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Nutritional Neuropathy

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Comparison of microwave ablation treatments in patients with renal secondary and primary hyperparathyroidism.

Haoyang Ma, Chun Ouyang, Yaoyu Huang, Changying Xing, Chen Cheng, Wei Liu, Donglan Yuan, Ming Zeng, Xiangbao Yu, Haibin Ren, Yanggang Yuan, Lina Zhang, Fangyan Xu, Ying Cui, Wenkai Ren, Hui Huang, Hanyang Qian, Boqiang Fan, Ningning Wang,

Purpose: Microwave ablation (MWA) is feasible for severe renal secondary hyperparathyroidism (SHPT) and primary hyperparathyroidism (PHPT) patients ineligible for parathyroidectomy (PTX). Here we compared the clinical manifestations and characteristics of parathyroid glands in these two groups, and summarized the techniques, safety and efficacy of MWA.Methods: Baseline clinical characteristics, ablation-related techniques, ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):66-76]

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Acquired long QT syndrome in chronic kidney disease patients.

Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li,

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):54-65]

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Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy.

Alejandra González-Duarte, Isabel Conceição, Leslie Amass, Marc F Botteman, John A Carter, Michelle Stewart,

INTRODUCTION:Hereditary (variant) transthyretin amyloidosis (ATTRv) with polyneuropathy (ATTR-PN) is a rare genetic disorder that causes progressive autonomic and sensorimotor neuropathy, severe disability, and death within 10 years of onset. Previous studies have primarily focused on how baseline cardiac characteristics affect mortality, but the impact of non-cardiac baseline characteristics is less defined. ... Read more >>

Neurol Ther (Neurology and therapy)
[2020, :]

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Cannabinoids Improve Gastrointestinal Symptoms in a Parenteral Nutrition-Dependent Patient With Chronic Intestinal Pseudo-Obstruction.

Boutaina Zemrani, Cécile Lambe, Olivier Goulet,

Chronic intestinal pseudo-obstruction (CIPO) is a rare and challenging cause of pediatric intestinal failure, requiring long-term parenteral nutrition in most cases. Despite optimal management, some patients experience chronic abdominal pain and recurrent obstructive episodes with a major impact on their quality of life. Cannabinoids have been successfully used in some ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2020, :]

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Not Always as It Seems: A Case of Ascending Paralysis.

Joseph P Staszel, MaryAnn Miknevich,

Although generally presenting as a chronic, progressive peripheral neuropathy, we present a case of acute alcoholic neuropathy initially mistaken for acute Guillain-Barré syndrome. Electrodiagnostic evaluation of alcoholic neuropathy reveals an axonal neuropathy and may be complicated by demyelination if comorbid nutritional deficiencies are present. This is in contrast to the ... Read more >>

Am J Phys Med Rehabil (American journal of physical medicine & rehabilitation)
[2020, 99(3):e32-e34]

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Subacute combined degeneration: a case of pernicious anaemia without haematological manifestations.

Matthew R Lavoie, Nicolette C Cohen, Timothy A Gregory, Peter V Weber,

Vitamin B12 deficiency can be caused by a diverse group of aetiologies. One of the less common of these is an autoimmune condition pernicious anaemia, so named after the most common physiological manifestation of B12 deficiency: anaemia. However, B12 is also necessary for nervous system function and its depletion can ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(3):]

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The Use of Vitamins and Coenzyme Q10 for the Treatment of Vascular Occlusion Diseases Affecting the Retina.

Beatriz Fernández-Vega, Javier Nicieza, Ana Álvarez-Barrios, Lydia Álvarez, Montserrat García, Carlos Fernández-Vega, José A Vega, Héctor González-Iglesias,

Nutritional supplementation with antioxidants and vitamins is widely recommended in the treatment of vascular disorders affecting the retina, although there is insufficient evidence on its effectiveness. The vitamin-like compound coenzyme Q10 (CoQ10) is a nutritional supplement of current interest to treat neurodegenerative diseases. Here, we report a retrospective clinical case ... Read more >>

Nutrients (Nutrients)
[2020, 12(3):]

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[Severe hypocupremia and familial amyloid polyneuropathy].

María Teresa Fernández López, Cristina Guillín Amarelle, José Antonio Mato Mato,

Introduction:Introduction: we report a patient with transthyretin familial amyloid polyneuropathy (TTR-FAP) and severe hypocupremia. Case report: a 79-year-old male with TTR-FAP and severe malnutrition. Laboratory tests showed low serum copper (Cu) and ceruloplasmin levels, as well as low urinary Cu levels. The patient reported neither digestive symptoms nor previous gastrointestinal ... Read more >>

Nutr Hosp (Nutricion hospitalaria)
[2020, 37(1):223-227]

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Prevalence of Diabetic Foot Ulcer and Associated Factors among Adult Diabetic Patients on Follow-Up Clinic at Jimma Medical Center, Southwest Ethiopia, 2019: An Institutional-Based Cross-Sectional Study.

Daba Abdissa, Tesfaye Adugna, Urge Gerema, Diriba Dereje,

Background Diabetic foot ulceration is a devastating complication of diabetes mellitus and is a major source of morbidity and mortality. So far, there are few published data on diabetic foot ulcers and its determinants among diabetic patients on follow-up at Jimma Medical Center. Hence, the aim of this study was ... Read more >>

(Journal of Diabetes Research)
[2020, 2020:]

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Diagnosis and Treatment of Hereditary Transthyretin Amyloidosis (hATTR) Polyneuropathy: Current Perspectives on Improving Patient Care.

Marco Luigetti, Angela Romano, Andrea Di Paolantonio, Giulia Bisogni, Mario Sabatelli,

Hereditary transthyretin amyloidosis (hATTR) with polyneuropathy (formerly known as Familial Amyloid Polyneuropathy) is a rare disease due to mutations in the gene encoding transthyretin (TTR) and characterized by multisystem extracellular deposition of amyloid, leading to dysfunction of different organs and tissues. hATTR amyloidosis represents a diagnostic challenge for neurologists considering ... Read more >>

Ther Clin Risk Manag (Therapeutics and clinical risk management)
[2020, 16:109-123]

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Nutritional neuropathies.

Kelly G Gwathmey, James Grogan,

Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length-dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the exception, often presenting with a non-length-dependent sensory neuropathy. Patients with cobalamin and copper deficiency neuropathy characteristically have concomitant myelopathy, whereas vitamin E ... Read more >>

Muscle Nerve (Muscle & nerve)
[2019, :]

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Omega-3 polyunsaturated fatty acid oral supplements for improving peripheral nerve health: a systematic review and meta-analysis.

Alexis Ceecee Zhang, Manikkuwadura Eranda Harshan De Silva, Richard J MacIsaac, Leslie Roberts, Jordan Kamel, Jennifer P Craig, Ljoudmila Busija, Laura E Downie,

CONTEXT:Peripheral nerve damage can occur in a variety of systemic conditions and can have a profound impact on functional and psychological health. Currently, therapeutic interventions for peripheral nerve damage are limited. OBJECTIVE:The aim of this systematic review, conducted in accordance with the Cochrane Collaboration's handbook and reported according to the ... Read more >>

Nutr. Rev. (Nutrition reviews)
[2020, 78(4):323-341]

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Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children.

In Jeong Lyu, Kyung-Ah Park, Sei Yeul Oh,

We investigated the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluated the associated risk factors. This cross-sectional study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assessed by disc enhanced-depth image spectral-domain (SD) optical coherence ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2238]

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In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain.

Paramita Basu, Arpita Basu,

Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(5):]

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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.

Jin Rui Liang, Emily Lingeman, Thao Luong, Saba Ahmed, Matthias Muhar, Truc Nguyen, James A Olzmann, Jacob E Corn,

Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but is poorly understood beyond a few autophagosomal receptors and remodelers. By using an ER-phagy reporter and genome-wide CRISPRi screening, we identified 200 high-confidence human ER-phagy factors. ... Read more >>

Cell (Cell)
[2020, 180(6):1160-1177.e20]

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Prevalence of Fabry disease in dialysis patients: Western Australia Fabry disease screening study - the FoRWARD study.

Sadia Jahan, Subashini Sarathchandran, Shamina Akhter, Jack Goldblatt, Samantha Stark, Douglas Crawford, Andrew Mallett, Mark Thomas,

AIM:To determine the prevalence of undiagnosed Fabry Disease (FD) in Western Australian (WA) patients undergoing dialysis. BACKGROUND:FD is a multisystem X-linked lysosomal storage disease caused by deficient activity of alpha-galactosidase-A (α-GAL-A). Affected individuals are at risk of developing small-fibre neuropathy, rash, progressive kidney disease, hypertrophic cardiomyopathy and ischaemic stroke. Diagnosis ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):10]

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Epidemiology and healthcare utilization of inpatient admissions in children with pediatric intestinal pseudo-obstruction.

Suruchi Batra, Sheikh Rahman, Md Sohel Rana, Sravan Matta, Anil Darbari,

BACKGROUND:Pediatric intestinal pseudo-obstruction is a rare disorder affecting gastrointestinal motility leading to chronic symptoms and hospitalizations. There is limited understanding of the epidemiology and healthcare burden. METHODS:We analyzed data from Kids' Inpatient Database from 2016, which includes inpatient discharge records from US hospitals. ICD-10 codes were used to identify patients ... Read more >>

Neurogastroenterol. Motil. (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(4):e13781]

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Relationship of Inflammation With Trigeminal Neuralgia.

Yuzhi Yao, Bowen Chang, Shiting Li,

OBJECTIVE:Trigeminal neuralgia (TN) is a common cranial nerve disease. Inflammation is suggested in many recent studies to be involved in neuropathic pain, but its role in TN remains unclear so far. Therefore, the current study aimed to explore the relationship of inflammation with TN. METHODS:The levels of inflammatory markers, such ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2020, 31(2):e110-e113]

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Compression of the S1 Nerve Root by an Extradural Vascular Malformation: A Case Report and Discussion of Atypical Causes of Lumbar Radiculopathy.

Jeffrey Thompson, Robert K Merrill, Sheeraz A Qureshi, Dante M Leven,

We present a case of lumbar radiculopathy due to a vascular malformation in the lumbar spine and discuss various causes of atypical lumbar radiculopathy. Lumbar radiculopathy is a condition of neurologic deficits and painful symptoms of the lower extremities due to nerve root compression, most commonly at the L5 and ... Read more >>

Int J Spine Surg (International Journal of Spine Surgery)
[2020, 14(1):96-101]

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Copper deficiency related myelopathy 40 years following a jejunoileal bypass.

Shawn Joshi, Mitra McLarney, Benjamin Abramoff,

Introduction:Acquired copper deficiency myelopathy is a rare disorder associated with hematologic abnormalities, peripheral neuropathy, and sensory ataxia. Although its clinical presentation and radiographic findings are similar to other nutrient deficiencies, practitioners often fail to diagnose copper deficiency. This report describes a case of copper deficiency decades after a jejunoileal bypass ... Read more >>

Spinal Cord Ser Cases (Spinal cord series and cases)
[2019, 5:104]

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ICU-acquired weakness.

Ilse Vanhorebeek, Nicola Latronico, Greet Van den Berghe,

Critically ill patients often acquire neuropathy and/or myopathy labeled ICU-acquired weakness. The current insights into incidence, pathophysiology, diagnostic tools, risk factors, short- and long-term consequences and management of ICU-acquired weakness are narratively reviewed. PubMed was searched for combinations of "neuropathy", "myopathy", "neuromyopathy", or "weakness" with "critical illness", "critically ill", "ICU", ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(4):637-653]

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Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial.

Sara Asadi, Mohammad Saeed Gholami, Fereydoun Siassi, Mostafa Qorbani, Gity Sotoudeh,

Depression in patients with diabetes is associated with poor glycemic control and linked to an increased risk for diabetes complications such as neuropathy. Curcumin has shown potential antidepressant-like activities in some studies. The present study is the first randomized controlled trial to test the efficacy of nano-curcumin supplementation on depression, ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2019, :]

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Prevalence of profound laryngeal sensory neuropathy in head and neck cancer survivors with feeding tube-dependent oropharyngeal dysphagia.

Omid B Mehdizadeh, Shumon I Dhar, Lisa Evangelista, Nogah Nativ-Zeltzer, Arnaud F Bewley, Peter C Belafsky,

BACKGROUND:Laryngopharyngeal sensory neuropathy (LSN) has been observed to be a contributing factor to swallowing dysfunction in head and neck cancer (HNC) survivors. METHODS:Retrospective review of 43 tube-dependent HNC survivors was conducted. LSN was assessed with direct palpation of the aryepiglottic fold and by traversing the true vocal folds without eliciting ... Read more >>

Head Neck (Head & neck)
[2019, :]

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Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory.

Tigran Makunts, Sama Alpatty, Kelly C Lee, Rabia S Atayee, Ruben Abagyan,

Proton-pump inhibitors, PPIs, are considered effective therapy for stomach acid suppression due to their irreversible inhibition of the hydrogen/potassium pump in the gastric parietal cells. They are widely prescribed and are considered safe for over-the-counter use. Recent studies have shown an association between PPI use and Alzheimer dementia, while others ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):17280]

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The Coming Age of Flavonoids in the Treatment of Diabetic Complications.

Teresa Caro-Ordieres, Gema Marín-Royo, Lucas Opazo-Ríos, Luna Jiménez-Castilla, Juan Antonio Moreno, Carmen Gómez-Guerrero, Jesús Egido,

Diabetes mellitus (DM), and its micro and macrovascular complications, is one of the biggest challenges for world public health. Despite overall improvement in prevention, diagnosis and treatment, its incidence is expected to continue increasing over the next years. Nowadays, finding therapies to prevent or retard the progression of diabetic complications ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

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