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Neuroinflammation

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Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases.

Huifangjie Li, William C Knight, Jinbin Xu,

Neurodegenerative diseases are a class of chronic and complex disorders featuring progressive loss of neurons in distinct brain areas. The mechanisms responsible for the disease progression in neurodegeneration are not fully illustrated. In this observational study, we have examined diverse biochemical parameters in the caudate and putamen of patients with ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):867-874]

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Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration.

Alexis D Rickman, Addison Hilyard, Bradlee L Heckmann,

Neuroinflammation and neurodegeneration are key components in the establishment and progression of neurodegenerative diseases including Alzheimer's Disease (AD). Over the past decade increasing evidence is emerging for the use of components of the canonical autophagy machinery in pathways that are characterized by LC3 lipidation yet are distinct from traditional macro-autophagy. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):246-250]

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The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson's disease.

Jing Wang, Xiao-Na Zhang, Jin-Ni Fang, Fei-Fei Hua, Jing-Yang Han, Zeng-Qiang Yuan, An-Mu Xie,

Previous studies have shown that the ATP-P2X4 receptor signaling pathway mediates the activation of the Nod-like receptor family protein 3 (NLRP3) inflammasome. The NLRP3 inflammasome may promote renal interstitial inflammation in diabetic nephropathy. As inflammation also plays an important role in the pathogenesis of Parkinson's disease, we hypothesized that the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):898-904]

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Promise of metformin for preventing age-related cognitive dysfunction.

Leelavathi N Madhu, Maheedhar Kodali, Ashok K Shetty,

The expanded lifespan of people, while a positive advance, has also amplified the prevalence of age-related disorders, which include mild cognitive impairment, dementia, and Alzheimer's disease. Therefore, competent therapies that could improve the healthspan of people have great significance. Some of the dietary and pharmacological approaches that augment the lifespan ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):503-507]

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Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms.

Mushfiquddin Khan, Fei Qiao, Pavan Kumar, S M Touhidul Islam, Avtar K Singh, Jeseong Won, Inderjit Singh,

Spinal cord injury (SCI) is associated with high production and excessive accumulation of pathological 4-hydroxy-trans-2-nonenal (4-HNE), a reactive aldehyde, formed by SCI-induced metabolic dysregulation of membrane lipids. Reactive aldehyde load causes redox alteration, neuroinflammation, neurodegeneration, pain-like behaviors, and locomotion deficits. Pharmacological scavenging of reactive aldehydes results in limited improved motor ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):185-193]

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Rutin pretreatment promotes microglial M1 to M2 phenotype polarization.

Guang-Ping Lang, Can Li, Ying-Ying Han,

Microglial cells are important resident innate immune components in the central nervous system that are often activated during neuroinflammation. Activated microglia can display one of two phenotypes, M1 or M2, which each play distinct roles in neuroinflammation. Rutin, a dietary flavonoid, exhibits protective effects against neuroinflammation. However, whether rutin is ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2499-2504]

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Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota.

Yi-Tong Lin, Qing-Qing Shi, Lei Zhang, Cai-Ping Yue, Zhi-Jun He, Xue-Xia Li, Qian-Jun He, Qiong Liu, Xiu-Bo Du,

Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):409-417]

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Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury.

Asit Kumar, Santosh Kumar,

Traumatic brain injury is a sudden trauma or blow on the head, and severe traumatic brain injury is a major cause of death and disability worldwide. The acute and chronic consequences following traumatic brain injury can lead to progressive secondary neurodegenerative changes and cognitive dysfunction. To date, there is no ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2349-2352]

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The gut microbiome: implications for neurogenesis and neurological diseases.

Cheng Liu, Shang-Yu Yang, Long Wang, Fang Zhou,

There is an increasing recognition of the strong links between the gut microbiome and the brain, and there is persuasive evidence that the gut microbiome plays a role in a variety of physiological processes in the central nervous system. This review summarizes findings that gut microbial composition alterations are linked ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):53-58]

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Neuroimmune connections between corticotropin-releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases.

Piplu Bhuiyan, Yi-Wei Wang, Huan-Huan Sha, Hong-Quan Dong, Yan-Ning Qian,

Corticotropin-releasing hormone is a critical component of the hypothalamic-pituitary-adrenal axis, which plays a major role in the body's immune response to stress. Mast cells are both sensors and effectors in the interaction between the nervous and immune systems. As first responders to stress, mast cells can initiate, amplify and prolong ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(11):2184-2197]

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Non-coding RNAs and other determinants of neuroinflammation and endothelial dysfunction: regulation of gene expression in the acute phase of ischemic stroke and possible therapeutic applications.

Mario Daidone, Marco Cataldi, Antonio Pinto, Antonino Tuttolomondo,

Ischemic stroke occurs under a variety of clinical conditions and has different pathogeneses, resulting in necrosis of brain parenchyma. Stroke pathogenesis is characterized by neuroinflammation and endothelial dysfunction. Some of the main processes triggered in the early stages of ischemic damage are the rapid activation of resident inflammatory cells (microglia, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(11):2154-2158]

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Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH.

Hanhai Zeng, Huaijun Chen, Min Li, Jianfeng Zhuang, Yucong Peng, Hang Zhou, Chaoran Xu, Qian Yu, Xiongjie Fu, Shenglong Cao, Jing Cai, Feng Yan, Gao Chen,

<h4>Background</h4>Neuroinflammation and oxidative stress plays an important role in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). This study is the first to show that activation of autophagy protein nuclear receptor binding factor 2 (NRBF2) could reduce endoplasmic reticulum stress (ERS)-associated inflammation and oxidative stress after SAH.<h4>Methods</h4>Male ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2021, 18(1):210]

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Microglia regulation of synaptic plasticity and learning and memory.

Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zhou,

Microglia are the resident macrophages of the central nervous system. Microglia possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state and constantly monitor their microenvironment and survey neuronal and synaptic activity. Through the C1q, C3 and CR3 "Eat Me" and CD47 and SIRPα ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):705-716]

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Whole-plant foods and their macromolecules: untapped approaches to modulate neuroinflammation in Alzheimer's disease.

Rui Huang, Zhenjun Zhu, Qingping Wu, Alaa El-Din Ahmed Bekhit, Shujian Wu, Mengfei Chen, Juan Wang, Yu Ding,

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Recently, sustained neuroinflammatory response in microglia and astrocytes has been found to cause the deposition of amyloid beta plaques and the hyperphosphorylation of tau protein, thereby accelerating AD progression. The lipoxin A4-transcription factor nuclear factor-kappa B and mitogen-activated protein kinase pathways have ... Read more >>

Crit Rev Food Sci Nutr (Critical reviews in food science and nutrition)
[2021, :1-19]

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[18F]DPA-714 PET imaging for the quantitative evaluation of early spatiotemporal changes of neuroinflammation in rat brain following status epilepticus

Yilong Cui,

<h4>Background: </h4> Most antiepileptic drug therapies are symptomatic and adversely suppress normal brain function by nonspecific inhibition of neuronal activity. In recent times, growing evidence has suggested that neuroinflammation triggered by epileptic seizures might be involved in the pathogenesis of epilepsy. Although the potential effectiveness of anti-inflammatory treatment for curing ... Read more >>

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EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.

Tongtong Liu, Ting Li, Xuhui Chen, Zuofan Li, Miaomiao Feng, Wenlong Yao, Li Wan, Chuanhan Zhang, Yue Zhang,

<h4>Background</h4>Central post-stroke pain (CPSP) is a chronic and intolerable neuropathic pain syndrome following a cerebral vascular insult, which negatively impacts the quality of life of stroke survivors but currently lacks efficacious treatments. Though its underlying mechanism remains unclear, clinical features of hyperalgesia and allodynia indicate central sensitization due to excessive ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2021, 18(1):211]

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Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions.

Latarsha Porcher, Sophie Bruckmeier, Steven D Burbano, Julie E Finnell, Nicole Gorny, Jennifer Klett, Susan K Wood, Michy P Kelly,

<h4>Background</h4>Despite widespread acceptance that neuroinflammation contributes to age-related cognitive decline, studies comparing protein expression of cytokines in the young versus old brains are surprisingly limited in terms of the number of cytokines and brain regions studied. Complicating matters, discrepancies abound-particularly for interleukin 6 (IL-6)-possibly due to differences in sex, species/strain, ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2021, 18(1):219]

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Pien-Tze-Huang attenuates neuroinflammation in cerebral ischaemia-reperfusion injury in rats through the TLR4/NF-κB/MAPK pathway.

Xiaoqin Zhang, Qing Zhang, Lili Huang, Mingzhen Liu, Zaixing Cheng, Yanfang Zheng, Wen Xu, Jinjian Lu, Jian Liu, Mingqing Huang,

<h4>Context</h4><i>Pien-Tze-Huang</i> (PTH) is traditionally applied to treat various inflammation-related diseases including stroke. However, literature regarding the anti-inflammatory effects and possible mechanisms of PTH in ischaemic stroke is unavailable.<h4>Objective</h4>This study investigates the anti-inflammatory effects and its underlying mechanism of PTH on ischaemic stroke.<h4>Materials and methods</h4>Cerebral ischaemia-reperfusion injury was induced through 2 h ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):828-839]

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A systematic review of molecular approaches that link mitochondrial dysfunction and neuroinflammation in Parkinson's disease.

Sugumar Mani, Murugan Sevanan, Alagudurai Krishnamoorthy, Sathiya Sekar,

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder that affects 1% of the population worldwide. Etiology of PD is likely to be multi-factorial such as protein misfolding, mitochondrial dysfunction, oxidative stress, and neuroinflammation that contributes to the pathology of Parkinson's disease (PD), numerous studies have shown that mitochondrial ... Read more >>

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2021, :]

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IL-1β and HMGB1 are anti-neurogenic to endogenous neural stem cells in the sclerotic epileptic human hippocampus.

Malik Zaben, Niels Haan, Feras Sharouf, Aminul Ahmed, Lars E Sundstrom, William P Gray,

<h4>Background</h4>The dentate gyrus exhibits life-long neurogenesis of granule-cell neurons, supporting hippocampal dependent learning and memory. Both temporal lobe epilepsy patients and animal models frequently have hippocampal-dependent learning and memory difficulties and show evidence of reduced neurogenesis. Animal and human temporal lobe epilepsy studies have also shown strong innate immune system ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2021, 18(1):218]

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The Protective Effects of GPR55 Against Hippocampal Neuroinflammation and Neurogenic Damage in CSDS Mice

Shiyu Shen, Rui Yu, Wei Li, Ling-Feng Liang, Qiuqin Han, Huijie Huang, Bing Li, Shifen Xu, Gencheng Wu, Yu-Qiu Zhang, Jin Yu,

<h4>Background: </h4> Depression is one of the most prevalent mental illnesses in the world today, the onset of depression is usually accompanied by neuroinflammation and neurogenic damage. Recently, G protein coupled receptor 55 (GPR55) has been associated with mood regulation as a third kind of cannabinoid receptor, and the activation ... Read more >>

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Classical HDACs in the regulation of neuroinflammation.

Yunjian Dai, Taofeng Wei, Zexu Shen, Yun Bei, Haoran Lin, Haibin Dai,

Neuroinflammation is a key factor of the pathology of various neurological diseases (brain injury, depression, neurodegenerative diseases). It is a complex and orderly process that relies on various types of glial cells and peripheral immune cells. Inhibition of neuroinflammation can reduce the severity of neurological diseases. The initiation, progression, and ... Read more >>

Neurochem Int (Neurochemistry international)
[2021, :105182]

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Necroptosis increases with age in the brain and contributes to age-related neuroinflammation.

Nidheesh Thadathil, Evan H Nicklas, Sabira Mohammed, Tommy L Lewis, Arlan Richardson, Sathyaseelan S Deepa,

Chronic inflammation of the central nervous system (CNS), termed neuroinflammation, is a hallmark of aging and a proposed mediator of cognitive decline associated with aging. Neuroinflammation is characterized by the persistent activation of microglia, the innate immune cells of the CNS, with damage-associated molecular patterns (DAMPs) being one of the ... Read more >>

Geroscience (GeroScience)
[2021, :]

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Hyperbaric oxygen therapy improves neurological function via the p38-MAPK/CCL2 signaling pathway following traumatic brain injury.

Yingzi Jiang, Yuwen Chen, Chunling Huang, Anqi Xia, Guohua Wang, Su Liu,

<h4>Objective</h4>The anti-inflammatory mechanisms of hyperbaric oxygenation (HBO) treatment on traumatic brain injury (TBI)-induced neuroinflammation remain unclear. The aim of this study was expected the effect of HBO on CCL2-related signaling pathway following severe TBI in rats.<h4>Methods</h4>The severe TBI model in rats was induced by controlled cortical impact. TBI rats were ... Read more >>

Neuroreport (Neuroreport)
[2021, 32(15):1255-1262]

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Immune modulations and immunotherapies for Alzheimer's disease: a comprehensive review.

Sara Mahdiabadi, Sara Momtazmanesh, George Perry, Nima Rezaei,

Alzheimer's disease (AD), the most common cause of dementia, is characterized by progressive cognitive and memory impairment ensued from neuronal dysfunction and eventual death. Intraneuronal deposition of tau proteins and extracellular senile amyloid-β plaques have ruled as the supreme postulations of AD for a relatively long time, and accordingly, a ... Read more >>

Rev Neurosci (Reviews in the neurosciences)
[2021, :]

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