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Nephrogenesis

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Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis.

Sabrina Leverrier-Penna, Alain Michel, Laetitia L Lecante, Nathalie Costet, Antonio Suglia, Christèle Desdoits-Lethimonier, Hugoline Boulay, Roselyne Viel, Jonathan M Chemouny, Emmanuelle Becker, Vincent Lavoué, Antoine D Rolland, Nathalie Dejucq-Rainsford, Cécile Vigneau, Séverine Mazaud-Guittot,

Acetaminophen, aspirin, and ibuprofen are mild analgesics commonly used by pregnant women, the sole current recommendation being to avoid ibuprofen from the fifth month of gestation. The nephrotoxicity of these three analgesics is well documented in adults, as is their interference with prostaglandins biosynthesis. Here we investigated the effect of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21718]

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Birthweight predicts glomerular filtration rate in adult-life: population based cross sectional study.

Issa Al Salmi, Suad Hannawi,

<h4>Introduction</h4>Worldwide, there is a global progressive rise of chronic kidney disease. In parallel, children born after intra-uterine growth retardation are surviving to adult-life and beyond. This study describes the association of birthweight with and estimated glomerular filtration rate (eGFR).<h4>Methods</h4>Australian Diabetes, Obesity and Lifestyle (AusDiab) study participants were asked to complete ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):664-675]

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p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli.

Bradley Miller, Oleg Palygin, Ashraf El-Meanawy, David L Mattson, Aron M Geurts, Alexander Staruschenko, Andrey Sorokin,

<h4>Aims</h4>Adaptor protein p66Shc, encoded by Shc1 gene, contributes to the pathogenesis of oxidative stress-related diseases. p66Shc ability to promote oxidative stress-related diseases requires phosphorylation of serine 36 residue (Ser36) and depends on translocation of p66Shc to the mitochondria. We tested the hypothesis that abnormal p66Shc-mediated reactive oxygen species (ROS) production ... Read more >>

Life Sci (Life sciences)
[2021, 279:119661]

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The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis.

Meredith P Schuh, Lyan Alkhudairy, Andrew Potter, S Steven Potter, Kashish Chetal, Kairavee Thakkar, Nathan Salomonis, Raphael Kopan,

<h4>Background</h4>Most nephrons are added in late gestation. Truncated extrauterine nephrogenesis in premature infants results in fewer nephrons and significantly increased risk for CKD in adulthood. To overcome the ethical and technical difficulties associated with studies of late-gestation human fetal kidney development, third-trimester rhesus macaques served as a model to understand ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2021, 32(5):1097-1112]

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Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney.

Yaniv Makayes, Elad Resnick, Liad Hinden, Elina Aizenshtein, Tomer Shlomi, Raphael Kopan, Morris Nechama, Oded Volovelsky,

<h4>Background</h4>Low nephron number at birth is associated with a high risk of CKD in adulthood because nephrogenesis is completed <i>in utero</i>. Poor intrauterine environment impairs nephron endowment <i>via</i> an undefined molecular mechanism. A calorie-restricted diet (CRD) mouse model examined the effect of malnutrition during pregnancy on nephron progenitor cells (NPCs).<h4>Methods</h4>Daily ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2021, :]

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Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesis

Rosemarie Ungricht, Laure Guibbal, Marie-Christine Lasbennes, Vanessa Orsini, Martin Beibel, Annick Waldt, Rachel Cuttat, Walter Carbone, Anne Basler, Guglielmo Roma, Florian Nigsch, Jan Tchorz, Dominic Hoepfner, Philipp Hoppe,

Human organoids allow studying proliferation, lineage specification, and three-dimensional tissue development. Due to the inherent multicellular complexity, interrogation by systematic genetic methodologies is challenging. Here, we present the first genome-wide CRISPR screen in iPSC-derived kidney organoids. The combination of genome editing, longitudinal sampling and sorting of specific cell populations enabled ... Read more >>

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Premature differentiation of nephron progenitors and dysregulation of gene pathways critical to kidney development in a model of preterm birth

Aleksandra Cwiek, Masako Suzuki, Kimberly deRonde, Mark Conaway, Kevin Bennett, Samir El Dahr, Kimberly Reidy, Jennifer Charlton,

Preterm birth is a leading cause of neonatal morbidity. Survivors have a greater risk for kidney dysfunction and hypertension. Little is known about the molecular changes that occur in the kidney of individuals born preterm. Here, we demonstrate that mice delivered two days prior to full term gestation undergo premature ... Read more >>

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3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney Development.

Sarah N Lipp, Kathryn R Jacobson, David S Hains, Andrew L Schwarderer, Sarah Calve,

<h4>Background</h4>The extracellular matrix (ECM) is a network of proteins and glycosaminoglycans that provides structural and biochemical cues to cells. In the kidney, the ECM is critical for nephrogenesis; however, the dynamics of ECM composition and how it relates to 3D structure during development is unknown.<h4>Methods</h4>Using embryonic day 14.5 (E14.5), E18.5, ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2021, :]

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Chromatin accessibility and microRNA expression in nephron progenitor cells during kidney development

Andrew Clugston, Andrew Bodnar, Débora Malta Cerqueira, Yu Leng Phua, Alyssa Lawler, Kristy Boggs, Andreas Pfenning, Jacqueline Ho, Dennis Kostka,

Mammalian nephrons originate from a population of nephron progenitor cells (NPCs), and it is known that NPCs’ transcriptomes change throughout nephrogenesis during healthy kidney development. To characterize chromatin accessibility and microRNA (miRNA) expression throughout this process, we collected NPCs from mouse kidneys at embryonic day 14.5 (E14.5) and postnatal day ... Read more >>

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Importance of Extra-Renal CYP24A1 Expression for Maintaining Mineral Homeostasis

Melody Shi, Alexander Grabner, Myles Wolf,

Abstract Calcium homeostasis involves a complex interplay between kidneys, parathyroid glands, intestine and bone. Specifically, 1,25(OH)2D3 is a key calciotropic hormone which stimulates intestinal calcium absorption. A growing body of evidence suggests that circulating levels of 1,25(OH)2D3 depend not only on its synthesis under the action of PTH in the ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2021, 5(Suppl 1):A234-A234]

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LGR6 marks nephron progenitor cells.

Ravian L van Ineveld, Thanasis Margaritis, Berend A P Kooiman, Femke Groenveld, Hendrikus C R Ariese, Philip Lijnzaad, Hannah R Johnson, Jeroen Korving, Ellen J Wehrens, Frank Holstege, Jacco van Rheenen, Jarno Drost, Anne C Rios, Frank L Bos,

<h4>Background</h4>Nephron progenitor cells (NPCs) undergo a stepwise process to generate all mature nephron structures. Mesenchymal to epithelial transition (MET) is considered a multistep process of NPC differentiation to ensure progressive establishment of new nephrons. However, despite this important role, to date, no marker for NPCs undergoing MET in the nephron ... Read more >>

Dev Dyn (Developmental dynamics : an official publication of the American Association of Anatomists)
[2021, :]

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The enpp4 ectonucleotidase regulates kidney patterning signalling networks inXenopusembryos

Karine Massé, Surinder Bhamra, Christian Paroissin, Lilly Maneta-Peyret, Eric Boué-Grabot, Elizabeth Jones,

The enpp ectonucleotidases regulate lipidic and purinergic signalling pathways by controlling the extracellular concentrations of purines and bioactive lipids. Although both pathways are key regulators of kidney physiology and linked to human renal pathologies, their roles during nephrogenesis remain poorly understood. We previously showed that the pronephros was a major ... Read more >>

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Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies Plastin 3 as a protein involved in glomerular integrity.

Camille Fédou, Mylène Camus, Ophélie Lescat, Guylène Feuillet, Ilka Mueller, Bryony Ross, Marie Buléon, Eric Neau, Melinda Alves, Dominique Goudounéche, Benjamin Breuil, Franck Boizard, Quentin Bardou, Audrey Casemayou, Ivan Tack, Sophie Dreux, Julie Batut, Patrick Blader, Odile Burlet-Schiltz, Stéphane Decramer, Brunhilde Wirth, Julie Klein, Jean Sébastien Saulnier-Blache, Bénédicte Buffin-Meyer, Joost P Schanstra,

Congenital anomalies of the kidney and the urinary tract (CAKUT) are the first cause of chronic kidney disease in childhood. Several genetic and environmental origins are associated with CAKUT, but most pathogenic pathways remain elusive. Considering the amniotic fluid (AF) composition as a proxy for fetal kidney development, we analyzed ... Read more >>

J Pathol (The Journal of pathology)
[2021, :]

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Microanatomy of the developing nephron in the fetal human kidney during late gestation.

Will W Minuth,

<h4>Background</h4>Clinical experiences reveal that the kidneys of preterm and low birth weight infants are highly vulnerable. Noxae of various molecular composition can damage the outer renal cortex, resulting in an early termination of nephron formation. However, in contrast to what is known about the rodent kidney, with reference to the ... Read more >>

Ann Anat (Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft)
[2021, 236:151705]

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Long-Term but Not Short-Term Maternal Fasting Reduces Nephron Number and Alters the Glomerular Filtration Barrier in Rat Offspring.

Abdullah Alshamrani, Waleed Aldahmash, Fawaz Falodah, Maria Arafah, Abdel Halim Harrath, Saleh Alwasel,

The present study examined the effects of maternal Ramadan-type fasting during selected days in the first, second, or third trimester, or during the entire pregnancy, on the kidney structure of male rat offspring. Pregnant rats were provided with food ad libitum during pregnancy (control group, C), or they were exposed ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(4):]

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Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus.

Letícia de Barros Sene, Wellerson Rodrigo Scarano, Adriana Zapparoli, José Antônio Rocha Gontijo, Patrícia Aline Boer,

<h4>Background</h4>Here, we have demonstrated that gestational low-protein (LP) intake offspring present lower birth weight, reduced nephron numbers, renal salt excretion, arterial hypertension, and renal failure development compared to regular protein (NP) intake rats in adulthood. We evaluated the expression of various miRNAs and predicted target genes in the kidney in ... Read more >>

PLoS One (PloS one)
[2021, 16(2):e0246289]

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Advances in understanding vertebrate nephrogenesis.

Joseph M Chambers, Rebecca A Wingert,

The kidney is a complex organ that performs essential functions such as blood filtration and fluid homeostasis, among others. Recent years have heralded significant advancements in our knowledge of the mechanisms that control kidney formation. Here, we provide an overview of vertebrate renal development with a focus on nephrogenesis, the ... Read more >>

Tissue Barriers (Tissue barriers)
[2020, 8(4):1832844]

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Glomerular developmental delay and proteinuria in the preterm neonatal rabbit.

Derek de Winter, Thomas Salaets, André Gie, Jan Deprest, Elena Levtchenko, Jaan Toelen,

Recent advances in neonatal care have improved the survival rate of those born premature. But prenatal conditions, premature birth and clinical interventions can lead to transient and permanent problems in these fragile patients. Premature birth (<36 gestational weeks) occurs during critical renal development and maturation. Some consequences have been observed ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0241384]

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The low affinity p75 neurotrophin receptor is down-regulated in congenital anomalies of the kidney and the urinary tract: Possible involvement in early nephrogenesis.

Camille Fédou, Ophélie Lescat, Guylène Feuillet, Marie Buléon, Eric Neau, Benjamin Breuil, Mélinda Alvès, Julie Batut, Patrick Blader, Stéphane Decramer, Jean Sébastien Saulnier-Blache, Julie Klein, Bénédicte Buffin-Meyer, Joost P Schanstra,

Congenital Anomalies of the Kidney and of the Urinary Tract (CAKUT) cover a broad range of disorders including abnormal kidney development caused by defective nephrogenesis. Here we explored the possible involvement of the low affinity p75 neurotrophin receptor (p75NTR) in CAKUT and nephrogenesis. In mouse, p75NTR was highly expressed in ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2020, 533(4):786-791]

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Targeting the Renin-Angiotensin-Aldosterone System to Prevent Hypertension and Kidney Disease of Developmental Origins.

Chien-Ning Hsu, You-Lin Tain,

The renin-angiotensin-aldosterone system (RAAS) is implicated in hypertension and kidney disease. The developing kidney can be programmed by various early-life insults by so-called renal programming, resulting in hypertension and kidney disease in adulthood. This theory is known as developmental origins of health and disease (DOHaD). Conversely, early RAAS-based interventions could ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(5):]

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Molecular causes of congenital anomalies of the kidney and urinary tract (CAKUT).

Stefan Kohl, Sandra Habbig, Lutz T Weber, Max C Liebau,

Congenital anomalies of the kidney and urinary tract (CAKUT) occur in 0.5-1/100 newborns and as a group they represent the most frequent cause for chronic kidney failure in children. CAKUT comprise clinically heterogeneous conditions, ranging from mild vesicoureteral reflux to kidney aplasia. Most forms of CAKUT share the pathophysiology of ... Read more >>

Mol Cell Pediatr (Molecular and cellular pediatrics)
[2021, 8(1):2]

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Programmed Adult Kidney Disease: Importance of Fetal Environment.

Rogério Argeri, Fernanda Thomazini, Débora Conte Kimura Lichtenecker, Karina Thieme, Maria do Carmo Franco, Guiomar Nascimento Gomes,

The Barker hypothesis strongly supported the influence of fetal environment on the development of chronic diseases in later life. Multiple experimental and human studies have identified that the deleterious effect of fetal programming commonly leads to alterations in renal development. The interplay between environmental insults and fetal genome can induce ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:586290]

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Single cell RNA sequencing uncovers cellular developmental sequences and novel potential intercellular communications in embryonic kidney.

Isao Matsui, Ayumi Matsumoto, Kazunori Inoue, Yusuke Katsuma, Seiichi Yasuda, Karin Shimada, Yusuke Sakaguchi, Masayuki Mizui, Jun-Ya Kaimori, Yoshitsugu Takabatake, Yoshitaka Isaka,

Kidney development requires the coordinated growth and differentiation of multiple cells. Despite recent single cell profiles in nephrogenesis research, tools for data analysis are rapidly developing, and offer an opportunity to gain additional insight into kidney development. In this study, single-cell RNA sequencing data obtained from embryonic mouse kidney were ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):73]

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Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.

Xuewen Xu, Xinyue Zhang, Linlin Gao, Chunfeng Liu, Kai You,

Hyperoxia is essential to manage in preterm infants but causes injury to immature kidney. Previous study indicates that hyperoxia causes oxidative damage to neonatal kidney and impairs renal development. However, the underlying mechanisms by which neonatal hyperoxia effects on immature kidney still need to be elucidated. Tight junction, among which ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2020, 2020:2641461]

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Prematurity, perinatal inflammatory stress, and the predisposition to develop chronic kidney disease beyond oligonephropathy.

Lieke A Hoogenboom, Tim G A M Wolfs, Matthias C Hütten, Carine J Peutz-Kootstra, Michiel F Schreuder,

Prematurity and perinatal stress, such as intrauterine growth restriction (IUGR) and chorioamnionitis, are pathological processes creating an impaired intrauterine environment. These intrauterine factors are associated with the development of proteinuria, hypertension, and chronic kidney disease (CKD) later in life. Initially, this was thought to be secondary to oligonephropathy, subsequent glomerular ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(7):1673-1681]

Cited: 2 times

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