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A novel contrast-induced acute kidney injury mouse model based on low-osmolar contrast medium.

Jiajia Wu, Jianxiao Shen, Wanpeng Wang, Na Jiang, Haijiao Jin, Xiajing Che, Zhaohui Ni, Yan Fang, Shan Mou,

The contrast-induced acute kidney injury (CI-AKI) has been becoming the third common cause of hospital-acquired acute kidney injury. An ideal animal model is essential for understanding the pathophysiology of CI-AKI. Previous CI-AKI studies were mostly performed on rats with high-osmolar contrast medium (HOCM), which is unsuitable for transgenic researches. This ... Read more >>

Ren Fail (Renal failure)
[2022, 44(1):1345-1355]

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Transcytosis-enabled active extravasation of tumor nanomedicine.

Quan Zhou, JunJun Li, Jiajia Xiang, Shiqun Shao, Zhuxian Zhou, Jianbin Tang, Youqing Shen,

Extravasation is the first step for nanomedicines in circulation to reach targeted solid tumors. Traditional nanomedicines have been designed to extravasate into tumor interstitium through the interendothelial gaps previously assumed rich in tumor blood vessels, i.e., the enhanced permeability and retention (EPR) effect. While the EPR effect has been validated ... Read more >>

Adv Drug Deliv Rev (Advanced drug delivery reviews)
[2022, :114480]

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