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Neurologic Myocardial Protection During Pediatric Cardiac Surgery

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Conversion from Off to On-Pump Coronary Artery Bypass Grafting. Is it Avoidable?

Khuzaima Tariq, Kashif Zia, Ali Mangi, Muneer Amanullah, Pervaiz A Chaudry, Musa Karim,

Background With the emergence of new technologies to stabilize the heart off-pump coronary artery bypass grafting (OPCAB), there is an increasing trend that is being observed throughout the world. In certain circumstances, OPCAB needs to be converted to on-pump CABG (ONCAB). In this study, we aim to identify certain risk factors mandating ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6791]

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Patterns of Multimorbidity and Differences in Healthcare Utilization and Complexity Among Acutely Hospitalized Medical Patients (≥65 Years) - A Latent Class Approach.

Helle Gybel Juul-Larsen, Line Due Christensen, Thomas Bandholm, Ove Andersen, Thomas Kallemose, Lillian Mørch Jørgensen, Janne Petersen,

Purpose:The majority of acutely admitted older medical patients are multimorbid, receive multiple drugs, and experience a complex treatment regime. To be able to optimize treatment and care, we need more knowledge of the association between different patterns of multimorbidity and healthcare utilization and the complexity thereof. The purpose was therefore ... Read more >>

Clin Epidemiol (Clinical Epidemiology)
[2020, 12:245-259]

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Getting an Early Start in Understanding Perinatal Asphyxia Impact on the Cardiovascular System.

Mihaela Roxana Popescu, Anca Maria Panaitescu, Bogdan Pavel, Leon Zagrean, Gheorghe Peltecu, Ana-Maria Zagrean,

Perinatal asphyxia (PA) is a burdening pathology with high short-term mortality and severe long-term consequences. Its incidence, reaching as high as 10 cases per 1000 live births in the less developed countries, prompts the need for better awareness and prevention of cases at risk, together with management by easily applicable ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2020, 8:68]

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Near-Infrared Spectroscopy Monitoring in Cardiac and Noncardiac Surgery: Pairwise and Network Meta-Analyses.

Christian Ortega-Loubon, Francisco Herrera-Gómez, Coralina Bernuy-Guevara, Pablo Jorge-Monjas, Carlos Ochoa-Sangrador, Juan Bustamante-Munguira, Eduardo Tamayo, F Javier Álvarez,

Goal-directed therapy based on brain-oxygen saturation (bSo2) is controversial and hotly debated. While meta-analyses of aggregated data have shown no clinical benefit for brain near-infrared spectroscopy (NIRS)-based interventions after cardiac surgery, no network meta-analyses involving both major cardiac and noncardiac procedures have yet been undertaken. Randomized controlled trials involving NIRS ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(12):]

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Volatile anesthetics versus total intravenous anesthesia in patients undergoing coronary artery bypass grafting: An updated meta-analysis and trial sequential analysis of randomized controlled trials.

Xue-Feng Jiao, Xue-Mei Lin, Xiao-Feng Ni, Hai-Long Li, Chuan Zhang, Chun-Song Yang, Hao-Xin Song, Qiu-Sha Yi, Ling-Li Zhang,

BACKGROUND:The benefits of volatile anesthetics in coronary artery bypass grafting (CABG) patients remain controversial. We aimed to conduct an updated meta-analysis to assess whether the use of volatile anesthetics during CABG could reduce mortality and other outcomes. METHODS:We searched eight databases from inception to June 2019 and included randomized controlled ... Read more >>

PLoS ONE (PloS one)
[2019, 14(10):e0224562]

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Dexmedetomidine: present and future directions.

Seongheon Lee,

Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties. Dexmedetomidine induces a unique sedative response, which shows an easy transition from sleep to wakefulness, thus allowing a patient to be cooperative and communicative when stimulated. Dexmedetomidine may produce less delirium than other ... Read more >>

Korean J Anesthesiol (Korean journal of anesthesiology)
[2019, 72(4):323-330]

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New Aspects in the Diagnosis and Therapy of Fetal Hypoplastic Left Heart Syndrome.

Oliver Graupner, Christian Enzensberger, Roland Axt-Fliedner,

Fetal hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease with a lethal prognosis without postnatal therapeutic intervention or surgery. The aim of this article is to give a brief overview of new findings in the field of prenatal diagnosis and the therapy of HLHS. As cardiac output ... Read more >>

Geburtshilfe Frauenheilkd (Geburtshilfe und Frauenheilkunde)
[2019, 79(8):863-872]

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Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management.

Jyotindra Narayan Goswami, Suvasini Sharma,

Drug-refractory epilepsy is a commonly prevalent pediatric neurological illness of global significance. Ketogenic diet (KD) is a time-tested therapeutic modality for refractory epilepsy, which has reemerged as a robust alternative to anti-epileptic pharmacotherapy. There is a growing body of evidence which supports the anti-seizure efficacy, safety profile and feasibility of ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric Disease and Treatment)
[2019, 15:3273-3285]

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The therapeutic effect of controlled reoxygenation on chronic hypoxia-associated brain injury.

Zhenzhen Tu, Xingqin Tan, Shangyingying Li, Jie Cui, Shengfen Tu, Li Jiang,

Cardiopulmonary bypass (CPB) is the most general technique applied in congenital heart disease (CHD). However, standard CPB poses a specific pathologic condition for patients during surgery: exposure to reoxygenation. When surgery is performed on cyanotic infants, standard CPB is usually initiated at a high concentration of oxygen without consideration of ... Read more >>

Biol Open (Biology open)
[2019, 8(12):]

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Effects of pulsatile minimal invasive extracorporeal circulation on fibrinolysis and organ protection in adult cardiac surgery-a prospective randomized trial.

Angelika Graßler, Robert Bauernschmitt, Irene Guthoff, Andreas Kunert, Markus Hoenicka, Günter Albrecht, Andreas Liebold,

Background:Minimal invasive extracorporeal circulation (MiECC) reduces the impact of cardiopulmonary bypass during cardiac surgery on inflammation and hemostasis. Pulsatile perfusion may enhance organ perfusion and help to prevent renal and neuronal damage. The present study investigated the impact of pulsatile MiECC in low-risk coronary artery bypass grafting (CABG) patients. Methods:CABG ... Read more >>

J Thorac Dis (Journal of Thoracic Disease)
[2019, 11(Suppl 10):S1453-S1463]

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Abstracts of the Meeting, The Centennial of the Romanian Internal Medicine in Cluj: 24 – 26 October 2019, Cluj-Napoca.

Med Pharm Rep (Medicine and pharmacy reports)
[2019, 92(Suppl No 4):S1-S27]

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Meta-analysis of targeted temperature management in animal models of cardiac arrest.

Hilmer Olai, Gustav Thornéus, Hannah Watson, Malcolm Macleod, Jonathan Rhodes, Hans Friberg, Niklas Nielsen, Tobias Cronberg, Tomas Deierborg,

BACKGROUND:Targeted temperature management (TTM) of 32 to 34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 indicated benefit on survival and neurological outcome. In 2013, a clinical trial showed no difference in outcome between TTM of 33 °C and TTM of 36 °C. In this meta-analysis, ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2020, 8(1):3]

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Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine.

Alexis R Cole, Dorothy A Perry, Ali Raza, Arthur P Nedder, Elizabeth Pollack, William L Regan, Sarah J van den Bosch, Brian D Polizzotti, Edward Yang, Daniel Davila, Onur Afacan, Simon K Warfield, Yangming Ou, Brenda Sefton, Allen D Everett, Jeffrey J Neil, Hart G W Lidov, John E Mayer, John N Kheir,

This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. With proper precautions, inhalational hydrogen may be administered safely through ... Read more >>

JACC Basic Transl Sci (JACC. Basic to translational science)
[2019, 4(2):176-187]

Cited: 2 times

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Does case-based blended-learning expedite the transfer of declarative knowledge to procedural knowledge in practice?

Bela Turk, Sebastian Ertl, Guoruey Wong, Patricia P Wadowski, Henriette Löffler-Stastka,

BACKGROUND:Case-Based Learning (CBL) has seen widespread implementation in undergraduate education since the early 1920s. Ample data has shown CBL to be an enjoyable and motivational didactic tool, and effective in assisting the expansion of declarative and procedural knowledge in academia. Although a plethora of studies apply multiple choice questions (MCQs) ... Read more >>

BMC Med Educ (BMC medical education)
[2019, 19(1):447]

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Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases.

Chien-Ning Hsu, Li-Tung Huang, You-Lin Tain,

Cardiovascular and neurological diseases can originate in early life. Melatonin, a biologically active substance, acts as a pleiotropic hormone essential for pregnancy and fetal development. Maternal melatonin can easily pass the placenta and provide photoperiodic signals to the fetus. Though melatonin uses in pregnant or lactating women have not yet ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(22):]

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Hurdles to Cardioprotection in the Critically Ill.

Louise E See Hoe, Nicole Bartnikowski, Matthew A Wells, Jacky Y Suen, John F Fraser,

Cardiovascular disease is the largest contributor to worldwide mortality, and the deleterious impact of heart failure (HF) is projected to grow exponentially in the future. As heart transplantation (HTx) is the only effective treatment for end-stage HF, development of mechanical circulatory support (MCS) technology has unveiled additional therapeutic options for ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(15):]

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Pro-Con Debate: Nitrous Oxide for Labor Analgesia.

Manuel C Vallejo, Mark I Zakowski,

This Pro-Con debate will provide the practitioner with an evidence-based knowledge approach to assist the clinician in determining whether to employ (Pro) or not to employ (Con) this technique in the obstetrical suite for labor analgesia. Nitrous oxide has been used safely in dentistry and medicine for many centuries. However, ... Read more >>

Biomed Res Int (BioMed Research International)
[2019, 2019:4618798]

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Nocebo Effects and Negative Suggestions in Daily Clinical Practice - Forms, Impact and Approaches to Avoid Them.

Ernil Hansen, Nina Zech,

Medical situations are hot spots in the life of a patient with potentially long lasting effects arising from the use of either negative expressions or encouraging statements, or the lack of empathy or a positive physician-patient relationship. Health care personnel should be aware of and evaluate what patients are exposed ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:77]

Cited: 2 times

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Obesity and hypovitaminosis D: causality or casualty?

Silvia Migliaccio, Andrea Di Nisio, Chiara Mele, Lorenzo Scappaticcio, Silvia Savastano, Annamaria Colao, ,

Epidemiological studies reported that vitamin D deficiency represents an increasingly widespread phenomenon in various populations. Vitamin D deficiency is considered a clinical syndrome determined by low circulating levels of 25-hydroxyvitamin D (25(OH)D), which is the biologically-inactive intermediate and represents the predominant circulating form. Different mechanisms have been hypothesized to explain ... Read more >>

Int J Obes Suppl (International journal of obesity supplements)
[2019, 9(1):20-31]

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"Streets of Fire" revisited: contact burns.

Areta Kowal-Vern, Marc R Matthews, Karen N Richey, Kathy Ruiz, Michael Peck, Arpana Jain, Kevin N Foster,

Background:Pavement-street contact burns are rare. This study compared recent contact burns to those published in "Pavement temperature and burns: Streets of Fire" in 1995. The hypothesis was that there were a significantly increased number of pavement-street burns, as a result of increased ambient temperatures, and that motor vehicle crash (MVC) ... Read more >>

Burns Trauma (Burns & trauma)
[2019, 7:32]

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Creation of a novel algorithm to identify patients with Becker and Duchenne muscular dystrophy within an administrative database and application of the algorithm to assess cardiovascular morbidity.

Jonathan H Soslow, Matthew Hall, W Bryan Burnette, Kan Hor, Joanne Chisolm, Christopher Spurney, Justin Godown, Meng Xu, James C Slaughter, Larry W Markham,

BACKGROUND:Outcome analyses in large administrative databases are ideal for rare diseases such as Becker and Duchenne muscular dystrophy. Unfortunately, Becker and Duchenne do not yet have specific International Classification of Disease-9/-10 codes. We hypothesised that an algorithm could accurately identify these patients within administrative data and improve assessment of cardiovascular ... Read more >>

Cardiol Young (Cardiology in the young)
[2019, 29(3):290-296]

Cited: 1 time

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Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature.

Sarah Schober, Karin Schilbach, Michaela Doering, Karin M Cabanillas Stanchi, Ursula Holzer, Patrick Kasteleiner, Jens Schittenhelm, Juergen F Schaefer, Ingo Mueller, Peter Lang, Rupert Handgretinger,

BACKGROUND:DNA ligase IV deficiency is a rare autosomal recessive disorder caused by hypomorphic mutations in the DNA ligase IV (LIG4) gene. DNA ligase IV is an essential protein for the development of a healthy immune system as well as for the protection of genomic integrity. Apart from typical stigmata, patients ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):346]

Cited: 1 time

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Report on advances for pediatricians in 2018: allergy, cardiology, critical care, endocrinology, hereditary metabolic diseases, gastroenterology, infectious diseases, neonatology, nutrition, respiratory tract disorders and surgery.

Carlo Caffarelli, Francesca Santamaria, Carla Mastrorilli, Angelica Santoro, Brunella Iovane, Maddalena Petraroli, Valeria Gaeta, Rosita Di Pinto, Melissa Borrelli, Sergio Bernasconi, Giovanni Corsello,

This review reported notable advances in pediatrics that have been published in 2018. We have highlighted progresses in allergy, cardiology, critical care, endocrinology, hereditary metabolic diseases, gastroenterology, infectious diseases, neonatology, nutrition, respiratory tract disorders and surgery. Many studies have informed on epidemiologic observations. Promising outcomes in prevention, diagnosis and treatment ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(1):126]

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The clinical management and outcomes of extremely preterm infants in Japan: past, present, and future.

Tetsuya Isayama,

There is a wide variation in neonatal mortality rates across regions and countries. Japan has one of the lowest neonatal mortality rates in the world; in particular, the mortality rate of extremely preterm infants (i.e., those born before 26 weeks of gestation) is much lower in Japan than in other ... Read more >>

Transl Pediatr (Translational pediatrics)
[2019, 8(3):199-211]

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Perioperative Outcomes of Using Different Temperature Management Strategies on Pediatric Patients Undergoing Aortic Arch Surgery: A Single-Center, 8-Year Study.

Yuanyuan Tong, Jinping Liu, Lihua Zou, Zhengyi Feng, Chun Zhou, Ruoning Lv, Yu Jin,

Background: With the widespread application of regional low-flow perfusion (RLFP), development of surgical techniques, and shortened circulatory arrest time, deep hypothermia is indispensable for organ protection. Clinicians have begun to increase the temperature to reduce hypothermia-related adverse outcomes. The aim of this study was to evaluate the safety and efficacy ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2018, 6:356]

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