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Neurosarcoidosis

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Isolated Bulbar Palsy: A Rare Presentation of Neurosarcoidosis.

Hammad S Chaudhry, Fateen Ata, Mohamed Abdelghani, Rashid Kazman, Ali Rahil,

Sarcoidosis, which is a non-caseating granulomatous chronic inflammatory disease, can affect virtually any organ system, including the central nervous system (CNS). Very rarely, patients may present solely with neurosarcoidosis. It commonly presents with unilateral or bilateral seventh nerve palsy. Rarely it can present as dangerous progressive bulbar palsy and is a ... Read more >>

Cureus (Cureus)
[2020, 12(2):e7010]

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[Case of isolated neurosarcoidosis requiring differentiation from tuberculous meningitis].

Ichiro Deguchi, Takashi Osada, Tomonari Suzuki, Shinya Tabata, Eiichi Arai, Akira Uchino, Takeshi Hayashi, Shinichi Takahashi, Suketaka Momoshima, Masaki Takao,

A 62-year-old woman was transported to our hospital for management of generalized clonic seizures. Cerebrospinal fluid examination showed an increased monocyte-dominant cell count, high protein concentration, and low glucose concentration that was 17% of the plasma glucose concentration. Contrast-enhanced cranial magnetic resonance imaging revealed diffuse leptomeningeal enhancement with multiple nodular ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2020, 60(3):213-218]

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Viscous Leptomeningeal Pseudotumoural Masses and Multiple Cranial Neuropathy - Severe Presentation of Neurosarcoidosis.

Rita Dias, Inês Henriques Ferreira, Raquel Faria,

We present a case of a 56-year-old man with a history of episcleritis (left) and cluster headache (left) who had a penetrating trauma of the left eye leading to amaurosis 1 month previously. Since then, he developed multiple cranial neuropathy of the right side (V, VII, VIII, IX, X, XI ... Read more >>

Eur J Case Rep Intern Med (European journal of case reports in internal medicine)
[2020, 7(3):001453]

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[Trident sign in spinal cord neurosarcoidosis].

M Bala, M Saucedo, L Bandeo, A Chertcoff, C Uribe-Roca, P Bonardo, M Fernández-Pardal, L Miquelini, J Méndez, R Reisin,

Rev Neurol (Revista de neurologia)
[2020, 70(5):193-194]

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Leukocyte profiles in blood and CSF distinguish neurosarcoidosis from multiple sclerosis.

Michael Heming, Lisa Lohmann, Andreas Schulte-Mecklenbeck, Tobias Brix, Catharina C Gross, Heinz Wiendl, Luisa Klotz, Gerd Meyer Zu Hörste,

Distinguishing neurosarcoidosis (NS) from multiple sclerosis (MS) remains challenging and available parameters lack discriminatory power. Comprehensive flow cytometry data of blood and CSF leukocytes of patients with NS (n = 24), MS (n = 49) and idiopathic intracranial hypertension (IIH, n = 52) were analyzed by machine learning algorithms. NS featured a specific immune cell pattern ... Read more >>

J. Neuroimmunol. (Journal of neuroimmunology)
[2020, 341:577171]

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Neurosarcoidosis presenting with isolated intracranial mass lesion and communicating hydrocephalus.

Beatriz Novo-González, Laura González-García, Gloria Samperiz-Abad, Samira Bakali-Badesa, Juan Alberdi-Viñas,

Isolated neurosarcoidosis is a very rare disease, which makes up 5-15% of sarcoidosis cases. Hydrocephalus is a rare clinical feature with a prevalence of 6% among these patients. Considering neurosarcoidosis in the differential diagnosis of a unique parenquimal mass lesion could help in the early identification of this disease. We ... Read more >>

Neurocirugia (Astur) (Neurocirugia (Asturias, Spain))
[2019, :]

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Severe visual impairment due to an optic neuropathy and central retinal vein occlusion in a sarcoidosis patient.

Miki Hiraoka,

BACKGROUND:The ophthalmic manifestation of neurosarcoidosis is varied. The complication of optic neuropathy and central retinal vein occlusion (CRVO) is rare in sarcoidosis. CASE REPORT:The patient was a 55-year-old female with systemic sarcoidosis suffering from visual loss as hand motion in her left eye. A fundus examination showed severe optic disc ... Read more >>

J Ophthalmic Inflamm Infect (Journal of ophthalmic inflammation and infection)
[2020, 10(1):6]

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Palatal myoclonus secondary to neurosarcoidosis.

Devanshi Dharaiya, Anza B Memon,

Palatal myoclonus can be primary or secondary. In primary palatal myoclonus, no obvious structural brain lesions can be found within the triangle of Guillain and Mollaret. Common causes of secondary myoclonus include stroke, demyelination, infections, trauma, and neurodegeneration. ... Read more >>

Clin Case Rep (Clinical Case Reports)
[2020, 8(3):587-588]

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The eclipse sign as a radiological presentation of neurosarcoidosis.

Marc Pineton de Chambrun, Damien Galanaud, Julien Haroche, Zahir Amoura, Fleur Cohen Aubart,

Neurosarcoidosis is a rare inflammatory neurological condition. We describe a challenging radiological presentation of neurosarcoidosis. The eclipse sign refers to hypo T1-weighted parenchymal or leptomeningeal images surrounded by circular gadolinium enhancement. The eclipse sign was identified in 3 out of 46 patients with histologically-proven neurosarcoidosis. The eclipse sign may correspond ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2019, :1-3]

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Hydrocephalus as the presenting symptom of sarcoidosis: A case report and review of literature.

Rachel J Saban, Meaghan M Berns, Mazen M Al-Hakim, Gustavo A Patino,

Hydrocephalus is rare in sarcoidosis, especially as the presenting symptom. Neurosarcoidosis as a cause of unexplained communicating hydrocephalus should be considered in cases of abnormal cerebrospinal fluid (CSF) and negative infectious and tumoral studies. ... Read more >>

Clin Case Rep (Clinical case reports)
[2020, 8(2):363-368]

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Intracranial vessel wall imaging: applications, interpretation, and pitfalls.

D J Leao, A Agarwal, S Mohan, G Bathla,

Vessel wall imaging (VWI) is being increasingly used as a non-invasive diagnostic method to evaluate the intra- and extracranial vascular bed. Whereas conventional vascular imaging primarily assesses the vessel lumen, VWI changes the focus of analysis toward the vessel wall. As the technical challenges of high spatial resolution, signal-to-noise ratio, ... Read more >>

Clin Radiol (Clinical radiology)
[2020, :]

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Neurosarcoidosis manifesting as panhypopituitarism.

Monique Oye, Michael Chahin, Nithya Krishnan, Pramod Reddy,

Panhypopituitarism secondary to Neurosarcoidosis is a rare however serious complication. This diagnosis should remain in the differential in patients with hypothalamic-pituitary dysfunction. Biopsy of lesions will give definitive diagnosis. ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(12):2472-2475]

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Differentiation between neurosarcoidosis and primary central nervous system vasculitis based on demographic, cerebrospinal and imaging features.

Didem Saygin, Stephen Jones, Priya Sundaram, Leonard H Calabrese, William Messner, Jinny O Tavee, Rula A Hajj-Ali,

OBJECTIVES:Neurosarcoidosis (NS) and primary angiitis of central nervous system (PACNS) are inflammatory diseases affecting central nervous system, with overlapping clinical and pathological characteristics. Distinguishing these diseases is important given distinct therapeutic implications. In this study, we aimed to compare demographic, CSF and MRI characteristics between these two conditions. METHODS:All the ... Read more >>

Clin. Exp. Rheumatol. (Clinical and experimental rheumatology)
[2020, :]

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Evaluating S100B as a serum biomarker for central neurosarcoidosis.

B P Moss, D C Patel, J O Tavee, D A Culver,

BACKGROUND:S100B is a calcium-binding protein found primarily in glial cells. In the setting of neuronal injury and disruption of the blood brain barrier, S100B can leak into the cerebrospinal fluid and systemic circulation. OBJECTIVES:To determine if serum S100B distinguishes patients with central neurosarcoidosis (NS) from patients with extra-neurologic sarcoidosis (ENS) ... Read more >>

Respir Med (Respiratory medicine)
[2020, 162:105855]

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En mann i 60-årene med gangvansker, dysartri og lett kognitiv svikt.

Ludmila Nordaa, Elin Bjelland Forsaa, Audun Odland, Soffien Ajmi,

BACKGROUND:Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is an immune-mediated, treatable and inflammatory CNS disease first reported by Pittock et al. (2010). CASE PRESENTATION:We describe a 66-year-old man with previous history of diabetes, atrial fibrillation and hypertension, who was admitted to hospital with reduced general ... Read more >>

Tidsskr. Nor. Laegeforen. (Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke)
[2020, 140(4):]

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Neurosarcoidosis presenting with a partial Claude syndrome.

Hao Meng Yip, Kirtana Vallabhaneni, David Williams,

Neurosarcoidosis when encountered by neurologists most commonly presents as cranial neuropathy, peripheral mononeuropathy,polyneuropathy, myopathy, meningitis or myelopathy. There are limited reports in the current literature on the cases of neurosarcoidosis patients presenting with ischaemic stroke. We discuss a 52-year-old patient with a known previous history of cutaneous sarcoidosis presenting with ... Read more >>

BMJ Case Rep (BMJ case reports)
[2019, 12(11):]

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18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography/Magnetic Resonance Imaging in Neurosarcoidosis.

Nikhil Seniaray, Anuj Jain,

A 41-year-old lady presented with headache and ophthalmoplegia of the left eye for 1 week and underwent magnetic resonance imaging (MRI) of the brain, which showed homogeneously enhancing nodular thickening of meninges in the left anterior and middle cranial fossa with perilesional white matter edema of the left fronto-temporal lobes ... Read more >>

Indian J Nucl Med (Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India)
[2019, 34(4):344-346]

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Value of Multimodal Imaging Approach to Diagnosis of Neurosarcoidosis.

Ilaria Sammarra, Gaetano Barbagallo, Angelo Labate, Baldassare Mondello, Giuseppe Albonico, Maurizio Maisano, Giuseppe Lucio Cascini, Aldo Quattrone, Antonio Gambardella,

BACKGROUND:Neurosarcoidosis is a highly variable condition with many clinical and radiological manifestations, that can lead to difficult identification of isolated central nervous system (CNS) forms, because it could mimic inflammatory, infective or neoplastic disorders. Conventional magnetic resonance imaging (MRI) is gold standard to evaluate CNS involvement in neurosarcoidosis, despite the ... Read more >>

Brain Sci (Brain sciences)
[2019, 9(10):]

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Panhypopituitarism from neurosarcoidosis in an adolescent: case report and literature review.

Anju Sukumaran,

Background Neurosarcoidosis is not a common entity from an endocrinology standpoint. Prompt diagnosis is essential in order to determine appropriate treatment and to establish prognosis. Case presentation Our case illustrates the difficulties encountered in making a diagnosis of sarcoidosis in an adolescent who presented with polyuria, polydipsia and hypernatremia. She ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2019, 32(9):1039-1042]

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Pediatric Sarcoidosis: A Review with Emphasis on Early Onset and High-Risk Sarcoidosis and Diagnostic Challenges.

Brian Chiu, Jackie Chan, Sumit Das, Zainab Alshamma, Consolato Sergi,

Sarcoidosis is a non-necrotizing granulomatous inflammatory syndrome with multisystemic manifestations. We performed a systematic review of sarcoidosis in the pediatric population with particular emphases on early onset sarcoidosis, high-risk sarcoidosis, and newly reported or unusual sarcoid-related diseases. Blau Syndrome and early onset sarcoidosis/ BS-EOS are seen in children younger than ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2019, 9(4):]

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Durvalumab induced sarcoid-like pulmonary lymphadenopathy.

Emma Sanderson, Hari Wimaleswaran, Clare Senko, Shane White, Christine F McDonald,

Immune checkpoint inhibitors (ICIs) have become pivotal in the treatment of lung cancer. An increasing number of immune-related adverse events (irAEs) have been recognized with their use. To our knowledge, this is the first published case of sarcoid-like pulmonary lymphadenopathy associated with durvalumab, a monoclonal antibody against programmed death ligand-1 ... Read more >>

Respirol Case Rep (Respirology case reports)
[2020, 8(3):e00542]

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Infliximab for relapsing neurosarcoidosis recurring after kidney transplantation: a case report.

Nicolas Hanset, Mawufemo Yawovi Tsevi, Thierry Duprez, Adrian Ivanoiu, Arnaud Devresse, Nathalie Demoulin, Nada Kanaan,

Neurological involvement of sarcoidosis is a rare condition, and its occurrence in the context of transplantation is exceptional. Moreover, treatment can be challenging. We report the unusual case of a patient transplanted with a kidney for end-stage renal disease secondary to sarcoidosis who experienced a neurological recurrence of the disease ... Read more >>

Acta Clin Belg (Acta clinica Belgica)
[2019, :1-3]

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Neurosarcoidosis Presenting as Isolated Bilateral Cerebellopontine Angle Tumors: Case Report and Review of the Literature.

Fred Crawford, Sameer A Alvi, Bledi Brahimaj, Richard Byrne, Mehmet Kocak, Richard Mark Wiet,

OBJECTIVES:To describe a unique case of isolated bilateral sarcoidosis of the cerebellopontine angle as well as the related imaging in the case. To conduct a literature review of the published articles regarding sarcoidosis of the cerebellopontine angle. DATA SOURCES:Representative case report from a single institution as well as PubMed and ... Read more >>

Ear Nose Throat J (Ear, nose, & throat journal)
[2019, 98(8):NP120-NP124]

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Brain miliary enhancement.

Joseph C J Bot, Linda Mazzai, Rogier E Hagenbeek, Silvia Ingala, Bob van Oosten, Esther Sanchez-Aliaga, Frederik Barkhof,

PURPOSE:Miliary enhancement refers to the presence of multiple small, monomorphic, enhancing foci on T1-weighted post-contrast MRI images. In the absence of a clear clinical presentation, a broad differential diagnosis may result in invasive procedures and possibly brain biopsy for diagnostic purposes. METHODS:An extensive review of the literature is provided for ... Read more >>

Neuroradiology (Neuroradiology)
[2020, 62(3):283-300]

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LncRNA SAMMSON overexpression distinguished glioblastoma patients from patients with diffuse neurosarcoidosis.

Jingwei Xie, Xinjun Wang, Shanshan Liu, Chao Chen, Fengze Jiang, Ke Mao, Fantao Zeng,

The MRI characteristics of diffuse neurosarcoidosis are similar to those of glioblastoma. Therefore, identification of novel biomarkers to distinguish these two diseases is needed. We found that lncRNA Survival Associated Mitochondrial Melanoma-Specific Oncogenic Non-Coding RNA (SAMMSON) was upregulated in plasma of glioblastoma patients but not in diffuse neurosarcoidosis patients comparing ... Read more >>

Neuroreport (Neuroreport)
[2019, 30(12):817-821]

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