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Sorbitol and PKC1 overexpression alleviate temperature sensitivity in chaperonin mutants of Saccharomyces cerevisiae.

Aswathy Narayanan, M Anaul Kabir,

CCT (Chaperonin containing TCP-1) is a constitutively expressed eukaryotic chaperonin complex involved in the proper folding of proteins like actin and tubulin. Temperature sensitive mutants of CCT complex have been employed in various genetic screens, acting as models to study human CCT, the defects of which are implicated in disease ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Swimming exercise reduces native ⍺-synuclein protein species in a transgenic C. elegans model of Parkinson's disease.

Minna Y Schmidt, Manish Chamoli, Gordon J Lithgow, Julie K Andersen,

Exercise has been historically recommended to prevent many disease conditions. Intense exercise in particular, has been shown to be beneficial for Parkinson's disease (PD) - stopping and even reversing symptoms in some patients. Recent research in mammalian animal models of Parkinson's have shown that exercise affects ⍺-synuclein aggregate species, considered ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Rapid degeneration of Drosophila olfactory neurons in Orco mutant maxillary palps.

Darya Task, Christopher J Potter,

<i>Drosophila melanogaster</i> vinegar flies have two olfactory organs: the antenna and maxillary palp. Olfactory neurons in these tissues respond to odorants via odorant receptors. Insect odorant receptors are heterotetramers of two proteins: an odorant binding OrX subunit and an Odorant Receptor Co-Receptor (Orco). Mutation of <i>Orco</i> disrupts odorant receptor formation, ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Effects of blunt force injuries in third-instar Drosophila larvae persist through metamorphosis and reduce adult lifespan.

Jorgo Lika, Rebeccah J Katzenberger, Barry Ganetzky, David A Wassarman,

Blunt force injuries are a significant cause of disability and death worldwide. Here, we describe a <i>Drosophila melanogaster</i> model of blunt force injury that can be used to investigate cellular and molecular mechanisms that underlie the short-term and long-term effects of injuries sustained at a juvenile stage of development. Injuries ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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The conserved MASRPF motif in the Attractin homolog, Distracted, is required for association with Drosophila E3-ligase Mgrn1.

Vindhya Nawaratne, Sirisha Kudumala, Priyanka Prakash Kakad, Tanja A Godenschwege,

In rodents, all three paralogs of the Attractin (Atrn) transmembrane protein family exhibit strong phenotypic overlap and are implicated in the regulation of the same G-protein coupled receptors (GPCR) as E3-ligase Mahogunin ring finger 1 (Mgrn1). Recently it was shown that the highly conserved intracellular MASRPF motif in mammal Multiple ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress.

Veronica H Ryan, Anne C Hart,

Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between <i>sym-2</i>, the gene encoding an ortholog of hnRNPF and hnRNPH, and <i>hrpa-1</i>, the ortholog of of the gene encoding hnRNPA2, which when mutated ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Genetic interactions in a C. elegans sod-1 ALS model: glutamatergic neuron degeneration.

Jennifer F Osborne, Katherine S Yanagi, Anne C Hart,

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Anti-oxidant MitoQ rescue of AWB chemosensory neuron impairment in a C. elegans model of X-linked Adrenoleukodystrophy.

Sanjib Guha, Aurora Pujol, Esther Dalfo,

X-linked Adrenoleukodystrophy (X-ALD) is a neurometabolic disorder caused by a defective peroxisomal ABCD1 transporter of very long-chain fatty acids (VLCFAs). We have characterized a nematode model of X-ALD with loss of the <i>pmp-4</i> gene, the worm orthologue of <i>ABCD1</i>. These mutants recapitulated the key hallmarks of X-ALD and importantly mitochondria ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer's disease Causes Activation of the Mitochondrial Unfolded Protein Response in C. elegans touch neurons.

Sanjib Guha, Sarah Fischer, Anson Cheng, Gail V W Johnson, Keith Nehrke,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans: Integration.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans III.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 1 time

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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans II.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 1 time

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Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases.

Huifangjie Li, William C Knight, Jinbin Xu,

Neurodegenerative diseases are a class of chronic and complex disorders featuring progressive loss of neurons in distinct brain areas. The mechanisms responsible for the disease progression in neurodegeneration are not fully illustrated. In this observational study, we have examined diverse biochemical parameters in the caudate and putamen of patients with ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):867-874]

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Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration.

Alexis D Rickman, Addison Hilyard, Bradlee L Heckmann,

Neuroinflammation and neurodegeneration are key components in the establishment and progression of neurodegenerative diseases including Alzheimer's Disease (AD). Over the past decade increasing evidence is emerging for the use of components of the canonical autophagy machinery in pathways that are characterized by LC3 lipidation yet are distinct from traditional macro-autophagy. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):246-250]

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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration.

Manuel A Fernandez-Parrilla, David Reyes-Corona, Yazmin M Flores-Martinez, Rasajna Nadella, Michael J Bannon, Lourdes Escobedo, Minerva Maldonado-Berny, Jaime Santoyo-Salazar, Luis O Soto-Rojas, Claudia Luna-Herrera, Jose Ayala-Davila, Juan A Gonzalez-Barrios, Gonzalo Flores, Maria E Gutierrez-Castillo, Armando J Espadas-Alvarez, Irma A Martínez-Dávila, Porfirio Nava, Daniel Martinez-Fong,

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system, a hallmark in Parkinson's disease. The human cerebral dopamine neurotrophic factor (hCDNF) has recently emerged as a strong candidate for Parkinson's disease therapy. This study shows that hCDNF expression in ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):854-866]

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The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson's disease.

Jing Wang, Xiao-Na Zhang, Jin-Ni Fang, Fei-Fei Hua, Jing-Yang Han, Zeng-Qiang Yuan, An-Mu Xie,

Previous studies have shown that the ATP-P2X4 receptor signaling pathway mediates the activation of the Nod-like receptor family protein 3 (NLRP3) inflammasome. The NLRP3 inflammasome may promote renal interstitial inflammation in diabetic nephropathy. As inflammation also plays an important role in the pathogenesis of Parkinson's disease, we hypothesized that the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):898-904]

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Heat shock factor 1 is a direct anti-amyloid factor: connecting neurodegeneration and uncontrolled growth.

Zijian Tang, Chengkai Dai,

Neural Regen Res (Neural regeneration research)
[2022, 17(3):559-560]

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Circulating extracellular vesicles: friends and foes in neurodegeneration.

Anna Picca, Flora Guerra, Riccardo Calvani, Hélio José Coelho-Junior, Cecilia Bucci, Emanuele Marzetti,

Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):534-542]

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Profile of the RNA in exosomes from astrocytes and microglia using deep sequencing: implications for neurodegeneration mechanisms.

Hui-Min Xie, Xing Su, Feng-Yuan Zhang, Chao-Lun Dai, Rong-Hua Wu, Yan Li, Xiao-Xiao Han, Xing-Mei Feng, Bin Yu, Shun-Xing Zhu, Song-Lin Zhou,

Glial cells play an important role in signal transduction, energy metabolism, extracellular ion homeostasis and neuroprotection of the central nervous system. However, few studies have explained the potential effects of exosomes from glial cells on central nervous system health and disease. In this study, the genes expressed in exosomes from ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):608-617]

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Transcranial magnetic stimulation in animal models of neurodegeneration.

Mohammad Uzair, Turki Abualait, Muhammad Arshad, Woo-Kyoung Yoo, Ali Mir, Reem Fahd Bunyan, Shahid Bashir,

Brain stimulation techniques offer powerful means of modulating the physiology of specific neural structures. In recent years, non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, have emerged as therapeutic tools for neurology and neuroscience. However, the possible repercussions of these techniques remain unclear, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):251-265]

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Neurological susceptibility to environmental exposures: pathophysiological mechanisms in neurodegeneration and multiple chemical sensitivity.

John Molot, Margaret Sears, Lynn Margaret Marshall, Riina I Bray,

The World Health Organization lists air pollution as one of the top five risks for developing chronic non-communicable disease, joining tobacco use, harmful use of alcohol, unhealthy diets and physical inactivity. This review focuses on how host defense mechanisms against adverse airborne exposures relate to the probable interacting and overlapping ... Read more >>

Rev Environ Health (Reviews on environmental health)
[2021, :]

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Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis.

Yan Lu, Qi Shan, Mei Ling, Xi-An Ni, Su-Su Mao, Bin Yu, Qian-Qian Cao,

Peripheral nerve injury repair requires a certain degree of cooperation between axon regeneration and Wallerian degeneration. Therefore, investigating how axon regeneration and degeneration work together to repair peripheral nerve injury may uncover the molecular mechanisms and signal cascades underlying peripheral nerve repair and provide potential strategies for improving the low ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):911-919]

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Nuclear sphingomyelin in neurodegenerative diseases.

Elisabetta Albi, Alice V Alessenko,

Neural Regen Res (Neural regeneration research)
[2021, 16(10):2028-2029]

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The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline.

Nira Cedres, Patricia Diaz-Galvan, Lucio Diaz-Flores, J-Sebastian Muehlboeck, Yaiza Molina, José Barroso, Eric Westman, Daniel Ferreira,

<h4>Aims</h4>To investigate the interplay between gray matter (GM) and white matter (WM) neurodegeneration in subjective cognitive decline (SCD), including thickness across the whole cortical mantle, hippocampal volume, and integrity across the whole WM.<h4>Methods</h4>We included 225 cognitively unimpaired individuals from a community-based cohort. Subjective cognitive complaints were assessed through 9 questions ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(16):19963-19977]

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Neurovascular ageing: transcriptomic readout and implications on therapeutic targeting in Alzheimer's disease.

Zhongqi Li, Bonaventure Ip, Vincent C T Mok, Ho Ko,

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2411-2412]

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