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Neurological Manifestations of Arsenic Intoxication

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The "wing-heeled" traveler.

Taylor Kain, Jordan Weinstein, Aaron Thompson, Andrea K Boggild,

Intoxication syndromes may be travel acquired, and are related to intentional or accidental inhalational or percutaneous exposures or ingestions. Due to their myriad clinical presentations, initial differential diagnosis of such intoxications in returned travelers is broad, and typically requires detailed history and laboratory investigations to disentangle. We herein use a ... Read more >>

Trop Dis Travel Med Vaccines (Tropical diseases, travel medicine and vaccines)
[2020, 6:2]

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Gallic acid and MiADMSA reversed arsenic induced oxidative/nitrosative damage in rat red blood cells.

Archna Panghal, Kshirod Bihari Sathua, S J S Flora,

Arsenic (As) is naturally occurring toxic metalloid which is considered as a serious environmental and health concern. Red blood cells are the prime target for any toxicants as their population is higher in systemic circulation. High prevalence of anaemia too has been reported from arsenic contaminated area, suggesting possible linkage ... Read more >>

Heliyon (Heliyon)
[2020, 6(2):e03431]

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On Neuropsychiatric Manifestations of Basal Ganglia Injury: A Report of Three Cases and Literature Review.

Heela Azizi, Alexander Kilpatrick, Olaniyi Olayinka, Olusegun Poopola, Maleeha Ahmad, Alexa Kahn, Tasmia Khan, Dina Rimawi, Shantale Williams, Sinthuja Jayaraj, Ivan Leung, Sherina Langdon, Mirna Iskander, Ali Chohan, Deepa Nuthalapati, Ulunma Umesi, Geetha Vyas, Ayotomide Oyelakin, Kodjovi Kodjo, Chiedozie Ojimba, Oluwole Jegede, Carolina Nisenoff, Ayodeji Jolayemi,

The basal ganglia have been considered to primarily play a role in motor processing. A growing body of theoretical and clinical evidence shows that in addition to the motor functions the basal ganglia play a key role in perceptual and visual disturbances. This role may be evident in patients with ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2019, 2019:3298791]

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Clinical Symptoms, Neurological Signs, and Electrophysiological Findings in Surviving Residents with Probable Arsenic Exposure in Toroku, Japan.

Nobuyuki Ishii, Hitoshi Mochizuki, Yuka Ebihara, Kazutaka Shiomi, Masamitsu Nakazato,

Chronic arsenic intoxication is known to cause multisystem impairment and is still a major threat to public health in many countries. In Toroku, a small village in Japan, arsenic mines operated from 1920 to 1962, and residents suffered serious sequelae of arsenic intoxication. We have performed annual medical examinations of ... Read more >>

Arch. Environ. Contam. Toxicol. (Archives of environmental contamination and toxicology)
[2018, 75(4):521-529]

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Treatment of lead and arsenic poisoning in anuric patients - a case report and narrative review of the literature.

Chun-Yuan Hsiao, Chip Gresham, Mark R Marshall,

BACKGROUND:Heavy metal poisoning can cause debilitating illness if left untreated, and its management in anuric patients poses challenges. Literature with which to guide clinical practice in this area is rather scattered. CASE PRESENTATION:We present a case of symptomatic lead and arsenic poisoning from use of Ayurvedic medicine in a 28-year-old ... Read more >>

BMC Nephrol (BMC nephrology)
[2019, 20(1):374]

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Circulating miRNAs Associated with Arsenic Exposure.

Rowan Beck, Paige Bommarito, Christelle Douillet, Matt Kanke, Luz M Del Razo, Gonzalo García-Vargas, Rebecca C Fry, Praveen Sethupathy, Miroslav Stýblo,

Arsenic (As) is a toxic metalloid. Inorganic arsenic (iAs) is a form of As commonly found in drinking water and in some foods. Overwhelming evidence suggests that people chronically exposed to iAs are at risk of developing cancer or cardiovascular, neurological, and metabolic diseases. Although the mechanisms underlying iAs-associated illness ... Read more >>

Environ. Sci. Technol. (Environmental science & technology)
[2018, 52(24):14487-14495]

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Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults.

Shibani Dhir, Maya Tarasenko, Eleonora Napoli, Cecilia Giulivi,

Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others are part of the antioxidant machinery. The brain is highly vulnerable to thiamine deficiency ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2019, 10:207]

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Cases of thallium intoxication in Syria: A diagnostic and a therapeutic challenge.

Ibrahim Almassri, Mohamed Sekkarie,

In mid-March 2015, a mother and her teenage daughter and son from Syria presented to a Syrian American Medical Society (SAMS) refugee clinic in the Beqaa Valley in Lebanon with the chief complaints of hair loss together with weakness and numbness of their lower extremities. They reported that on March ... Read more >>

Avicenna J Med (Avicenna journal of medicine)
[2018, 8(3):78-81]

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ACMT 2020 Annual Scientific Meeting Abstracts – New York, NY.

J Med Toxicol (Journal of medical toxicology : official journal of the American College of Medical Toxicology)
[0, :1-53]

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Diagnosis and management of Guillain-Barré syndrome in ten steps.

Sonja E Leonhard, Melissa R Mandarakas, Francisco A A Gondim, Kathleen Bateman, Maria L B Ferreira, David R Cornblath, Pieter A van Doorn, Mario E Dourado, Richard A C Hughes, Badrul Islam, Susumu Kusunoki, Carlos A Pardo, Ricardo Reisin, James J Sejvar, Nortina Shahrizaila, Cristiane Soares, Thirugnanam Umapathi, Yuzhong Wang, Eppie M Yiu, Hugh J Willison, Bart C Jacobs,

Guillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2019, 15(11):671-683]

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State of the science review of the health effects of inorganic arsenic: Perspectives for future research.

Paul B Tchounwou, Clement G Yedjou, Udensi K Udensi, Maricica Pacurari, Jacqueline J Stevens, Anita K Patlolla, Felicite Noubissi, Sanjay Kumar,

Human exposure to inorganic arsenic (iAs) is a global health issue. Although there is strong evidence for iAs-induced toxicity at higher levels of exposure, many epidemiological studies evaluating its effects at low exposure levels have reported mixed results. We comprehensively reviewed the literature and evaluated the scientific knowledge on human ... Read more >>

Environ. Toxicol. (Environmental toxicology)
[2019, 34(2):188-202]

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Practical approach to the patient with acute neuromuscular weakness.

Rajeev Nayak,

Acute neuromuscular paralysis (ANMP) is a clinical syndrome characterized by rapid onset muscle weakness progressing to maximum severity within several days to weeks (less than 4 wk). Bulbar and respiratory muscle weakness may or may not be present. It is a common neurological emergency which requires immediate and careful investigations ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2017, 5(7):270-279]

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A Successfully Treated Case of Criminal Thallium Poisoning.

Tetsuya Yumoto, Kohei Tsukahara, Hiromichi Naito, Atsuyoshi Iida, Atsunori Nakao,

Thallium was once commonly used as a household rodent or ant killer, but many countries have banned such use due to unintentional or criminal poisonings of humans. A common initial clinical manifestation of thallium poisoning is gastrointestinal symptoms followed by delayed onset of neurological symptoms and alopecia. These clinical characteristics ... Read more >>

J Clin Diagn Res (Journal of clinical and diagnostic research : JCDR)
[2017, 11(4):OD01-OD02]

Cited: 2 times

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Re-emergence of thiamine deficiency disease in the Pacific islands (2014-15): A case-control study.

Eric J Nilles, Atarota Manaia, Bineta Ruaia, Clare Huppatz, Catherine Ward, Peter George, Christiaan Sies, Alessio Cangiano, James Sejvar, André Reiffer, Teatoa Tira,

BACKGROUND:From late 2014 multiple atolls in Kiribati reported an unusual and sometimes fatal illness. We conducted an investigation to identify the etiology of the outbreak on the most severely affected atoll, Kuria, and identified thiamine deficiency disease as the cause. Thiamine deficiency disease has not been reported in the Pacific ... Read more >>

PLoS ONE (PloS one)
[2018, 13(6):e0198590]

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Alopecia and Associated Toxic Agents: A Systematic Review.

Vicky Yu, Margit Juhász, Audris Chiang, Natasha Atanaskova Mesinkovska,

Importance/Objective:There are a number of toxic agents that can cause alopecia. In this review we summarize the known substances that cause alopecia as one of the clinical signs of overdose or toxicity. Evidence Review:A search was conducted using PubMed, EMBASE, and Cochrane for studies describing hair loss of any type ... Read more >>

Skin Appendage Disord (Skin appendage disorders)
[2018, 4(4):245-260]

Cited: 1 time

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Emerging various environmental threats to brain and overview of surveillance system with zebrafish model.

Rafael Vargas, Johny Ponce-Canchihuamán,

Pathologies related to neurotoxicity represent an important percentage of the diseases that determine the global burden of diseases. Neurotoxicity may be related to the increasing levels of potentially neurotoxic agents that pollute the environment, which generates concern, since agents that affect children may increase the incidence of neurodevelopmental disorders, affecting ... Read more >>

Toxicol Rep (Toxicology Reports)
[2017, 4:467-473]

Cited: 3 times

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Epidemiology of Peripheral Neuropathy: An Indian Perspective.

Sweety Trivedi, Alak Pandit, Goutam Ganguly, Shyamal Kumar Das,

Peripheral neuropathy (PN) is a common disorder and presents as diagnostic and therapeutic challenge to physicians and neurologists. In epidemiological studies from India from various regions the overall prevalence of PN varied from 5 to 2400 per 10,000 population in various community studies. India is composed of a multiethnic, multicultural ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2017, 20(3):173-184]

Cited: 1 time

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Lead Poisoning in Opium Abuser in Iran: A Systematic Review.

Kambiz Soltaninejad, Shahin Shadnia,

Substance abuse and its consequences are major health hazards in the world. Opium addiction is a common form of substance abuse in Iran. Adulteration of illegal substances in the process of production and distribution of the drug in black market with many types of materials have been reported. One of ... Read more >>

Int J Prev Med (International journal of preventive medicine)
[2018, 9:3]

Cited: 4 times

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Advances in Multi-Functional Ligands and the Need for Metal-Related Pharmacology for the Management of Alzheimer Disease.

Abha Sharma, Vidhu Pachauri, S J S Flora,

Alzheimer's disease (AD) is the age linked neurodegenerative disorder with no disease modifying therapy currently available. The available therapy only offers short term symptomatic relief. Several hypotheses have been suggested for the pathogenesis of the disease while the molecules developed as possible therapeutic agent in the last decade, largely failed ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:1247]

Cited: 1 time

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Alcoholic cardiomyopathy : The result of dosage and individual predisposition.

B Maisch,

The individual amount of alcohol consumed acutely or chronically decides on harm or benefit to a person's health. Available data suggest that one to two drinks in men and one drink in women will benefit the cardiovascular system over time, one drink being 17.6 ml 100 % alcohol. Moderate drinking can reduce ... Read more >>

Herz (Herz)
[2016, 41(6):484-493]

Cited: 8 times

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Erythromelalgia: a cutaneous manifestation of neuropathy?

María Bibiana Leroux,

The low prevalence of erythromelalgia, classified as an orphan disease, poses diagnostic and therapeutic difficulties. The aim of this review is to be an update of the specialized bibliography. Erythromelalgia is an infrequent episodic acrosyndrome affecting mainly both lower limbs symmetrically with the classic triad of erythema, warmth and burning ... Read more >>

An Bras Dermatol (Anais brasileiros de dermatologia)
[2018, 93(1):86-94]

Cited: 2 times

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Suicide behaviour and arsenic levels in drinking water: a possible association?: A review of the literature about the effects of arsenic contamination in drinking water on suicides.

Gianmarco Troiano, Isabella Mercurio, Paola Melai, Nicola Nante, Massimo Lancia, Mauro Bacci,

A considerable part of the global population is exposed to arsenic-contaminated drinking water which is the main source of inorganic arsenic(As) exposure in humans. Arsenic exposure interferes with the action of enzymes, essential cations, and transcriptional events in cells throughout the body, and a multitude of multisystemic non-cancer effects might ... Read more >>

Egypt J Forensic Sci (Egyptian journal of forensic sciences)
[2017, 7(1):2]

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Chromated copper arsenate-treated wood: a potential source of arsenic exposure and toxicity in dermatology.

Amy Yuntzu-Yen Chen, Thomas Olsen,

Arsenic-contaminated drinking water presents a serious health hazard in certain geographic locations around the world. Chromated copper arsenate, a pesticide and preservative that was used to pressure treat residential lumber in the United States beginning in the 1940s and was banned by the Environmental Protection Agency in 2003, poses a ... Read more >>

Int J Womens Dermatol (International journal of women's dermatology)
[2016, 2(1):28-30]

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Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals.

Maria Elena Ferrero,

Exposure to environmental and occupational toxicants is responsible for adverse effects on human health. Chelation therapy is the only procedure able to remove toxic metals from human organs and tissue, aiming to treat damage related to acute and/or chronic intoxication. The present review focuses on the most recent evidence of ... Read more >>

Biomed Res Int (BioMed research international)
[2016, 2016:8274504]

Cited: 5 times

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Peripheral neuropathy in limbic encephalitis with anti-glutamate receptor antibodies: Case report and systematic literature review.

Yi-Chia Wei, Chin-Chang Huang, Chi-Hung Liu, Hung-Chou Kuo, Jainn-Jim Lin,

INTRODUCTION:Autoantibodies to the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor and N-methyl-d-aspartate (NMDA) receptor are known to be the causes of autoimmune encephalitis particularly limbic encephalitis. The involvement of the peripheral nervous system is rarely reported. METHODS:We analyzed the serial nerve conduction studies of a previously reported case of anti-AMPA receptor encephalitis, who ... Read more >>

Brain Behav (Brain and behavior)
[2017, 7(9):e00779]

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