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Neurologic Disease and Pregnancy

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Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes.

Shou-Di He, Sheng-Guang Huang, Hui-Jun Zhu, Xiao-Guang Luo, Kang-Han Liao, Jie-Yao Zhang, Ning Tan, De-Yu Li,

Context: Oridonin exhibits various pharmacological and physiological activities, including antioxidant, antibacterial, anti-inflammatory, pro-apoptotic, anticancer and neurological effects. However, its role in rheumatoid arthritis (RA) is yet to be revealed.Objective: We evaluated the effects of oridonin on the survival and autophagy of RA-fibroblast-like synoviocytes (FLSs).Materials and methods: RA-FLSs were treated with ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):146-151]

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A comparison of individual-level vs. hypothetically pooled mercury biomonitoring data from the Maternal Organics Monitoring Study (MOMS), Alaska, 1999-2012.

Emily Mosites, Ernesto Rodriguez, Samuel P Caudill, Thomas W Hennessy, James Berner,

Biomonitoring for heavy metals is important to assess health risks, especially in Arctic communities where rural residents rely on locally harvested foods. However, laboratory testing for blood contaminants is expensive and might not be sustainable for long-term monitoring. We assessed whether pooled specimen biomonitoring could be a part of a ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1726256]

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Late diagnosis of Lesch-Nyhan disease complicated with end-stage renal disease and tophi burst: a case report.

Cahyani Gita Ambarsari, Daffodilone Cahyadi, Lenny Sari, Oryza Satria, Felly Sahli, Thyrza Laudamy Darmadi, Agustina Kadaristiana,

Background: Lesch-Nyhan disease (LND) is a rare X-linked recessive inborn error of purine metabolism. Late diagnosis of LND may cause significant morbidity. LND cases have never been reported in Indonesia.Case report: A 15-year-old male who had been diagnosed with cerebral palsy was referred to our hospital due to renal failure ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):113-121]

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Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases.

Jose A Fernández-Albarral, Rosa de Hoz, Ana I Ramírez, Inés López-Cuenca, Elena Salobrar-García, María D Pinazo-Durán, José M Ramírez, Juan J Salazar,

Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1408-1416]

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Autosomal dominant SPG9: intrafamilial variability and onset during pregnancy.

C Marelli, S Badiou, S Genestet, L Larrieu, P Damier, W Camu, M Planes, M Koenig, C Guissart,

INTRODUCTION:The ALDH18A1 gene, encoding delta-1-pyrroline-5-carboxylate synthase (P5CS), is responsible for an autosomal recessive disease with severe developmental delay; more recently, ALDH18A1 was found to be responsible for SPG9, an autosomal dominant (AD) spastic paraplegia. CASE REPORT:We report a three-generation family with AD SPG9, initially suspected because of low citrulline on ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Recommendations for neurological, obstetrical and gynaecological care in women with multiple sclerosis: a statement by a working group convened by the Section of Multiple Sclerosis and Neuroimmunology of the Polish Neurological Society.

Alicja Kalinowska, Alina Kułakowska, Monika Adamczyk-Sowa, Krzysztof Czajkowski, Katarzyna Kurowska, Bronisława Pietrzak, Piotr Radziszewski, Konrad Rejdak, Halina Bartosik-Psujek,

INTRODUCTION:Multiple sclerosis (MS) is the most common non-traumatic neurological cause of disability in young adults, affecting women 1-3 times more often than men. Several specific challenges arise from the fact that young women diagnosed with MS often have to make decisions related to treatment and family planning at the same ... Read more >>

Neurol. Neurochir. Pol. (Neurologia i neurochirurgia polska)
[2020, :]

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Quantitative Assessment of Parental Somatic Mosaicism for Copy-Number Variant (CNV) Deletions.

Qian Liu, Christopher M Grochowski, Weimin Bi, James R Lupski, Paweł Stankiewicz,

As genome sequencing methodologies have become more sensitive in detecting low-frequency rare-variant events, the link between post-zygotic mutagenesis and somatic mosaicism in the etiology of several human genetic conditions other than cancers has become more clear. Given that current clinical-genomics diagnostic methods have limited detection sensitivity for mosaic events, a ... Read more >>

Curr Protoc Hum Genet (Current protocols in human genetics)
[2020, 106(1):e99]

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Muscle weakness of the lower limbs after epidural anesthesia in a pregnant woman with undiscovered systemic lupus erythematosus.

Lan Wu, Xiao-Qin Jiang, Ya-Qin Xiong, Xue-Mei Lin,

Chin. Med. J. (Chinese medical journal)
[2020, 133(5):621-622]

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Neuromyelitis optica spectrum disorders and pregnancy: therapeutic considerations.

Yang Mao-Draayer, Sandra Thiel, Elizabeth A Mills, Tanuja Chitnis, Michelle Fabian, Ilana Katz Sand, M Isabel Leite, Sven Jarius, Kerstin Hellwig,

Neuromyelitis optica spectrum disorders (NMOSD) are a type of neurological autoimmune disease characterized by attacks of CNS inflammation that are often severe and predominantly affect the spinal cord and optic nerve. The majority of individuals with NMOSD are women, many of whom are of childbearing age. Although NMOSD are rare, ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2020, 16(3):154-170]

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Stroke in Pregnancy: A Focused Update.

Eliza C Miller, Lisa Leffert,

Ischemic stroke (IS) and hemorrhagic stroke (HS) can be devastating complications during pregnancy and the puerperium that are thought to occur in approximately 30 in 100,000 pregnancies. In high-risk groups, such as women with preeclampsia, the incidence of both stroke subtypes, combined, is up to 6-fold higher than in pregnant ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2020, 130(4):1085-1096]

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Fetal subdural hematoma, sickle cell disease and storage pool disease: A case report.

Antonella Iannaccone, Marvin Darkwah Oppong, Philipp Dammann, Rainer Kimmig, Angela Köninger,

A fetal subdural hematoma (SDH) was diagnosed in a patient with sickle cell disease (SCD) during a routine ultrasound exam in the 30th week of pregnancy. A scan performed a few days earlier had revealed no abnormalities. After interdisciplinary consultation with neurosurgeons and neonatologists, a cesarean section was performed since ... Read more >>

Case Rep Womens Health (Case reports in women's health)
[2020, 26:e00183]

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A Successful Pregnancy with Amyotrophic Lateral Sclerosis.

P D M Pathiraja, S K Ranaraja,

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neurone disease that is rarely seen in the obstetric population. We present a 32-year-old patient who presented in her fourth pregnancy with a background history of ALS. There was complete involvement of the upper and lower motor neurone system and bulbar system ... Read more >>

Case Rep Obstet Gynecol (Case reports in obstetrics and gynecology)
[2020, 2020:1247178]

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Wallerian degeneration of bilateral cerebral peduncles after acute carbon monoxide poisoning.

Sui-Yi Xu, Chang-Xin Li, Le-Yi Li, Yu Song, Yi Sui,

BACKGROUND:Cases of Wallerian degeneration of bilateral cerebral peduncles after acute carbon monoxide poisoning have not yet been reported. To date, most of the delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) lesions captured in magnetic resonance imaging (MRI) has been located in the subcortical white matter and basal ganglia. Here ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):96]

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Mutation analysis and prenatal diagnosis of 419 cases of Spinal Muscular Atrophy in China

Xiangdong Kong, YingJie Sun, Xuechao Zhao, Zhenhua Zhao,

<title>Abstract</title> <p> Background Spinal muscular atrophy (SMA) is a common and lethal autosomal recessive neurodegenerative disease, which is caused by mutations of the survival motor neuron 1 (SMN1) gene. At present, the gene therapy medicine for SMA, i.e. , Spinraza (Nusinersen), has been approved by the FDA, bringing ... Read more >>

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Maternal complications in molecularly confirmed diandric and digynic triploid pregnancies: single institution experience and literature review.

D Massalska, J Bijok, A Kucińska-Chahwan, J G Zimowski, K Ozdarska, A Raniszewska, G M Panek, T Roszkowski,

OBJECTIVES:Assessment of the maternal complications in molecularly confirmed diandric and digynic triploid pregnancies. METHODS:Sonographic features, biochemical results, and clinical presentation were analyzed. Beta-hCG level was controlled after diandric triploidy. RESULTS:The study included nine diandric and twelve digynic triploid pregnancies at the mean gestational age at diagnosis of 14.9 and 18.0 ... Read more >>

Arch. Gynecol. Obstet. (Archives of gynecology and obstetrics)
[2020, :]

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An autopsy case of GM1 gangliosidosis type II in a patient who survived a long duration with artificial respiratory support.

Akiko Uchino, Makiko Nagai, Naomi Kanazawa, Masaaki Ichinoe, Nobuyuki Yanagisawa, Kaori Adachi, Eiji Nanba, Hiroyuki Ishiura, Jun Mitsui, Shoji Tsuji, Kinuko Suzuki, Shigeo Murayama, Kazutoshi Nishiyama,

GM1 gangliosidosis is a storage disorder with autosomal recessive inheritance caused by deficiency of β-galactosidase (GLB1), which is a lysosomal hydrolase, due to mutations in GLB1. We describe here an autopsy case of GM1 gangliosidosis in a female patient who survived for 38 years with a long period of artificial respiratory ... Read more >>

Neuropathology (Neuropathology : official journal of the Japanese Society of Neuropathology)
[2020, :]

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Suitable indications of eculizumab for patients with refractory generalized myasthenia gravis.

Munenori Oyama, Kensuke Okada, Masayuki Masuda, Yuko Shimizu, Kazumasa Yokoyama, Akiyuki Uzawa, Naoki Kawaguchi, Ryotaro Ikeguchi, Yasunobu Hoshino, Taku Hatano, Yukiko Ozawa, Jin Nakahara, Hitoshi Aizawa, Kazuo Kitagawa, Nobutaka Hattori, Satoshi Kuwabara, Hiroyuki Murai, Shigeaki Suzuki,

Background:Eculizumab is a humanized monoclonal antibody that targets complement protein C5 and inhibits terminal complement-mediated damage at the neuromuscular junction. Recently, the REGAIN study showed that eculizumab was effective and well tolerated in patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis (gMG). However, there is no consensus regarding which ... Read more >>

Ther Adv Neurol Disord (Therapeutic advances in neurological disorders)
[2020, 13:1756286420904207]

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Pregnancy and the Postpartum Period in Women With Relapsing-Remitting Multiple Sclerosis Treated With Old and New Disease-Modifying Treatments: A Real-World Multicenter Experience.

Aurora Zanghì, Emanuele D'Amico, Graziella Callari, Clara Grazia Chisari, Giovanna Borriello, Luigi Maria Edoardo Grimaldi, Francesco Patti,

Introduction: Trends of disease activity during pregnancy, the postpartum period, and until 24 months from the delivery in the era of new drugs for the treatment of relapsing-remitting multiple sclerosis (RRMS) need to be investigated. Methods: In this cross-sectional Italian multicenter study, women with RRMS were included; the disease-modifying treatment ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:105]

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Homocysteine: Its Possible Emerging Role in At-Risk Population Groups.

Elena Azzini, Stefania Ruggeri, Angela Polito,

Increased plasma homocysteine is a risk factor for several pathological disorders. The present review focused on the role of homocysteine (Hcy) in different population groups, especially in risk conditions (pregnancy, infancy, old age), and on its relevance as a marker or etiological factor of the diseases in these age groups, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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Antenatal diagnosis of absence of septum pellucidum.

Imane Ben M'Barek, Mikael Tassin, Agnes Guët, Isabelle Simon, Valerie Mairovitz, Laurent Mandelbrot, Olivier Picone,

The absence of septum pellucidum (ASP) is a rare disease, which affects the structure of the brain. It is either isolated or associated with various congenital brain malformations. The diagnosis of ASP can be performed by second-trimester ultrasound. When the ASP is isolated, prenatal counseling is optimistic regarding neurological outcome, ... Read more >>

Clin Case Rep (Clinical Case Reports)
[2020, 8(3):498-503]

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Cytomegalovirus infection during pregnancy: State of the science.

Marianne Leruez-Ville, Ina Foulon, Robert Pass, Yves Ville,

Cytomegalovirus is the most common congenital infection, affecting 0.5-2% of all live births and the main non-genetic cause of congenital sensorineural hearing loss and neurological damage. Congenital CMV can follow maternal primary infection or non-primary infection. Sensori-neurological morbidity is confined to the first trimester with up to 40-50% of infected ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2020, :]

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Family planning is the second most relevant factor for treatment decisions after disease activity - Commentary.

Vilija G Jokubaitis, Ruth Dobson,

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2020, :1352458520907902]

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Prognostic value of amplitude-integrated EEG in neonates with high risk of neurological sequelae.

Xiao Yuan, Wenqing Kang, Juan Song, Jing Guo, Lanlan Guo, Ruili Zhang, Shasha Liu, Yaodong Zhang, Dapeng Liu, Yong Wang, Xue Ding, Huimin Dong, Xi Chen, Yanchao Cheng, Xiaoli Zhang, Falin Xu, Changlian Zhu,

OBJECTIVE:To determine the efficacy and the prognostic value of amplitude-integrated electroencephalography (aEEG) in term and near-term neonates with high risk of neurological sequelae. METHODS:Infants of ≥35 weeks of gestation diagnosed with neonatal encephalopathy or with high risk of brain injury were included. All eligible infants underwent aEEG within 6 h after clinical ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(2):210-218]

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Pregnancy outcomes in interferon-beta-exposed patients with multiple sclerosis: results from the European Interferon-beta Pregnancy Registry.

Kerstin Hellwig, Yvonne Geissbuehler, Meritxell Sabidó, Catrinel Popescu, Alessandra Adamo, Joachim Klinger, Asher Ornoy, Peter Huppke, ,

BACKGROUND:Family planning is an important consideration for women with multiple sclerosis (MS), who are often diagnosed during their reproductive years. Currently, limited data are available on pregnancy outcomes in patients exposed to interferon-beta (IFN-beta) before or during pregnancy. Here, we present the cumulative pregnancy exposure data and prevalence of pregnancy ... Read more >>

J. Neurol. (Journal of neurology)
[2020, :]

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Case series: Hearing loss in neuromyelitis optica spectrum disorders.

Madina Tugizova, Haojun Feng, Anna Tomczak, Kristen Steenerson, May Han,

BACKGROUND:Aquaporin 4 (AQP4)- and myelin oligodendrocyte glycoprotein (MOG)-associated neuromyelitis optica spectrum disorders (NMOSD) are thought to primarily affect the central nervous system (CNS). However, emerging evidence suggests that there are extra-CNS manifestations of NMOSD, including myopathies, gastrointestinal dysfunction, renal involvement and adverse pregnancy outcomes.1 METHODS: Three patients who reported hearing ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 41:102032]

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