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Neurologic Manifestations of Ependymoma

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The spectrum of malignancies presenting with neurological manifestations: A prospective observational study.

Dhruv Batra, Hardeep S Malhotra, Ravindra K Garg, Kiran P Malhotra, Neeraj Kumar, Madan L Brahma Bhatt, Rajesh Verma, Praveen K Sharma, Imran Rizvi,

Introduction:A neurological consultation is needed in nearly 45% of patients suffering from cancer. The present study was planned to evaluate the clinical, radiological and histopathological spectrum of patients with an underlying malignancy and presenting with a neurological complaint. Materials and Methods:We prospectively evaluated all patients provisionally diagnosed either with a ... Read more >>

J Family Med Prim Care (Journal of family medicine and primary care)
[2019, 8(11):3726-3735]

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Chronic Back Pain in a Young Female Patient: A Case of Ependymoma Originating from the Conus Medullaris.

Siti Fairus Asahar, Khasnur Abd Malek, Wan Najwa Wan Mohd Zohdi, Alan Basil Peter,

We present the case of a 14-year-old Malay girl with an ependymoma of the conus medullaris who presented to multiple general practitioner clinics with a 24-month history of chronic low back pain. The pain was symptomatically managed as a simple musculoskeletal pain and sciatica. Further imaging to aid diagnosis was ... Read more >>

Korean J Fam Med (Korean journal of family medicine)
[2020, 41(1):68-72]

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Parkinsonism caused by Intracranial ependymoma: A rare case report and literature review.

Yue Lou, Yanwen Wang, Liying Zhuang, Miao Cai, Xiaoli Liu,

Background:Ependymomas, especially intracranial ependymomas, are rare neoplasms of the CNS. The clinical courses of patients with intracranial ependymomas can be quite variable. At present, data on parkinsonism caused by ependymomas are scarce. Case presentation:A 13-year-old girl presented with parkinsonism symptoms of clumsiness in her left leg and hand. Her mother ... Read more >>

Aging Med (Milton) (Aging medicine (Milton (N.S.W)))
[2019, 2(4):223-226]

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Cervicomedullary Ependymoma with Hemorrhage: A Case Report and Review of Literature.

Raja K Kutty, Kazumi Ohmori, Yasuhiro Yamada, Yoko Kato,

Ependymoma is a rare tumor central nervous system that arises from the ependymal lining of the ventricles or the central canal of the spinal cord. They are of neuroectodermal in origin and constitute about 30%-86% of tumors arising in the spinal cord. The occurrence of these tumors in the cervicomedullary ... Read more >>

Asian J Neurosurg (Asian journal of neurosurgery)
[2020, 15(1):190-193]

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Glioblastoma Multiforme Associated with Arteriovenous Malformation: A Case Report and Literature Review.

Thara Tunthanathip, Kanet Kanjanapradit,

Although microvascular proliferation can be observed in glioblastoma, obvious vascularity coupled with coexisting cerebral arteriovenous malformation (AVM) is extremely rare. This report is of a rare case of glioblastoma, coexisting with a cerebral AVM. A 20-year-old male presented with progressive right hemiparesis within 1 month. Cranial magnetic resonance imaging revealed ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(1):103-106]

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Cavernoma of the Right Lateral Ventricle: A Rare Case Report.

Uday Kiran Katari, Govindappagari Venkateswara Prasanna, Divya Tejaswi Gopidesi,

Intraventricular cavernoma (IVC) is a rare pathological entity constituting 2.5%-10.8% of cerebral cavernomas. The lateral ventricles are the most frequent site, followed by the third and fourth ventricles. IVCs usually attain a large size compared to parenchymal cavernomas and cause signs and symptoms mainly due to mass effect. IVCs lack ... Read more >>

Asian J Neurosurg (Asian journal of neurosurgery)
[2019, 14(4):1222-1225]

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Neuraxis Metastases Of Primary Central Nervous System Tumors: A Review Of Clinicopathological And Radiographic Characters Of 198 Cases In A Single Center.

Hailong Liu, Junping Zhang, Yongqiang Liu, Youliang Sun, Cheng Li, Chunyu Gu, Haoran Wang, Hongwei Zhang, Chunjiang Yu, Mingshan Zhang,

Background:Neuraxis metastases (NM) from systemic and central nervous system (CNS) tumors have become increasingly common. However, a lack of systematic information restricts the development of the accurate diagnosis and treatment. The aim of this study is to facilitate the understanding of NM arising from CNS tumors in the largest cohort. ... Read more >>

Cancer Manag Res (Cancer management and research)
[2019, 11:9829-9841]

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The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies.

Nikolaos Antoniou, Nefeli Lagopati, Dimitrios Ilias Balourdas, Michail Nikolaou, Alexandros Papalampros, Panagiotis V S Vasileiou, Vassilios Myrianthopoulos, Athanassios Kotsinas, Yosef Shiloh, Michalis Liontos, Vassilis G Gorgoulis,

The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. ... Read more >>

Cancers (Basel) (Cancers)
[2019, 12(1):]

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Ganglioglioma of the Right Cerebrothalamus in a 7-Year-Old Quarter Horse Cross Gelding.

Charlotte Easton-Jones, Kevin Woolard, F Charles Mohr, Melissa A Roy, Monica Aleman,

Intracranial neoplasia in horses is rare compared to other species. Detailed information such as neurological, electroencephalographic, and histopathological examination of horses with intracranial neoplasia associated with seizures is scarce in the literature. Furthermore, ganglioglioma has not been reported in the horse. A 7-year-old Quarter horse cross Paint gelding was examined ... Read more >>

Front Vet Sci (Frontiers in veterinary science)
[2019, 6:356]

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Intratumoral Susceptibility Signals Reflect Biomarker Status in Gliomas.

Ling-Wei Kong, Jin Chen, Heng Zhao, Kun Yao, Sheng-Yu Fang, Zheng Wang, Yin-Yan Wang, Shou-Wei Li, Shou-Wei Li,

Susceptibility-weighted imaging (SWI) can be a useful tool to depict vascular structures in brain tumors as well as micro-bleedings, which represent tumor invasion to blood vessels and could also be representative of tumoral angiogenesis. In this study, we investigated the relationship between SWI features and glioma grades, and the expression ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):17080]

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[Superficial siderosis of the central nervous system caused by myxopapillary ependymoma of conus medullaris and cauda equine: a case report and literature review].

L Xu, M J Hu, Y Y Li, H D Qu, W D Qian, X L Liu,

Superficial siderosis of the central nervous system (SSCNS) is a rare disorder caused by hemosiderin deposits in the subpial layers of the brain and spinal cord due to prolonged or recurrent low-grade bleeding into the cerebrospinal fluid (CSF). Central nervous system tumor could be one of the sources of bleeding. ... Read more >>

Beijing Da Xue Xue Bao (Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences)
[2019, 51(4):769-774]

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Prognostic factors of patients with Gliomas - an analysis on 335 patients with Glioblastoma and other forms of Gliomas.

Jianfeng Liang, Xiaomin Lv, Changyu Lu, Xun Ye, Xiaolin Chen, Jia Fu, Chenghua Luo, Yuanli Zhao,

BACKGROUND:The prognosis of glioma is poor, despite recent advances in diagnosis and treatment of the disease. It is important to investigate the clinical characteristics and prognostic factors of glioma so as to provide basis for treatment and management of patients. METHOD:A total of 335 patients with glioma were included in ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):35]

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Clinical Applications of Cerebrospinal Fluid Circulating Tumor DNA as a Liquid Biopsy for Central Nervous System Tumors.

Weiwei Yan, Tingting Xu, Hui Zhu, Jinming Yu,

Central nervous system (CNS) malignancies are associated with poor prognosis, as well as exceptional morbidity and mortality, likely as a result of low rates of early diagnosis and limited knowledge of the tumor growth and resistance mechanisms, dissemination, and evolution in the CNS. Monitoring patients with CNS malignancies for treatment ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2020, 13:719-731]

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Coexisting Spinal Intramedullary and Intracranial Tuberculomas in an Immunocompetent Child.

Vaishali R Ghane, Preeti Shanbag, Ashish Meshram,

Pediatric neurotuberculosis manifests commonly as tuberculous meningitis and intracranial tuberculomas. The ratio of occurrence of intracranial to intraspinal tuberculoma reported is 42:1. Intramedullary tuberculomas (IMTs) are rare, and the coexistence of intramedullary and intracranial tuberculoma is extremely rare. We report a case of coexisting intramedullary and intracranial tuberculoma in a ... Read more >>

J Pediatr Neurosci (Journal of pediatric neurosciences)
[2019, 14(3):143-147]

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Occlusive radiation cerebral vasculopathy implies medical complexity: a case report.

Dana Ghazaleh, Azizullah Beran, Brent Berry, Malik Ghannam,

BACKGROUND:Cranial irradiation is one of the main treatment modalities for central nervous system tumors. It carries many complications, one being occlusive radiation vasculopathy of large vessels. It is an underrecognized etiology for stroke, especially in the younger population. The pathophysiological process is controversial, but there is much literature supporting the ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2019, 13(1):170]

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Trends in phenotype in the English paediatric neurofibromatosis type 2 cohort stratified by genetic severity.

Dorothy Halliday, Beatrice Emmanouil, Grace Vassallo, Karine Lascelles, James Nicholson, Saleel Chandratre, Geetha Anand, Martin Wasik, Pieter Pretorius, D Gareth Evans, Allyson Parry, ,

Childhood onset neurofibromatosis type 2 can be severe and genotype dependent. We present a retrospective phenotypic analysis of all ascertained children in England <age 18 (N = 87; male 61%). Mean age at last review was 13.9 years with mean follow-up 6.5 years. Patients were stratified using a validated score (1A/1B:no NF2 pathogenic_variant ... Read more >>

Clin. Genet. (Clinical genetics)
[2019, 96(2):151-162]

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Primary Spinal Astrocytomas: A Literature Review.

John Ogunlade, James G Wiginton, Christopher Elia, Tiffany Odell, Sanjay C Rao,

Primary spinal astrocytoma is a subtype of glioma, the most common spinal cord tumor found in the intradural intramedullary compartment. Spinal astrocytomas account for 6-8% of all spinal cord tumors and are primarily low grade (World Health Organization grade I (WHO I) or WHO II). They are seen in both ... Read more >>

Cureus (Cureus)
[2019, 11(7):e5247]

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MYCN amplification drives an aggressive form of spinal ependymoma.

David R Ghasemi, Martin Sill, Konstantin Okonechnikov, Andrey Korshunov, Stephen Yip, Peter W Schutz, David Scheie, Anders Kruse, Patrick N Harter, Marina Kastelan, Marlies Wagner, Christian Hartmann, Julia Benzel, Kendra K Maass, Mustafa Khasraw, Ronald Sträter, Christian Thomas, Werner Paulus, Christian P Kratz, Hendrik Witt, Daisuke Kawauchi, Christel Herold-Mende, Felix Sahm, Sebastian Brandner, Marcel Kool, David T W Jones, Andreas von Deimling, Stefan M Pfister, David E Reuss, Kristian W Pajtler,

Spinal ependymal tumors form a histologically and molecularly heterogeneous group of tumors with generally good prognosis. However, their treatment can be challenging if infiltration of the spinal cord or dissemination throughout the central nervous system (CNS) occurs and, in these cases, clinical outcome remains poor. Here, we describe a new ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2019, 138(6):1075-1089]

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APRIL and BAFF: novel biomarkers for central nervous system lymphoma.

Matthias Mulazzani, Marion Huber, Sabine Borchard, Sigrid Langer, Barbara Angele, Elisabeth Schuh, Edgar Meinl, Martin Dreyling, Tobias Birnbaum, Andreas Straube, Uwe Koedel, Louisa von Baumgarten,

BACKGROUND:Early diagnosis of CNS lymphoma (CNSL) is essential for successful therapy of this rapidly progressing brain tumor. However, in patients presenting with focal brain lesions, fast and reliable diagnosis of PCNSL remains a challenge. A proliferation-inducing ligand (APRIL) and B cell activating factor (BAFF) are important factors in the pathophysiology, ... Read more >>

J Hematol Oncol (Journal of hematology & oncology)
[2019, 12(1):102]

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An intramedullary "flame" recognized as being an intramedullary spinal cord metastasis from esophageal cancer.

Assunta Grillo, Raffaella Capasso, Angelica Petrillo, Ferdinando De Vita, Renata Conforti,

Intramedullary spinal cord metastases are rarely encountered in patients suffering from extra - central nervous system primary cancer, with only 2 described cases reported in the literature deriving from esophageal cancer. Intramedullary spinal cord metastases may occur at any level of the spinal cord but cervical location is the most ... Read more >>

J Radiol Case Rep (Journal of radiology case reports)
[2019, 13(7):14-20]

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BRAF V600E mutation in Juvenile Xanthogranuloma family neoplasms of the central nervous system (CNS-JXG): a revised diagnostic algorithm to include pediatric Erdheim-Chester disease.

J Picarsic, T Pysher, H Zhou, M Fluchel, T Pettit, M Whitehead, L F Surrey, B Harding, G Goldstein, Y Fellig, M Weintraub, B C Mobley, P M Sharples, M L Sulis, E L Diamond, R Jaffe, K Shekdar, M Santi,

The family of juvenile xanthogranuloma family neoplasms (JXG) with ERK-pathway mutations are now classified within the "L" (Langerhans) group, which includes Langerhans cell histiocytosis (LCH) and Erdheim Chester disease (ECD). Although the BRAF V600E mutation constitutes the majority of molecular alterations in ECD and LCH, only three reported JXG neoplasms, ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2019, 7(1):168]

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Surgical Treatment of Intra- and Juxtamedullary Spinal Cord Tumors: A Population Based Observational Cohort Study.

Oscar Persson, Alexander Fletcher-Sandersjöö, Gustav Burström, Erik Edström, Adrian Elmi-Terander,

Objective: Intramedullary spinal cord tumors (IMSCT) are rare entities and high-level evidence regarding optimal treatment is lacking. We aim to describe the demographics, histopathological distribution, onset symptoms, treatment strategies, and functional outcome for patients surgically treated for IMSCT. Methods: We performed a retrospective review of a consecutive population-based cohort of ... Read more >>

Front Neurol (Frontiers in Neurology)
[2019, 10:814]

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Fluorescein Application in Cranial and Spinal Tumors Enhancing at Preoperative MRI and Operated With a Dedicated Filter on the Surgical Microscope: Preliminary Results in 279 Patients Enrolled in the FLUOCERTUM Prospective Study.

Jacopo Falco, Claudio Cavallo, Ignazio G Vetrano, Camilla de Laurentis, Lampros Siozos, Marco Schiariti, Morgan Broggi, Paolo Ferroli, Francesco Acerbi,

Objective: Sodium fluorescein, a green, water soluble dye, is used as neurosurgical fluorescent tracer thanks to its property to accumulate in cerebral regions of blood-brain barrier (BBB) disruption. The authors report the preliminary results of a prospective observational study regarding the use of fluorescein-guided technique for the resection of suspected ... Read more >>

Front Surg (Frontiers in surgery)
[2019, 6:49]

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Survival and Prognosis of Patients with Pilocytic Astrocytoma: A Single-Center Study.

Jae Hui Park, Nani Jung, Seok Jin Kang, Heung Sik Kim, El Kim, Hee Jung Lee, Hye Ra Jung, Misun Choe, Ye Jee Shim,

BACKGROUND:Pilocytic astrocytoma (PA) is a brain tumor that is relatively more common in children and young adults. METHODS:We retrospectively reviewed the medical records of patients with PA treated at a single center between 1988 and 2018. RESULTS:We included 31 subjects with PA. The median age at diagnosis was 13.4 years, ... Read more >>

Brain Tumor Res Treat (Brain tumor research and treatment)
[2019, 7(2):92-97]

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Continuous EEG monitoring after brain tumor surgery.

Kristin Elf, Elisabeth Ronne-Engström, Robert Semnic, Elham Rostami-Berglund, Jimmy Sundblom, Maria Zetterling,

BACKGROUND:Prolonged seizures generate cerebral hypoxia and increased intracranial pressure, resulting in an increased risk of neurological deterioration, increased long-term morbidity, and shorter survival. Seizures should be recognized early and treated promptly. The aim of the study was to investigate the occurrence of postoperative seizures in patients undergoing craniotomy for primary ... Read more >>

Acta Neurochir (Wien) (Acta neurochirurgica)
[2019, 161(9):1835-1843]

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