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Neuroblastoma

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MicroRNA-145 overexpression inhibits neuroblastoma tumorigenesis in vitro and in vivo.

Jing Zhao, Kai Zhou, Liang Ma, Huanyu Zhang,

Neuroblastoma (NB) is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). It is well known that miR-145 functions as a tumor suppressor in several types of cancer. However, the impact of miR-145 ... Read more >>

Bioengineered (Bioengineered)
[2020, 11(1):219-228]

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Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease.

Gaia Fancellu, Karam Chand, Daniel Tomás, Elisabetta Orlandini, Luca Piemontese, Diana F Silva, Sandra M Cardoso, Sílvia Chaves, M Amélia Santos,

Pursuing the widespread interest on multi-target drugs to combat Alzheimer´s disease (AD), a new series of hybrids was designed and developed based on the repositioning of the well-known acetylcholinesterase (AChE) inhibitor, tacrine (TAC), by its coupling to benzofuran (BF) derivatives. The BF framework aims to endow the conjugate molecules with ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):211-226]

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Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer's disease.

Jie Fu, Fengqi Bao, Min Gu, Jing Liu, Zhipeng Zhang, Jiaoli Ding, Sai-Sai Xie, Jinsong Ding,

A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment of AD. Most of these compounds exhibited strong and clearly selective inhibition to eeAChE. Among them, compound 4c was identified as the most potent inhibitor to both eeAChE and hAChE ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):118-128]

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Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus).

Mariella E Güere, Jørn Våge, Helene Tharaldsen, Sylvie L Benestad, Turid Vikøren, Knut Madslien, Petter Hopp, Christer M Rolandsen, Knut H Røed, Michael A Tranulis,

The emergence of CWD in Europe in 2016 and the first natural infection in wild reindeer warranted disease management. This led to the testing of 2424 hunted or culled reindeer during 2016-2018, from the infected subpopulation in the Nordfjella mountain range in Southern Norway. To identify any association between PRNP ... Read more >>

Prion (Prion)
[2020, 14(1):1-10]

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Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase.

Mikhail Krasavin, Raivis Žalubovskis, Aiga Grandāne, Ilona Domračeva, Petr Zhmurov, Claudiu T Supuran,

The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and - hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia and oxidative stress, may both ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):506-510]

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Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation.

Su Hwan Bae, Mi Ran Yoo, Ye Yeong Kim, In Kyung Hong, Mi Hee Kim, Seung Hak Lee, Dae Yul Kim,

Macrophage migration inhibitory factor (MIF) is a chemokine that plays an essential role in immune system function. Previous studies suggested that MIF protects neurons in ischemic conditions. However, few studies are reported on the role of MIF in neurological recovery after ischemic stroke. The purpose of this study is to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1483-1489]

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The N-formyl peptide receptors: contemporary roles in neuronal function and dysfunction.

Peter J G Cussell, Margarita Gomez Escalada, Nathaniel G N Milton, Andrew W J Paterson,

N-formyl peptide receptors (FPRs) were first identified upon phagocytic leukocytes, but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor family. FPRs are expressed within neuronal tissues and markedly in the central nervous system, where FPR interactions with endogenous ligands have been implicated ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1191-1198]

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A mimetic peptide of α2,6-sialyllactose promotes neuritogenesis.

Shuang-Xi Chen, Jia-Hui He, Yong-Jian Mi, Hui-Fan Shen, Melitta Schachner, Wei-Jiang Zhao,

Oxidative stress contributes to the pathogenesis of neurodegenerative diseases. With the aim to find reagents that reduce oxidative stress, a phage display library was screened for peptides mimicking α2,6-sialyllactose (6'-SL), which is known to beneficially influence neural functions. Using Sambucus nigra lectin, which specifically binds to 6'-SL, we screened a ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1058-1065]

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EWSR1(22q12) Translocation Positive Pediatric Adrenal Tumor with Loss of 1p, 11q, and Unbalanced Gain of 17q: Neuroblastoma or Ewing Sarcoma?

Mehmet Azizoglu, Ugur Demirsoy, Ibrahim Kulac, Safiye Aktas, Funda Çorapcioglu,

Background: Although neuroblastoma and Ewing sarcoma/Primitive neuroectodermal tumor are different clinical entities, they are both a member of small round blue cell tumors and can mimic each other's behavior in clinical and molecular aspects. Case report: A 3 year-old girl with an abdominal mass was found to have a small round ... Read more >>

Fetal Pediatr Pathol (Fetal and pediatric pathology)
[2020, :1-6]

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A Scientometric Analysis of Neuroblastoma Research

Illya Martynov, Jessica Klima-Frysch, Joachim Schoenberger,

<title>Abstract</title> <p> Background: Thousands of research articles on neuroblastoma have been published over the past few decades; however, the heterogeneity and variable quality of scholarly data may challenge scientists or clinicians to survey all of the available information. Hence, holistic measurement and analyzation of neuroblastoma-related literature with the ... Read more >>

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Association of MYC gene polymorphisms with neuroblastoma risk in Chinese children: A four-center case-control study.

Jing Pan, Jinhong Zhu, Mi Wang, Tianyou Yang, Chao Hu, Jiliang Yang, Jiao Zhang, Jiwen Cheng, Haixia Zhou, Huimin Xia, Jing He, Yan Zou,

BACKGROUND:Neuroblastoma is one of the most common malignant tumors in childhood. Polymorphisms in proto-oncogene MYC are implicated in many cancers, although their role in neuroblastoma remains unclear. In the present study, we attempted to investigate the association between MYC gene polymorphisms and neuroblastoma susceptibility in Chinese children. METHODS:We included two ... Read more >>

J Gene Med (The journal of gene medicine)
[2020, :e3190]

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Schwann cell plasticity regulates neuroblastic tumor cell differentiation

Tamara Weiss, Sabine Taschner-Mandl, Andrea Bileck, Fikret Rifatbegovic, Helena Sorger, Max Kauer, Christian Frech, Reinhard Windhager, Christopher Gerner, Peter Ambros, Inge Ambros,

ABSTRACT The remarkable plasticity of Schwann cells (SCs) enables the acquisition of repair-specific functions essential for peripheral nerve regeneration. We hypothesized that this plastic potential is manifested in stromal SCs found within mostly benign-behaving peripheral neuroblastic tumors. To shed light on the cellular state and impact of stromal SCs, we ... Read more >>

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Descriptive and prognostic value of a computational model of metastasis in high-risk neuroblastoma

Sebastien Benzekry, Coline Sentis, Carole Coze, Laetitia Tessonnier, Nicolas Andre,

High Risk Neuroblastoma (HRNB) is the second most frequent solid tumor in children. Prognosis remains poor despite multimodal therapies. Mathematical models have been developed to describe metastasis, but their prognosis value has yet to be determined and none exists in neuroblastoma. We established such a model for HRNB relying on ... Read more >>

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A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma.

Marianna Szemes, Zsombor Melegh, Jacob Bellamy, Alexander Greenhough, Madhu Kollareddy, Daniel Catchpoole, Karim Malik,

The Wnt and bone morphogenetic protein (BMP) signaling pathways are known to be crucial in the development of neural crest lineages, including the sympathetic nervous system. Surprisingly, their role in paediatric neuroblastoma, the prototypic tumor arising from this lineage, remains relatively uncharacterised. We previously demonstrated that Wnt/b-catenin signaling can have ... Read more >>

Cells (Cells)
[2020, 9(3):]

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Ginkgo biloba Prevents Oxidative Stress-Induced Apoptosis Blocking p53 Activation in Neuroblastoma Cells.

Francesco Di Meo, Rossana Cuciniello, Sabrina Margarucci, Paolo Bergamo, Orsolina Petillo, Gianfranco Peluso, Stefania Filosa, Stefania Crispi,

Oxidative stress has been associated to neuronal cell loss in neurodegenerative diseases. Neurons are post-mitotic cells that are very sensitive to oxidative stress-especially considering their limited capacity to be replaced. Therefore, reduction of oxidative stress, and inhibiting apoptosis, will potentially prevent neurodegeneration. In this study, we investigated the neuroprotective effect ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2020, 9(4):]

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Iodine-131 metaiodobenzylguanidine (131I-mIBG) treatment in relapsed/refractory neuroblastoma.

Yoch Anongpornjossakul, Wattanun Sriwatcharin, Kanungnij Thamnirat, Wichana Chamroonrat, Arpakorn Kositwattanarerk, Chirawat Utamakul, Chanika Sritara, Payap Chokesuwattanasakul, Nintita Sripaiboonkij Thokanit, Samart Pakakasama, Usanarat Anurathapan, Pongpak Pongphitcha, Chanisa Chotipanich, Suradej Hongeng,

BACKGROUND:I-meta-iodo-benzylguanidine (I-mIBG) therapy has been used in treatment of for advanced neuroblastoma for many years with promising results. There are several studies regarding predictors and outcomes of I-mIBG therapies in relapsed/refractory neuroblastoma patients. OBJECTIVE:To identify the predictors and outcomes of I-mIBG treatment in relapsed/refractory neuroblastoma. METHODS:This study was a retrospective ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2020, 41(4):336-343]

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Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma.

Xinyao Meng, Erhu Fang, Xiang Zhao, Jiexiong Feng,

BACKGROUND:The association between long noncoding RNAs (lncRNAs) and spontaneous regression of neuroblastoma (NB) has rarely been investigated and remains unknown. OBJECTIVE:To identify prognostic lncRNAs involved in the spontaneous regression of NB. METHODS:Differential expression analyses were performed between those samples with an outcome of death in stage 4 NB group and ... Read more >>

Cancer Med (Cancer medicine)
[2020, :]

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A direct comparison of selective BH3-mimetics reveals BCL-XL, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma.

Annika Bierbrauer, Maureen Jacob, Meike Vogler, Simone Fulda,

BACKGROUND:Despite advances in the treatment of neuroblastoma, patients with high-risk disease still have dismal survival prognosis. Neuroblastoma cells display elevated expression of the antiapoptotic BCL-2 proteins, suggesting that BH3-mimetics may be a promising treatment option. Here, we investigated the role of BCL-2, BCL-XL and MCL-1 in neuroblastoma. METHODS:A panel of ... Read more >>

Br. J. Cancer (British journal of cancer)
[2020, :]

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The Complementary Role of 68Ga-DOTATATE PET/CT in Neuroblastoma.

Tuğçe Telli, Eser Lay Ergün, Bilge Volkan Salanci, Pinar Özgen Kiratli,

A girl diagnosed with neuroblastoma at 33 months underwent I-MIBG scan after surgery and chemoradiotherapy. Although MIBG scan showed complete response, the bone marrow biopsy showed refractory disease. Therefore, she underwent Ga-DOTATATE PET/CT, which revealed bone marrow involvement and Ga-DOTATATE-avid brain metastasis. Rare physiological pineal gland uptake was also depicted. ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2020, 45(4):326-329]

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MYCN Silencing by RNA Interference Induces Neurogenesis and Suppresses Proliferation in Models of Neuroblastoma with Resistance to Retinoic Acid.

Ruhina Maeshima, Dale Moulding, Andrew W Stoker, Stephen L Hart,

Neuroblastoma (NB) is the most common solid tumor in childhood. Twenty percent of patients display MYCN amplification, which indicates a very poor prognosis. MYCN is a highly specific target for an NB tumor therapy as MYCN expression is absent or very low in most normal cells, while, as a transcription ... Read more >>

Nucleic Acid Ther (Nucleic acid therapeutics)
[2020, :]

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Lysosomal Dysfunction and Autophagy Blockade Contribute to MDMA-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells.

I-Hsun Li, Jui-Hu Shih, Ting-Yin Yeh, Hung-Che Lin, Ming-Hua Chen, Yuahn-Sieh Huang,

Methylenedioxymethamphetamine (MDMA) is a psychostimulant with high abuse potential and severe neurotoxicity. According to our previous study, MDMA promotes autophagosome accumulation and contributes to cell death in cultured cortical and serotonergic neurons. However, the detailed mechanism underlying autophagy dysfunction remains unclear. Lysosomes play an important role in autophagic degradation. The ... Read more >>

Chem. Res. Toxicol. (Chemical research in toxicology)
[2020, :]

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Autologous stem cell transplant for high-risk neuroblastoma: Achieving cure with low-cost adaptations.

Richa Jain, Rekha Hans, Sidharth Totadri, Amita Trehan, Ratti Ram Sharma, Prema Menon, Rakesh Kapoor, Akshay Kumar Saxena, Bhagwant Rai Mittal, Prateek Bhatia, Nandita Kakkar, Radhika Srinivasan, Arvind Rajwanshi, Neelam Varma, Ram Samujh, Neelam Marwaha, Deepak Bansal,

BACKGROUND: The majority of patients in low- and middle-income countries (LMIC) are unable to receive optimal therapy, including autologous stem cell transplant (ASCT) for high-risk neuroblastoma. Management is intensive and multidisciplinary; survival is often poor. We report a single-center outcome of high-risk neuroblastoma, with adaptations optimized for LMIC. PROCEDURE: The study was ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28273]

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Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells.

Santa Cirmi, Marilena Celano, Giovanni Enrico Lombardo, Valentina Maggisano, Antonio Procopio, Diego Russo, Michele Navarra,

Several studies published in the last decade suggest that the beneficial role of extra-virgin olive oil (EVOO) in human health is mostly attributable to the main secoiridoid derivatives (oleuropein, oleocanthal, and oleacein). Anti-cancer properties have also been demonstrated for certain compounds present in small quantities in EVOO, including oleuropein and ... Read more >>

Food Funct (Food & function)
[2020, :]

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High-dose 131I-metaiodobenzylguanidine therapy in patients with high-risk neuroblastoma in Japan.

Daiki Kayano, Hiroshi Wakabayashi, Kenichi Nakajima, Rie Kuroda, Satoru Watanabe, Anri Inaki, Ayane Toratani, Norihito Akatani, Takafumi Yamase, Yuji Kunita, Tomo Hiromasa, Aki Takata, Hiroshi Mori, Shintaro Saito, Raita Araki, Junichi Taki, Seigo Kinuya,

OBJECTIVE:The aim of the study was to investigate the outcomes and prognostic factors of high-dose 131I-metaiodobenzylguanidine (131I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan. METHODS:We retrospectively analyzed 20 patients with refractory or relapsed high-risk NBL who underwent 131I-MIBG therapy with an administration dose ranging from 444 ... Read more >>

Ann Nucl Med (Annals of nuclear medicine)
[2020, :]

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CAMKV Is a Candidate Immunotherapeutic Target in MYCN Amplified Neuroblastoma.

Robyn T Sussman, Jo Lynne Rokita, Kevin Huang, Pichai Raman, Komal S Rathi, Daniel Martinez, Kristopher R Bosse, Maria Lane, Lori S Hart, Tricia Bhatti, Bruce Pawel, John M Maris,

We developed a computational pipeline designed to use RNA sequencing (n = 136) and gene expression profiling (n = 250) data from neuroblastoma tumors to identify cell surface proteins predicted to be highly expressed in MYCN amplified neuroblastomas and with little or no expression in normal human tissues. We then ... Read more >>

Front Oncol (Frontiers in Oncology)
[2020, 10:302]

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