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Neurocognition

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Cerebrospinal Fluid Norepinephrine and Neurocognition in HIV and Methamphetamine Dependence.

Rowan Saloner, Mariana Cherner, Jennifer E Iudicello, Robert K Heaton, Scott L Letendre, Ronald J Ellis,

OBJECTIVE:HIV disease and methamphetamine (METH) dependence share overlapping mechanisms of neurotoxicity that preferentially compromise monoamine-rich frontostriatal circuitry. However, norepinephrine (NE) function is poorly understood in HIV and METH dependence. We evaluated associations between cerebrospinal fluid (CSF) NE and HIV, METH dependence, and neurocognition. METHODS:Participants included 125 adults, stratified by HIV ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 85(2):e12-e22]

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The impact of neurocognition on mentalizing in euthymic bipolar disorder versus schizophrenia.

George Konstantakopoulos, Nikoleta Ioannidi, Constantin Psarros, Panayiotis Patrikelis, Pentagiotissa Stefanatou, Eugenia Kravariti,

Introduction: Theory of mind (ToM) or mentalizing deficits have been found in schizophrenia (SZ) and bipolar disorder (BD), but their relationships to patients' coexistent neurocognitive deficits are still unclear. The present study aimed to explore the possible differential involvement of neurocognitive deficits in ToM impairments in SZ and euthymic BD. ... Read more >>

Cogn Neuropsychiatry (Cognitive neuropsychiatry)
[2020, :1-16]

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Dual antiretroviral therapies are effective and safe regimens in the central nervous system of neurologically symptomatic people living with HIV.

Mattia Trunfio, Walter Rugge, Lorenzo Mighetto, Daniela Vai, Cristiana Atzori, Marco Nigra, Simone Domini, Enrica Borgogno, Giulia Guastamacchia, Stefano Bonora, Giovanni Di Perri, Andrea Calcagno,

OBJECTIVE:Aim of this study was to compare cerebrospinal fluid (CSF) virological control, biomarkers and neurocognition of neurologically symptomatic patients on dual antiretroviral therapies (dual therapy) vs. 2 nucleoside reverse transcriptase inhibitors-based three-drug regimens (triple therapy). DESIGN:Retrospective monocentric cross-sectional study. METHODS:We analysed data from people living with HIV undergoing lumbar puncture ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(13):1899-1906]

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Objective and subjective sleep measures are associated with neurocognition in aging adults with and without HIV.

Laura M Campbell, Maulika Kohli, Ellen E Lee, Christopher N Kaufmann, Michael Higgins, Jeremy D Delgadillo, Robert K Heaton, Mariana Cherner, Ronald J Ellis, David J Moore, Raeanne C Moore,

OBJECTIVE:Poor sleep quality is related to worse neurocognition in older adults and in people with HIV (PWH); however, many previous studies have relied only on self-report sleep questionnaires, which are inconsistently correlated with objective sleep measures. We examined relationships between objective and subjective sleep quality and neurocognition in persons with ... Read more >>

Clin Neuropsychol (The Clinical neuropsychologist)
[2020, :1-20]

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Modelling change in neurocognition, symptoms and functioning in young people with emerging mental disorders.

Jacob J Crouse, Kate M Chitty, Django White, Rico S C Lee, Ahmed A Moustafa, Sharon L Naismith, Jan Scott, Daniel F Hermens, Ian B Hickie,

Mental disorders and their functional impacts evolve dynamically over time. Neurocognition and clinical symptoms are commonly modelled as predictors of functioning, however, studies tend to rely on static variables and adult samples with chronic disorders, with limited research investigating change in these variables in young people with emerging mental disorders. ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2020, 131:22-30]

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Is There Any Evidence of Premature, Accentuated and Accelerated Aging Effects on Neurocognition in People Living with HIV? A Systematic Review.

Htein Linn Aung, Maral Aghvinian, Hetta Gouse, Reuben N Robbins, Bruce J Brew, Limin Mao, Lucette A Cysique,

Despite evidence of premature, accentuated and accelerated aging for some age-related conditions such as cardiovascular diseases in people living with HIV (PLHIV), the evidence for these abnormal patterns of aging on neurocognition remains unclear. Further, no systematic review has been dedicated to this issue. Using PRISMA guidelines, we searched standard ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, :]

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The neurocognitive effects of a past cannabis use disorder in a diverse sample of people living with HIV.

Cara L Crook, Micah J Savin, Desiree Byrd, Angela C Summers, Vanessa A Guzman, Emily P Morris, Kayla Tureson, Maral Aghvinian, Heining Cham, Monica Rivera Mindt,

People living with HIV (PLWH) report higher rates of cannabis use than the general population, a trend likely to continue in light of recent policy changes and the reported therapeutic benefits of cannabis for PLWH. Therefore, it is important to better understand cannabis-associated effects on neurocognition, especially as PLWH are ... Read more >>

AIDS Care (AIDS care)
[2020, :1-10]

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Predictors of social and role outcomes in first episode psychosis: A prospective 12-month study of social cognition, neurocognition and symptoms.

Sian Lowri Griffiths, Max Birchwood, Aneela Khan, Stephen J Wood,

BACKGROUND:Poor functioning is common in psychosis, with predictors of poor outcome including negative symptoms and deficits in neurocognition (NC) and social cognition (SC). The extent to which these variables contribute unique variance in social and role trajectories remains inconclusive. Identifying robust predictors of outcome will inform targeted interventions in early ... Read more >>

Early Interv Psychiatry (Early intervention in psychiatry)
[2020, :]

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Hierarchical Pathways from Sensory Processing to Cognitive, Clinical, and Functional Impairments in Schizophrenia.

Daisuke Koshiyama, Michael L Thomas, Makoto Miyakoshi, Yash B Joshi, Juan L Molina, Kumiko Tanaka-Koshiyama, Joyce Sprock, David L Braff, Neal R Swerdlow, Gregory A Light,

Cognitive impairment is a hallmark of schizophrenia and a robust predictor of functional outcomes. Impairments are found in all phases of the illness and are only moderately attenuated by currently approved therapeutics. Neurophysiological indices of sensory discrimination (ie, mismatch negativity (MMN) and P3a amplitudes) and gamma-band auditory steady-state response (ASSR; ... Read more >>

(Schizophrenia bulletin)
[2020, :]

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Suicide Ideation and Neurocognition Among 9- and 10-Year Old Children in the Adolescent Brain Cognitive Development (ABCD) Study.

Rebekah S Huber, Chandni Sheth, Perry F Renshaw, Deborah A Yurgelun-Todd, Erin C McGlade,

OBJECTIVE:During the past decade, the pediatric suicide rate has nearly tripled. Yet, little is known about suicide behavior (SB) in children. Identification of risk factors associated with SB during childhood may be critical to preventing future attempts. The purpose of this study was to examine the relationship between neurocognitive performance ... Read more >>

Arch Suicide Res (Archives of suicide research : official journal of the International Academy for Suicide Research)
[2020, :1-15]

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Randomised controlled trial of Compensatory Cognitive Training and a Computerised Cognitive Remediation programme.

Frances Dark, Ellie Newman, Victoria Gore-Jones, Veronica De Monte, Marta I Garrido, Ilvana Dzafic,

BACKGROUND:Compensation and adaptation therapies have been developed to improve community functioning via improving neurocognitive abilities in people with schizophrenia. Various modes of delivering compensation and adaptation therapies have been found to be effective. The aim of this trial is to compare two different cognitive interventions, Compensatory Cognitive Training (CCT) and ... Read more >>

Trials (Trials)
[2020, 21(1):810]

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Asymptomatic Malaria Co-infection of HIV-infected Adults in Nigeria: Prevalence of and Impact on Cognition, Mood and Biomarkers of Systemic Inflammation.

Ajay R Bharti, J Allen McCutchan, Anya Umlauf, Oluwakemi K Okwuegbuna, Scott Letendre, Mariana Cherner, Tricia Burdo, Jibreel Jumare, Kenneth Williams, William Blattner, Walter Royal,

BACKGROUND:HIV and malaria are associated with immunological perturbations and neurocognitive disorders even when asymptomatic. However, the effect of asymptomatic malaria (AM) in HIV-infected adults on neurocognitive impairment (NCI) is not well understood. This study investigated the biomarkers of systemic inflammation and neurocognition in dually-infected Nigerian adults. METHODS:We assessed the HIV ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, :]

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Impact of emotionally negative information on attentional processes in normal aging and Alzheimer's disease.

Jessica Bourgin, Laetitia Silvert, Céline Borg, Alexandrine Morand, Mathilde Sauvée, Olivier Moreaud, Pascal Hot,

Impairments of emotional processing have been reported in Alzheimer's disease (AD), consistently with the existence of early amygdala atrophy in the pathology. In this study, we hypothesized that patients with AD might show a deficit of orientation toward emotional information under conditions of visual search. Eighteen patients with AD, 24 ... Read more >>

Brain Cogn (Brain and cognition)
[2020, 145:105624]

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Depressive Symptoms Differentially Predict Neurocognition in Latinx and Non-Hispanic White People Living with HIV.

Emily P Morris, Desiree Byrd, Angela C Summers, Kayla Tureson, Vanessa Guzman, Cara L Crook, Monica Rivera Mindt,

OBJECTIVES:Depression is common in people living with HIV (PLWH) and can contribute to neurocognitive dysfunction. Depressive symptoms in PLWH are often measured by assessing only cognitive/affective symptoms. Latinx adults, however, often express depressive symptoms in a somatic/functional manner, which is not typically captured in assessments of depression among PLWH. Given ... Read more >>

J Int Neuropsychol Soc (Journal of the International Neuropsychological Society : JINS)
[2020, :1-12]

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Modelling of self-management in schizophrenia: The role of neurocognition, self-efficacy and motivation.

Chenxi Zhou, Zheng Li,

AIMS AND OBJECTIVES:This study aimed to address the interrelationships among neurocognition, self-efficacy, motivation and self-management in individuals with schizophrenia. BACKGROUND:Self-management performance of individuals with schizophrenia is relatively poor. The effect of neurocognitive impairment on self-management in schizophrenia remains inconsistent, which may be attributed to the neglect of possible mediating factors. ... Read more >>

J Clin Nurs (Journal of clinical nursing)
[2020, :]

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Can sex influence the neurocognition of language? Evidence from Parkinson's disease.

Jana Reifegerste, Ivy V Estabrooke, Lauren E Russell, João Veríssimo, Karim Johari, Barbara Wilmarth, Fernando L Pagan, Charbel Moussa, Michael T Ullman,

Parkinson's disease (PD), which involves basal ganglia degeneration, affects language as well as motor function. However, which aspects of language are impaired in PD and under what circumstances remain unclear. We examined whether lexical and grammatical aspects of language are differentially affected in PD, and whether this dissociation is moderated ... Read more >>

Neuropsychologia (Neuropsychologia)
[2020, :107633]

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Effectiveness of cognitive remediation in the ultra-high risk state for psychosis.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

(World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):401-402]

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The Effects of Low-Risk Drinking on Neurocognition Among Older Persons Living With HIV as Compared to Those Without HIV.

Maulika Kohli, Emily W Paolillo, Rowan Saloner, Anya Umlauf, Ronald Ellis, David J Moore,

BACKGROUND:Heavy alcohol use negatively impacts neurocognition, but some studies report neurocognitive benefits associated with light drinking among HIV-seronegative (HIV-) older persons, suggesting a nonlinear or an inverted "J-shaped" association of alcohol consumption on neurocognition. Alcohol use is common among people with HIV (PWH); however, the association between recent "low-risk" alcohol ... Read more >>

Alcohol Clin Exp Res (Alcoholism, clinical and experimental research)
[2020, 44(7):1389-1399]

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The association of metacognition with emotion recognition and perspective taking in a Russian sample with psychosis.

Paul H Lysaker, Nikita Chernov, Tatyana Moiseeva, Marta Sozinova, Nadezhda Dmitryeva, Vitaliy Alyoshin, Marina Kukla, Courtney Wiesepape, Olga Karpenko, Georgiy Kostyuk,

OBJECTIVE:Schizophrenia may reflect an interactive network of disturbances in cognition. In this study we have examined the relationship between two forms of cognition: metacognition and social cognition among a sample with schizophrenia (n = 41), early episode psychosis (n = 37), and major depression (n = 30) gathered in Moscow, Russia. METHODS:Metacognition was assessed with the ... Read more >>

J Clin Psychol (Journal of clinical psychology)
[2020, :]

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Overconfidence in social cognitive decision making: Correlations with social cognitive and neurocognitive performance in participants with schizophrenia and healthy individuals.

Michelle M Perez, Bianca A Tercero, David L Penn, Amy E Pinkham, Philip D Harvey,

It has been reported that people with schizophrenia are frequently overconfident relative to their performance, a trait observed in healthy individuals as well. In schizophrenia, impaired self-assessments have been found to be associated with functional impairments in various domains. Previous studies examining the correlation of overconfidence and task performance within ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, :]

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Neurocognition and the Suicidal Process.

S B Rutter, N Cipriani, E C Smith, E Ramjas, D H Vaccaro, M Martin Lopez, W R Calabrese, D Torres, P Campos-Abraham, M Llaguno, E Soto, M Ghavami, M M Perez-Rodriguez,

Early thinking about cognitive process and suicidal behaviors tended to focus on the immediate situation surrounding the individual - typically the underlying psychiatric condition that was seen as leading to his or her distress. However, we now know that the cognitive processes involved in a range of suicidal thoughts and ... Read more >>

Curr Top Behav Neurosci (Current topics in behavioral neurosciences)
[2020, :]

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Role of anxiety, depression and neurocognition for cognitive behavioural therapy pre-therapy skills in people living with dementia, older and younger adults✰.

Joshua Stott, Tim Cadman, Katrina Scior, Janina Brede, Georgina Charlesworth,

BACKGROUND:Anxiety and depression are common in people living with dementia (PLWD) and Cognitive behavioural therapy (CBT) seems to be one of the few efficacious interventions. However, PLWD's ability to engage with CBT has been questioned due to the presumed impact of neurocognitive impairment on core skills necessary to engage with ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 276:1022-1029]

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Reading the Mind in the Eyes Test: Relationship with Neurocognition and Facial Emotion Recognition in Non-Clinical Youths.

Eunchong Seo, Se Jun Koo, Ye Jin Kim, Jee Eun Min, Hye Yoon Park, Minji Bang, Eun Lee, Suk Kyoon An,

OBJECTIVE:The Reading the Mind in the Eyes Test (RMET) is a common measure of the Theory of Mind. Previous studies found a correlation between RMET performance and neurocognition, especially reasoning by analogy; however, the nature of this relationship remains unclear. Additionally, neurocognition was shown to play a significant role in ... Read more >>

Psychiatry Investig (Psychiatry investigation)
[2020, 17(8):835-839]

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Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis.

Alison McLaverty, Kelly A Allott, Maximus Berger, Rob Hester, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schäfer, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric Y H Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, G Paul Amminger,

BACKGROUND:Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations. METHOD:Erythrocyte levels of total omega-3-and ... Read more >>

Early Interv Psychiatry (Early intervention in psychiatry)
[2020, :]

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Cumulative Burden of Depression and Neurocognitive Decline Among Persons With HIV: A Longitudinal Study.

Emily W Paolillo, Elizabeth C Pasipanodya, Raeanne C Moore, Brian W Pence, Joseph Hampton Atkinson, David J Grelotti, Igor Grant, Robert K Heaton, David J Moore,

BACKGROUND:Higher cumulative burden of depression among people with HIV (PWH) is associated with poorer health outcomes; however, longitudinal relationships with neurocognition are unclear. This study examined hypotheses that among PWH, (1) higher cumulative burden of depression would relate to steeper declines in neurocognition, and (2) visit-to-visit depression severity would relate ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 84(3):304-312]

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