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Foetal ductus arteriosus constriction unrelated to non-steroidal anti-Inflammatory drugs: a case report and literature review.

Giovanna Battistoni, Ramona Montironi, Jacopo Di Giuseppe, Luca Giannella, Giovanni Delli Carpini, Alessandra Baldinelli, Marco Pozzi, Andrea Ciavattini,

Foetal ductus arteriosus (DA) constriction can be found in complex foetal heart malformations, but rarely as an isolated defect. Although many cases of DA constriction are usually related to Non-steroidal Anti-Inflammatory Drugs (NSAIDs) maternal intake, other causes remain without an established aetiology and are referred to as idiopathic. Recently, a ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):860-873]

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The use of paracetamol for first-line treatment of acute sore throat. A descriptive generic qualitative study of GPs and patients.

Kimberley De Vocht, Tycho Debie, Hilde Bastiaens, Sibyl Anthierens,

<h4>Background</h4>Paracetamol is recommended as first-line treatment for an acute sore throat. However, in primary care, antibiotics are still frequently prescribed as first-line management for sore throat.<h4>Objectives</h4>We aimed to explore the views and experiences of general practitioners (GPs) and patients regarding paracetamol for sore throat to understand why guidelines are often ... Read more >>

Eur J Gen Pract (The European journal of general practice)
[2021, 27(1):60-67]

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Drug interactions detected by a computer-assisted prescription system in primary care patients in Spain: MULTIPAP study.

Eloísa Rogero-Blanco, Isabel Del-Cura-González, Mercedes Aza-Pascual-Salcedo, Francisca García de Blas González, Carmen Terrón-Rodas, Sergio Chimeno-Sánchez, Eva García-Domingo, Juan A López-Rodríguez, ,

<h4>Background</h4>Drug interactions increase the risk of treatment failure, intoxication, hospital admissions, consultations and mortality. Computer-assisted prescription systems can help to detect interactions.<h4>Objectives</h4>To describe the drug-drug interaction (DDI) and drug-disease interaction (DdI) prevalence identified by a computer-assisted prescription system in patients with multimorbidity and polypharmacy. Factors associated with clinically relevant interactions ... Read more >>

Eur J Gen Pract (The European journal of general practice)
[2021, 27(1):90-96]

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Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery.

Brett Doleman, Jo Leonardi-Bee, Thomas P Heinink, Hannah Boyd-Carson, Laura Carrick, Rahil Mandalia, Jon N Lund, John P Williams,

Postoperative pain is a common consequence of surgery and can have many negative perioperative effects. It has been suggested that the administration of analgesia before a painful stimulus may improve pain control. We defined pre-emptive nonsteroidal anti-inflammatories (NSAIDs) as those given before surgery but not continued afterwards and preventive NSAIDs ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2021, 6:CD012978]

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Longitudinal assessment of B-RAF V595E levels in the peripheral cell-free tumor DNA of a 10-year-old spayed female Korean Jindo dog with unresectable metastatic urethral transitional cell carcinoma for monitoring the treatment response to a RAF inhibitor (sorafenib).

Jung-Hyun Kim, Dana Hyunjung Ahn, Je-Sung Moon, Hyun-Jung Han, Kieun Bae, Kyong-Ah Yoon,

Transitional cell carcinoma (TCC) is the most common malignant tumor of the canine urinary tract. In this case study, a dog with metastatic urethral TCC was treated with sorafenib. The tumor expression levels of receptor tyrosine kinase genes, including <i>VEGFR-1, VEGFR-2, PDGFR-α, PDGFR-β, ALK, EGFR, ErbB2</i>, and <i>B-RAF</i>, were analyzed. ... Read more >>

Vet Q (The veterinary quarterly)
[2021, 41(1):153-162]

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Comparative Efficacy of 6 Topical Pharmacological Agents for Preventive Interventions of Postoperative Sore Throat After Tracheal Intubation: A Systematic Review and Network Meta-analysis.

Ge Wang, Yang Qi, LiNa Wu, GuiChun Jiang,

<h4>Background</h4>Topical pharmacological agents typically used to treat postoperative sore throat (POST) after tracheal intubation include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, lidocaine, Glycyrrhiza (licorice), and N-methyl-d-aspartate (NMDA) receptor antagonists (including ketamine and magnesium). However, the optimal prophylactic drug remains elusive.<h4>Methods</h4>The literature published before September 8, 2019 was searched on the PubMed, ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(1):58-67]

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Trends in Use of Prescription Nonsteroidal Anti-inflammatory Medications Before vs After Implementation of a Florida Law Restricting Opioid Prescribing for Acute Pain.

Shailina Keshwani, Ivanna Grande, Michael Maguire, Amie Goodin, Scott M Vouri, Juan M Hincapie-Castillo,

<h4>Importance</h4>Previous research has shown an immediate reduction in new opioid users and use after implementation of the opioid supply restriction laws. Assessment of the association between opioid restrictions and alternative treatment options, such as nonsteroidal anti-inflammatory drugs (NSAIDs), is needed to evaluate potential unintended consequences for patients requiring analgesia.<h4>Objective</h4>To evaluate ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(6):e2113383]

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Do NSAIDs Really Interfere with Healing after Surgery?

Stephan A Schug,

Perioperative analgesia should be multimodal to improve pain relief, reduce opioid use and thereby adverse effects impairing recovery. Non-steroidal anti-inflammatory drugs (NSAIDs) are an important non-opioid component of this approach. However, besides potential other adverse effects, there has been a longstanding discussion on the potentially harmful effects of NSAIDs on ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(11):]

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Potential Characteristics for Prediction of the Efficacy of Non-Steroid Anti-Inflammatory Drugs for Migraine Treatment: A Retrospective Cohort Study

Heng-Le Wei, Jin-Jin Wang, Gang-Ping Zhou, Yu-Sheng Yu, Hong Zhang,

<h4>Background: </h4> Although several special medications for migraine are currently available, non-steroid anti-inflammatory drugs (NSAIDs) are still the first-line pharmacological option. A considerable proportion of migraineurs still be unresponsive to NSAIDs for reasons that remain unknown. The study aimed to develop significant characteristics to predict the efficacy of NSAIDs for ... Read more >>

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Non-steroidal anti-inflammatory agents and anastomotic leak rates across colorectal cancer operations and anastomotic sites: A systematic review and meta-analysis of anastomosis specific leak rate and confounding factors.

S L Kastora, L L Osborne, R Jardine, G Kounidas, B Carter, P K Myint,

<h4>Background</h4>Surgical intervention presents a fundamental therapeutic choice in the management of colorectal malignancies. Complications, the most serious one being anastomotic leak (AL), still have detrimental effects upon patients' morbidity and mortality. We aimed to assess whether NSAIDs, and their sub-categories, increase AL in colonic anastomoses and to identify whether this ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, :]

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National drug utilization trend of analgesics in China: an analysis of procurement data at 793 public hospitals from 2013 to 2018.

Honghao Shi, Xianwen Chen, Xueli Liu, He Zhu, Fei Yu, Carolina Oi Lam Ung, Wai Sin Chan, Hao Hu, Sheng Han,

<h4>Background</h4>This research aimed to evaluate analgesic utilization in public hospitals from 2013 to 2018 by analyzing the procurement data of 793 hospitals in China.<h4>Methods</h4>This study applied a retrospective observational study by using a database of the Chinese Pharmaceutical Association. The final dataset covers 30 provinces and municipalities in China, with ... Read more >>

J Pharm Policy Pract (Journal of pharmaceutical policy and practice)
[2021, 14(1):45]

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Can Ultrasound Therapy Be an Environmental-Friendly Alternative to Non-Steroidal Anti-Inflammatory Drugs in Knee Osteoarthritis Treatment?

Rodica Ana Ungur, Viorela Mihaela Ciortea, Laszlo Irsay, Alina Deniza Ciubean, Bogdana Adriana Năsui, Răzvan Andrei Codea, Victoria Emilia Singurean, Oana Bianca Groza, Simona Căinap, Georgiana Smaranda Martiș Petruț, Cristin Borda, Ileana Monica Borda,

The non-steroidal anti-inflammatory drugs (NSAIDs) are the most used drugs in knee OA (osteoarthritis) treatment. Despite their efficiency in pain and inflammation alleviation, NSAIDs accumulate in the environment as chemical pollutants and have numerous genetic, morphologic, and functional negative effects on plants and animals. Ultrasound (US) therapy can improve pain, ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2021, 14(11):]

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NSAIDs not linked to worse COVID-19 outcomes.

Sarah Onuora,

Nat Rev Rheumatol (Nature reviews. Rheumatology)
[2021, :]

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Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings.

Maureen F Cooney,

Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used for pediatric pain management in the emergency setting and postoperatively. This narrative literature review evaluates pain relief, opioid requirements, and adverse effects associated with NSAID use. A PubMed search was conducted to identify randomized controlled trials evaluating the use of conventional systemic NSAIDs ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2021, :]

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The Effects of Chemotherapy on Circulating Plasma Carotenoids and Fat-Soluble Vitamins in Breast Cancer Patients

Djawed Bennouna, Tonya Orchard, Maryam Lustberg, Rachel Kopec,

Abstract <h4>Objectives</h4> Chemotherapy upregulates inflammatory processes as measured by circulating concentrations of pro-inflammatory cytokines and their signaling lipids. Our objective was to observe if breast cancer chemotherapy influenced the circulating concentrations of provitamin A and non-provitamin A carotenoids and fat-soluble vitamins (FSVs) in free-living patients. <h4>Methods</h4> Serum samples were collected ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2021, 5(Suppl 2):70-70]

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Prevalence use of nonsteroidal anti-inflammatory drugs in the general population with COVID-19 and associated COVID-19 risk, hospitalization, severity, death, and safety outcomes: A systematic review and meta-analysis

huilei zhao, Shanshan huang, kaibo mei, wen shao, jing zhang, jianyong ma, wengen zhu, yuan jiang, peng yu, xiao liu,

<h4>Introduction: </h4> Recent reports of potential harmful effects of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with Corona Virus Disease 2019 (COVID-19) have provoked great concern. Therefore, the safety of NSAIDs is still questioned. Methods We searched the PubMed, EMBASE, Cochrane Library and Web of Science databases from December 2019 ... Read more >>

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Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study.

Milena Simic, Alison R Harmer, Maria Agaliotis, Lillias Nairn, Lisa Bridgett, Lyn March, Milana Votrubec, John Edmonds, Mark Woodward, Richard Day, Marlene Fransen,

<h4>Background</h4>The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis.<h4>Methods</h4>A longitudinal study was conducted within a randomised controlled trial, the "Long-term Evaluation of Glucosamine Sulfate" (LEGS study). Recruitment occurred in 2007-2009, with ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2021, 23(1):160]

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Effects of NSAIDs on pre-osteoblast viability and osteogenic differentiation.

Chrystalleni Hadjicharalambous, Kalliopi Alpantaki, Maria Chatzinikolaidou,

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of a variety of musculoskeletal conditions, injuries and after surgery for postoperative pain management. Their use has been associated with impaired bone healing, possibly due to a multifactorial function, which may include inhibition of osteoblast recruitment and differentiation. However, up ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2021, 22(1):740]

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Prevalence use of nonsteroidal anti-inflammatory drugs in the general population with COVID-19 and associated COVID-19 risk, hospitalization, severity, death, and safety outcomes: A systematic review and meta-analysis

Huilei Zhao, Shanshan Huang, Kaibo Mei, Wen Shao, Jing Zhang, Jianyong Ma, Wengen Zhu, Yuan Jiang, Peng Yu, Xiao Liu,

<h4>Introduction</h4> Recent reports of potential harmful effects of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with Corona Virus Disease 2019 (COVID-19) have provoked great concern. Therefore, the safety of NSAIDs is still questioned. <h4>Methods</h4> We searched the PubMed, EMBASE, Cochrane Library and Web of Science databases from December 2019 to January ... Read more >>

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Non-steroidal anti-inflammatory drug use in COVID-19.

Kristian Kragholm, Christian Torp-Pedersen, Emil Fosbol,

Lancet Rheumatol (The Lancet. Rheumatology)
[2021, :]

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Do Nonsteroidal Anti-Inflammatory or COX-2 Inhibitor Drugs Increase the Nonunion or Delayed Union Rates After Fracture Surgery?: A Propensity-Score-Matched Study.

Hyojune Kim, Do-Hoon Kim, Dong Min Kim, Erica Kholinne, Eui-Sup Lee, Wael Mohammed Alzahrani, Ji Wan Kim, In-Ho Jeon, Kyoung Hwan Koh,

<h4>Background</h4>The effects of nonsteroidal anti-inflammatory drugs (NSAIDs)/cyclooxygenase (COX)-2 inhibitors on postoperative fracture-healing are controversial. Thus, we investigated the association between NSAID/COX-2 inhibitor administration and postoperative nonunion or delayed union of fractures. We aimed to determine the effects of NSAID/COX-2 inhibitor administration on postoperative fracture-healing with use of a common data ... Read more >>

J Bone Joint Surg Am (The Journal of bone and joint surgery. American volume)
[2021, :]

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Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19.

Ki Kwang Oh, Md Adnan, Dong Ha Cho,

Non-steroidal anti-inflammatory drugs (NSAIDs) showed promising clinical efficacy toward COVID-19 (Coronavirus disease 2019) patients as potent painkillers and anti-inflammatory agents. However, the prospective anti-COVID-19 mechanisms of NSAIDs are not evidently exposed. Therefore, we intended to decipher the most influential NSAIDs candidate(s) and its novel mechanism(s) against COVID-19 by network pharmacology. ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):9606]

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Non-inferiority Trial Investigating the Efficacy of Non-steroidal Anti-inflammatory Drugs and Antimicrobial Treatment of Mild to Moderate Clinical Mastitis in Dairy Cows With Long-lasting Udder Diseases.

Volker Krömker, Anne Schmenger, Doris Klocke, Ellen Maria Mansion-de Vries, Nicole Wente, Yanchao Zhang, Stefanie Leimbach,

To reduce ineffective antimicrobial usage in the treatment of non-severe clinical mastitis (CM) in cows with long-lasting udder diseases, non-antibiotic therapy with a non-steroidal anti-inflammatory drug (NSAID) was conducted and evaluated in a non-blinded, positively controlled, non-inferiority trial. Therefore, three-time systemic ketoprofen treatment at intervals of 24 h was evaluated ... Read more >>

Front Vet Sci (Frontiers in veterinary science)
[2021, 8:660804]

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A Malaysian Delphi consensus on managing knee osteoarthritis.

Swan Sim Yeap, Syamsul Rizal Abu Amin, Hazlyna Baharuddin, Kar Chai Koh, Joon Kiong Lee, Verna Kar Mun Lee, Nor Hamdan Mohamad Yahaya, Cheh Chin Tai, Maw Pin Tan,

<h4>Background</h4>The 2013 Malaysian Clinical Practice Guidelines on the Management of Osteoarthritis (OA) recommend a linear step-up approach to manage knee OA. However, patients with knee OA often require a multimodal approach to address OA-related pain symptoms and functional limitations. This consensus aimed to provide doctors with an updated set of ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2021, 22(1):514]

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Acid-sensing ion channel 3: An analgesic target.

Jasdip Singh Dulai, Ewan St John Smith, Taufiq Rahman,

Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activation by extracellular protons mediate a transient inward current inducing cellular excitability. ASIC subunits exhibit differential tissue ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):94-127]

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