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Neuromuscular and Myopathic Complications of HIV

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Neurological Immune Related Adverse Events Associated with Nivolumab, Ipilimumab, and Pembrolizumab Therapy-Review of the Literature and Future Outlook.

Nora Möhn, Gernot Beutel, Ralf Gutzmer, Philipp Ivanyi, Imke Satzger, Thomas Skripuletz,

Immune checkpoint inhibitor (ICI) therapy has revolutionized the management of various cancers with previously poor prognosis. Despite its great efficacy, the therapy is associated with a wide spectrum of immune-related adverse events (irAE) including neurological symptoms which can affect all parts of the central and peripheral nervous system. Even though ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(11):]

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Impact of pharmacological agents on mitochondrial function: a growing opportunity?

Megan L Stoker, Emma Newport, James C Hulit, A Phillip West, Karl J Morten,

Present-day drug therapies provide clear beneficial effects as many diseases can be driven into remission and the symptoms of others can be efficiently managed; however, the success of many drugs is limited due to both patient non-compliance and adverse off-target or toxicity-induced effects. There is emerging evidence that many of ... Read more >>

Biochem. Soc. Trans. (Biochemical Society transactions)
[2019, 47(6):1757-1772]

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Differential diagnosis of idiopathic inflammatory myopathies in adults - the first step when approaching a patient with muscle weakness.

Piotr Szczęsny, Katarzyna Świerkocka, Marzena Olesińska,

Despite its misleading adjective, the most commonly used diagnostic criteria of idiopathic inflammatory myopathies (IIM) are applicable only after all other non-autoimmune muscle diseases have been excluded. It makes differential diagnosis the first step when approaching a patient with muscle weakness. This article is designed to list the most common ... Read more >>

Reumatologia (Reumatologia)
[2018, 56(5):307-315]

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Beta-thalassemia major complicated by intracranial hemorrhage and critical illness polyneuropathy.

S Sanju, M S Tullu, S Karande, M N Muranjan, P Parekh,

Intracranial hemorrhage (ICH) is rarely seen in patients with thalassemia. A seven-year-old male, known case of beta-thalassemia major, on irregular packed cell transfusions (elsewhere) and non-compliant with chelation therapy, presented with congestive cardiac failure (Hb-3 gm/dl). He received three packed red cell transfusions over 7 days (cumulative volume 40 cc/kg). ... Read more >>

J Postgrad Med (Journal of postgraduate medicine)
[2019, 65(3):171-176]

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Peripheral nerve disease secondary to systemic conditions in children.

Jo M Wilmshurst, Robert A Ouvrier, Monique M Ryan,

This review is an overview of systemic conditions that can be associated with peripheral nervous system dysfunction. Children may present with neuropathic symptoms for which, unless considered, a causative systemic condition may not be recognized. Similarly, some systemic conditions may be complicated by comorbid peripheral neuropathies, surveillance for which is ... Read more >>

Ther Adv Neurol Disord (Therapeutic advances in neurological disorders)
[2019, 12:1756286419866367]

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Severe Rhabdomyolysis as an Unusual Presentation of Primary Human Immunodeficiency Virus Infection.

Myint M Noe, Akriti G Jain, Sonia Shahid, Umair Majeed,

Rhabdomyolysis is characterized by muscle necrosis and leakage of toxic intracellular contents into the circulatory system. It is most commonly caused by trauma, physical exertion, drugs, toxins, and a variety of infections; only rarely is it associated with acute human immunodeficiency virus (HIV) infection alone. The severity of illness ranges ... Read more >>

Cureus (Cureus)
[2018, 10(7):e3041]

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How to do it: investigate exertional rhabdomyolysis (or not).

Peter M Fernandes, Richard J Davenport,

Rhabdomyolysis is the combination of symptoms (myalgia, weakness and muscle swelling) and a substantial rise in serum creatine kinase (CK) >50 000 IU/L; there are many causes, but here we specifically address exertional rhabdomyolysis. The consequences of this condition can be severe, including acute kidney injury and requirement for higher level ... Read more >>

Pract Neurol (Practical neurology)
[2019, 19(1):43-48]

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Lipid Myopathies.

Elena Maria Pennisi, Matteo Garibaldi, Giovanni Antonini,

Disorders of lipid metabolism affect several tissues, including skeletal and cardiac muscle tissues. Lipid myopathies (LM) are rare multi-systemic diseases, which most often are due to genetic defects. Clinically, LM can have acute or chronic clinical presentation. Disease onset can occur in all ages, from early stages of life to ... Read more >>

J Clin Med (Journal of clinical medicine)
[2018, 7(12):]

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Diagnosis and management of Guillain-Barré syndrome in ten steps.

Sonja E Leonhard, Melissa R Mandarakas, Francisco A A Gondim, Kathleen Bateman, Maria L B Ferreira, David R Cornblath, Pieter A van Doorn, Mario E Dourado, Richard A C Hughes, Badrul Islam, Susumu Kusunoki, Carlos A Pardo, Ricardo Reisin, James J Sejvar, Nortina Shahrizaila, Cristiane Soares, Thirugnanam Umapathi, Yuzhong Wang, Eppie M Yiu, Hugh J Willison, Bart C Jacobs,

Guillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2019, 15(11):671-683]

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Neuromuscular diseases associated with Human Immunodeficiency Virus infection.

Devin E Prior, Nancy Song, Jeffrey A Cohen,

From the most common distal symmetric polyneuropathy (Bilgrami and O'Keefe, 2014) to the rare motor neuron diseases, HIV infection is associated with pathology at all levels of the peripheral nervous system. HIV infection can cause these conditions due to viral exposure itself, the resulting immune dysregulation, opportunistic infections found in ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2018, 387:27-36]

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PROCEEDINGS OF THE XIX CONGRESS OF THE ITALIAN SOCIETY OF MYOLOGY: Bergamo, ItalyJune 05-08, 2019.

Acta Myol (Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology)
[2019, 38(2):45-144]

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Inclusion Body Myositis: Update on Pathogenesis and Treatment.

Elie Naddaf, Richard J Barohn, Mazen M Dimachkie,

Inclusion body myositis is the most common acquired myopathy after the age of 50. It is characterized by progressive asymmetric weakness predominantly affecting the quadriceps and/or finger flexors. Loss of ambulation and dysphagia are major complications of the disease. Inclusion body myositis can be associated with cytosolic 5'-nucleotidase 1A antibodies. ... Read more >>

Neurotherapeutics (Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics)
[2018, 15(4):995-1005]

Cited: 2 times

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Neuromuscular complications of HIV infection.

Michelle Kaku, David M Simpson,

With the introduction of combination antiretroviral therapy, human immunodeficiency virus (HIV)-infected individuals are living longer, and are commonly confronted with chronic neuromuscular complications. The spectrum of neuromuscular disorders in patients living with HIV infection is wide, and is caused by HIV per se and its products, particular antiretroviral drugs, or ... Read more >>

Handb Clin Neurol (Handbook of clinical neurology)
[2018, 152:201-212]

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A severe case of neuro-Sjögren's syndrome induced by pembrolizumab.

Jaqueline Ghosn, Alex Vicino, Olivier Michielin, George Coukos, Thierry Kuntzer, Michel Obeid,

BACKGROUND:The prevalence of connective tissue disease (CTD) induced by immune checkpoint inhibitors (CPIs) in the absence of pre-existing autoimmunity is unknown. CASE PRESENTATION:We report the case of a melanoma patient treated for 8 months with pembrolizumab who developed a subacute ataxic sensory neuronopathy (SNN), including a right trigeminal neuropathy. Salivary gland ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2018, 6(1):110]

Cited: 4 times

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Advances in pediatrics in 2017: current practices and challenges in allergy, endocrinology, gastroenterology, genetics, immunology, infectious diseases, neonatology, nephrology, neurology, pulmonology from the perspective of Italian Journal of Pediatrics.

Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Bertrand Tchana, Giuliana Valerio, Alberto Verrotti, Mariella Valenzise, Sergio Bernasconi, Giovanni Corsello,

This review provides an overview of a remarkable number of significant studies in pediatrics that have been published over the past year in the Italian Journal of Pediatrics. We have selected information from papers presented in the Journal that deal with allergy, endocrinology, gastroenterology, genetics, immunology, infectious diseases, neonatology, nephrology, ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):82]

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Myositis-Related Interstitial Lung Diseases: Diagnostic Features, Treatment, and Complications.

Courtney Shappley, Julie J Paik, Lesley Ann Saketkoo,

Curr Treatm Opt Rheumatol (Current treatment options in rheumatology)
[2019, 5(1):56-83]

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Development and validation of a guide for the continuity of care in perioperative medication management.

Carmen Matoses-Chirivella, Andrés Navarro-Ruíz, Blanca Lumbreras,

BACKGROUND:Increased longevity and the prevalence of associated pathologies is leading to more hospital admissions involving chronic patients with multiple pathological problems. In orthopedic surgical patients, it is very important to individually evaluate the risk/benefit of maintaining or suppressing chronic medications. For certain medications, there are consensus recommendations, but for others, ... Read more >>

J Orthop Traumatol (Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology)
[2018, 19(1):4]

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Unusual case of hemidiaphragmatic paralysis secondary to cervical herpes zoster.

Muhammad Adnan Saleem, Zeeshan Mustafa, Noman Qayyum, Muhammad Badar Ganaie,

Hemidiaphragmatic paralysis is usually caused by surgery, malignancy or trauma and rarely by viral infections. Herpes zoster (shingles) results in varied neurological complications, but peripheral motor involvement or diaphragmatic paralysis is rare. We report the case of an 87-year-old male who presented with worsening breathlessness soon after an episode of ... Read more >>

BMJ Case Rep (BMJ case reports)
[2018, 2018:]

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Neurologic Complications of Transplantation.

Rajat Dhar,

Neurologic disturbances including encephalopathy, seizures, and focal deficits complicate the course 10-30% of patients undergoing organ or stem cell transplantation. While much or this morbidity is multifactorial and often associated with extra-cerebral dysfunction (e.g., graft dysfunction, metabolic derangements), immunosuppressive drugs also contribute significantly. This can either be through direct toxicity ... Read more >>

Neurocrit Care (Neurocritical care)
[2018, 28(1):4-11]

Cited: 1 time

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Exertional rhabdomyolysis leading to acute kidney injury: when genetic defects are diagnosed in adult life.

David Cucchiari, Irene Colombo, Ottavia Amato, Manuel Alfredo Podestà, Francesco Reggiani, Rossella Valentino, Irene Faravelli, Silvia Testolin, Maurizio Moggio, Salvatore Badalamenti,

Rhabdomyolysis is a common cause of acute kidney injury (AKI) that is usually triggered by trauma. However, less common causes of rhabdomyolysis may precipitate AKI as well, possibly representing a diagnostic challenge even for the experienced nephrologist. Genetic defects of muscle metabolism represent one of these causes and can be ... Read more >>

CEN Case Rep (CEN case reports)
[2018, 7(1):62-65]

Cited: 1 time

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Peptide-conjugate antisense based splice-correction for Duchenne muscular dystrophy and other neuromuscular diseases.

Maria K Tsoumpra, Seiji Fukumoto, Toshio Matsumoto, Shin'ichi Takeda, Matthew J A Wood, Yoshitsugu Aoki,

Duchenne muscular dystrophy (DMD) is an X-linked disorder characterized by progressive muscle degeneration, caused by the absence of dystrophin. Exon skipping by antisense oligonucleotides (ASOs) has recently gained recognition as therapeutic approach in DMD. Conjugation of a peptide to the phosphorodiamidate morpholino backbone (PMO) of ASOs generated the peptide-conjugated PMOs ... Read more >>

EBioMedicine (EBioMedicine)
[2019, 45:630-645]

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A Randomized Clinical Trial Comparing Three Different Exercise Strategies for Optimizing Aerobic Capacity and Skeletal Muscle Performance in Older Adults: Protocol for the DART Study.

Dallin Tavoian, David W Russ, Timothy D Law, Janet E Simon, Paul J Chase, Emily Hill Guseman, Brian C Clark,

Background: Age-related declines in physical function lead to decreased independence and higher healthcare costs. Individuals who meet the endurance and resistance exercise recommendations can improve their physical function and overall fitness, even into their ninth decade. However, most older adults do not exercise regularly, and the majority of those who ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2019, 6:236]

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Progression of intervention-focused research for Gulf War illness.

Jeremy E Chester, Mazhgan Rowneki, William Van Doren, Drew A Helmer,

The Persian Gulf War of 1990 to 1991 involved the deployment of nearly 700,000 American troops to the Middle East. Deployment-related exposures to toxic substances such as pesticides, nerve agents, pyridostigmine bromide (PB), smoke from burning oil wells, and petrochemicals may have contributed to medical illness in as many as ... Read more >>

Mil Med Res (Military Medical Research)
[2019, 6(1):31]

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Atypical Skeletal Muscle Profiles in Human Immunodeficiency Virus-Infected Asymptomatic Middle-Aged Adults.

Thanh Tran, Viola Guardigni, Karol M Pencina, Anthony A Amato, Michael Floyd, Brooke Brawley, Brian Mozeleski, Jennifer McKinnon, Erin Woodbury, Emily Heckel, Zhuoying Li, Tom Storer, Paul E Sax, Monty Montano,

Background:Human immunodeficiency virus (HIV)-infected individuals are at increased risk of age-associated functional impairment, even with effective antiretroviral therapy (ART). A concurrent characterization of skeletal muscle, physical function, and immune phenotype in aviremic middle-aged HIV-infected adults represents a knowledge gap in prognostic biomarker discovery. Methods:We undertook a prospective observational study of ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 66(12):1918-1927]

Cited: 7 times

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Practical approach to the patient with acute neuromuscular weakness.

Rajeev Nayak,

Acute neuromuscular paralysis (ANMP) is a clinical syndrome characterized by rapid onset muscle weakness progressing to maximum severity within several days to weeks (less than 4 wk). Bulbar and respiratory muscle weakness may or may not be present. It is a common neurological emergency which requires immediate and careful investigations ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2017, 5(7):270-279]

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