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SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia.

Jun Takouda, Sayako Katada, Takuya Imamura, Tsukasa Sanosaka, Kinichi Nakashima,

The brain consists of three major cell types: neurons and two glial cell types (astrocytes and oligodendrocytes). Although they are generated from common multipotent neural stem/precursor cells (NS/PCs), embryonic NS/PCs cannot generate all of the cell types at the beginning of brain development. NS/PCs first undergo extensive self-renewal to expand ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00749]

Cited: 1 time

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A shared transcriptional code orchestrates temporal patterning of the central nervous system.

Andreas Sagner, Isabel Zhang, Thomas Watson, Jorge Lazaro, Manuela Melchionda, James Briscoe,

The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate nervous system are incompletely understood. Here, we provide evidence of a global temporal patterning program comprising sets of transcription factors that stratifies neurons based on the developmental time at which they are generated. This transcriptional code ... Read more >>

PLoS Biol (PLoS biology)
[2021, 19(11):e3001450]

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MicroRNA-361-5p Aggravates Acute Pancreatitis by Promoting Interleukin-17A Secretion via Impairment of Nuclear Factor IA-Dependent Hes1 Downregulation.

Menglong Song, Yifan Wang, Ping Zhou, Jiandong Wang, Haidong Xu, Jun Zheng,

This study set out to explore the potential role of microRNA-361-5p (miR-361-5p) in acute pancreatitis through regulation of interleukin-17A (IL-17A). We first identified the expression of miR-361-5p, IL-17A, nuclear factor IA (NFIA), and hes family bHLH transcription factor 1 (Hes1) in serum samples collected from patients with acute pancreatitis, caerulein-induced ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2021, 64(22):16541-16552]

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Nuclear Factor I in neurons, glia and during the formation of Müller glia-derived progenitor cells in avian, porcine and primate retinas.

Heithem M El-Hodiri, Warren A Campbell, Lisa E Kelly, Evan C Hawthorn, Maura Schwartz, Archana Jalligampala, Maureen A McCall, Kathrin Meyer, Andy J Fischer,

The regenerative potential of Müller glia (MG) is extraordinary in fish, poor in chick and terrible in mammals. In the chick model, MG readily reprogram into proliferating Müller glia-derived progenitor cells (MGPCs), but neuronal differentiation is very limited. The factors that suppress the neurogenic potential of MGPCs in the chick ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2021, :]

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Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development.

Sayako Katada, Jun Takouda, Takumi Nakagawa, Mizuki Honda, Katsuhide Igarashi, Takuya Imamura, Yasuyuki Ohkawa, Shoko Sato, Hitoshi Kurumizaka, Kinichi Nakashima,

During neocortical development, tight regulation of neurogenesis-to-astrogenesis switching of neural precursor cells (NPCs) is critical to generate a balanced number of each neural cell type for proper brain functions. Accumulating evidence indicates that a complex array of epigenetic modifications and the availability of extracellular factors control the timing of neuronal ... Read more >>

Genes Dev (Genes & development)
[2021, 35(21-22):1431-1444]

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Transcriptome profiling of lncRNA and co-expression network in the vaginal epithelial tissue of women with lubrication disorders.

Jingjing Zhang, Jing Zhang, Shengnan Cong, Jingyi Feng, Lianjun Pan, Yuan Zhu, Aixia Zhang, Jiehua Ma,

<h4>Background</h4>Vaginal lubrication is a crucial physiological response that occurs at the beginning of sexual arousal. However, research on lubrication disorders (LD) is still in its infancy, and the role of long non-coding RNAs (lncRNAs) in LD remains unclear. This study aimed to explore the function of lncRNAs in the pathogenesis ... Read more >>

PeerJ (PeerJ)
[2021, 9:e12485]

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Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1 mutant cells.

Stephen D Lee, Jungeun Song, Veronique G LeBlanc, Marco A Marra,

Capicua (CIC)'s transcriptional repressor function is implicated in neurodevelopment and in oligodendroglioma (ODG) aetiology. However, CIC's role in these contexts remains obscure, primarily from our currently limited knowledge regarding its biological functions. Moreover, CIC mutations in ODG invariably co-occur with a neomorphic IDH1/2 mutation, yet the functional relationship between these ... Read more >>

J Pathol (The Journal of pathology)
[2021, :]

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The miR-223/nuclear factor I-A axis regulates inflammation and cellular functions in intestinal tissues with necrotizing enterocolitis.

Yu Zheng Wu, Kathy Yuen Yee Chan, Kam Tong Leung, Hugh Simon Lam, Yuk Him Tam, Kim Hung Lee, Karen Li, Pak Cheung Ng,

We previously demonstrated that microRNA(miR)-223 is overexpressed in intestinal tissue of infants with necrotizing enterocolitis (NEC). The objective of the current study was to identify the target gene of miR-223 and to investigate the role of the miR-223/nuclear factor I-A (NFIA) axis in cellular functions that underpin the pathophysiology of ... Read more >>

FEBS Open Bio (FEBS open bio)
[2021, 11(7):1907-1920]

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MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cell Chondrogenesis: Toward Articular Cartilage.

Daniel J Vail, Rodrigo A Somoza, Arnold I Caplan,

The production of a clinically useful engineered cartilage is an outstanding and unmet clinical need. High-throughput RNA sequencing provides a means of characterizing the molecular phenotype of populations of cells and can be leveraged to better understand differences among source cells, derivative engineered tissues, and target phenotypes. In this study, ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2021, :]

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Recurrent NFIA K125E substitution represents a loss-of-function allele: Sensitive in vitro and in vivo assays for nontruncating alleles.

Tomoko Uehara, Rikako Sanuki, Yurie Ogura, Atsushi Yokoyama, Takeshi Yoshida, Hiroshi Futagawa, Hiroshi Yoshihashi, Mamiko Yamada, Hisato Suzuki, Toshiki Takenouchi, Kohei Matsubara, Hiromi Hirata, Kenjiro Kosaki, Toshiyuki Takano-Shimizu,

Nuclear factor I A (NFIA) is a transcription factor that belongs to the NFI family. Truncating variants or intragenic deletion of the NFIA gene are known to cause the human neurodevelopmental disorder known as NFIA-related disorder, but no patient heterozygous for a missense mutation has been reported. Here, we document ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2021, 185(7):2084-2093]

Cited: 1 time

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Comparative genomics provides insights into the aquatic adaptations of mammals.

Yuan Yuan, Yaolei Zhang, Peijun Zhang, Chang Liu, Jiahao Wang, Haiyu Gao, A Rus Hoelzel, Inge Seim, Meiqi Lv, Mingli Lin, Lijun Dong, Haoyang Gao, Zixin Yang, Francesco Caruso, Wenzhi Lin, Rute R da Fonseca, Ding Wang, Xianyan Wang, Marianne H Rasmussen, Mingming Liu, Jinsong Zheng, Liyuan Zhao, Paula F Campos, Hui Kang, Maria Iversen, Yue Song, Xinyu Guo, Jiao Guo, Yating Qin, Shanshan Pan, Qiwu Xu, Lingfeng Meng, Yunga A, Shanshan Liu, Simon Ming-Yuen Lee, Xin Liu, Xun Xu, Huanming Yang, Guangyi Fan, Kun Wang, Songhai Li,

The ancestors of marine mammals once roamed the land and independently committed to an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for centuries. Here, we generated high-quality genome assemblies of 17 marine mammals (11 cetaceans and six pinnipeds), including eight assemblies at the chromosome level. Incorporating previously published data, ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(37):]

Cited: 1 time

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Nuclear Factor I in neurons, glia and during the formation of Müller glia-derived progenitor cells in avian, porcine and primate retinas

Heithem El-Hodiri, Warren Campbell, Lisa Kelly, Evan Hawthorn, Maura Schwartz, Archana Jalligampala, Maureen McCall, Kathrin Meyer, Andy Fischer,

The regenerative potential of Müller glia (MG) is extraordinary in fish, poor in chick and terrible in mammals. In the chick model, MG readily reprogram into proliferating Müller glia-derived progenitor cells (MGPCs), but neuronal differentiation is very limited. The factors that suppress the neurogenic potential of MGPCs in the chick ... Read more >>

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Novel t(1;8)(p31.3;q21.3) NFIA-RUNX1T1 Translocation in an Infant Erythroblastic Sarcoma.

Rebecca L King, Parwiz J Siaghani, Katy Wong, Kerstin Edlefsen, Lisa Shane, Matthew T Howard, Kaaren K Reichard, Ming Mai, David S Viswanatha, Patricia T Greipp, Tony A Goble, Maritza Ruiz, Harneet Hara,

<h4>Objectives</h4>Pure erythroid leukemia (PEL) is exceptionally rare in the pediatric setting. Four pediatric PEL cases with t(1;16)(p31;q24) NFIA-CBFA2T3 were reported previously. We present a case of an infant with PEL presenting with erythroblastic sarcoma and harboring a novel t(1;8)(p31.3;q21.3) NFIA-RUNX1T1 fusion detected by RNA sequencing and conventional karyotype.<h4>Methods</h4>Bone marrow (BM) ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2021, 156(1):129-138]

Cited: 2 times

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Control of neurogenic competence in mammalian hypothalamic tanycytes.

Sooyeon Yoo, Juhyun Kim, Pin Lyu, Thanh V Hoang, Alex Ma, Vickie Trinh, Weina Dai, Lizhi Jiang, Patrick Leavey, Leighton Duncan, Jae-Kyung Won, Sung-Hye Park, Jiang Qian, Solange P Brown, Seth Blackshaw,

Hypothalamic tanycytes, radial glial cells that share many features with neuronal progenitors, can generate small numbers of neurons in the postnatal hypothalamus, but the identity of these neurons and the molecular mechanisms that control tanycyte-derived neurogenesis are unknown. In this study, we show that tanycyte-specific disruption of the NFI family ... Read more >>

Sci Adv (Science advances)
[2021, 7(22):]

Cited: 2 times

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Macrophages-derived exosomal lncRNA LIFR-AS1 promotes osteosarcoma cell progression via miR-29a/NFIA axis.

Hongliang Zhang, Yiyang Yu, Jun Wang, Yu Han, Tingting Ren, Yi Huang, Chenglong Chen, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou, Wei Guo,

<h4>Background</h4>Osteosarcoma (OS) is the most common primary malignant bone tumor in young people. Tumor-associated macrophages (TAMs) have been reported to play an important role in the development of osteosarcoma. However, the detailed molecular mechanisms remain largely unknown and need to be elucidated. Recently, exosomes have been reported as the crucial ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):192]

Cited: 4 times

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Gene regulatory networks controlling temporal patterning, neurogenesis, and cell fate specification in the mammalian retina

Pin Lyu, Thanh Hoang, Clayton Santiago, Eric Thomas, Andrew Timms, Haley Appel, Megan Gimmen, Nguyet Le, Lizhi Jiang, Dong Won Kim, Siqi Chen, David Espinoza, Ariel Telger, Kurt Weir, Brian Clark, Timothy Cherry, Jiang Qian, Seth Blackshaw,

Gene regulatory networks (GRNs), consisting of transcription factors and their target cis- regulatory sequences, control neurogenesis and cell fate specification in the developing central nervous system, but their organization is poorly characterized. In this study, we performed integrated single-cell RNA- and scATAC-seq analysis in both mouse and human retina to ... Read more >>

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Exosomal circEhmt1 Released from Hypoxia-Pretreated Pericytes Regulates High Glucose-Induced Microvascular Dysfunction via the NFIA/NLRP3 Pathway.

Lin Ye, Hui Guo, Yuan Wang, Yun Peng, Yongxin Zhang, Shu Li, Meina Yang, Ling Wang,

Diabetic retinopathy (DR) is a frequently occurring microvascular complication induced by long-term hyperglycemia. Pericyte-endothelial cell crosstalk is critical for maintaining vascular homeostasis and remodeling; however, the molecular mechanism underlying that crosstalk remains unknown. In this study, we explored the crosstalk that occurs between endothelial cells and pericytes in response to ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:8833098]

Cited: 1 time

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Regulatory start-stop elements in 5’ untranslated regions pervasively modulate translation

Justin Rendleman, Mahabub Pasha Mohammad, Matthew Pressler, Shuvadeep Maity, Vladislava Hronová, Zhaofeng Gao, Anna Herrmannová, Amy Lei, Kristina Allgoewer, Daniel Sultanov, Will Edward Hinckley, Krzysztof Szkop, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou, Leoš Shivaya Valášek, Christine Vogel,

Translation includes initiation, elongation, and termination, followed by ribosome recycling. We characterize a new sequence element in 5’ untranslated regions that consists of an adjacent start and stop codon and thereby excludes elongation. In these start-stop elements, an initiating ribosome is simultaneously positioned for termination without having translocated. At the ... Read more >>

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NFIA and NFIB function as tumour suppressors in high-grade glioma in mice.

Kok-Siong Chen, Zorana Lynton, Jonathan W C Lim, Thomas Robertson, Richard M Gronostajski, Jens Bunt, Linda J Richards,

Nuclear factor one (NFI) transcription factors are implicated in both brain development and cancer in mice and humans and play an essential role in glial differentiation. NFI expression is reduced in human astrocytoma samples, particularly those of higher grade, whereas over-expression of NFI protein can induce the differentiation of glioblastoma ... Read more >>

Carcinogenesis (Carcinogenesis)
[2021, 42(3):357-368]

Cited: 1 time

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Correction to: CANPMR syndrome and chromosome 1p32-p31 deletion syndrome coexist in two related individuals affected by simultaneous haplo-insufficiency of CAMTA1 and NFIA genes.

Emanuele G Coci, Udo Koehler, Thomas Liehr, Armin Stelzner, Christian Fink, Hendrik Langen, Joachim Riedel,

Mol Cytogenet (Molecular cytogenetics)
[2021, 14(1):17]

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Identification of a DNA Methylation Episignature in the 22q11.2 Deletion Syndrome.

Kathleen Rooney, Michael A Levy, Sadegheh Haghshenas, Jennifer Kerkhof, Daniela Rogaia, Maria Giovanna Tedesco, Valentina Imperatore, Amedea Mencarelli, Gabriella Maria Squeo, Eleonora Di Venere, Giuseppe Di Cara, Alberto Verrotti, Giuseppe Merla, Matthew L Tedder, Barbara R DuPont, Bekim Sadikovic, Paolo Prontera,

The 22q11.2 deletion syndrome (22q11.2DS) is the most common genomic disorder in humans and is the result of a recurrent 1.5 to 2.5 Mb deletion, encompassing approximately 20-40 genes, respectively. The clinical presentation of the typical deletion includes: Velocardiofacial, Di George, Opitz G/BBB and Conotruncalanomaly face syndromes. Atypical deletions (proximal, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(16):]

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Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients.

Tiit Nikopensius, Priit Niibo, Toomas Haller, Triin Jagomägi, Ülle Voog-Oras, Neeme Tõnisson, Andres Metspalu, Mare Saag, Chris Pruunsild,

<h4>Background</h4>Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. Genetic association studies have revealed several JIA susceptibility loci with the strongest effect size observed in the human leukocyte antigen (HLA) region. Genome-wide association studies have augmented the number of JIA-associated loci, particularly for non-HLA genes. The ... Read more >>

Clin Rheumatol (Clinical rheumatology)
[2021, 40(10):4157-4165]

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Generation of Pulmonary Endothelial Progenitor Cells for Cell-based Therapy Using Interspecies Mouse-Rat Chimeras.

Guolun Wang, Bingqiang Wen, Xiaomeng Ren, Enhong Li, Yufang Zhang, Minzhe Guo, Yan Xu, Jeffrey A Whitsett, Tanya V Kalin, Vladimir V Kalinichenko,

<b>Rationale:</b> Although pulmonary endothelial progenitor cells (EPCs) hold promise for cell-based therapies for neonatal pulmonary disorders, whether EPCs can be derived from pluripotent embryonic stem cells (ESCs) or induced pluripotent stem cells remains unknown.<b>Objectives:</b> To investigate the heterogeneity of pulmonary EPCs and derive functional EPCs from pluripotent ESCs.<b>Methods:</b> Single-cell RNA ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(3):326-338]

Cited: 2 times

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The histone demethylase PHF8 regulates astrocyte differentiation and function.

Simona Iacobucci, Natalia Padilla, Martina Gabrielli, Claudia Navarro, Marta Lombardi, Marta Vicioso-Mantis, Claudia Verderio, Xavier de la Cruz, Marian A Martínez-Balbás,

Epigenetic factors have been shown to play a crucial role in X-linked intellectual disability (XLID). Here, we investigate the contribution of the XLID-associated histone demethylase PHF8 to astrocyte differentiation and function. Using genome-wide analyses and biochemical assays in mouse astrocytic cultures, we reveal a regulatory crosstalk between PHF8 and the ... Read more >>

Development (Development (Cambridge, England))
[2021, 148(12):]

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ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma.

Husam Babikir, Lin Wang, Karin Shamardani, Francisca Catalan, Sweta Sudhir, Manish K Aghi, David R Raleigh, Joanna J Phillips, Aaron A Diaz,

<h4>Background</h4>Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic, predictive of response to chemotherapy, and correlate with distinct tumor microenvironments.<h4>Results</h4>To reconcile these findings, we profile 22 human IDH-mutant gliomas using ... Read more >>

Genome Biol (Genome biology)
[2021, 22(1):311]

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