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Vagus nerve plays a pivotal role in CD4+ T cell differentiation during CVB3-induced murine acute myocarditis.

Li Yue-Chun, Xiao-Hong Gu, Ge Li-Sha, De-Pu Zhou, Chao Xing, Xiao-Ling Guo, Lu-Lu Pan, Shi-Yang Song, Li-Li Yu, Guang-Yi Chen, Jia-Feng Lin, Mao-Ping Chu,

Abnormalities in CD4<sup>+</sup> T cell (Th cell) differentiation play an important role in the pathogenesis of viral myocarditis (VMC). Our previous studies demonstrated that activation of the cholinergic anti-inflammatory pathway (CAP) alleviated the inflammatory response. In addition, we observed that right cervical vagotomy aggravates VMC by inhibiting CAP. However, the ... Read more >>

Virulence (Virulence)
[2021, 12(1):360-376]

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The cardiovascular aspect of COVID-19.

Joseph Adu-Amankwaah, Richard Mprah, Adebayo Oluwafemi Adekunle, Marie Louise Ndzie Noah, Gabriel Komla Adzika, Jeremiah Ong'achwa Machuki, Hong Sun,

The coronavirus disease-2019 (COVID-19), an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2), has hit the world very hard by affecting millions of people across countries hence posing a major health threat on a global scale. This novel virus is thought to enter and cause infection in its ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):227-236]

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Blood alcohol levels in Finnish victims of non-ischaemic sudden cardiac death.

Janna P Kauppila, Lasse Pakanen, Katja Porvari, Juha Vähätalo, Lauri Holmström, Juha S Perkiömäki, Heikki V Huikuri, M Juhani Junttila,

<h4>Introduction</h4>Non-ischaemic heart disease (NIHD) is the underlying pathology in∼20% of all sudden cardiac deaths (SCDs). Heavy drinking is known to be associated with SCD due to ischaemic heart disease, but studies on association of recent alcohol consumption and SCD in patients with NIHD are scarce. We evaluated the blood alcohol ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):413-419]

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Effects of vitamin D3 supplementation in gilthead seabream (Sparus aurata) juveniles fed diets high in plant based feedstuffs

David Dominguez, Daniel Montero, Maria Jesus Zamorano, Pedro Castro, Ramon Fontanillas, Philip Antony Jesu Prabhu, Marisol Izquierdo,

Modern aquaculture feeds tend to contain lower levels of fish based ingredients, while increasing the content of plant ingredients. However, this may alter the vitamin profile of the feeds, leading to unbalanced vitamin supply. Requirements for several vitamins have been established for species such as carps and salmonids, but adequate ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2021, 543:Not Available]

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Differences between genetic dilated cardiomyopathy and myocarditis in children presenting with severe cardiac dysfunction.

Ferran Gran, Andrea Fidalgo, Paola Dolader, Marta Garrido, Alexandra Navarro, Jaume Izquierdo-Blasco, Joan Balcells, Marta Codina-Sola, Paula Fernandez-Alvarez, Anna Sabaté-Rotés, Pedro Betrián, Joaquín Fernández-Doblas, Raúl Abella, Ferran Roses-Noguer,

Acute myocarditis is an inflammatory disease of the myocardium, and it can present as severe heart failure in children. Differential diagnosis with genetic cardiomyopathy can be difficult. The objective of this study is to identify patterns of clinical presentation and to assess invasive and non-invasive measures to differentiate patients with ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2021, :]

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Myocarditis and pericarditis after vaccination for COVID‐19

Blake Hudson, Ryan Mantooth, Matthew DeLaney,

Abstract Two previously healthy males presented to the emergency symptoms with signs of pericarditis/myocarditis after being vaccinated with an mRNA vaccine for COVID‐19. ... Read more >>

J Am Coll Emerg Physicians Open (Journal of the American College of Emergency Physicians open)
[2021, 2(4):]

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Acute Myocarditis after SARS-CoV-2 Vaccination in a 24-Year-Old Man Miocardite aguda após vacinação anti -SARS-CoV-2 num homem de 24 anos

Paolo Cimaglia, Paolo Tolomeo, Claudio Rapezzi,

Rev Port Cardiol (Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology)
[2021, :]

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Risk of Myocarditis from COVID-19 Infection in People Under Age 20: A Population-Based Analysis

Mendel Singer, Ira Taub, David Kaelber,

<h4>ABSTRACT</h4> <h4>Background</h4> There have been recent reports of myocarditis (including myocarditis, pericarditis or myopericarditis) as a side-effect of mRNA-based COVID-19 vaccines, particularly in young males. Less information is available regarding the risk of myocarditis from COVID-19 infection itself. Such data would be helpful in developing a complete risk-benefit analysis for ... Read more >>

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Whole-genome sequencing analysis of clozapine-induced myocarditis

Ankita Narang, Paul Lacaze, Kathlyn Ronaldson, John McNeil, Mahesh Jayaram, Naveen Thomas, Rory Sellmer, David Crockford, Robert Stowe, Steven Greenway, Christos Pantelis, Chad Bousman,

<h4>ABSTRACT</h4> One of the concerns limiting the use of clozapine in schizophrenia treatment is the risk of rare but potentially fatal myocarditis. Our previous genome-wide association study and human leucocyte antigen analyses identified putative loci associated with clozapine-induced myocarditis. However, the contribution of DNA variation in cytochrome P450 genes, copy ... Read more >>

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Myocarditis with COVID-19 mRNA Vaccines.

Biykem Bozkurt, Ishan Kamat, Peter J Hotez,

Myocarditis has been recognized as a rare complication of coronavirus 2019 (COVID-19) mRNA vaccinations, especially in young adult and adolescent males. According to the U.S. Centers for Disease Control (CDC), myocarditis/pericarditis rates are approximately 12.6 cases per million doses of second dose mRNA vaccine among 12-39-year-olds. In reported cases, patients ... Read more >>

Circulation (Circulation)
[2021, :]

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Clozapine-associated myocarditis in the World Health Organization’s pharmacovigilance database: Focus on reports from various countries.

Carlos De Las Cuevas, Emilio J Sanz, Can-Jun Ruan, Jose de Leon,

<h4>Introduction</h4>The incidence of clozapine-associated myocarditis varies by country. These variations were explored in VigiBase, the World Health Organization's global database which has >25 million spontaneously reported adverse drug reaction (ADR) reports from 145 national drug agencies.<h4>Methods</h4>On January 15, 2021, a search of Vigibase since inception focused on myocarditis in clozapine ... Read more >>

Rev Psiquiatr Salud Ment (Revista de psiquiatria y salud mental)
[2021, :]

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Myopericarditis following mRNA COVID-19 Vaccination in Adolescents 12 through 18 Years of Age

Bibhuti B. Das, Utkarsh Kohli, Preeti Ramachandran, Hoang H. Nguyen, Gerald Greil, Tarique Hussain, Animesh Tandon, Colin Kane, Sarvani Avula, Chioma Duru, Sannya Hede, Kavita Sharma, Devyani Chowdhury, Sunil Patel, Christopher Mercer, Nita Ray Chaudhuri, Bhavi Patel, Danyal Khan, Jocelyn Y. Ang, Basim Asmar, Joselito Sanchez, Karyssa Ann Bobosky, Clinton D. Cochran, Bassam M. Gebara, Ismael E. Gonzalez Rangel, Graham Krasan, Owais Siddiqui, Muhammad Waqas, Nidal El-Wiher, Bishara J. Freij,

<h4>Objectives</h4> To characterize the clinical course and outcomes of children who developed probable myopericarditis after vaccination with the Pfizer- BioNTech (BNT162b2) COVID-19 mRNA vaccine. <h4>Study design</h4> A cross-sectional study of 32 children, aged 12 through 18 years, diagnosed with probable myopericarditis following COVID-19 mRNA vaccination as per the CDC criteria ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, :]

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Recurrent Myocarditis After the First Dose of SARS-CoV-2 mRNA-1273 Vaccine

Giuseppe Di Tano, Luigi Moschini, Elva Vicenta Calvaruso, Gian Battista Danzi,

<h4>Background: </h4> Several cases of myocarditis associated with COVID-19 mRNA vaccines have recently been reported in which the mechanism of vaccine-induced myocarditis has not been clearly identified. Case presentation. We describe the case of a 29-year-old man who had an episode of recurrent acute myocarditis (confirmed by cardiac magnetic resonance) ... Read more >>

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Clinical Outcome and Risk Factors for Acute Fulminant Myocarditis Supported by Venoarterial Extracorporeal Membrane Oxygenation: an Analysis of Nationwide CSECLS Database in China Mainland

Tong Hao, Yu Jiang, Changde Wu, Chenglong Li, Chuang Chen, Jianfeng Xie, Chun Pan, Fengmei Guo, Yingzi Huang, Ling Liu, Haixiu Xie, Zhongtao Du, Xiaotong Hou, Songqiao liu, Yi Yang, Haibo Qiu,

<h4>Purpose: </h4> To assess the outcomes and risk factors for adult patients with acute fulminant myocarditis supported with venoarterial extracorporeal membrane oxygenation (VA ECMO) in China mainland. <h4>Methods: </h4>: Data were extracted from Chinese Society of ExtraCorporeal Life Support (CSECLS) Registry database. Data from adult patients who were diagnosed with ... Read more >>

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COVID-19 Vaccine and Myocarditis

Husam M. Salah, Jawahar L. Mehta,

Am J Cardiol (The American journal of cardiology)
[2021, :]

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Entrectinib-related myocarditis in a young female patient with metastatic non-small cell lung cancer.

Marta Fonseca, Daniel H Chen, John Malcolm Walker, Arjun K Ghosh,

A 51-year-old woman presented with a 2-week history of off balance, left lower limb weakness and neglect and neck pain radiating down the right arm. Investigations revealed a metastatic, ROS1 fusion-positive, non-small cell lung cancer, and treatment with entrectinib, a recently approved multikinase inhibitor, was started. Two weeks after, she ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(7):]

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Brugada-like pattern and myocarditis in a child with multisystem inflammatory syndrome: overlap or differential diagnosis?

Isabella Piazza, Hussam Ali, Paolo Ferrero,

Eur Heart J Case Rep (European heart journal. Case reports)
[2021, 5(7):ytab289]

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Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review.

Shujing Liang, Jingxian Yang, Yun Lin, Tong Li, Wenrong Zhao, Jun Zhao, Chunyan Dong,

Immunotherapy begins to be widely used due to the increasing exploration and gratifying effects in multiple cancers. Chordoma, as a rare bone malignant tumor, often recurs and metastasizes after undergoing surgery and radiotherapy. Therefore, immunotherapy can be explored as an emerging, potentially effective treatment to improve the survival rate and ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:682262]

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COVID-19-associated myocarditis presenting as new-onset heart failure and atrial fibrillation.

Sean Gaine, Patrick Devitt, John Joseph Coughlan, Ian Pearson,

A 58-year-old man presented to the emergency department with recent-onset palpitations and progressive exertional dyspnoea. ECG demonstrated new-onset atrial fibrillation. Transthoracic echocardiogram showed global impairment in left ventricular systolic function with left ventricular ejection fraction of 20%. Cardiac MRI (CMRI) demonstrated generalised severe myocarditis. A SARS-CoV-2 PCR was positive for ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(7):]

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Targeted treatment in viral-associated inflammatory cardiomyopathy.

Ahmad Amin, Sepideh Taghavi, Maryam Chenaghlou, Elahe Zare, Monireh Kamali, Nasim Naderi,

Detection of viruses like HHV-6 in endomyocardial biopsy or serum serology of patients with myocarditis or heart failure features unresponsive to conventional heart failure therapies could be a potential targeted treatment especially in refractory cases. ... Read more >>

Clin Case Rep (Clinical case reports)
[2021, 9(7):e04518]

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Focus on Autoimmune Myocarditis in Graves' Disease: A Case-Based Review.

Lujin Wu, Wei Wang, Qianru Leng, Nana Tang, Ning Zhou, Yan Wang, Dao Wen Wang,

The manifestations of hyperthyroidism-related myocardial damage are multitudinous, including arrhythmia, dilated cardiomyopathy, valvular diseases, and even cardiogenic shock. Acute myocarditis induced by thyrotoxicosis had been reported in a few studies. However, attention on its prevalence and underlying mechanisms is sorely lacking. Its long-term harm is often ignored, and it may ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:678645]

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Use of mRNA COVID-19 Vaccine After Reports of Myocarditis Among Vaccine Recipients: Update from the Advisory Committee on Immunization Practices - United States, June 2021.

Julia W Gargano, Megan Wallace, Stephen C Hadler, Gayle Langley, John R Su, Matthew E Oster, Karen R Broder, Julianne Gee, Eric Weintraub, Tom Shimabukuro, Heather M Scobie, Danielle Moulia, Lauri E Markowitz, Melinda Wharton, Veronica V McNally, José R Romero, H Keipp Talbot, Grace M Lee, Matthew F Daley, Sara E Oliver,

In December 2020, the Food and Drug Administration (FDA) issued Emergency Use Authorizations (EUAs) for the Pfizer-BioNTech COVID-19 (BNT162b2) vaccine and the Moderna COVID-19 (mRNA-1273) vaccine,<sup>†</sup> and the Advisory Committee on Immunization Practices (ACIP) issued interim recommendations for their use in persons aged ≥16 years and ≥18 years, respectively.<sup>§</sup> In ... Read more >>

MMWR Morb Mortal Wkly Rep (MMWR. Morbidity and mortality weekly report)
[2021, 70(27):977-982]

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Pediatric Fulminant Myocarditis in Japan: A Retrospective Nationwide Database Study of Hospital Volume, Management Practices, and Mortality.

Shingo Ohki, Koji Hosokawa, Shinichi Tomioka, Masumi Matsuoka, Kiyohide Fushimi, Shinya Matsuda, Nobuaki Shime,

<h4>Objectives</h4>Pediatric fulminant myocarditis is a subset of pediatric acute myocarditis associated with critical illness. We aimed to compare mortality and other outcomes such as length of hospital stay between pediatric fulminant myocarditis and nonfulminant myocarditis. For the subgroup of patients with fulminant myocarditis, we also aimed to describe the current ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(7):e391-e401]

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Global, Regional, and National Burden of Myocarditis From 1990 to 2017: A Systematic Analysis Based on the Global Burden of Disease Study 2017.

Xiqiang Wang, Xiang Bu, Linyan Wei, Jing Liu, Dandan Yang, Douglas L Mann, Aiqun Ma, Tomohiro Hayashi,

<b>Objective:</b> The global trends in myocarditis burden over the past two decades remain poorly understood and might be increasing during the coronavirus disease 2019 (COVID-19) worldwide pandemic. This study aimed to provide comprehensive estimates of the incidence, mortality, and disability-adjusted life years (DALYs) for myocarditis globally from 1990 to 2017. ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:692990]

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Presence of active myocarditis at the 6 month follow-up appointment for a severe form of COVID-19: a case report.

Maxence Meyer, Thomas Vogel, Anita Meyer, Florentin Constancias, Louise F Porter, Georges Kaltenbach, Elise Schmitt, Saïd Chayer, Floriane Zeyons, Marianne Riou, Samira Fafi-Kremer, Aurélie Velay, Soraya El Ghannudi,

Here, we present the case of an 81-year-old male patient, who was hospitalized for a severe form of COVID-19. Transthoracic echocardiogram (TTE) performed 1 month after symptom onset was normal. Respiratory evolution was favourable, and the patient was discharged at Day 78. At 6 months, despite a good functional recovery, he presented ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, :]

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