-19 patients

Wanqi Yu, Kristen E. Rohli, Shujuan Yang, Peng Jia,

With the increasing prevalence of obesity, there is a growing awareness of its impact on infectious diseases. In past epidemics of influenza A and Middle East respiratory syndrome (MERS) coronavirus, obesity has been identified as a risk factor influencing the severity of illness in infected persons. The severe acute respiratory ... Read more >>

J Diabetes Complications (Journal of diabetes and its complications)
[2020, :]

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COVID-19: Obesity, deprivation and death.

A Hamish Rw Simpson, Cameron J Simpson, Helen Frost, Susan C Welburn,

J Glob Health (Journal of global health)
[2020, 10(2):020389]

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Nutritional modulation of leptin expression and leptin action in obesity and obesity-asociated complications.

S Montserrat-de la Paz, A Pérez-Pérez, T Vilariño-Garcia, C Jimenez-Cortegana, F J G Muriana, M C Millan-Linares, V Sanchez-Margalet,

In obesity, an elevated accumulation and dysregulation of adipose tissue, due to an imbalance between energy intake and energy expenditure, usually coexists with the loss of responsiveness to leptin in central nervous system, and subsequently with hyperleptinemia. Leptin, a peptide hormone mainly produced by white adipose tissue, regulates energy homeostasis ... Read more >>

J Nutr Biochem (The Journal of nutritional biochemistry)
[2020, :108561]

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Body mass index rather than the phenotype impacts precocious ultrasound cardiovascular risk markers in polycystic ovary syndrome.

Srdjan Pandurevic, Luca Bergamaschi, Carmine Pizzi, Laura Patton, Paola Rucci, Francesca Corzani, Carolina Cecchetti, Carla Pelusi, Paola Altieri, Valentina Vicennati, Guido Di Dalmazi, Flaminia Fanelli, Djuro Macut, Uberto Pagotto, Alessandra Gambineri,

Objective:Research into cardiovascular disease (CV) prevention has demonstrated a variety of ultrasound (US) markers predicting risk in the general population but which have been scarcely used for polycystic ovary syndrome (PCOS). Obesity is a major factor contributing to CV disease in the general population, and it is highly prevalent in ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2021, 184(1):199-208]

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Correlation of Telomere Length in Adipose Tissue and Leukocytes and its Association with Postsurgical Weight Loss.

Resham L Gurung, Yiamunaa M, Angela Mei Chung Moh, Rajkumar Dorajoo, Sylvia Liu, Jian-Jun Liu, Asim Shabbir, Jimmy Bok Yan So, Chun Hai Tan, Anton Kui Sing Cheng, Su Chi Lim,

OBJECTIVE:The aim of this study was to determine the relationship between telomere length (TL) in subcutaneous adipose tissue (SAT), visceral adipose tissues (VAT), and leukocytes, as well as to examine the associations of TL in these tissues with postsurgical weight loss in Asians with severe obesity. METHODS:Presurgery TL was measured ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2020, 28(12):2424-2430]

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Strengthening resistance to the COVID-19 pandemic and fostering future resilience requires concerted action on obesity.

Angela M Jackson-Morris, Rachel Nugent, Johanna Ralston, Olivia Barata Cavalcante, John Wilding,

Initial observations showed that people with chronic noncommunicable diseases were at heightened risk of severe COVID-19 and adverse outcomes. Subsequently, data from various countries have revealed obesity as an independent and significant factor, with people who are overweight/have obesity significantly more likely to be hospitalized, require ICU treatment, and to ... Read more >>

Glob Health Action (Global health action)
[2020, 13(1):1804700]

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Maternal-infant nutrition and development programming of offspring appetite and obesity.

Mina Desai, Michael G Ross,

In the United States and Mexico, the obesity epidemic represents a significant public health problem. Although obesity is often attributed to a Western-style, high-fat diet and decreased activity, there is now compelling evidence that this, in part, occurs because of the developmental programming effects resulting from exposure to maternal overnutrition. ... Read more >>

Nutr Rev (Nutrition reviews)
[2020, 78(Supplement_2):25-31]

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