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Neurosyphilis

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Clinical and laboratory characteristics of ocular syphilis and neurosyphilis among individuals with and without HIV infection.

Dony Mathew, Derrick Smit,

BACKGROUND/AIMS:In the era of increasing incidence of syphilis globally, ocular syphilis is re-emerging as an important cause of uveitis. The aim of this study was to determine the clinical and laboratory characteristics of ocular- and neurosyphilis among individuals with and without HIV infection. METHODS:Retrospective analysis of patients diagnosed with ocular ... Read more >>

Br J Ophthalmol (The British journal of ophthalmology)
[2020, :]

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Prevalence of Self-Reported Neurologic and Ocular Symptoms in Early Syphilis Cases.

Laura A S Quilter, Alex de Voux, Rachel M Amiya, Erin Davies, Robin R Hennessy, Roxanne P Kerani, Robbie Madera, James Matthias, Victoria M Pearson, Jaime K Walters, Craig Wilson, Sarah Kidd, Elizabeth Torrone,

BACKGROUND:Neurosyphilis, a complication of syphilis, can occur at any stage of infection. Measuring the prevalence of neurosyphilis is challenging and there are limited data on the prevalence of neurologic or ocular symptoms among patients with syphilis. We sought to describe the prevalence of neurologic and/or ocular symptoms among early syphilis ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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The Treponema pallidum outer membrane protein Tp92 activates endothelial cells via the chemerin/CMKLR1 pathway.

Rui-Li Zhang, Qian-Qiu Wang,

Endothelium damage caused by Treponema pallidum is the key step in the systemic dissemination and pathophysiology of syphilis, particularly cardiovascular syphilis and neurosyphilis. However, the molecular mechanisms supporting endothelium damage of syphilis are undefined. The outer membrane proteins were thought to be involved. Tp92 was first identified as an outer ... Read more >>

Int. J. Med. Microbiol. (International journal of medical microbiology : IJMM)
[2020, 310(3):151416]

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Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

Adeodatus Haule, Betrand Msemwa, Evarista Mgaya, Peter Masikini, Samuel Kalluvya,

<title>Abstract</title> <p> BACKGROUND HIV-syphilis co-infection is a combination that enhances rapid progression of early syphilis or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~8% of healthy outpatients, and older studies have suggested that up to 23.5% of HIV-syphilis ... Read more >>

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Ocular and neurosyphilis: epidemiology and approach to management.

Ameeta E Singh,

PURPOSE OF REVIEW:In the context of a resurgence of syphilis worldwide, it can be anticipated that a rise in cases of ocular, otic, and neurosyphilis will also be seen. This article reviews the current epidemiology, manifestations, and approach to management and treatment. RECENT FINDINGS:Although studies continue investigating alternate approaches and ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(1):66-72]

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Bilateral ocular involvement with syphilis in a known HIV patient.

Boon Lin Teh, Mohammad Kamran Khan, Ambreen Butt, Lucia Kuffova,

Am J Ophthalmol Case Rep (American Journal of Ophthalmology Case Reports)
[2020, 18:100638]

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Cerebrospinal fluid treponemal antibody titres: a breakthrough in the diagnosis of neurosyphilis.

Khalil G Ghanem,

Sex Transm Infect (Sexually transmitted infections)
[2020, :]

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Technologies, strategies and approaches for testing populations at risk of sexually transmitted infections: a systematic review protocol to inform prevention and control in EU/EEA countries.

Suzanna C Francis, Arun Parajuli, Otilia Mardh, Jane Falconer, Aura Andreasen, Emma Harding-Esch, ,

OBJECTIVES:This protocol outlines a systematic review methodology, aiming to assess the recent evidence-base for the impact of testing strategies and approaches on access to testing, testing coverage, and linkage to care for populations at risk for specific curable sexually transmitted infections (STIs) (chlamydia, gonorrhoea, syphilis, trichomoniasis, and Mycoplasma genitalium infections). ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):64]

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Immunoblot and Polymerase Chain Reaction to Diagnose Ocular Syphilis and Neurosyphilis in HIV-positive and HIV-negative Patients.

Derrick Smit, Melanie De Graaf, David Meyer, Jolanda D F de Groot-Mijnes,

Purpose: To evaluate immunoblot (IB) and polymerase chain reaction (PCR) to diagnose ocular- and neurosyphilis.Methods: Prospective cross-sectional study. Aqueous humor (AH) and cerebrospinal fluid (CSF) samples were tested for treponemal DNA or antibodies to treponemal antigens.Results: Thirteen of 106 cases had positive syphilis serology of which 69.2% were HIV+ (median ... Read more >>

Ocul. Immunol. Inflamm. (Ocular immunology and inflammation)
[2020, :1-7]

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Multi-syphilitic gummas in pituitary and cerebellopontine angle in a patient.

Kaiguo Xia, Zhangchao Guo, Xiangguo Xia, Yang Ming, Ligang Chen, Xianglong Li, Chuanhong Zhong,

PURPOSE:Multi-syphilitic gummas in pituitary and cerebellopontine angle (CPA) are extremely rare and easily misdiagnosed especially in patients with antibiotic abuse. We write this paper for clinicians to better understanding of cerebral gumma. METHODS:We report a patient with syphilitic gummas in pituitary and left CPA. The definite diagnosis is made by ... Read more >>

Pituitary (Pituitary)
[2020, :]

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Eyes As the Window to Syphilis: A Rare Case of Ocular Syphilis As the Initial Presentation of Syphilis.

Shweta Paulraj, Prashanth Ashok Kumar, Harvir Singh Gambhir,

In the pre-antibiotic era, neurosyphilis (NS) was common, occurring in 34% of patients with syphilis. Currently, there has been a rising trend in syphilis with HIV-infected patients being more prone to develop NS. Ocular involvement is very rare in NS and accounts for only 1%-5% of the cases in the United ... Read more >>

Cureus (Cureus)
[2020, 12(2):e6998]

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Cerebrospinal fluid TPPA titres in the diagnosis of neurosyphilis.

Fareed Shiva, David Goldmeier, Paul Lane, Helen Ethiopia, Alan Winston,

Sex Transm Infect (Sexually transmitted infections)
[2020, :]

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Imaging of Diffuse Neurosyphilis Affecting the Corticospinal Tracts and Cerebellum.

Roya Moheimani, David Blumeyer, Mari Tobati, Ziyad Ayyoub,

PM R (PM & R : the journal of injury, function, and rehabilitation)
[2020, 12(3):330-331]

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False positives in the ultrasound diagnosis of giant cell arteritis: some diseases can also show the halo sign.

Elisa Fernández-Fernández, Irene Monjo-Henry, Gema Bonilla, Chamaida Plasencia, María-Eugenia Miranda-Carús, Alejandro Balsa, Eugenio De Miguel,

OBJECTIVES:To describe the frequency and causes for the presence of a halo sign on the ultrasound of patients without a diagnosis of GCA. METHODS:In total, 305 patients with temporal artery colour Doppler ultrasound showing the presence of halo sign (intima-media thickness ≥0.34 mm for temporal arteries [TAs] and ≥1 mm for axillary ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, :]

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A Case of Secondary Syphilis with the Extragenital Chancre on the Nipple.

Xiao Yan Wang, Juliandri, Zi Jing Liu, Jia Wen Zhang, Yun Yi Liu, Da-Guang Wang, Yang Xu,

Syphilis is a sexually transmitted disease caused by Treponema pallidum. The signs and symptoms of syphilis vary depending on which of the four stages it presents. The primary stage of syphilis classically presents with a painless ulcer (chancre). We report a case of the extragenital chancre on the nipple which ... Read more >>

Case Rep Dermatol Med (Case reports in dermatological medicine)
[2020, 2020:2391907]

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Neurosyphilis presenting with myelitis-case series and literature review.

Yali Wu, Wenqing Wu,

Syphilitic myelitis is an extremely rare manifestation of neurosyphilis and often misdiagnosed. However, a small amount of literature describe its clinical manifestations and neuroimaging features, and there is no relevant data on the prognosis, especially the long follow-up prognosis. In this paper, four syphilitic myelitis patients admitted to our hospital ... Read more >>

J. Infect. Chemother. (Journal of Infection and Chemotherapy)
[2020, 26(2):296-299]

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Reversible orolingual dyskinesia in a case of juvenile onset psychosis and cognitive decline.

Vikram V Holla, Ravi Yadav, Vishwanath Iyer, S P Chaithra, Albert Stezin, Pramod Kumar Pal,

Parkinsonism Relat. Disord. (Parkinsonism & related disorders)
[2020, :]

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Neurosyphilis Presenting as Intermittent Explosive Disorder and Acute Psychosis.

Harneel S Saini, Matthew Sayre, Ishveen Saini, Nehad Elsharkawy,

We present a case of a patient with tertiary syphilis, manifesting as acute psychosis, auditory hallucinations and intermittent explosive disorder with pending legal ramifications for physical violence. Our patient had been seen and treated by a psychologist with Aripiprazole for his erratic and aggressive behavior coupled with his new found psychosis ... Read more >>

Cureus (Cureus)
[2019, 11(12):e6337]

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The Modern Epidemic of Syphilis.

Khalil G Ghanem, Sanjay Ram, Peter A Rice,

N. Engl. J. Med. (The New England journal of medicine)
[2020, 382(9):845-854]

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Molecular diagnostic of syphilis.

Luis Otero Guerra, Fernando Vázquez Valdés,

Syphilis is a sexually transmitted infection caused by Treponema pallidum subsp. pallidum with an increasing incidence in Spain and in the rest of the world. Diagnosis is based mainly on serology, since direct diagnosis by dark field microscopy presents difficulties that limit its widespread use. Molecular biology techniques can be ... Read more >>

Enferm. Infecc. Microbiol. Clin. (Enfermedades infecciosas y microbiologia clinica)
[2020, 38 Suppl 1:7-11]

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UNILATERAL OPTIC NEURITIS AND CENTRAL RETINAL VASCULITIS DUE TO OCULAR SYPHILIS.

Murtaza S Khan, Dulanji K Kuruppu, Tanav A Popli, Ramana S Moorthy, Devin D Mackay,

PURPOSE:Report a case of concurrent unilateral optic neuritis and central retinal artery occlusion as the presenting signs of syphilis. METHODS:A case report of a 22-year-old man with progressive unilateral vision loss. RESULTS:With no known previous history of syphilis, genital lesions, or other extraocular manifestations, the patient presented with pain with ... Read more >>

Retin Cases Brief Rep (Retinal cases & brief reports)
[2020, 14(1):35-38]

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Creutzfeldt-Jakob Disease Mimicking Neurosyphilis: A Complex Presentation, Histopathological Findings, and Special Precautions for Autopsy.

Rhonda Mittenzwei, Louis Dibernardo, Christine Hulette, William T Harrison,

Creutzfeldt-Jakob disease (CJD) is a complex and rapidly fatal prion infection of the central nervous system with characteristic clinical and pathological findings. Herein, we present the case of an 80-year-old man with a 2-month history of rapid cognitive decline and ataxic gait. He was found to have a positive rapid ... Read more >>

Am J Forensic Med Pathol (The American journal of forensic medicine and pathology)
[2019, 40(4):371-375]

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Diagnosis of Syphilitic Bilateral Papillitis Mimicking Papilloedema.

Alicia Gonzalez-Martinez, Sonia Quintas, Diego Celdrán Vivancos, José Cebrián, José Vivancos,

Syphilis produces myriad nonspecific signs and symptoms. For example, optic disk swelling might be seen in patients with syphilis as a result of cranial hypertension (papilloedema), inflammatory optic neuritis with papillitis, or optic perineuritis. We report a case involving differential diagnosis of syphilitic bilateral papillitis mimicking papilloedema. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(1):171-173]

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Successful Treatment of Human Immunodeficiency Virus-Associated Highly Active Antiretroviral Therapy-Resistant Vacuolar Myelopathy with Intravenous Immunoglobulin.

Lidiia N Prakhova, Aleksandr G Ilves, Svetlana N Kizhlo, Zhanna I Savintseva,

For the first time, human immunodeficiency virus (HIV)-associated vacuolar myelopathy (VM) was detailed in an autopsy-based study of 89 cases in 1985. This condition is the most common cause for spinal cord lesions in HIV patients. VM's pathogenic mechanism remains unclear; however, it is assumed that the disease can be ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(2):220-222]

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A man in his forties with acute onset of speech impairment and unilateral paresis.

Silje Holt Jahr, Aija Zuleron Myro, Kjetil Vegge, Patricia Campbell,

BACKGROUND:Stroke has several causes and the diagnostic investigation can be challenging. Neurosyphilis occurs when Treponema pallidum infects the central nervous system, and is a rare cause of stroke. CASE PRESENTATION:A man in in his late forties with diabetes mellitus and overweight presented with headache, speech impairment and right-sided stroke symptoms. ... Read more >>

Tidsskr. Nor. Laegeforen. (Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke)
[2019, 139(18):]

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