Full Text Journal Articles about
Narcolepsy

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Narcolepsy Type 1: What have we learned from immunology?

Birgitte Rahbek Kornum,

Narcolepsy Type 1 is hypothesized to be an autoimmune disease targeting the hypocretin/orexin neurons in hypothalaus. Ample genetic and epidemiological evidence points in the direction of a pathogenesis involving the immune system, but this is not considered proof of autoimmunity. Infact, it remains a matter of debate how to prove ... Read more >>

Sleep (Sleep)
[2020, :]

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Population and Noncompartmental Model Pharmacokinetic Analyses of Sodium Oxybate Support Weight-Based Dosing in Children and Adolescents With Narcolepsy With Cataplexy.

Cuiping Chen, Carol L Rosen, Chad Ruoff, Leslie H Boyce, Rupa Parvataneni, Katie Zomorodi, Scott Brantley, Mark Sale, Giuseppe Plazzi,

The pharmacokinetics (PK) of sodium oxybate (SXB) was evaluated in a subset of participants from a study of SXB treatment in children (aged 7-11 years; n=11) and adolescents (aged 12-17 years; n=18) with narcolepsy with cataplexy. PK evaluation was conducted over 2 nights during the period when participants received a ... Read more >>

Clin Transl Sci (Clinical and translational science)
[2020, :]

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The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study.

Mona S Aldosari, Awad H Olaish, Samar Z Nashwan, Mahmoud M A Abulmeaty, Ahmed S BaHammam,

PURPOSE:The effects of caffeine on drowsiness and reaction time in patients with narcolepsy are unclear. We aimed to assess the effects of caffeine as add-on therapy in narcolepsy patients. METHODS:A randomized, double-blind, placebo-control clinical pilot trial was conducted with a parallel, two-arm trial allocation ratio of 1:1. Participants attended two ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2020, :]

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To Split or to Lump? Classifying the Central Disorders of Hypersomnolence.

R Fronczek, I Arnulf, C R Baumann, K Maski, F Pizza, L M Trotti,

The classification of the central disorders of hypersomnolence has undergone multiple iterations in an attempt to capture biologically meaningful disease entities in the absence of known pathophysiology. Accumulating data suggest that further refinements may be necessary. At the 7th International Symposium on Narcolepsy, a group of clinician-scientists evaluated data in ... Read more >>

Sleep (Sleep)
[2020, :]

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CSF levels of the endocannabinoid anandamide are reduced in patients with untreated narcolepsy type 1: a pilot study.

Andrea Romigi, Monica Bari, Claudio Liguori, Francesca Izzi, Cinzia Rapino, Marzia Nuccetelli, Natalia Battista, Sergio Bernardini, Diego Centonze, Nicola Mercuri, Fabio Placidi, Mauro Maccarrone,

Background The endocannabinoid system (ECs) is involved in excitatory/inhibitory balance mechanisms within the CNS. Growing evidence shows that endocannabinois may influence both hypothalamic orexinergic and histaminergic neurons involved in narcolepsy physiopathology, thus indicating that endocannabinoids may play an intrinsic role modulating sleep and wake. Objective To measure endocannabinoids levels in ... Read more >>

CNS Neurol Disord Drug Targets (CNS & neurological disorders drug targets)
[2020, :]

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The relationship between shift-work, sleep, and mental health among paramedics in Australia.

Wahaj Anwar A Khan, Russell Conduit, Gerard A Kennedy, Melinda L Jackson,

OBJECTIVES:This study aimed to investigate the prevalence of sleep and mental health issues, the role of chronotype, and the relationship between these variables in Australian paramedics. DESIGN:A cross-sectional study. SETTINGS:Cross-sectional survey. MEASUREMENTS:Paramedics were invited to complete an online survey to assess stress, posttraumatic stress disorder (PTSD), depression, anxiety, daytime sleepiness, ... Read more >>

Sleep Health (Sleep health)
[2020, :]

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Sensitivity to gene dosage and gene expression affects genes with copy number variants observed among neuropsychiatric diseases.

Maria Yamasaki, Takashi Makino, Seik-Soon Khor, Hiromi Toyoda, Taku Miyagawa, Xiaoxi Liu, Hitoshi Kuwabara, Yukiko Kano, Takafumi Shimada, Toshiro Sugiyama, Hisami Nishida, Nagisa Sugaya, Mamoru Tochigi, Takeshi Otowa, Yuji Okazaki, Hisanobu Kaiya, Yoshiya Kawamura, Akinori Miyashita, Ryozo Kuwano, Kiyoto Kasai, Hisashi Tanii, Tsukasa Sasaki, Makoto Honda, Katsushi Tokunaga,

BACKGROUND:Copy number variants (CNVs) have been reported to be associated with diseases, traits, and evolution. However, it is hard to determine which gene should have priority as a target for further functional experiments if a CNV is rare or a singleton. In this study, we attempted to overcome this issue ... Read more >>

BMC Med Genomics (BMC Medical Genomics)
[2020, 13(1):55]

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Risk of bone fractures in patients with narcolepsy: a nationwide population-based cohort study.

En-Ting Chang, Cheng-Li Lin, Shih-Fen Chen, Chung-Y Hsu, Yu-Chih Shen,

OBJECTIVES:Narcolepsy symptoms, such as excessive daytime sleepiness or cataplexy, can pose a risk to safety. Stimulants or antidepressants have been used to treat these symptoms. The study investigated the risk of bone fractures in narcolepsy patients. Also, the exposure pattern of stimulants and antidepressants to the risk of bone fractures ... Read more >>

Sleep Med. (Sleep medicine)
[2020, 70:55-59]

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Adherence to wakefulness promoting medication in patients with narcolepsy.

Laura Pérez-Carbonell, Elaine Lyons, Valentina Gnoni, Sean Higgins, Abidemi I Otaiku, Guy D Leschziner, Panagis Drakatos, Grainne d'Ancona, Brian D Kent,

OBJECTIVE:Narcolepsy management usually requires lifelong pharmacotherapy. However, we know little about adherence to prescribed treatment in narcolepsy. We assessed adherence to wakefulness-promoting agents in narcolepsy patients. PATIENTS AND METHODS:We retrospectively assessed adherence to wakefulness promoting medication in patients with narcolepsy using the Medicines Possession Ratio (MPR). Three levels of adherence ... Read more >>

Sleep Med. (Sleep medicine)
[2020, 70:50-54]

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Neuroimaging of Narcolepsy and Primary Hypersomnias.

Carlo Cavaliere, Mariachiara Longarzo, Stuart Fogel, Maria Engström, Andrea Soddu,

Advances in neuroimaging open up the possibility for new powerful tools to be developed that potentially can be applied to clinical populations to improve the diagnosis of neurological disorders, including sleep disorders. At present, the diagnosis of narcolepsy and primary hypersomnias is largely limited to subjective assessments and objective measurements ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420905829]

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HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic.

Mink Schinkelshoek, Rolf Fronczek, Willem Verduijn, Geert Haasnoot, Sebastiaan Overeem, Claire Donjacour, Astrid van der Heide, Dave Roelen, Frans Claas, Gert Jan Lammers,

We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 ... Read more >>

J. Neuroimmunol. (Journal of neuroimmunology)
[2020, 342:577210]

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Excessive Daytime Sleepiness Measurements in Children With Attention Deficit Hyperactivity Disorder.

Stéphanie Bioulac, Jacques Taillard, Pierre Philip, Patricia Sagaspe,

Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood. It is a heterogeneous disorder in terms of clinical presentation that is probably due to the frequent occurrence of comorbidity. Children with ADHD more frequently report sleep disorders (notably delayed sleep phase syndrome) and excessive daytime ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:3]

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HLA and sleep parameter associations in post-H1N1 narcolepsy type 1 patients and first-degree relatives.

Hilde T Juvodden, Marte K Viken, Sebjørg E H Nordstrand, Rannveig Viste, Lars T Westlye, Per M Thorsby, Benedicte A Lie, Stine Knudsen-Heier,

STUDY OBJECTIVES:To explore HLA (human leukocyte antigen) in post-H1N1 narcolepsy type 1 patients (NT1), first-degree relatives and healthy controls, and assess HLA associations with clinical and sleep parameters in patients and first-degree relatives. METHODS:Ninety post-H1N1 NT1 patients and 202 of their first-degree relatives were HLA-genotyped (next generation sequencing) and phenotyped ... Read more >>

Sleep (Sleep)
[2020, 43(3):]

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Nocturnal Rapid Eye Movement Sleep Without Atonia can Be a Diagnostic Parameter in Differentiating Narcolepsy Type 1 From Type 2.

Mehmet Ilker Yon, Filiz Azman, Merve Ecem Yon, F Irsel Tezer,

PURPOSE:We aimed to compare rapid eye movement sleep without atonia (RSWA), tonic RSWA, and phasic RSWA indices during polysomnography as a potential biomarker between narcolepsy type 1 and type 2. METHODS:Medical files, polysomnography, and multiple sleep latency tests of patients with narcolepsy were evaluated retrospectively. A total of three adolescents ... Read more >>

J Clin Neurophysiol (Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society)
[2020, :]

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Resting-state brain network topological properties and the correlation with neuropsychological assessment in adolescent narcolepsy.

Fulong Xiao, Karen Spruyt, Chao Lu, Dianjiang Zhao, Jun Zhang, Fang Han,

STUDY OBJECTIVES:To evaluate functional connectivity and topological properties of brain networks, and to investigate the association between brain topological properties and neuropsychiatric behaviors in adolescent narcolepsy. METHODS:Resting-state functional magnetic resonance imaging and neuropsychological assessment were applied in 26 adolescent narcolepsy patients and 30 healthy controls. Functional magnetic resonance imaging data ... Read more >>

Sleep (Sleep)
[2020, :]

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Physiology of gangliosides and the role of antiganglioside antibodies in human diseases.

Gianni Cutillo, Anna-Helena Saariaho, Seppo Meri,

Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human body. They play important roles in protecting us against immune attacks, yet they can become targets for autoimmunity and act as receptors for microbes, like the influenza viruses, and toxins, such as the ... Read more >>

Cell. Mol. Immunol. (Cellular & molecular immunology)
[2020, 17(4):313-322]

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A Cautionary Tale About Narcolepsy and Deferrals to the Civilian Network.

Sarah Kinkennon,

Mil Med (Military medicine)
[2020, :]

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Update on Persistent Excessive Daytime Sleepiness in Obstructive Sleep Apnea.

Sogol Javaheri, Shahrokh Javaheri,

Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder and subjective excessive daytime sleepiness (EDS) is the cardinal symptom for which many individuals seek medical advice. Positive airway pressure (PAP) devices, first line treatment for OSA, eliminates EDS in most patients. However, a subset of patients suffers from persistent ... Read more >>

Chest (Chest)
[2020, :]

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Structural Organization of Dream Experience During Daytime Soremp Sleep of Patients with Narcolepsy Type 1.

Carlo Cipolli, Fabio Pizza, Claudia Bellucci, Michela Mazzetti, Giovanni Tuozzi, Stefano Vandi, Giuseppe Plazzi,

STUDY OBJECTIVE:To assess the frequency of dream experience (DE) developed during naps at Multiple Sleep Latency Test (MSLT) by patients with narcolepsy type-1 (NT1) and establish, using story-grammar analysis, the structural organization of DEs developed during naps with sleep onset REM period (SOREMP) sleep compared with their DEs during early-and ... Read more >>

Sleep (Sleep)
[2020, :]

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Association between genetic risk scores and risk of narcolepsy: a case-control study.

Hui Ouyang, Fang Han, Zechen Zhou, Qiwen Zheng, Yangyang Wang, Jun Zhang,

Background:Genome-wide association studies (GWASs) have identified a large number of single-nucleotide polymorphisms (SNPs) associated with narcolepsy. However, the sum impact of these SNPs on defining the genomic risk of narcolepsy remains unknown. In the present study, we investigated the associations between genetic risk scores (GRSs) and narcolepsy along with their ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(4):103]

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Giving a voice to Cataplectic experience: recalls from patients with narcolepsy type 1.

Christian Franceschini, Chiara Fante, Maria Claudia Folli, Maria Filosa, Fabio Pizza, Elena Antelmi, Francesca Ingravallo, Giuseppe Plazzi,

OBJECTIVE:to assess the narratives from the recalled accounts of cataplexy attacks of patients with narcolepsy type 1 (NT1). METHODS:twenty-two male adult patients meeting the International Classification of Sleep Disorders criteria for the diagnosis of NT1 referring to the Narcolepsy Center of the University of Bologna in the year 2017 underwent ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2020, :]

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Narcolepsy Severity Scale: A reliable tool assessing symptom severity and consequences.

Yves Dauvilliers, Lucie Barateau, Regis Lopez, Anna Laura Rassu, Sofiene Chenini, Severine Beziat, Isabelle Jaussent,

STUDY OBJECTIVES:To define clinically relevant Narcolepsy Severity Scale (NSS) score ranges, confirm its main performances and sensitivity to medications, and determine whether items need to be weighted. METHODS:143 consecutive untreated and 238 treated adults with narcolepsy type 1 (NT1) completed the NSS, a 15-item self-administered questionnaire (score: 0-57) that assesses ... Read more >>

Sleep (Sleep)
[2020, :]

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Pitolisant: A Review in Narcolepsy with or without Cataplexy.

Yvette N Lamb,

Pitolisant (Wakix®), an orally available, first-in-class antagonist/inverse agonist of the histamine 3 receptor, is approved in the EU (as of March 2016) for the treatment of narcolepsy with or without cataplexy in adults and in the USA (as of August 2019) for the treatment of excessive daytime sleepiness (EDS) in ... Read more >>

CNS Drugs (CNS drugs)
[2020, 34(2):207-218]

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Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis.

Jean Pierre Pallais, Catherine M Kotz, Milos Stanojlovic,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1039-1040]

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Orexin in Respiratory and Autonomic Regulation, Health and Diseases.

Savannah Barnett, Aihua Li,

Orexin neurons, located in the hypothalamus, produce orexin-A and orexin-B neuropeptides and send widespread projections throughout the central nervous system, including many nuclei that are critically involved in sleep-wake, cardiorespiratory, and autonomic regulation. Significant progress has been made to better understand the roles of orexins in the control of breathing ... Read more >>

Compr Physiol (Comprehensive Physiology)
[2020, 10(2):345-363]

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