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Neuroprotective Agents in Stroke

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Exercise promotes recovery after motoneuron injury via hormonal mechanisms.

Cory Chew, Dale R Sengelaub,

Injuries to spinal motoneurons manifest in a variety of forms, including damage to peripheral axons, neurodegenerative disease, or direct insult centrally. Such injuries produce a variety of negative structural and functional changes in both the directly affected and neighboring motoneurons. Exercise is a relatively simple behavioral intervention that has been ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1373-1376]

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Efficacy of cattle encephalon glycoside and ignotin in patients with acute cerebral infarction: a randomized, double-blind, parallel-group, placebo-controlled study.

Hui Zhang, Chuan-Ling Li, Feng Wan, Su-Juan Wang, Xiu-E Wei, Yan-Lei Hao, Hui-Lin Leng, Jia-Min Li, Zhong-Rui Yan, Bao-Jun Wang, Ren-Shi Xu, Ting-Min Yu, Li-Chun Zhou, Dong-Sheng Fan,

Cattle encephalon glycoside and ignotin (CEGI) injection is a compound preparation formed by a combination of muscle extract from healthy rabbits and brain gangliosides from cattle, and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries. However, there is still a need for ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1266-1273]

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Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury.

Iman O Sherif, Alaa A Alshaalan, Nora H Al-Shaalan,

Remote renal injury is a drastic consequence of hepatic ischemia/reperfusion (IR) injury. Vildagliptin (V) is a dipeptidyl peptidase-4 inhibitor that has a hepatorenal protective effect against models of liver and renal IR. This research was done to explore the protective role of vildagliptin against renal injury following hepatic IR injury ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):208-215]

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Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation.

Su Hwan Bae, Mi Ran Yoo, Ye Yeong Kim, In Kyung Hong, Mi Hee Kim, Seung Hak Lee, Dae Yul Kim,

Macrophage migration inhibitory factor (MIF) is a chemokine that plays an essential role in immune system function. Previous studies suggested that MIF protects neurons in ischemic conditions. However, few studies are reported on the role of MIF in neurological recovery after ischemic stroke. The purpose of this study is to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1483-1489]

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Remote ischemic conditioning approach for the treatment of ischemic stroke.

Seyed Mohammad Seyedsaadat, David F Kallmes, Waleed Brinjikji,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1033-1034]

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Adrenomedullin: an important participant in neurological diseases.

Feng-Jiao Li, Si-Ru Zheng, Dong-Mei Wang,

Adrenomedullin, a peptide with multiple physiological functions in nervous system injury and disease, has aroused the interest of researchers. This review summarizes the role of adrenomedullin in neuropathological disorders, including pathological pain, brain injury and nerve regeneration, and their treatment. As a newly characterized pronociceptive mediator, adrenomedullin has been shown ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1199-1207]

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Achyranthes bidentata polypeptides prevent apoptosis by inhibiting the glutamate current in cultured hippocampal neurons.

Rong-Lu Pan, Wen-Qing Hu, Jie Pan, Li Huang, Cheng-Cheng Luan, Hong-Mei Shen,

Glutamate-induced excitotoxicity plays a critical role in the neurological impairment caused by middle cerebral artery occlusion. Achyranthes bidentata polypeptides have been shown to protect against neurological functional damage caused by middle cerebral artery occlusion, but the underlying neuroprotective mechanisms and the relationship to glutamate-induced excitotoxicity remain unclear. Therefore, in the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1086-1093]

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Hydrogels for neuroprotection and functional rewiring: a new era for brain engineering.

Rocío Fernandez-Serra, Rebeca Gallego, Paloma Lozano, Daniel González-Nieto,

The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal pathologies. High-performance preclinical results have failed at clinical level, as it has been the case for a wide variety of neuroprotective agents and cell-based therapies employed to treat high prevalent ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):783-789]

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Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review.

Yazdan Naderi, Yunes Panahi, George E Barreto, Amirhosein Sahebkar,

To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and considering the inclusion and exclusion criteria of the study. Studies were included if focal cerebral ischemia model was performed in mammals and including a control ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):773-782]

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MiR-137 Boosts the Neuroprotective Effect of Endothelial Progenitor Cell Derived-Exosomes in Oxyhemoglobin Treated SH-SY5Y Cells Partially via COX2/PGE2 Pathway

Huaizhang Shi, Ji Bihl, Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang,

<title>Abstract</title> <p> Background: We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. Additionally, miR-137 is reported to regulate ferroptosis and to be involved in the neuroprotection against ischemic ... Read more >>

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Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats.

Li-Jun Jiang, Zhen-Xing Xu, Ming-Fu Wu, Gai-Qin Dong, Li-Li Zhang, Jun-Yan Gao, Chen-Xi Feng, Xing Feng,

Secondary brain damage caused by hyperactivation of autophagy and inflammatory responses in neurons plays an important role in hypoxic-ischemic brain damage (HIBD). Although previous studies have implicated Toll-like receptor 4 (TLR4) and nuclear factor kappa-B (NF-κB) in the neuroinflammatory response elicited by brain injury, the role and mechanisms of the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1316-1325]

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Insight into the molecular sex dimorphism of ischemic stroke in rat cerebral cortex: focus on neuroglobin, sex steroids and autophagy.

Estefanía Acaz-Fonseca, María Castelló-Ruiz, María C Burguete, Alicia Aliena-Valero, Juan B Salom, Germán Torregrosa, Luis M García-Segura,

Including sex is of paramount importance in preclinical and clinical stroke research, and molecular studies dealing in depth with sex differences in stroke pathophysiology are needed. To gain insight into the molecular sex dimorphism of ischemic stroke in rat cerebral cortex, male and female adult rats were subjected to transient ... Read more >>

Eur. J. Neurosci. (The European journal of neuroscience)
[2020, :]

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The role of cofilin in age-related neuroinflammation.

Amsha S Alsegiani, Zahoor A Shah,

Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active "pro-inflammatory" state, causing chronic low-grade neuroinflammation. Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years, the underlying causes remain unclear. The identification of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1451-1459]

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Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke.

Qian Li, Yuze Cao, Chun Dang, Bin Han, Ranran Han, Heping Ma, Junwei Hao, Lihua Wang,

Cytosolic double-stranded DNA (dsDNA) is a danger signal that is tightly monitored and sensed by nucleic acid-sensing pattern recognition receptors. We study the inflammatory cascade on dsDNA recognition and investigate the neuroprotective effect of cyclic GMP-AMP (cGAMP) synthase (cGAS) antagonist A151 and its mechanisms of neuroprotection in a mouse model ... Read more >>

EMBO Mol Med (EMBO molecular medicine)
[2020, :e11002]

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Hypothermia but not NMDA receptor antagonism protects against stroke induced by distal middle cerebral arterial occlusion in mice.

Che-Wei Liu, Kate Hsiurong Liao, Hsin Tseng, Ching Mei Wu, Hsiao-Yun Chen, Ted Weita Lai,

Excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR) is believed to be a primary mechanism of neuronal injury following stroke. Thus, many drugs and therapeutic peptides were developed to inhibit either the NMDAR at the cell surface or its downstream intracellular death-signaling cascades. Nevertheless, the majority of focal ischemia studies concerning ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229499]

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Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6.

Lu Liu, Lijuan Gu, Manli Chen, Yueying Zheng, Xiaoxing Xiong, Shengmei Zhu,

Stroke remains a leading cause of death, disability, and medical care burden worldwide. However, transformation from laboratory findings toward effective pharmacological interventions for clinical stroke has been unsatisfactory. Novel evidence has been gained on the underlying mechanisms and therapeutic potential related to the transient receptor potential (TRP) channels in several ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:]

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NLRP3 Depletion Fails to Mitigate Inflammation but Restores Diminished Phagocytosis in BV-2 Cells After In Vitro Hypoxia.

Isabelle Schölwer, Pardes Habib, Clara Voelz, Leoni Rolfes, Cordian Beyer, Alexander Slowik,

Post-hypoxic/ischemic neuroinflammation is selectively driven by sterile inflammation, which implies the interplay of brain-intrinsic immune cells with other neural cells and immigrated peripheral immune cells. The resultant inflammatory cascade evolves extra- and intracellular pathogen and danger-associated receptors. The latter interacts with multiprotein complexes termed inflammasomes. The NLRP3 inflammasome is one ... Read more >>

Mol. Neurobiol. (Molecular neurobiology)
[2020, :]

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The Apelin/APJ System in Psychosis and Neuropathy.

Shuang-Yu Lv, Wei-Dong Chen, Yan-Dong Wang,

Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2020, 11:]

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Ischemic postconditioning exerts neuroprotective effect through negatively regulating PI3K/Akt2 signaling pathway by microRNA-124.

Wei Miao, Yong Yan, Tian-Hao Bao, Wen-Ji Jia, Fei Yang, Ying Wang, Yu-Hong Zhu, Mei Yin, Jian-Hong Han,

Ischemic stroke is a serious threat to human life and health, which is often accompanied by cerebral ischemia-reperfusion (I/R) injury in clinic. Ischemic postconditioning (IPostC) is a short period of mild non-fatal ischemia in the early stage of cerebral I/R injury. However, there are few reports about the protective effect ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 126:109786]

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Benefits of hypothermia in neonatal arterial ischemic strokes: A preclinical study.

Mathilde Chevin, Stéphane Chabrier, Mickaël Dinomais, Barry J Bedell, Guillaume Sébire,

BACKGROUND:There is currently no targeted treatment available for neonatal arterial ischemic strokes (NAIS). Epidemiological studies demonstrated that perinatal infection/inflammation, peripartum hypoxia, and occlusion of the internal carotid tree are the main determinants of NAIS. The well-established benefit of therapeutic hypothermia (HT) in neonatal encephalopathy due to diffuse hypoxia-ischemia provides a ... Read more >>

Int. J. Dev. Neurosci. (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience)
[2020, :]

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Neuroprotective Effect of Danhong Injection on Cerebral Ischemia-Reperfusion Injury in Rats by Activation of the PI3K-Akt Pathway.

Chen Feng, Haofang Wan, Yangyang Zhang, Li Yu, Chongyu Shao, Yu He, Haitong Wan, Weifeng Jin,

Many traditional Chinese medicines, including Danhong injection (DHI), can be used to treat cerebral ischemia-reperfusion injury and have neuroprotective effects on the brain; however, few studies have explored the mechanism by which this effect is generated. In this study, we investigated the neuroprotective effect of DHI against cerebral ischemia-reperfusion injury ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2020, 11:298]

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Acupuncture promotes functional recovery after cerebral hemorrhage by upregulating neurotrophic factor expression.

Dan Li, Qiu-Xin Chen, Wei Zou, Xiao-Wei Sun, Xue-Ping Yu, Xiao-Hong Dai, Wei Teng,

Acupuncture is widely used in the treatment of cerebral hemorrhage, and it improves outcomes in experimental animal models and patients. However, the mechanisms underlying the effectiveness of acupuncture treatment for cerebral hemorrhage are still unclear. In this study, a model of intracerebral hemorrhage was produced by injecting 50 μL autologous ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1510-1517]

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Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action.

Bruno P Meloni, Frank L Mastaglia, Neville W Knuckey,

There are virtually no clinically available neuroprotective drugs for the treatment of acute and chronic neurological disorders, hence there is an urgent need for the development of new neuroprotective molecules. Cationic arginine-rich peptides (CARPs) are an expanding and relatively novel class of compounds, which possess intrinsic neuroprotective properties. Intriguingly, CARPs ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:108]

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Effect of In-Hospital Remote Ischemic Perconditioning on Brain Infarction Growth and Clinical Outcomes in Patients With Acute Ischemic Stroke: The RESCUE BRAIN Randomized Clinical Trial.

Fernando Pico, Bertrand Lapergue, Marc Ferrigno, Charlotte Rosso, Elena Meseguer, Marie-Laure Chadenat, Frederic Bourdain, Michael Obadia, Catherine Hirel, Duc Long Duong, Sandrine Deltour, Philippe Aegerter, Julien Labreuche, Amina Cattenoy, Didier Smadja, Hassan Hosseini, Benoit Guillon, Valérie Wolff, Yves Samson, Charlotte Cordonnier, Pierre Amarenco,

Importance:Treatment with remote ischemic perconditioning has been reported to reduce brain infarction volume in animal models of stroke. Whether this neuroprotective effect was observed in patients with acute ischemic stroke remains unknown. Objective:To determine whether treatment with remote ischemic perconditioning administered to the leg of patients with acute ischemic stroke ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, :]

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Anti-neuroinflammatory effect of 3,4-dihydroxybenzaldehyde in ischemic stroke.

Xiufang Li, Bin Xiang, Ting Shen, Chun Xiao, Rong Dai, Fangyan He, Qing Lin,

BACKGROUND:Increasing evidence from human and animal studies suggests that cerebral ischemic diseases are associated with nerve dysfunction and neuroinflammation. Therefore, alleviating neuroinflammation is a potential way to treat ischemic stroke. Gastrodia elata Blume (GEB) is a traditional Chinese medicine used to treat central nervous system diseases and related conditions, such ... Read more >>

Int. Immunopharmacol. (International immunopharmacology)
[2020, 82:106353]

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