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Oncogenic Ras cooperates with knockdown of the tumor suppressor Lkb1 by RNAi to override organ size limits in Drosophila wing tissue.

Briana Brown Rackley, Evan Kiely, Chang-Soo Seong, Manali Rupji, Melissa Gilbert-Ross,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Circular RNA circ_0010235 sponges miR-338-3p to play oncogenic role in proliferation, migration and invasion of non-small-cell lung cancer cells through modulating KIF2A.

Yanan Zhu, Chunling Ma, Aiai Lv, Changwei Kou,

<h4>Background</h4>Circular RNA microarray analysis showed hsa_circ_0010235 (circ_0010235) was highly upregulated in non-small-cell lung cancer (NSCLC) patients; however, its role in carcinogenesis and development of NSCLC cells was unrevealed. Here, we intended to investigate role and mechanism of circ_0010235 in NSCLC proliferation, migration and invasion.<h4>Methods and results</h4>Expression of circ_0010235, microRNA (miR)-338-3p ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):693-706]

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Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer.

Jia Yang, Ran Hao, Yunlong Zhang, Haibin Deng, Wenjing Teng, Zhongqi Wang,

<h4>Background</h4>The underlying circular RNAs (circRNAs)-related competitive endogenous RNA (ceRNA) mechanisms of pathogenesis and prognosis in non-small cell lung cancer (NSCLC) remain unclear.<h4>Methods</h4>Differentially expressed circRNAs (DECs) in two Gene Expression Omnibus datasets (GSE101684 and GSE112214) were identified by utilizing R package (Limma). Circinteractome and StarBase databases were used to predict circRNA ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):611]

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Long non-coding RNA MCM3AP antisense RNA 1 promotes non-small cell lung cancer progression through targeting microRNA-195-5p.

Dijian Shen, Jianqiang Li, Kaiyi Tao, Youhua Jiang,

Lung cancer (LC) ranks first among all causes of cancer-related death, with non-small cell lung cancer (NSCLC) taking up 85% of lung cancer cases. Although lncRNA MCM3AP antisense RNA 1 (MCM3AP-AS1) has been reported to be an oncogenic factor in NSCLC, its detailed mechanism in NSCLC is unknown. In this ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3525-3538]

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Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression.

Chuan-Cui Zhang, Yuhua Li, Xian-Zhen Feng, Dian-Bo Li,

As a type of non-coding RNA, circular RNA (circRNA) figures prominently in human cancer progression. Nonetheless, the expression, function, and regulatory mechanism of circ_0001287 in non-small cell lung cancer (NSCLC) remain obscure. In this work, quantitative real-time polymerase chain reaction (qRT-PCR) was implemented to quantify circ_0001287 and miR-21 expressions in ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):414-425]

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Clinicopathological and prognostic significance of NM23 expression in patients with non-small cell lung cancer : A systematic review and meta-analysis

Shi-hui Min, Qiang-qiang Zheng,

Abstract <h4>Background:</h4> There is a heated debate on the clinicopathological features and prognostic significance with non-metastasis 23 (NM23) expression in patients with non-small cell lung cancer (NSCLC). Thus, we conducted this meta-analysis to evaluate the clinicopathological features and prognostic significance of NM23 for NSCLC patients. <h4>Methods:</h4> Pubmed, Embase, and Web ... Read more >>

Medicine (Madr) (Medicine)
[2021, 100(47):]

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Identification of Prognostic Gene Biomarkers in Non-Small Cell Lung Cancer Progression by Integrated Bioinformatics Analysis.

Panagiotis Giannos, Konstantinos S Kechagias, Annamaria Gal,

The progression of non-small cell lung cancer (NSCLC) is linked to epithelial-mesenchymal transition (EMT), a biologic process that enables tumor cells to acquire a migratory phenotype and resistance to chemo- and immunotherapies. Discovery of novel biomarkers in NSCLC progression is essential for improved prognosis and pharmacological interventions. In the current ... Read more >>

Biology (Basel) (Biology)
[2021, 10(11):]

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Identification of the ferroptosis-related long non-coding RNAs signature to improve the prognosis prediction and immunotherapy response in patients with NSCLC.

Meng Li, Yanpeng Zhang, Meng Fan, Hui Ren, Mingwei Chen, Puyu Shi,

Non-small cell lung cancer (NSCLC) is the most prevalent type of lung carcinoma with an unfavorable prognosis. Ferroptosis is involved in the development of multiple cancers. Whereas, the prognostic value of ferroptosis-related lncRNAs in NSCLC remains uncertain. Gene expression profiles and clinical information of NSCLC were retrieved from the TCGA ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2021, 14(1):286]

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Clinical Effectiveness of Immune Checkpoint Inhibitors in Non-Small-Cell Lung Cancer with a Poor Performance Status.

Kyoichi Kaira, Hisao Imai, Atsuto Mouri, Ou Yamaguchi, Hiroshi Kagamu,

Immune checkpoint inhibitors (ICIs) are standard treatments for patients with lung cancer. PD-1/PD-L1 or CTLA4 antibodies are chosen as the first-line therapy, contributing to the long-term survival and tolerability. Unlike molecular targeting agents, such as gefitinib, lung cancer patients with a poor performance status (PS) display unsatisfactory clinical improvements after ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2021, 57(11):]

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Targeted next-generation sequencing for cancer-associated gene mutation and copy number detection in 206 patients with non-small-cell lung cancer.

Songbai Zheng, Xiaodan Wang, Ying Fu, Beibei Li, Jianhua Xu, Haifang Wang, Zhen Huang, Hui Xu, Yurong Qiu, Yaozhou Shi, Kui Li,

The knowledge of genetic variation in Chinese patients with non-small-cell lung cancer (NSCLC) is still limited. We aimed to profile this genetic variation in 206 Chinese patients with NSCLC using next-generation sequencing. Tumor tissues or whole-blood samples were collected and subjected to whole-exome targeted next-generation sequencing, which included 565 tumor-associated genes, for somatic gene mutation screening ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):791-802]

Cited: 2 times

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Identification of circRNA_001846 as putative non-small cell lung cancer biomarker.

Fan Yang, Chunlan Ma, Jing Qiu, Xiaoli Feng, Kai Yang,

CircRNAs play diverse roles in the regulation of oncogenic processes, yet the roles of these circRNAs in non-small cell lung cancer (NSCLC) remain to be fully clarified. Herein, patterns of circRNA expression in NSCLC tissues and paracancerous tissues were assessed, and the relationships between these circRNAs and NSCLC patient clinical ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8690-8697]

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Anti-EGFR monoclonal antibody plus chemotherapy for treating advanced non-small cell lung cancer : A meta-analysis

Wenqing Luo, Yuanqi Li, Fei Ye, Qiangming Li, Guoqing Zhang, Jindong Li, Xiangnan Li,

Abstract <h4>Background:</h4> The use of standard cytotoxic chemotherapy seems to have reached a “treatment plateau”. The application of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) is a new strategy for non-small-cell lung cancer (NSCLC) therapy. We aimed to comprehensively assess the efficacy and safety of anti-EGFR-mAbs plus chemotherapy as ... Read more >>

Medicine (Madr) (Medicine)
[2021, 100(47):]

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Knockdown of hsa_circ_0000729 Inhibits the Tumorigenesis of Non-Small Cell Lung Cancer Through Mediation of miR-1281/FOXO3 Axis.

Xiao Xie, Fangbao Ding, Haibo Xiao,

<h4>Background</h4>Non-small cell lung cancer (NSCLC) is a subtype of lung cancer which seriously threatens the health of people. Circular RNAs (CircRNAs) are endogenous RNAs which have stable closed structure; they are known to be involved in tumorigenesis of NSCLC. Meanwhile, hsa_circ_0000729 was reported to be upregulated in NSCLC. Nevertheless, the ... Read more >>

Cancer Manag Res (Cancer management and research)
[2021, 13:8445-8455]

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Knock-down of microRNA miR-556-5p increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via activating NLR family pyrin domain containing 3 (NLRP3)-mediated pyroptotic cell death.

Feng Shi, Luquan Zhang, Xing Liu, Yue Wang,

MicroRNAs (miRNAs) are small non-coding RNAs that are closely associated with cancer progression and drug resistance, however, up until now, the involvement of miR-556-5p in regulating cisplatin-sensitivity in non-small cell lung cancer (NSCLC) has not been studied. In the present study, we found that miR-556-5p was significantly upregulated in the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6332-6342]

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Targeting the miR-6734-3p/ZEB2 axis hampers development of non-small cell lung cancer (NSCLC) and increases susceptibility of cancer cells to cisplatin treatment.

Linying Wei, Jianyang Jiang,

The unclear pathogenesis mechanisms and resistance of cancer cells to chemical drugs serious limits the development of effective treatment strategies for non-small cell lung cancer (NSCLC). In this study, we managed to investigate this issue, and identify potential cancer associated biomarkers for NSCLC diagnosis, prognosis and treatment. This study found ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2499-2510]

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CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.

Jia Yu, Haining Zhang, Chunsheng Zhao, Guanghui Li, Yingying Zhang, Yang Sun,

<h4>Background</h4>Circular RNAs (circRNAs) participate in the genesis and progression of tumors, including non-small cell lung cancer (NSCLC). At present, the role and regulatory mechanisms of circRNAs in NSCLC have not been fully elucidated. The aim of this study was to explore the role and regulatory mechanism of circRNA hsa_circ_0008037 (circ_0008037) ... Read more >>

Thorac Cancer (Thoracic cancer)
[2021, :]

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Zebrafish xenograft model for studying mechanism and treatment of non-small cell lung cancer brain metastasis.

Ruo-Yue Fan, Jia-Qi Wu, Yu-Yang Liu, Xiang-Yu Liu, Si-Tong Qian, Chong-Yong Li, Ping Wei, Zhe Song, Ming-Fang He,

<h4>Background</h4>Brain metastasis (BM) is thought to be related to the mortality and poor prognosis of non-small cell lung cancer (NSCLC). Despite promising development of NSCLC treatment, the treatment of NSCLC BM is still not optimistic due to the existence of the blood-brain barrier (BBB) that prevent drug penetration, as well ... Read more >>

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2021, 40(1):371]

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Silencing of the lncRNA H19 enhances sensitivity to X-ray and carbon-ions through the miR-130a-3p /WNK3 signaling axis in NSCLC cells.

Xueshan Zhao, Xiaodong Jin, Qiuning Zhang, Ruifeng Liu, Hongtao Luo, Zhen Yang, Yichao Geng, Shuangwu Feng, Chengcheng Li, Lina Wang, Xiaohu Wang, Qiang Li,

The lncRNA H19 is believed to act as an oncogene in various types of tumors and is considered to be a therapeutic target and diagnostic marker. However, the role of the lncRNA H19 in regulating the radiosensitivity of non-small cell lung cancer (NSCLC) cells is unknown. The expression profiles of ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):644]

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Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC.

Shi-Wei Chen, Shu-Qiang Zhu, Xu Pei, Bai-Quan Qiu, Dian Xiong, Xiang Long, Kun Lin, Feng Lu, Jian-Jun Xu, Yong-Bing Wu,

<h4>Background</h4>CD8<sup>+</sup> T cells play a critical role in the innate antitumour immune response. Recently, CD8<sup>+</sup> T cell dysfunction has been verified in various malignant cancers, including non-small cell lung cancer (NSCLC). However, the molecular biological mechanisms of CD8<sup>+</sup> T cell dysfunction in human NSCLC are still unclear.<h4>Methods</h4>The expression of circular ... Read more >>

Mol Cancer (Molecular cancer)
[2021, 20(1):144]

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Prognostic characterization of immune molecular subtypes in non-small cell lung cancer to immunotherapy.

Chenlu Li, Jingjing Pan, Jing Luo, Xupeng Chen,

<h4>Background</h4>Non-small cell lung cancer (NSCLC) was usually associated with poor prognosis and invalid therapeutical response to immunotherapy due to biological heterogeneity. It is urgent to screen reliable biomarkers, especially immunotherapy-associated biomarkers, that can predict outcomes of these patients.<h4>Methods</h4>Gene expression profiles of 1026 NSCLC patients were collected from The Cancer Genome ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2021, 21(1):389]

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CircRPPH1 promotes cell proliferation, migration and invasion of non-small cell lung cancer (NSCLC) via the PI3K/AKT and JAK2/STAT3 signaling axes.

Jian-Wen Xiong, Si-Bei Song, Lin-Min Xiong, Chuan-Hui Duan, Qian Song, Dong-Liang Yu, Xiao-Qiang Zhang,

Non-small cell lung cancer (NSCLC) has markedly increased morbidity and mortality rate worldwide. Circular RNAs (circRNAs) were shown to regulate NSCLC progression. But, the underlying pathways of the circRPPH1-mediated regulation of NSCLC still need further exploration. We evaluated circRPPH1 levels in NSCLC tissues and cell lines via qRT-RCR. Moreover, using ... Read more >>

J Biochem (Journal of biochemistry)
[2021, :]

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Silencing tumor-intrinsic CD73 enhances the chemosensitivity of NSCLC and potentiates the anti-tumoral effects of cisplatin: An in vitro study.

Elham Baghbani, Saeed Noorolyai, Shima Rahmani, Dariush Shanehbandi, Mahdi Abdoli Shadbad, Leili Aghebati-Maleki, Ahad Mokhtarzadeh, Oronzo Brunetti, Rossella Fasano, Nicola Silvestris, Behzad Baradaran,

Besides suppressing anti-tumoral immune responses, tumor-intrinsic inhibitory immune checkpoints have been implicated in tumor development. Herein, we aimed to investigate the significance of tumor-intrinsic CD73, as an inhibitory immune checkpoint, in non-small cell lung cancer (NSCLC) development and propose a novel therapeutic approach. We investigated the cell viability, chemosensitivity, apoptosis, ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, :112370]

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The dawn of a new era, adjuvant EGFR inhibition in resected non-small cell lung cancer.

Barbara Melosky, Parneet Cheema, Rosalyn A Juergens, Natasha B Leighl, Geoffrey Liu, Paul Wheatley-Price, Adrian Sacher, Stephanie Snow, Ming-Sound Tsao, Deanna McLeod, Quincy Chu,

<h4>Background</h4>Adjuvant platinum-based chemotherapy is standard of care for patients with resected stage IIA/B or IIIA NSCLC. Overall survival is suboptimal due to the high metastatic potential of early-stage NSCLC and there is substantial clinical need for additional efficacious adjuvant treatment options.<h4>Methods</h4>PubMed (all time to 4 February 2021) and related conference ... Read more >>

Ther Adv Med Oncol (Therapeutic advances in medical oncology)
[2021, 13:17588359211056306]

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Circular RNA circVAPA contributes to non-small-cell lung cancer progression via miR-342-3p-dependent regulation of ZEB2.

Xiaoyang Liu, Yang Cheng, Yan Wang, Yinhong Zhang,

<h4>Background</h4>Accumulating evidence demonstrated that circular RNAs (circRNAs) play pivotal regulatory roles in the pathology of cancers. Disclosing the roles and molecular mechanisms of circRNAs in tumorigenesis and development is essential to identify novel diagnostic and therapeutic targets. In this study, we explored the role of circVAPA in non-small-cell lung cancer ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2021, 19(1):335]

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Circ_SETD3 regulates gefitinib sensitivity and tumor progression by miR-873-5p-dependent regulation of APPBP2 in non-small cell lung cancer.

Jun Sheng, Leyi Liu, Ting Dong, Xiang Wu,

Previous data have shown the prominent clinical efficacy of gefitinib in non-small cell lung cancer (NSCLC) patients. However, its therapeutic efficacy is limited because of the development of gefitinib resistance. This research is designed to investigate the role of circRNA SET domain containing 3, actin histidine (circ_SETD3) in the sensitivity ... Read more >>

J Chemother (Journal of chemotherapy (Florence, Italy))
[2021, :1-13]

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