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The Role of Oxytocin in Social Circuits and Social Behavior in Dementia.

Olivier Piguet, Rebekah M Ahmed, Fiona Kumfor,

Administration of intranasal oxytocin has been found to improve social cognition in a number of brain conditions, including autism spectrum disorder and schizophrenia. Whether this approach is relevant in dementias is currently unknown, particularly in frontotemporal dementia, a younger-onset dementia characterized clinically by marked changes in social cognition and behavior ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2384:67-80]

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Comparison shopping: Is neuropsychological evaluation more expensive than neuroimaging?

Natalie E Kurniadi, Jeremy J Davis,

<h4>Objective</h4>This study empirically examined if neuropsychological evaluation (NPE) is expensive compared to other diagnostic procedures such as neuroimaging.<h4>Method</h4>We aggregated data on charges for NPE and common neuroimaging procedures (e.g., head CT and brain MRI) from hospitals in the U.S. Charges for five-hour NPE and eight-hour NPE were compared to charges ... Read more >>

Clin Neuropsychol (The Clinical neuropsychologist)
[2021, :1-12]

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Provisional research criteria for the behavioral variant of Alzheimer’s disease A systematic review and meta-analysis

Ossenkoppele, E.H. Singleton, Groot, Anke Dijkstra, Willem Eikelboom, William Seeley, Bruce Miller, Laforce, Scheltens, J.M. Papma, G.D. Rabinovici, Y.A.L. Pijnenburg,

<h4>ABSTRACT</h4> <h4>Importance</h4> The behavioral variant of Alzheimer’s disease (bvAD) is characterized by early and predominant behavioral deficits caused by AD pathology. This AD phenotype is insufficiently understood and lacks standardized clinical criteria, limiting reliability and reproducibility of diagnosis and scientific reporting. <h4>Objective</h4> To perform a systematic review and meta-analysis of ... Read more >>

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Neuroimaging Correlates of Syndromal Anxiety Following Traumatic Brain Injury: A Systematic Review of the Literature.

Sahar Jahed, Nicholas O Daneshvari, Angela L Liang, Lisa N Richey, Barry R Bryant, Akshay Krieg, Michael J C Bray, Tejus Pradeep, Licia P Luna, Nicholas T Trapp, Melissa B Jones, Daniel A Stevens, Carrie Roper, Eric L Goldwaser, Emily Berich-Anastasio, Alexandra Pletnikova, Katie Lobner, Daniel J Lee, Margo Lauterbach, Haris I Sair, Matthew E Peters,

<h4>Background</h4>Traumatic brain injury (TBI) can precipitate new-onset psychiatric symptoms or worsen existing psychiatric conditions. To elucidate specific mechanisms for this interaction, neuroimaging is often used to study both psychiatric conditions and TBI. This systematic review aims to synthesize the existing literature of neuroimaging findings among patients with anxiety after TBI.<h4>Methods</h4>We ... Read more >>

J Acad Consult Liaison Psychiatry (Journal of the Academy of Consultation-Liaison Psychiatry)
[2021, :]

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Using Receptor Autoradiography to Visualize and Quantify Oxytocin and Vasopressin 1a Receptors in the Human and Nonhuman Primate Brain.

Sara M Freeman,

Despite its development almost 40 years ago, receptor autoradiography remains a regular and reliable practice for the localization of oxytocin and vasopressin receptors in brain tissue sections. It is used across many laboratories, institutions, and animal species to characterize and quantify the distribution and density of these receptors at baseline and/or ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2384:105-125]

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PET Neuroimaging of Neurologic Disease: Methods, Clinical and Research Applications

Keenan Walker, Murat Bilgel,

<p>Positron emission tomography (PET) is a functional imaging technique that can be used to visualize physiological activity or molecular processes in the whole body or specific organs. For several decades, PET imaging has been used to expand our understanding of neurobiology and neurologic disease. In addition to playing an increasing ... Read more >>

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A population receptive field model of the magnetoencephalography response.

Eline R Kupers, Akhil Edadan, Noah C Benson, Wietske Zuiderbaan, Maartje C de Jong, Serge O Dumoulin, Jonathan Winawer,

Computational models which predict the neurophysiological response from experimental stimuli have played an important role in human neuroimaging. One type of computational model, the population receptive field (pRF), has been used to describe cortical responses at the millimeter scale using functional magnetic resonance imaging (fMRI) and electrocorticography (ECoG). However, pRF ... Read more >>

Neuroimage (NeuroImage)
[2021, 244:118554]

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Tipping the scales: how clinical assessment shapes the neural correlates of Parkinson's disease mild cognitive impairment.

Ignacio Aracil-Bolaños, Frederic Sampedro, Juan Marín-Lahoz, Andrea Horta-Barba, Saül Martínez-Horta, José María Gónzalez-de-Echávarri, Jesús Pérez-Pérez, Helena Bejr-Kasem, Berta Pascual-Sedano, Mariángeles Botí, Antonia Campolongo, Cristina Izquierdo, Alexandre Gironell, Beatriz Gómez-Ansón, Jaime Kulisevsky, Javier Pagonabarraga,

Mild cognitive impairment in Parkinson's disease (PD-MCI) is associated with consistent structural and functional brain changes. Whether different approaches for diagnosing PD-MCI are equivalent in their neural correlates is presently unknown. We aimed to profile the neuroimaging changes associated with the two endorsed methods of diagnosing PD-MCI. We recruited 53 ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2021, :]

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ILAE Neuroimaging Task Force Highlight: harnessing optimized imaging protocols for drug-resistant childhood epilepsy.

Sara Larivière, Paolo Federico, Yotin Chinvarun, Graeme Jackson, Victoria Morgan, Stefan Rampp, Anna Elisabetta Vaudano, Irene Wang, Fernando Cendes, Cyrus G Boelman, Andrea Bernasconi, Neda Bernasconi, Boris C Bernhardt, Dewi V Schrader,

The ILAE Neuroimaging Task Force aims to publish educational case reports highlighting basic aspects related to neuroimaging in epilepsy consistent with the educational mission of the ILAE. Previous quantitative MRI studies have established important imaging markers of epilepsy-related pathology, including features sensitive to hippocampal cell loss and reactive astrogliosis. Here, ... Read more >>

Epileptic Disord (Epileptic disorders : international epilepsy journal with videotape)
[2021, :]

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Psychiatric disorders in China: strengths and challenges of contemporary research and clinical services

Xiao Chang, Qiyong Gong, Chunbo Li, Weihua Yue, Xin Yu, Shuqiao Yao, Jianfeng Feng,

China accounts for 17% of the global disease burden attributable to mental, neurological and substance use disorders. As a country undergoing profound societal change, China faces growing challenges to reduce the disease burden caused by psychiatric disorders. In this review, we aim to present an overview of progress in neuroscience ... Read more >>

Psychol Med (Psychological medicine)
[0, 51(12):1978-1991]

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MR spectroscopy and diffusion imaging in people with human immunodeficiency virus: Relationships to clinical and immunologic findings.

Susan Morgello, Korhan Buyukturkoglu, Jacinta Murray, Mike Veenstra, Joan W Berman, Desiree Byrd, Matilde Inglese,

<h4>Background and purpose</h4>People with human immunodeficiency virus (HIV; PWH) present a complex array of immunologic and medical disorders that impact brain structure and metabolism, complicating the interpretation of neuroimaging. This pilot study of well-characterized multi-morbid PWH examined how medical and immunologic factors predicted brain characteristics on proton MR spectroscopy (1H-MRS) ... Read more >>

J Neuroimaging (Journal of neuroimaging : official journal of the American Society of Neuroimaging)
[2021, :]

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Informing the study of suicidal thoughts and behaviors in distressed young adults: The use of a machine learning approach to identify neuroimaging, psychiatric, behavioral, and demographic correlates.

Caroline W Oppenheimer, Michele Bertocci, Tsafrir Greenberg, Henry W Chase, Richelle Stiffler, Haris A Aslam, Jeanette Lockovich, Simona Graur, Genna Bebko, Mary L Phillips,

Young adults are at high risk for suicide, yet there is limited ability to predict suicidal thoughts and behaviors. Machine learning approaches are better able to examine a large number of variables simultaneously to identify combinations of factors associated with suicidal thoughts and behaviors. The current study used LASSO regression ... Read more >>

Psychiatry Res Neuroimaging (Psychiatry research. Neuroimaging)
[2021, 317:111386]

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Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis.

Maria N Zakharova, Anna A Abramova,

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive muscle wasting, breathing and swallowing difficulties resulting in patient's death in two to five years after disease onset. In amyotrophic lateral sclerosis, both upper and lower motor neurons of the corticospinal tracts are involved in the process of neurodegeneration, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):65-73]

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Intracortical surface-based MR diffusivity to investigate neurologic and psychiatric disorders: a review.

Frederic Sampedro, Jaime Kulisevsky,

Diffusion tensor imaging (DTI) allows the quantification of water diffusivity within the cerebral cortex. Alterations in cortical mean diffusivity (MD) have been suggested to reflect microstructural damage. Interestingly, microstructural changes can be detected in the absence of macrostructural alterations such as cortical thinning or gray matter volume loss. However, volume-based ... Read more >>

J Neuroimaging (Journal of neuroimaging : official journal of the American Society of Neuroimaging)
[2021, :]

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Linking Neighborhood Resources to Children's Brain Development: Risk, Resilience, and Open Questions.

Monica E Ellwood-Lowe,

Biol Psychiatry Cogn Neurosci Neuroimaging (Biological psychiatry. Cognitive neuroscience and neuroimaging)
[2021, 6(9):848-850]

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Optic nerve sheath diameter measurement by ultrasound: Evaluation of a standardized protocol.

Jakob Pansell, Max Bell, Peter Rudberg, Ola Friman, Charith Cooray,

Treatment of elevated intracranial pressure (ICP) is central to neurocritical care, but not all patients are eligible for invasive ICP-monitoring. A promising noninvasive option is ultrasound measurement of the optic nerve sheath diameter (ONSD). However, meta-analyses of ONSD for elevated ICP show wide confidence intervals. This might be due to ... Read more >>

J Neuroimaging (Journal of neuroimaging : official journal of the American Society of Neuroimaging)
[2021, :]

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Complementing canonical fMRI with functional Quantitative Susceptibility Mapping (fQSM) in modern neuroimaging research.

Marta Lancione, Mauro Costagli, Giacomo Handjaras, Michela Tosetti, Emiliano Ricciardi, Pietro Pietrini, Luca Cecchetti,

Functional Quantitative Susceptibility Mapping (fQSM) allows for the quantitative measurement of time-varying magnetic susceptibility across cortical and subcortical brain structures with a potentially higher spatial specificity than conventional fMRI. While the usefulness of fQSM with General Linear Model and "On/Off" paradigms has been assessed, little is known about the potential ... Read more >>

Neuroimage (NeuroImage)
[2021, 244:118574]

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Using OPMs to measure neural activity in standing, mobile participants: Neural responses in standing, mobile participants.

Robert A Seymour, Nicholas Alexander, Stephanie Mellor, George C O'Neill, Tim M Tierney, Gareth R Barnes, Eleanor A Maguire,

Optically pumped magnetometer-based magnetoencephalography (OP-MEG) can be used to measure neuromagnetic fields while participants move in a magnetically shielded room. Head movements in previous OP-MEG studies have been up to 20 cm translation and ∼30° rotation in a sitting position. While this represents a step-change over stationary MEG systems, naturalistic ... Read more >>

Neuroimage (NeuroImage)
[2021, :118604]

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(Un)common space in infant neuroimaging studies: a systematic review of infant templates

Alexander Dufford, Alice Hahn, Hannah Peterson, Silvia Gini, Saloni Mehta, Alexis Alfano, Dustin Scheinost,

In neuroimaging, spatial normalization is an important step that maps an individual’s brain onto a template brain permitting downstream statistical analyses. Yet, in infant neuroimaging, there remain several technical challenges that have prevented the establishment of a standardized template for spatial normalization. Thus, many different approaches are used in the ... Read more >>

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Deep learning methods improve polygenic risk analysis and prediction for Alzheimer’s disease

Xiaopu Zhou, Yu Chen, Fanny Ip, Yuanbing Jiang, Han Cao, Huan Zhong, Jiahang Chen, Tao Ye, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie Lo, Estella Tong, Alzheimer’s Disease Neuroimaging Initiative Alzheimer’s Dise Initiative, Vincent Mok, Timothy Kwok, Qihao Guo, Kin Mok, Maryam Shoai, John Hardy, Lei Chen, Amy Fu, Nancy Ip,

Recent advances in genetic sequencing have enabled comprehensive genetic analyses of human diseases, resulting in the identification of numerous genetic risk factors for heritable disorders including Alzheimer’s disease (AD). Such analyses enable AD risk prediction well before disease onset, which is critical for early interventions. However, current analytical approaches have ... Read more >>

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High School Sports-Related Concussion and the Effect of a Jugular Vein Compression Collar: A Prospective Longitudinal Investigation of Neuroimaging and Neurofunctional Outcomes.

Weihong Yuan, Jed A Diekfuss, Kim D Barber Foss, Jonathan A Dudley, James L Leach, Megan E Narad, Christopher A DiCesare, Scott Bonnette, Jeffery N Epstein, Kelsey Logan, Mekibib Altaye, Gregory D Myer,

Sports-related concussion (SRC) can exert serious acute and long-term consequences on brain microstructure, function, and behavioral outcomes. We aimed to quantify the alterations in white matter (WM) microstructure and global network organization, and the decrements in behavioral and cognitive outcomes from pre-season to post-concussion in youth athletes who experienced SRC. ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Association between neuroimaging findings and neurological sequelae in patients with congenital cytomegalovirus infection.

M Escobar Castellanos, S de la Mata Navazo, M Carrón Bermejo, M García Morín, Y Ruiz Martín, J Saavedra Lozano, M C Miranda Herrero, E Barredo Valderrama, P Castro de Castro, M Vázquez López,

<h4>Background</h4>Congenital cytomegalovirus (CMV) infection is an important cause of disability. There is little evidence on the prognostic value of lesions identified in neuroimaging studies.<h4>Aim</h4>The study aimed to assess the severity of lesions detected with brain MRI and transfontanellar ultrasound and their relationship with long-term neurological deficits.<h4>Patients and methods</h4>We performed a ... Read more >>

Neurologia (Engl Ed) (Neurologia (Barcelona, Spain))
[2021, :]

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Who benefits most from expectancy effects? A combined neuroimaging and antidepressant trial in depressed older adults.

Sigal Zilcha-Mano, Meredith L Wallace, Patrick J Brown, Joel Sneed, Steven P Roose, Bret R Rutherford,

Depressed patients' expectations of improvement drive placebo effects in antidepressant clinical trials, yet there is considerable heterogeneity in the magnitude of expectancy effects. The present study seeks to identify those individuals who benefit most from expectancy effects using baseline neuroimaging and cognitive measures. Older adult outpatients diagnosed with major depressive ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):475]

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Correction to: The Strategic Biomarker Roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological update.

Marina Boccardi, Alessandra Dodich, Emiliano Albanese, Angèle Gayet-Ageron, Cristina Festari, Nicholas J Ashton, Gérard N Bischof, Konstantinos Chiotis, Antoine Leuzy, Emma E Wolters, Martin Walter, Gil D Rabinovici, Maria Carrillo, Alexander Drzezga, Oskar Hansson, Agneta Nordberg, Rik Ossenkoppele, Victor L Villemagne, Bengt Winblad, Giovanni Frisoni, Valentina Garibotto,

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, :]

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Structural and functional brain changes in X-linked Charcot-Marie-Tooth disease: insights from a multimodal neuroimaging study.

Efstratios Karavasilis, Foteini Christidi, Eirini Pantou, Georgia Angelopoulou, Dimitrios Kasselimis, Marianthi Breza, Zoi Kontogeorgiou, Dimitrios Filippiadis, Constantin Potagas, Georgia Karadima, Georgios Koutsis, Georgios Velonakis,

<h4>Purpose</h4>Brain involvement in X-linked Charcot-Marie-Tooth disease (CMTX) has been previously reported. We studied the brain structural and functional integrity using a multimodal neuroimaging approach in patients with no current central nervous system (CNS) symptoms, in order to further delineate the disease's phenotype.<h4>Methods</h4>Seventeen CMTX patients with no current CNS symptoms and ... Read more >>

Neuroradiology (Neuroradiology)
[2021, :]

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