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Neural Tube Defects in the Neonatal Period

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From cause to care: Can a triple approach to better population data improve the global outlook of congenital heart disease?

Lorenzo D Botto,

Congenital heart disease (CHD) is common, costly, and critical. Approximately half of all infant deaths due to congenital anomalies are associated with CHD or neural tube defects. As infant mortality improves due to better infection control and peripartum care, congenital anomalies are becoming a key driver of pediatric survival and ... Read more >>

Am J Med Genet C Semin Med Genet (American journal of medical genetics. Part C, Seminars in medical genetics)
[2020, 184(1):23-35]

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Bilateral Bochdalek Hernias Associated with Arnold-Chiari I Malformation.

Julian Fazi, Visad Patel, Cara Bryan,

A Bochdalek hernia is a posterolateral diaphragmatic defect that is either congenital or acquired. The contents of the hernia range from fat to intra-abdominal organs. They are primarily pathologies of neonates and most commonly occur unilaterally. These hernias have been described in isolation and as one part of a group ... Read more >>

Case Rep Radiol (Case reports in radiology)
[2020, 2020:1931879]

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Changes in maternal age and prevalence of congenital anomalies during the enactment of China's universal two-child policy (2013-2017) in Zhejiang Province, China: An observational study.

Xiaohui Zhang, Lijin Chen, Xuemiao Wang, Xiaoyan Wang, Menghan Jia, Saili Ni, Wei He, Shankuan Zhu,

BACKGROUND:China implemented a partial two-child policy (2013) followed by a universal two-child policy (2015), replacing the former one-child policy mandated by the government. The changes affect many aspects of China's population as well as maternal and infant health, but their potential impact on birth defects (BDs) remains unknown. In this ... Read more >>

PLoS Med. (PLoS medicine)
[2020, 17(2):e1003047]

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Prevalence and patterns of birth defects among newborns in Southwestern Ethiopia: Retrospective study

Soressa Geneti, Girmai Gebru, Demisew Amenu, Lemessa Dube,

<title>Abstract</title> <p> Background : Intrauterine development can be considered as normal development as well as abnormal development. Abnormal development commonly called birth defects occur because of interference of normal development from genetic disorders, environmental factors and the combination of both genetic and environment factors during the critical period ... Read more >>

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Effects of Preconception Care and Periconception Interventions on Maternal Nutritional Status and Birth Outcomes in Low- and Middle-Income Countries: A Systematic Review.

Zohra S Lassi, Sophie Ge Kedzior, Wajeeha Tariq, Yamna Jadoon, Jai K Das, Zulfiqar A Bhutta,

Pregnancy in adolescence and malnutrition are common challenges in low- and middle-income countries (LMICs), and are associated with many complications and comorbidities. The preconception period is an ideal period for intervention as a preventative tactic for teenage pregnancy, and to increase micronutrient supplementation prior to conception. Over twenty databases and ... Read more >>

Nutrients (Nutrients)
[2020, 12(3):]

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Cannabis Consumption Patterns Explain the East-West Gradient in Canadian Neural Tube Defect Incidence: An Ecological Study.

Albert Stuart Reece, Gary Kenneth Hulse,

While a known link between prenatal cannabis exposure and anencephaly exists, the relationship of prenatal cannabis exposure with neural tube defects (NTDs) generally has not been defined. Published data from Canada Health and Statistics Canada were used to assess this relationship. Both cannabis use and NTDs were shown to follow ... Read more >>

Glob Pediatr Health (Global Pediatric Health)
[2019, 6:2333794X19894798]

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Maternal Folic Acid Supplementation Mediates Offspring Health via DNA Methylation.

Huan-Yu Liu, Song-Mei Liu, Yuan-Zhen Zhang,

The clinical significance of periconceptional folic acid supplementation (FAS) in the prevention of neonatal neural tube defects (NTDs) has been recognized for decades. Epidemiological data and experimental findings have consistently been indicating an association between folate deficiency in the first trimester of pregnancy and poor fetal development as well as ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2020, :]

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Triple Use of Autologous Amnion Graft in the Treatment of Meningomyelocele and Split Cord Malformation.

Louis de Weerd, Kristin Sjåvik, Lars Kjelsberg Pedersen, Sven Weum, Rune Otto Hennig,

This article describes the triple use of autologous amnion graft as a new procedure in the treatment of myelomeningocele and in myelomeningocele with split cord malformation. The first amnion graft was used as a physical and mechanical barrier to protect the myelomeningocele (MMC) from desiccation and mechanical stress directly after ... Read more >>

Plast Reconstr Surg Glob Open (Plastic and Reconstructive Surgery Global Open)
[2020, 8(1):e2539]

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Agnathia-microstomia-synotia syndrome (otocephaly).

Cristina Díaz Del Arco, Agustín Oliva, Adela Pelayo Alarcón,

Autops Case Rep (Autopsy & case reports)
[2020, 10(1):e2020152]

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Clinical application of exosomes and circulating microRNAs in the diagnosis of pregnancy complications and foetal abnormalities.

Haiou Yang, Qianqian Ma, Yu Wang, Zhenhua Tang,

During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalities. The early prediction or accurate diagnosis of related diseases is a concern of researchers. Liquid biopsy can be analysed for ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):32]

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Determinants of Low Fifth Minute Apgar Score among Newborn Delivered in Jimma University Medical Center, Southwest Ethiopia.

Bekalu Getachew, Tesema Etefa, Adissu Asefa, Behailu Terefe, Diriba Dereje,

Background:Apgar score is currently an accepted method for newborn infant assessment immediately after delivery. Low fifth minute Apgar score was strongly associated with the risk of neonatal and infant death. Even though much has been done, still, the levels of neonatal mortality in sub-Saharan African countries including Ethiopia were significant. ... Read more >>

Int J Pediatr (International journal of pediatrics)
[2020, 2020:9896127]

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A Review of Obstetrical Outcomes and Complications in Pregnant Women after Bariatric Surgery.

Yasmeen A Haseeb,

Bariatric surgery (BS) is a novel treatment for weight reduction with longer lasting health benefits. This review aimed to summarise the available evidence regarding the fetomaternal outcomes and the most common challenges and complications in pregnancies following BS. Google Scholar (Google LLC, Mountain View, California, USA) and PubMed® (National Library ... Read more >>

Sultan Qaboos Univ Med J (Sultan Qaboos University medical journal)
[2019, 19(4):e284-e290]

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Prevalence of congenital malformations at the "Les Orangers" Maternity and Reproductive Health Hospital of Rabat: Descriptive study of 470 anomalies

KHENATA FORCI, MOHAMED ALAMI, EL BOUAITI, MERIEM SLAOUI, ASSMAA ALA, AMAL IZGUA,

<title>Abstract</title> <p> Congenital malformations are described in about 3% of live births and 20% of stillbirths. In the industrialized countries, they represent one of the main causes of infant mortality, morbidity and handicap. In our country, as in all developing countries, the prevalence of congenital anomalies is not ... Read more >>

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Neuropathic Pain due to Neurofibromatosis Treated With Transcutaneous Electrical Nerve Stimulation in a Pregnant Patient: A Case Report.

Victor Caño Silva, Ancor Serrano Afonso,

A patient with neurofibromatosis type 1 presented to the pain clinic with neuropathic pain. Thoracolumbar magnetic resonance imagining revealed meningocele T12-L2 with cauda equina distortion. After becoming pregnant, the patient interrupted opioid treatment, refusing pharmacological treatment until the pain became unbearable. Transcutaneous electrical nerve stimulation (TENS) was proposed. The patient ... Read more >>

A A Pract (A&A practice)
[2019, 13(9):329-331]

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Neural Tube Defects in Pregnancies Among Women With Diagnosed HIV Infection - 15 Jurisdictions, 2013-2017.

Jennita Reefhuis, Lauren F FitzHarris, Kristen Mahle Gray, Steven Nesheim, Sarah C Tinker, Jennifer Isenburg, Benjamin T Laffoon, Joseph Lowry, Karalee Poschman, Janet D Cragan, Fay K Stephens, Jane E Fornoff, Cheryl A Ward, Tri Tran, Ashley E Hoover, Eirini Nestoridi, Laura Kersanske, Monika Piccardi, Morgan Boyer, Mary M Knapp, Abdel R Ibrahim, Marilyn L Browne, Bridget J Anderson, Dipal Shah, Nina E Forestieri, Jason Maxwell, Kimberlea W Hauser, Godwin U Obiri, Rachel Blumenfeld, Dana Higgins, Carla P Espinet, Bernardita López, Katherine Zielke, Latoya P Jackson, Charles Shumate, Kacey Russell, Margaret A Lampe,

In May 2018, a study of birth defects in infants born to women with diagnosed human immunodeficiency virus (HIV) infection in Botswana reported an eightfold increased risk for neural tube defects (NTDs) among births with periconceptional exposure to antiretroviral therapy (ART) that included the integrase inhibitor dolutegravir (DTG) compared with ... Read more >>

MMWR Morb. Mortal. Wkly. Rep. (MMWR. Morbidity and mortality weekly report)
[2020, 69(1):1-5]

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Pregnancy and Multiple Sclerosis: An Update on the Disease Modifying Treatment Strategy and a Review of Pregnancy's Impact on Disease Activity.

Guoda Varytė, Jolita Zakarevičienė, Diana Ramašauskaitė, Dalia Laužikienė, Audronė Arlauskienė,

Pregnancy rates are rapidly increasing among women of reproductive age diagnosed with multiple sclerosis (MS). Through pre-conception, pregnancy and post-partum periods, there is a need for disease control management, to decrease chances of MS relapses while avoiding potential risks to the mother and the fetus. However, pregnancy is not always ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(2):]

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Management of psoriasis in pregnancy - a review of the evidence to date.

Clara Ferreira, Alexandra Azevedo, Miguel Nogueira, Tiago Torres,

The onset of psoriasis collides with women's reproductive timeframe, and pregnancy brings challenges to its treatment. Indeed, the health of both mother and foetus must be considered. When choosing to treat pregnant women affected by psoriasis with pharmacological therapy, it is important to be aware of all possible options and ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Nutritional Gaps and Supplementation in the First 1000 Days.

Katrina Beluska-Turkan, Renee Korczak, Beth Hartell, Kristin Moskal, Johanna Maukonen, Diane E Alexander, Norman Salem, Laura Harkness, Wafaa Ayad, Jacalyn Szaro, Kelly Zhang, Nalin Siriwardhana,

Optimized nutrition during the first 1000 days (from conception through the 2nd birthday) is critical for healthy development and a healthy life for the newborn. Pregnancy and the postpartum period are accompanied by physiological changes, increased energy needs, and changing requirements in the nutrients critical for optimal growth and development. ... Read more >>

Nutrients (Nutrients)
[2019, 11(12):]

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Dietary Folate Intake and Folic Acid Supplements among Pregnant Women from Southern Italy: Evidence from the "Mamma & Bambino" Cohort.

Martina Barchitta, Andrea Maugeri, Roberta Magnano San Lio, Giuliana Favara, Claudia La Mastra, Maria Clara La Rosa, Antonella Agodi,

Folate requirement among women who plan to become pregnant should be raised to 600 μg/day during the periconceptional period. To meet this need, several countries began to promote the use of folic acid supplements before and during pregnancy. Here, we investigated prevalence and determinants of dietary folate intake and folic ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(2):]

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Management of Restless Legs Syndrome in Pregnancy and Lactation.

Marjan Jahani Kondori, Bhanu Prakash Kolla, Katherine M Moore, Meghna P Mansukhani,

Restless legs syndrome (RLS) affects about 20% of all pregnant women. RLS symptoms are usually moderate to severe in intensity during pregnancy and can result in insomnia, depression, and other adverse outcomes. Although iron deficiency has been implicated as a potential etiological factor, other mechanisms can also play a role. ... Read more >>

J Prim Care Community Health (Journal of primary care & community health)
[2020, 11:2150132720905950]

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A hospital-based birth defects surveillance system in Kampala, Uganda.

Daniel Mumpe-Mwanja, Linda Barlow-Mosha, Dhelia Williamson, Diana Valencia, Robert Serunjogi, Ayoub Kakande, Joyce Namale-Matovu, Jolly Nankunda, Doreen Birabwa-Male, Margaret Achom Okwero, Jesca Nsungwa-Sabiiti, Philippa Musoke,

BACKGROUND:In 2010, the World Health Assembly passed a resolution calling upon countries to prevent birth defects where possible. Though birth defects surveillance programs are an important source of information to guide implementation and evaluation of preventive interventions, many countries that shoulder the largest burden of birth defects do not have ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2019, 19(1):372]

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Trabeculectomy in pregnancy: Case studies and literature review.

Nandini R Banad, Nikhil Choudhari, Siddharth Dikshit, Chandrasekhar Garudadri, Sirisha Senthil,

Glaucoma management during pregnancy is a challenge for the patient and doctor. During pregnancy, the intraocular pressure (IOP) decreases. However, some women with preexisting glaucoma have elevated IOP requiring enhanced medical treatment. Glaucoma refractory to medical treatment combined with disease progression may necessitate laser trabeculoplasty or surgical intervention. Surgery during ... Read more >>

Indian J Ophthalmol (Indian journal of ophthalmology)
[2020, 68(3):420-426]

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Antenatal and postnatal diagnoses of visible congenital malformations in a sub-Saharan African setting: a prospective multicenter cohort study.

Igor Kamla, Nelly Kamgaing, Serge Billong, Joel Noutakdie Tochie, Paul Tolefac, Vincent de Paul Djientcheu,

BACKGROUND:Visible congenital malformations (VCMs) are one of the principal causes of disability in the world. Prenatal diagnosis is a paramount mandatory integral part of the follow up of pregnancies with VCM of the foetus in high-income setting. We aimed to determine the incidence of prenatal diagnosis of VCMs in a low-resource ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):457]

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Prevalence and Associated Factors of Perinatal Asphyxia in Neonates Admitted to Ayder Comprehensive Specialized Hospital, Northern Ethiopia: A Cross-Sectional Study.

Gebrehiwot Teklehaimanot Gebregziabher, Fikaden Berhe Hadgu, Haftom Temesgen Abebe,

Background:Perinatal asphyxia is defined as the inability of the newborn to initiate and sustain enough respiration after delivery and is characterized by a marked impairment of gas exchange. It is one of the most common causes of neonatal mortality and morbidity. There are very few studies on perinatal asphyxia in ... Read more >>

Int J Pediatr (International journal of pediatrics)
[2020, 2020:4367248]

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MRI depiction of fetal brain abnormalities.

Cory M Pfeifer, Scott D Willard, Patricia Cornejo,

Intracranial abnormalities are commonly suspected findings on antenatal ultrasound that require evaluation by magnetic resonance imaging. This review depicts multiple abnormalities imaged as a means to guide clinicians in proper diagnosis. ... Read more >>

Acta Radiol Open (Acta Radiologica Open)
[2019, 8(12):2058460119894987]

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