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Insights from human sleep research on neural mechanisms of Alzheimer's disease.

Susanna Cordone, Luigi De Gennaro,

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1251-1252]

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Electro-clinical and neurodevelopmental outcome in six children with early diagnosis of tuberous sclerosis complex and role of the genetic background.

M N Savini, A Mingarelli, A Peron, F La Briola, F Cervi, R M Alfano, M P Canevini, A Vignoli,

BACKGROUND:Seizures in individuals affected by tuberous sclerosis complex (TSC) commonly develop in the first year of life, are often preceded by a progressive deterioration of the electroencephalogram (EEG), and likely influence developmental outcome. Although early diagnosis of TSC has offered a tremendous opportunity to monitor affected patients before seizure onset, ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):36]

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Early-onset dementia: diagnostic challenges.

Bushra Elhusein, Omer Bakri Mahgoub, Abdalla Khairi,

A 56-year-old man was brought to our hospital by his family, seeking medical treatment for the patient's long-standing progressive word-finding difficulties, forgetfulness, agitation and social withdrawal. After multiple previous physician consultations, the patient was mistakenly diagnosed with epilepsy and prescribed multiple anticonvulsants, to which his above mentioned symptoms were unresponsive. ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(3):]

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Excessive Daytime Sleepiness Measurements in Children With Attention Deficit Hyperactivity Disorder.

Stéphanie Bioulac, Jacques Taillard, Pierre Philip, Patricia Sagaspe,

Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood. It is a heterogeneous disorder in terms of clinical presentation that is probably due to the frequent occurrence of comorbidity. Children with ADHD more frequently report sleep disorders (notably delayed sleep phase syndrome) and excessive daytime ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:3]

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Intranasal dexmedetomidine is an effective sedative agent for electroencephalography in children.

Hang Chen, Fei Yang, Mao Ye, Hui Liu, Jing Zhang, Qin Tian, Ruiqi Liu, Qing Yu, Shangyingying Li, Shengfen Tu,

BACKGROUND:Intranasal dexmedetomidine (DEX), as a novel sedation method, has been used in many clinical examinations of infants and children. However, the safety and efficacy of this method for electroencephalography (EEG) in children is limited. In this study, we performed a large-scale clinical case analysis of patients who received this sedation ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2020, 20(1):61]

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Sleep Stage Classification Using Time-Frequency Spectra From Consecutive Multi-Time Points.

Ziliang Xu, Xuejuan Yang, Jinbo Sun, Peng Liu, Wei Qin,

Sleep stage classification is an open challenge in the field of sleep research. Considering the relatively small size of datasets used by previous studies, in this paper we used the Sleep Heart Health Study dataset from the National Sleep Research Resource database. A long short-term memory (LSTM) network using a ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:14]

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Analyzing clinical and genetic characteristics of a cohort with multiple congenital anomalies-hypotonia-seizures syndrome (MCAHS).

Xianru Jiao, Jiao Xue, Pan Gong, Xinhua Bao, Ye Wu, Yuehua Zhang, Yuwu Jiang, Zhixian Yang,

OBJECTIVE:To summarize and extend the phenotypic characterization of Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome, and to discuss genotype-phenotype correlations. METHODS:Collecting clinical information of 17 patients with pathogenic variants in PIGN, PIGA, and PIGT. Genetic studies were performed on all patients. RESULTS:There were 7 patients with 15 PIGN mutations (one patient carrying 3 ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):78]

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Perinatal thalamic injury: MRI predictors of electrical status epilepticus in sleep and long-term neurodevelopment.

Bart van den Munckhof, Anne F Zwart, Lauren C Weeke, Nathalie H P Claessens, Joost D J Plate, Alexander Leemans, Hugo J Kuijf, Heleen C van Teeseling, Frans S S Leijten, Manon J N Benders, Kees P J Braun, Linda S de Vries, Floor E Jansen,

OBJECTIVE:Perinatal thalamic injury is associated with epilepsy with electrical status epilepticus in sleep (ESES). The aim of this study was to prospectively quantify the risk of ESES and to assess neuroimaging predictors of neurodevelopment. METHODS:We included patients with perinatal thalamic injury. MRI scans were obtained in the neonatal period, around ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 26:102227]

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Measuring Cot-Side the Effects of Parenteral Nutrition on Preterm Cortical Function.

Viviana Marchi, Nathan Stevenson, Ninah Koolen, Raffaele Mazziotti, Francesca Moscuzza, Stefano Salvadori, Rossella Pieri, Paolo Ghirri, Andrea Guzzetta, Sampsa Vanhatalo,

Early nutritional compromise after preterm birth is shown to affect long-term neurodevelopment, however, there has been a lack of early functional measures of nutritional effects. Recent progress in computational electroencephalography (EEG) analysis has provided means to measure the early maturation of cortical activity. Our study aimed to explore whether computational ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2020, 14:]

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A Patient With CAD Deficiency Responsive to Uridine and Literature Review.

Ling Zhou, Han Xu, Tianshuang Wang, Ye Wu,

CAD encodes a multifunctional enzyme involved in de novo pyrimidine biosynthesis, and pyrimidine can be alternatively recycled from uridine. Trio whole-exome sequencing identified CAD compound heterozygous mutations in a new male patient with global developmental delay (DD), refractory epilepsy, and anemia with anisopoikilocytosis. We further reviewed all published cases with ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:64]

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Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient.

Frank A Rasulo, Tommaso Togni, Stefano Romagnoli,

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901. ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):100]

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SWS Brain-Wave Music May Improve the Quality of Sleep: An EEG Study.

Dongrui Gao, Siyu Long, Hua Yang, Yibo Cheng, Sijia Guo, Yue Yu, Tiejun Liu, Li Dong, Jing Lu, Dezhong Yao,

Aim:This study investigated the neural mechanisms of brain-wave music on sleep quality. Background:Sleep disorders are a common health problem in our society and may result in fatigue, depression, and problems in daytime functioning. Previous studies have shown that brain-wave music generated from electroencephalography (EEG) signals could emotionally affect our nervous ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:67]

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The future of sleep health: a data-driven revolution in sleep science and medicine.

Ignacio Perez-Pozuelo, Bing Zhai, Joao Palotti, Raghvendra Mall, Michaël Aupetit, Juan M Garcia-Gomez, Shahrad Taheri, Yu Guan, Luis Fernandez-Luque,

In recent years, there has been a significant expansion in the development and use of multi-modal sensors and technologies to monitor physical activity, sleep and circadian rhythms. These developments make accurate sleep monitoring at scale a possibility for the first time. Vast amounts of multi-sensor data are being generated with ... Read more >>

NPJ Digit Med (NPJ digital medicine)
[2020, 3:42]

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Train Your Brain? Can We Really Selectively Train Specific EEG Frequencies With Neurofeedback Training.

Emilie Dessy, Olivier Mairesse, Martine van Puyvelde, Aisha Cortoos, Xavier Neyt, Nathalie Pattyn,

Neurofeedback (NFB) is an operant conditioning procedure whereby an individual learns to self-regulate the electrical activity of his/her brain. Initially developed as a treatment intervention for pathologies with underlying EEG dysfunctions, NFB is also used as a training tool to enhance specific cognitive states required in high-performance situations. The original ... Read more >>

Front Hum Neurosci (Frontiers in Human Neuroscience)
[2020, 14:22]

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Electroencephalographic alpha band power enhancement during rapid eye movement sleep in rapid eye movement sleep behavior disorder

Zhijun Qiu, Liang Zhang, Huaying Tao,

<title>Abstract</title> <p> Objective Rapid eye movement (REM) sleep behavior disorder (RBD) is a common sleep disorder in the elderly. We aim to reveal the physiological mechanism underlying RBD by analyzing changes in the electroencephalographic (EEG) spectrum during REM sleep.Methods Twenty patients with RBD monitored using video polysomnography and ... Read more >>

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Concern of Photosensitive Seizures Evoked by 3D Video Displays or Virtual Reality Headsets in Children: Current Perspective.

Lawrence Tychsen, Liu Lin Thio,

This review assesses the risk of a photic-induced seizure in a child during viewing of 3D (binocular 3 dimensional, stereoscopic) movies or games, either on standard video displays or when wearing a virtual reality (VR) headset. Studies published by pediatric epilepsy experts emphasize the low risk of 3D viewing even ... Read more >>

Eye Brain (Eye and brain)
[2020, 12:45-48]

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Retrospective analysis of cases of intraoperative awareness in a large multi-hospital health system reported in the early postoperative period.

Amanda S Deis, Michael P Schnetz, James W Ibinson, Keith M Vogt,

BACKGROUND:Awareness with recall under general anesthesia remains a rare but important issue that warrants further study. METHODS:We present a series of seven cases of awareness that were identified from provider-reported adverse event data from the electronic anesthesia records of 647,000 general anesthetics. RESULTS:The low number of identified cases suggests an ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2020, 20(1):62]

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Validity Prediction of Amplitude-Integrated EEG in Early Neuromotor Development Outcomes in High-Risk Neonates.

Jian Guo, Wentao Wang, Qili Zhou,

With the continuous advancement of medical technology, the survival rate of high-risk children is increasing year by year, but the developmental problems that have gradually become apparent in the later stages have a serious impact on the quality of life of children. Amplitude-integrated EEG is an EEG monitoring technology developed ... Read more >>

Comput Math Methods Med (Computational and Mathematical Methods in Medicine)
[2020, 2020:]

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aEEG Use in Pediatric Critical Care-An Online Survey.

Nora Bruns, Ursula Felderhoff-Müser, Christian Dohna-Schwake, Joachim Woelfle, Hanna Müller,

Background: Evidence supporting continuous EEG monitoring in pediatric intensive care is increasing, but continuous full-channel EEG is a scarce resource. Amplitude-integrated EEG (aEEG) monitors are broadly available in children's hospitals due to their use in neonatology and can easily be applied to older patients. Objective: The aim of this survey ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2020, 8:3]

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Weakly encoded memories due to acute sleep restriction can be rescued after one night of recovery sleep.

Daniel Baena, Jose L Cantero, Lluís Fuentemilla, Mercedes Atienza,

Sleep is thought to play a complementary role in human memory processing: sleep loss impairs the formation of new memories during the following awake period and, conversely, normal sleep promotes the strengthening of the already encoded memories. However, whether sleep can strengthen deteriorated memories caused by insufficient sleep remains unknown. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1449]

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Coexistence of Anti-SOX1 and Anti-GABAB Receptor Antibodies with Autoimmune Encephalitis in Small Cell Lung Cancer: A Case Report.

Wei Qin, Xiao Wang, Jing Yang, Wenli Hu,

Anti-γ-aminobutyric acid B receptor (anti-GABABR) encephalitis is a rare type of autoimmune encephalitis (AE). Although it responds well to immunomodulating therapy and has favorable prognosis, anti-GABABR AE has often been misdiagnosed as infectious encephalitis. Herein, we present a case of a 59-year-old female with anti-GABABR AE associated with small cell ... Read more >>

Clin Interv Aging (Clinical interventions in aging)
[2020, 15:171-175]

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Association between Loss of Sleep-specific Waves and Age, Sleep Efficiency, Body Mass Index, and Apnea-Hypopnea Index in Human N3 Sleep.

Weiguang Li, Ying Duan, Jiaqing Yan, He Gao, Xiaoli Li,

Sleep spindles (SS) and K-complexes (KC) play important roles in human sleep. It has been reported that age, body mass index (BMI), and apnea-hypopnea index (AHI) may influence the number of SS or KC in non-rapid-eye-movement (NREM) 2 (N2) sleep. In this study, we investigated whether the loss of SS ... Read more >>

Aging Dis (Aging and disease)
[2020, 11(1):73-81]

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Prognostic value of amplitude-integrated EEG in neonates with high risk of neurological sequelae.

Xiao Yuan, Wenqing Kang, Juan Song, Jing Guo, Lanlan Guo, Ruili Zhang, Shasha Liu, Yaodong Zhang, Dapeng Liu, Yong Wang, Xue Ding, Huimin Dong, Xi Chen, Yanchao Cheng, Xiaoli Zhang, Falin Xu, Changlian Zhu,

OBJECTIVE:To determine the efficacy and the prognostic value of amplitude-integrated electroencephalography (aEEG) in term and near-term neonates with high risk of neurological sequelae. METHODS:Infants of ≥35 weeks of gestation diagnosed with neonatal encephalopathy or with high risk of brain injury were included. All eligible infants underwent aEEG within 6 h after clinical ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(2):210-218]

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Clonidine Versus Chloral Hydrate for Recording Sleep EEG in Children.

Mahmoud Reza Ashrafi, Hossein Mohebbi, Mahmoud Mohamadi, Elham Azizi, Gholam Reza Zamani, Alireza Tavasoli, Reza Shervin Badv, Firozeh Hosseini,

Objective:One of the difficulties to conduct electroencephalography (EEG) in pediatric patient population is that they are not always cooperative during the procedure. Different medications are used to induce sedation during EEG recording. In order to find a medication with the least adverse effects and high efficacy, the current study aimed ... Read more >>

Iran J Child Neurol (Iranian journal of child neurology)
[2020, 14(1):85-92]

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Interhemispheric and Intrahemispheric Connectivity From the Left Pars Opercularis Within the Language Network Is Modulated by Transcranial Stimulation in Healthy Subjects.

Woo-Kyoung Yoo, Marine Vernet, Jeong Hoon Kim, Anna-Katharine Brem, Shahid Bashir, Fritz Ifert-Miller, Chang-Hwan Im, Mark Eldaief, Alvaro Pascual-Leone,

Neural activity related to language can be modulated within widespread networks following learning or in response to disruption—including the experimental application of noninvasive brain stimulation. However, the spatiotemporal characteristics of such modulation remain insufficiently explored. The present study combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to explore the modulation ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2020, 14:]

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