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Neonatal Sepsis

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Maternal hypothermia from environmental exposure in the third trimester.

Margot Rosenthal, Vanessa Poliquin, Adelicia Yu,

A primigravida at 32 weeks gestation developed hypothermia after prolonged exposure to the elements at -30.0°C. Her core temperature dropped to 29.8°C with associated foetal bradycardia. Passive rewarming was undertaken with forced warm air blankets and warmed IV fluids. The foetal heart rate normalised once normothermia was achieved. Serial foetal ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1710894]

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Up-regulation of BTLA expression in myeloid dendritic cells in neonatal sepsis associated with the treatment outcome and down-regulation of DC function

Guanghui Chen, Wandang Wang, Xuran Yang, Mingfa Guo, Zhifeng Pan, Mingjin Qiu, Jingyi Wu, Jing Jia, Yingliang Liang, Wenting Zheng,

<title>Abstract</title> <p> Background: Neonatal sepsis is an acute life-threatening condition in neonates, and a proper innate inflammatory is essential for prevention of the systemic inflammation associated with sepsis. As the most potential antigen-presenting innate immune cells, dentritic cells (DCs) dysfunction has been verified detrimental for sepsis. B and ... Read more >>

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Efficacy of colistin in multidrug-resistant neonatal sepsis: experience from a tertiary care center in Karachi, Pakistan.

Gul Ambreen, Muhammad Sohail Salat, Kashif Hussain, Syed Shamim Raza, Umer Ali, Iqbal Azam, Junaid Iqbal, Zafar Fatmi,

OBJECTIVE:Infections with multidrug-resistant organisms (MDROs) such as Gram-negative bacteria have high morbidity and mortality with limited treatment options. Colistin, an antibiotic active against MDRO, was rarely used due to frequent adverse effects, but its use has now been recommended among adults. In this study, we determined the efficacy of colistin ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2020, :]

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Can we improve early identification of neonatal late-onset sepsis? A validated prediction model.

Ori Goldberg, Nofar Amitai, Gabriel Chodick, Reuben Bromiker, Oded Scheuerman, Haim Ben-Zvi, Gil Klinger,

OBJECTIVE:No single test can accurately identify neonatal late-onset sepsis (LOS). Our aim was to use clinical evaluation with laboratory tests to rapidly assess sepsis risk. STUDY DESIGN:A retrospective case-control study was performed in a tertiary Neonatal Center during the years 2016-2019. Infants with bacteriologically confirmed LOS were compared with control ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, :]

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Preclinical Detection of Non-catheter Related Late-onset Sepsis in Preterm Infants by Fecal Volatile Compounds Analysis: A Prospective, Multi-center Cohort Study.

Daniel J C Berkhout, Hendrik J Niemarkt, Peter Andriessen, Daniel C Vijlbrief, Marije K Bomers, Veerle Cossey, Christian V Hulzebos, Anton H van Kaam, Boris W Kramer, Richard A van Lingen, Alfian N Wicaksono, James A Covington, Mirjam M van Weissenbruch, Marc A Benninga, Nanne K H de Boer, Tim G J de Meij,

BACKGROUND:Late onset sepsis (LOS) in preterm infants is preceded by fecal volatile organic compound (VOC) alterations, suggesting an etiologic role of gut microbiota in LOS rather than being primarily caused by central venous catheters (CVC). To increase our knowledge about the involvement of the gut microbiota in LOS, we analyzed ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, 39(4):330-335]

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Intravenous pentoxifylline is well tolerated in critically ill preterm infants with sepsis or necrotizing enterocolitis.

Simone S Schüller, Kristina Kempf, Lukas Unterasinger, Tobias Strunk, Angelika Berger,

Pentoxifylline (PTX) is a candidate adjuvant medication for the treatment of sepsis and necrotizing enterocolitis in preterm infants. There is only limited data on safety and compatibility with other commonly used intravenous medications. This retrospective single-center study of 198 preterm infants (September 2012-September 2018) was performed at a level IV ... Read more >>

Eur. J. Pediatr. (European Journal of Pediatrics)
[2020, :]

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Neutrophil Volume, conductivity and scatter (VCS) as a screening tool in neonatal sepsis.

Prerana Nesargi, H S Niranjan, Prathik Bandiya, Naveen Benakappa,

The initial evaluation of a suspected sepsis in a neonate is always challenging. There are many methods to screen a neonate with suspected sepsis. One of newer method is to assess the changes in neutrophil volume conductivity and scatter. The objective of this study was to establish changes in Neutrophil ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4457]

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Comparison of the management recommendations of the Kaiser Permanente neonatal early-onset sepsis risk calculator (SRC) with NICE guideline CG149 in infants ≥34 weeks' gestation who developed early-onset sepsis.

Rachel Morris, Steve Jones, Sujoy Banerjee, Andrew Collinson, Hannah Hagan, Hannah Walsh, Graham Thornton, Ian Barnard, Chris Warren, Jennifer Reid, Alison Busfield, Jean Matthes,

OBJECTIVE:To compare the management recommendations of the Kaiser Permanente neonatal early-onset sepsis risk calculator (SRC) with National Institute for Health and Care Excellence (NICE) guideline CG149 in infants ≥34 weeks' gestation who developed early-onset sepsis (EOS). DESIGN:Retrospective multicentre study. SETTING:Five maternity services in South West of England and Wales. PATIENTS:70 ... Read more >>

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2020, :]

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Emergence of Cronobacter sakazakii in Cases of Neonatal Sepsis in Upper Egypt: First Report in North Africa.

Amal A Elkhawaga, Helal F Hetta, Naglaa S Osman, Amal Hosni, Mohamed A El-Mokhtar,

Background and Aim:Cronobacter sakazakii (C. sakazakii) has attracted considerable attention as an emerging neonatal pathogen and has been associated with outbreaks of life-threatening septicemia, necrotizing enterocolitis, and meningitis in neonates and infants globally. No data about the role of C. sakazakii as a cause of neonatal sepsis in North Africa ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:215]

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Management of newborns at increased risk for early-onset sepsis in perinatology department.

Joana Caldeira Santos, Joana Reis, Maria Adriana Rangel, Anabela João, António Vinhas da Silva,

Introduction: Assessing newborn infants at risk for early-onset sepsis (EOS) is a common clinical task conducted by pediatricians. A change in the internal protocol for managing neonates at risk was implemented in 2016. Unlike the previous protocol, which determined laboratory testing in asymptomatic newborns in the presence of one risk ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-5]

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Maternal activation of the EGFR prevents translocation of gut-residing pathogenic Escherichia coli in a model of late-onset neonatal sepsis.

Kathryn A Knoop, Paige E Coughlin, Alexandria N Floyd, I Malick Ndao, Carla Hall-Moore, Nurmohammad Shaikh, Andrew J Gasparrini, Brigida Rusconi, Marilyn Escobedo, Misty Good, Barbara B Warner, Phillip I Tarr, Rodney D Newberry,

Late-onset sepsis (LOS) is a highly consequential complication of preterm birth and is defined by a positive blood culture obtained after 72 h of age. The causative bacteria can be found in patients' intestinal tracts days before dissemination, and cohort studies suggest reduced LOS risk in breastfed preterm infants through ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, :]

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The practice of blood volume submitted for culture in a neonatal intensive care unit.

Moni Pankhuri Singh, Kiran Kumar Balegar V, Rajeshwar Reddy Angiti,

BACKGROUND:Neonatal sepsis is the leading cause of mortality and morbidity in neonatal intensive care units. The volume of blood taken for culture remains one of the most important factors in isolating microorganisms. OBJECTIVES:To evaluate the impact of the intervention on the blood volume submitted for culture and to identify factors ... Read more >>

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2020, :]

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Extracorporeal Membrane Oxygenation for Group B Streptococcal Sepsis in Neonates: A Retrospective Study of the Extracorporeal Life Support Organization Registry.

Luregn J Schlapbach, Mark D Chatfield, Peter Rycus, Graeme MacLaren,

OBJECTIVES:Neonatal group B streptococcal sepsis remains a leading cause of neonatal sepsis globally and is characterized by unique epidemiologic features. Extracorporeal membrane oxygenation has been recommended for neonatal septic shock refractory to conventional management, but data on extracorporeal membrane oxygenation in group B streptococcal sepsis are scarce. We aimed to ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Effect of Synthetic Vitamin A and Probiotics Supplementation for Prevention of Morbidity and Mortality during the Neonatal Period. A Systematic Review and Meta-Analysis of Studies from Low- and Middle-Income Countries.

Aamer Imdad, Faseeha Rehman, Evan Davis, Suzanna Attia, Deepika Ranjit, Gamael Saint Surin, Sarah Lawler, Abigail Smith, Zulfiqar A Bhutta,

Background: Suboptimal nutritional status of a newborn is a risk factor for short- and long-term morbidity and mortality. The objectives of this review were to assess the efficacy and effectiveness of neonatal synthetic vitamin A supplementation, dextrose gel and probiotic supplementation for prevention of morbidity and mortality during infancy in ... Read more >>

Nutrients (Nutrients)
[2020, 12(3):]

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Emergence of Cronobacter sakazakii in Cases of Neonatal Sepsis in Upper Egypt: First Report in North Africa.

Amal A. Elkhawaga, Helal F. Hetta, Naglaa S. Osman, Amal Hosni, Mohamed A. El-Mokhtar,

Background and AimCronobacter sakazakii (C. sakazakii) has attracted considerable attention as an emerging neonatal pathogen and has been associated with outbreaks of life-threatening septicemia, necrotizing enterocolitis, and meningitis in neonates and infants globally. No data about the role of C. sakazakii as a cause of neonatal sepsis in North Africa ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:]

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Challenges in developing a consensus definition of neonatal sepsis.

Matthew McGovern, Eric Giannoni, Helmut Kuester, Mark A Turner, Agnes van den Hoogen, Joseph M Bliss, Joyce M Koenig, Fleur M Keij, Jan Mazela, Rebecca Finnegan, Marina Degtyareva, Sinno H P Simons, Willem P de Boode, Tobias Strunk, Irwin K M Reiss, James L Wynn, Eleanor J Molloy, ,

Sepsis remains a leading cause of morbidity and mortality in the neonatal population, and at present, there is no unified definition of neonatal sepsis. Existing consensus sepsis definitions within paediatrics are not suited for use in the NICU and do not address sepsis in the premature population. Many neonatal research ... Read more >>

Pediatr. Res. (Pediatric research)
[2020, :]

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A Prospective Cohort Study of Factors Associated with Empiric Antibiotic De-escalation in Neonates Suspected with Early Onset Sepsis (EOS).

Nazedah Ain Ibrahim, Mohd Makmor Bakry, Nurul Ain Mohd Tahir, Nur Rashidah Mohd Zaini, Noraida Mohamed Shah,

BACKGROUND:Prolonged empiric antibiotic use, resulting from diagnostic uncertainties, in suspected early onset sepsis (EOS) cases constitutes a significant problem. Unnecessary antibiotic use increases the risk of antibiotic resistance. Furthermore, prolonged antibiotic use increases the risk of mortality and morbidity in neonates. Proactive measures including empiric antibiotic de-escalation are crucial to ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2020, :]

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Serial clinical observation for management of newborns at risk of early-onset sepsis.

Alberto Berardi, Luca Bedetti, Caterina Spada, Laura Lucaccioni, Adam Frymoyer,

PURPOSE OF REVIEW:Current management approaches for asymptomatic neonates at risk of early onset sepsis remain controversial. Strategies based entirely on clinical observation (SCO, serial clinical observation) have gained consensus. RECENT FINDINGS:We briefly compare different strategies for managing asymptomatic newborns suggested in four high-income countries. Then this review details the existing ... Read more >>

Curr. Opin. Pediatr. (Current opinion in pediatrics)
[2020, 32(2):245-251]

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The role of maternal infection in preterm birth: evidence from the Brazilian Multicentre Study on Preterm Birth (EMIP).

Ricardo P. Tedesco, Rafael B. Galvão, Jose Paulo Guida, Renato Passini-Júnior, Giuliane J. Lajos, Marcelo L. Nomura, Patricia M. Rehder, Tabata Z. Dias, Renato T. Souza, Jose G. Cecatti,

OBJECTIVES:Evidence suggests that infection or inflammation is a major contributor to early spontaneous preterm birth (sPTB). Therefore, this study aimed to investigate the development and causes of maternal infection associated with maternal and neonatal outcomes in women with sPTB.METHODS:This was a secondary analysis of a multicenter cross-sectional study with a ... Read more >>

Clinics (Sao Paulo) (Clinics)
[2020, 75:]

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Neonatal sepsis: need for consensus definition, collaboration and core outcomes.

Eleanor J Molloy, James L Wynn, Joseph Bliss, Joyce M Koenig, Fleur M Keij, Matt McGovern, Helmut Kuester, Mark A Turner, Eric Giannoni, Jan Mazela, Marina Degtyaeva, Tobias Strunk, Sinno H P Simons, Jan Janota, Franz B Plotz, Ages van den Hoogen, Willem de Boode, Luregn J Schlapbach, Irwin K M Reiss, ,

Pediatr. Res. (Pediatric Research)
[2020, :]

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Peripheral blood markers of sepsis in foals born from mares with experimentally ascending placentitis.

Luciana de Araujo Borba, Carlos Eduardo Wayne Nogueira, Fábio Raphael Pascoti Bruhn, Gabriela Castro da Silva, Lorena Soares Feijó, Igor F Canisso, Bruna da Rosa Curcio,

BACKGROUND:Neonatal sepsis is a leading cause of neonatal death during the first-week postfoaling. Despite recent advancements in the diagnosis and treatment of sepsis in the newborn foal, the non-specific clinical signs and subtle nature of this disease may result in delayed diagnosis until severe progression of the disease; thus, early ... Read more >>

Vet. Rec. (The Veterinary record)
[2020, :]

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Neonatal Early-Onset Sepsis Calculator and Antibiotic Therapy.

Qi Zhang, Wenquan Niu,

JAMA Pediatr (JAMA pediatrics)
[2020, :]

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Neonatal Early-Onset Sepsis Calculator and Antibiotic Therapy-Reply.

Niek B Achten, Claus Klingenberg, Frans B Plötz,

JAMA Pediatr (JAMA pediatrics)
[2020, :]

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Neonatal sepsis in low-income countries: epidemiology, diagnosis and prevention.

Constantin Radu Popescu, Miranda M M Cavanagh, Bentry Tembo, Msandeni Chiume, Norman Lufesi, David M Goldfarb, Niranjan Kissoon, Pascal M Lavoie,

Introduction: Sepsis accounts for up to one-third of neonatal deaths in the world each year. The World Health Organization acknowledges neonatal sepsis as a major global health concern, and that the highest burden occurs in low- and middle-income countries (LMICs). Despite major research and clinical progress in this area, we ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2020, :1-10]

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Neonatal Early-Onset Sepsis Calculator and Antibiotic Therapy.

Zubair H Aghai,

JAMA Pediatr (JAMA pediatrics)
[2020, :]

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