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Full Text Journal Articles about
Nosocomial and Healthcare Associated Pneumonia

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Risk factors for corticosteroid insufficiency during the sub-acute phase of acute traumatic brain injury.

Xin Chen, Yan Chai, Shao-Bo Wang, Jia-Chong Wang, Shu-Yuan Yue, Rong-Cai Jiang, Jian-Ning Zhang,

Hypothalamic-pituitary-adrenal axis dysfunction may lead to the occurrence of critical illness-related corticosteroid insufficiency. Critical illness-related corticosteroid insufficiency can easily occur after traumatic brain injury, but few studies have examined this occurrence. A multicenter, prospective, cohort study was performed to evaluate the function of the hypothalamic-pituitary-adrenal axis and the incidence of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1259-1265]

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Advances in molecular diagnostic tests for pneumonia.

Catia Cilloniz, Adamanthia Liapikou, Antoni Torres,

PURPOSE OF REVIEW:Pneumonia is the main global cause of sepsis, and has been associated with high morbidity and high short and long-term mortality rates. As it may be caused by a wide spectrum of microorganisms, microbial diagnosis is challenging and the choice of adequate therapy remains an important problem. This ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):241-248]

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An overview of ceftolozane sulfate + tazobactam for treating hospital acquired pneumonia.

Ibai Los-Arcos, Joaquin Burgos, Vicenç Falcó, Benito Almirante,

Introduction: Ceftolozane-tazobactam is a combination of a new cephalosporin, with activity similar to that of ceftazidime, and a known inhibitor of beta-lactamases. This compound shows excellent activity against most gram-negative organisms causative of hospital-acquired pneumonia (HAP) or ventilator-acquired pneumonia (VAP), including extended spectrum beta-lactamase (ESBL)-producing Enterobacterales and multidrug-resistant (MDR) Pseudomonas ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2020, :1-9]

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[Nosocomial pneumonia].

Joachim Großmann, Sebastian Schulz-Stübner,

Nosocomial pneumonia is one of the leading entities of nosocomial infections in Germany and worldwide with invasive ventilation being one of the major risk factors. However nosocomial pneumonia without ventilator support is an underappreciated complication as demonstrated by prevalence studies of the European Centre for Disease Control in 2011 and ... Read more >>

Dtsch. Med. Wochenschr. (Deutsche medizinische Wochenschrift (1946))
[2020, 145(6):371-382]

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Strategies for prediction of drug-resistant pathogens and empiric antibiotic selection in community-acquired pneumonia.

Ryan Gil, Brandon J Webb,

PURPOSE OF REVIEW:Although most patients with community-acquired pneumonia (CAP) are appropriately treated with narrow-spectrum antibiotics, predicting which patients require coverage of drug-resistant pathogens (DRP) remains a challenge. The 2019 American Thoracic Society/Infectious Diseases Society of America CAP guidelines endorse using locally validated prediction models for DRP. Here we review risk ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):249-259]

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Update in adult community-acquired pneumonia: key points from the new American Thoracic Society/Infectious Diseases Society of America 2019 guideline.

Joshua P Metlay, Grant W Waterer,

PURPOSE OF REVIEW:The American Thoracic Society and Infectious Diseases Society of America recently released their joint guideline for the diagnosis and treatment of adults with community-acquired pneumonia (CAP). The co-chairs of the guideline committee provide a summary of the guideline process, key recommendations from the new guideline and future directions ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):203-207]

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Effects of hospital-acquired pneumonia on long-term recovery and hospital resource utilization following moderate to severe traumatic brain injury.

Raj G Kumar, Matthew R Kesinger, Shannon B Juengst, Maria M Brooks, Anthony Fabio, Kristen Dams-OʼConnor, Mary Jo Pugh, Jason L Sperry, Amy K Wagner,

BACKGROUND:Individuals with traumatic brain injury (TBI) have extended inpatient hospital stays that include prolonged mechanical ventilation, increasing risk for infections, including pneumonia. Studies show the negative short-term effects of hospital-acquired pneumonia (HAP) on hospital-based outcomes; however, little is known of its long-term effects. METHODS:A prospective cohort study was conducted. National ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, 88(4):491-500]

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Cortisol total/CRP ratio for the prediction of hospital-acquired pneumonia and initiation of corticosteroid therapy in traumatic brain-injured patients.

Linpei Jia, Hongliang Zhang,

Crit Care (Critical care (London, England))
[2020, 24(1):77]

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Hospital-Acquired Pneumonia. Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) Guidelines. 2019 Update.

Antoni Torres, José Barberán, Adrian Ceccato, Ignacio Martin-Loeches, Miguel Ferrer, Rosario Menéndez, David Rigau,

Hospital-acquired pneumonia (HAP) is the second leading cause of nosocomial infection, and increases morbidity and mortality. It is currently classified into three groups: HAP not requiring artificial ventilation, HAP requiring artificial ventilation, and HAP acquired during artificial ventilation, also known as ventilator-acquired pneumonia (VAP). The latest guidelines for the management ... Read more >>

Arch. Bronconeumol. (Archivos de bronconeumologia)
[2020, 56 Suppl 1:11-19]

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S-nitroso-N-acetylpenicillamine (SNAP) Impregnated Endotracheal Tubes for Prevention of Ventilator-Associated Pneumonia.

Katie H Homeyer, Priyadarshini Singha, Marcus J Goudie, Hitesh Handa,

The chances of ventilator-associated pneumonia (VAP) increases 6- to 20-fold when an endotracheal tube is placed in a patient. VAP is one of the most common hospital-acquired infections and comprises 86% of the nosocomial pneumonia cases. This work introduces the idea of nitric oxide-releasing endotracheal tubes (NORel-ETTs) fabricated by the ... Read more >>

Biotechnol. Bioeng. (Biotechnology and bioengineering)
[2020, :]

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Incidence and Predictors of Nonventilator Hospital-Acquired Pneumonia in a Community Hospital.

Christopher M Patty, Alisha Sandidge-Renteria, Sabrina Orique, Craig Dixon, Emma Camarena, Rose Newsom, Alicia Schneider,

BACKGROUND:Nonventilator hospital-acquired pneumonia (NV-HAP) is a common hospital-acquired condition that is amenable to basic nursing care interventions. PURPOSE:The purpose of this study was to determine the incidence of NV-HAP in a California community hospital and to identify the patient and nursing care factors including missed nursing care associated with its ... Read more >>

J Nurs Care Qual (Journal of nursing care quality)
[2020, :]

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Prognostic factors in nursing and healthcare-associated pneumonia.

Akira Yamagata, Akihiro Ito, Yosuke Nakanishi, Tadashi Ishida,

BACKGROUND AND OBJECTIVE:Nursing and healthcare-associated pneumonia (NHCAP) is a category of healthcare-associated pneumonia modified for the healthcare system in Japan. To date, only a few studies have examined the prognostic factors of NHCAP in a prospective cohort. This study aimed to investigate the prognostic factors related to 30-day mortality in ... Read more >>

J. Infect. Chemother. (Journal of Infection and Chemotherapy)
[2020, :]

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Molecular characterization of methicillin-resistant Staphylococcus aureus clinical strains from the endotracheal tubes of patients with nosocomial pneumonia.

Roberto Cabrera, Laia Fernández-Barat, Anna Motos, Rubén López-Aladid, Nil Vázquez, Mauro Panigada, Francisco Álvarez-Lerma, Yuly López, Laura Muñoz, Pedro Castro, Jordi Vila, Antoni Torres,

BACKGROUND:Among all cases of nosocomial pneumonia, Staphylococcus aureus is the second most prevalent pathogen (17.8%). In Europe, 29.9% of the isolates are oxacillin-resistant. The changing epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) nosocomial infections and the decreasing susceptibility to first-line antibiotics leave clinicians with few therapeutic options. The objective of our ... Read more >>

Antimicrob Resist Infect Control (Antimicrobial resistance and infection control)
[2020, 9(1):43]

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Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia

Nathan Peiffer-Smadja, Lila BOUADMA, Vincent MATHY, Kahina ALLOUCHE, Juliette PATRIER, Martin REBOUL, Philippe MONTRAVERS, Jean-François TIMSIT, Laurence ARMAND-LEFEVRE,

<title>Abstract</title> <p> Background: Early appropriate antibiotic therapy reduces morbidity and mortality of severe pneumonia. However, the emergence of bacterial resistance requires the earliest use of antibiotics with the narrowest possible spectrum. The Unyvero Hospitalized Pneumonia (HPN, Curetis) test is a multiplex PCR (M-PCR) system detecting 21 bacteria and ... Read more >>

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[Conventional respiratory support therapy for Severe Acute Respiratory Infections (SARI): Clinical indications and nosocomial infection prevention and control].

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Severe acute respiratory infection (SARI) diseases (such as SARS, MERS, pH1N1) can rapidly progress to acute respiratory failure with high lethality. The outbreak of a novel coronavirus infection can lead to 15%~ 30% patients developing into acute respiratory distress syndrome (ARDS). Respiratory support is the most important therapy for SARI ... Read more >>

Zhonghua Jie He He Hu Xi Za Zhi (Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases)
[2020, 43(3):189-194]

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In Vitro Activity of Ceftazidime-Avibactam Against Isolates from Respiratory and Blood Specimens from Patients with Nosocomial Pneumonia, including Ventilator-Associated Pneumonia, in a Phase 3 Clinical Trial.

Gregory G Stone, Patricia A Bradford, Margaret Tawadrous, Dianna Taylor, Mary Jane Cadatal, Zhangjing Chen, Joseph W Chow,

Nosocomial pneumonia (NP), including ventilator-associated pneumonia (VAP), is increasingly associated with multidrug-resistant Gram-negative pathogens. This study describes the in vitro activity of ceftazidime-avibactam, ceftazidime, and relevant comparator agents against bacterial pathogens isolated from patients with NP, including VAP, enrolled in a ceftazidime-avibactam phase 3 trial (ClinicalTrials.gov identifier NCT01808092). Gram-positive pathogens ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2020, :]

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Clinical factors influencing the performance of bacterial multiplex polymerase chain reaction in patients with community-onset pneumonia.

Ga Eun Park, Kyong Ran Peck, Jae-Hoon Ko, Cheol-In Kang, Sun Young Cho, Doo Ryeon Chung, Nam Yong Lee,

The etiologic diagnostic yield of community-onset pneumonia (COP) using conventional methods is low. Bacterial multiplex polymerase chain reaction (mPCR) has been shown to be more sensitive than conventional methods. This study assessed the clinical factors influencing bacterial mPCR results in patients with COP. Patients with COP admitted to a tertiary ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2020, :]

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Considerations in the Selection of Renal Dosage Adjustments for Patients with Serious Infections and Lessons Learned from the Development of Ceftazidime-Avibactam.

Jianguo Li, Mark Lovern, Todd Riccobene, Timothy J Carrothers, Paul Newell, Shampa Das, Angela K Talley, Margaret Tawadrous,

An extensive clinical development program (comprising two phase 2 and five phase 3 trials) has demonstrated the efficacy and safety of ceftazidime-avibactam in the treatment of adults with complicated intra-abdominal infection (cIAI), complicated urinary tract infection (cUTI), and hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP). During the phase 3 clinical ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2020, 64(4):]

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Hospital-acquired Pneumonia and Ventilator-associated Pneumonia in Children: A Prospective Natural History and Case-Control Study.

Jessica E Ericson, John McGuire, Marian G Michaels, Adam Schwarz, Robert Frenck, Jaime G Deville, Swati Agarwal, Adam M Bressler, Jamie Gao, Tracy Spears, Daniel K Benjamin, P Brian Smith, John S Bradley, ,

BACKGROUND:Clinical trials for antibiotics designed to treat hospital-acquired and ventilator-associated bacterial pneumonias (HABP/VABP) are hampered by making these diagnoses in a way that is acceptable to the United States Food and Drug Administration and consistent with standards of care. We examined laboratory and clinical features that might improve pediatric HABP/VABP ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, :]

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Clinical metagenomics bioinformatics pipeline for the identification of hospital-acquired pneumonia pathogens antibiotic resistance genes from bronchoalveolar lavage samples

Maud Tournoud, Etienne Ruppé, Guillaume Perrin, Stéphane Schicklin, Ghislaine Guigon, Pierre Mahé, Vladimir Lazarevic, Sébastien Hauser, Caroline Mirande, Albrice Levrat, Karen Louis, Gaspard Gervasi, Jacques Schrenzel,

Abstract Background Shortening the time-to-result for pathogen detection and identification and antibiotic susceptibility testing for patients with Hospital-Acquired and Ventilator-Associated pneumonia (HAP-VAP) is of great interest. For this purpose, clinical metagenomics is a promising non-hypothesis driven alternative to traditional culture-based solutions: when mature, it would allow direct sequencing all microbial ... Read more >>

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Pharmacokinetics and intrapulmonary concentrations of high-dose tigecycline in critically ill patients with severe infections

Gennaro Pascale, Lucia Lisi, Gabriella Ciotti, Maria Vallecoccia, Salvatore Cutuli, Laura Cascarano, Camilla Gelormini, Giuseppe Bello, Luca Montini, Simone Carelli, Valentina Gravio, Mario Tumbarello, Maurizio Sanguinetti, Pierluigi Navarra, Massimo Antonelli,

<title>Abstract</title> <p> Background In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day) has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data are available. We investigated plasmatic and pulmonary concentrations of HD TGC in the treatment of severe infections. Methods This was a single ... Read more >>

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Accuracy and reliability of electronic versus CDC surveillance criteria for non-ventilator hospital-acquired pneumonia.

Haiyan Ramirez Batlle, Michael Klompas, ,

Nonventilator hospital-acquired pneumonia (NV-HAP) is one of the most common healthcare-associated infections, but most hospitals do not track it. We created a pilot electronic definition for NV-HAP and compared its accuracy to Centers for Disease Control and Prevention (CDC) criteria. Kappa values for the electronic definition and CDC criteria versus ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2020, 41(2):219-221]

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Early enteral nutrition in patients with severe traumatic brain injury: a propensity score-matched analysis using a nationwide inpatient database in Japan.

Hiroyuki Ohbe, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga,

BACKGROUND:Whether enteral nutrition (EN) should be administered early in severe traumatic brain injury (TBI) patients has not been fully addressed. OBJECTIVE:The present study aimed to evaluate whether early EN can reduce mortality or nosocomial pneumonia among severe TBI patients. METHODS:Using the Japanese Diagnosis Procedure Combination inpatient database from April 2014 ... Read more >>

Am. J. Clin. Nutr. (The American journal of clinical nutrition)
[2020, 111(2):378-384]

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[Standardized diagnosis and treatment of colorectal cancer during the outbreak of corona virus disease 2019 in Renji hospital].

Y Luo, M Zhong,

Corona virus disease 2019 (COVID-19) is currently raging in China. It has been proven that COVID-19 can be transmitted from human to human and cause hospital infection, which seriously threatens surgical staffs and inpatients. Although colorectal surgery is not a front-line subject in the fight against the epidemic, but in ... Read more >>

Zhonghua Wei Chang Wai Ke Za Zhi (Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery)
[2020, 23(3):211-216]

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Rapid ultrasensitive diagnosis of pneumonia caused by Acinetobacter baumannii using a combination of enrichment and phage-based qPCR assay

Hongping Wei, Junping Yu, Jun Luo, Mengwei Jiang, Jin Xiong, Junhua Li,

<title>Abstract</title> <p> Background Accurate and rapid identification of ventilator associated or nosocomial pneumonia caused by Acinetobacter baumannii ( A. baumannii ) could improve the treatment.Methods In current study, we developed a phage-based real-time quantitative PCR (qPCR) combined with enrichment culture for rapid and specific detection of viable A. ... Read more >>

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