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Missense mutation of a conserved residue in UNC-112 (kindlin) eliminates binding to PAT-4 (ILK).

Hiroshi Qadota, Andres F Oberhauser, Guy M Benian,

<i>C. elegans</i> UNC-112 (kindlin) is required for muscle sarcomere assembly, and is one component of a conserved four-protein complex that associates with the cytoplasmic tail of integrin at the base of integrin adhesion complexes in muscle. The four-protein complex consists of UNC-112 (kindlin), PAT-4 (integrin linked kinase; ILK), PAT-6 (alpha-parvin), ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Transgenic reporter analysis of ChIP-Seq-defined enhancers identifies novel target genes for the terminal selector UNC-3/Collier/Ebf.

Yinan Li, Paschalis Kratsios,

Terminal selector-type transcription factors are key regulators of neuronal identity and function (Hobert and Kratsios, 2019; Kratsios and Hobert, 2018). Mechanistically, terminal selectors are thought to act directly through binding at the <i>cis</i>-regulatory region of genes (termed "terminal identity genes") that encode, among others, neurotransmitter [NT] synthesis proteins, ion channels, ... Read more >>

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[2021, 2021:]

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Widespread gpa-4 promoter-driven expression during Caenorhabditis elegans development.

Jaime Osuna-Luque, Collin Y Ewald, Peter Meister,

The <i>gpa-4</i> promoter-driven expression is described as specific for ASIL and ASIR chemosensory neurons in the nematode <i>Caenorhabditis elegans</i>, yet this was mostly examined in adult animals. Here we used a recombination-mediated reporter to test the previously used <i>gpa-4</i> promoter expression. This reporter highlights all cells in which the <i>gpa-4</i> ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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EGL-4 promotes turning behavior of C. elegans males during mating.

Shapour Rahmani, Simon Tuck,

During mating, <i>C. elegans</i> males whose tails have reached the head or tail of their intended mates are able to switch to scanning the other side by performing a turn during which the male's tail curls ventrally all the while keeping in contact with the hermaphrodite. The ability to execute ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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The Caenorhabditis elegans tmc-1 is involved in egg-laying inhibition in response to harsh touch.

Eva Kaulich, Denise S Walker, Yi-Quan Tang, William Ronald Schafer,

The conserved family of Transmembrane channel-like (TMC) proteins has attracted significant interest since two members appear to be key components of the mammalian hair cell mechanotransducer involved in hearing. <i>C. elegans</i> expresses two TMC proteins, TMC-1 and TMC-2. TMC-1 is widely expressed in in both muscles and the nervous system. ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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GPN-1/glypican and UNC-52/perlecan do not appear to function in BMP signaling to pattern the C. elegans postembryonic mesoderm.

Melisa S DeGroot, Robert Greer, Jun Liu,

Heparan sulfate proteoglycans (HSPGs) are diverse macromolecules consisting of a protein core modified with glycosaminoglycan (GAG) chains. HSPGs, including glypicans and perlecans, have been implicated in shaping the extracellular matrix (ECM) to affect growth factor signaling. Here, we tested if GPN-1/glypicanor UNC-52/perlecan plays a role in the bone morphogenetic protein ... Read more >>

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[2021, 2021:]

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Efficient generation of a single-copy eft-3p::TIR1::F2A:: BFP::AID*::NLS allele in the C. elegans ttTi5605 insertion site through recombination-mediated cassette exchange.

An A Vo, Max T Levenson, James Matthew Ragle, Jordan D Ward,

The auxin-inducible degron (AID) system is a widely used system to conditionally deplete proteins. Using CRISPR/Cas9-based genome editing in <i>C. elegans</i>, we recently generated a set of single-copy, tissue-specific and pan-somatic TIR1-expressing strains carrying a BFP reporter inserted in single-copy into two commonly used, well-characterized genetic loci. However, we were ... Read more >>

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[2021, 2021:]

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The primordial germ line is refractory to perturbations of actomyosin regulator function in C. elegans L1 larvae.

Jack Bauer, Léa Lacroix, Jean-Claude Labbé,

Cytokinesis, the separation of daughter cells at the end of mitosis, relies on the coordinated activity of several regulators of actomyosin assembly and contractility (Green et al. 2012). These include the small GTPase RhoA (RHO-1) and its guanine-nucleotide exchange factor Ect2 (ECT-2), the scaffold protein Anillin (ANI-1), the non-muscle myosin ... Read more >>

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[2021, 2021:]

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Synergistic effects of hmp-2/β-catenin and sma-1H-spectrin on epidermal morphogenesis in Caenorhabditis elegans.

Sydney Wieberg, Harper Euwer, Anna Gerst, Stephanie L Maiden,

The F-actin, spectrin, and microtubule cytoskeletons are important mediators of embryonic epidermal morphogenesis in <i>Caenorhabditis elegans</i>. While SMA-1/β<sub>H</sub>-spectrin is known to organize actin bundles that connect to cadherin-based adhesions, the role of microtubules in the developing epidermis is not well understood. To determine if the spectrin cytoskeleton also plays a ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Swimming exercise reduces native ⍺-synuclein protein species in a transgenic C. elegans model of Parkinson's disease.

Minna Y Schmidt, Manish Chamoli, Gordon J Lithgow, Julie K Andersen,

Exercise has been historically recommended to prevent many disease conditions. Intense exercise in particular, has been shown to be beneficial for Parkinson's disease (PD) - stopping and even reversing symptoms in some patients. Recent research in mammalian animal models of Parkinson's have shown that exercise affects ⍺-synuclein aggregate species, considered ... Read more >>

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[2021, 2021:]

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Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster.

Heiko Meyer, Annika Buhr, Patrick Callaerts, Ronja Schiemann, Mariana F Wolfner, Steven J Marygold,

The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is associated with numerous human diseases. Here, we present a comprehensive list and classification of M13 family members in <i>Drosophila melanogaster</i>. Seven <i>Neprilysin</i> (<i>Nep</i>) ... Read more >>

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[2021, 2021:]

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The Joubert syndrome protein CEP41 is excluded from the distal segment of cilia in C. elegans.

Sebiha Cevik, Oktay I Kaplan,

Rare diseases are a fundamental issue in today's world, affecting more than 300 million individuals worldwide. According to data from Orphanet and OMIM, about 50-60 new conditions are added to the list of over 6,000 clinically distinct diseases each year, rendering disease diagnosis and treatment even more challenging. Ciliopathies comprise ... Read more >>

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[2021, 2021:]

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ifas-1 is upregulated by fungal infection in a GPA-12 and STA-2-independent manner in the Caenorhabditis elegans epidermis.

Shizue Omi, Xing Zhang, Nishant Thakur, Nathalie Pujol,

Skin infection with the fungus <i>Drechmeria coniospora</i> leads to a transcriptional response in the worm epidermis. This involves an increased expression of a group of antimicrobial peptide (AMP) genes including those in the <i>nlp-29</i> and <i>cnc-2</i> clusters. The major pathways leading to the expression of these AMP genes have been ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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N-terminally endogenous mKate2-tagged HIM-4 in Caenorhabditis elegans.

Shinji Ihara,

The gene <i>him-4</i> encodes the <i>C. elegans</i> homolog of hemicentin, an evolutionarily conserved extracellular matrix protein. Despite being an extracellular matrix protein, mutations in him-4 result in pleiotropic defects during development and demonstrate tissue fragility. While previous studies in <i>C. elegans</i> have confirmed the localization of either transgenic HIM-4::GFP or ... Read more >>

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[2021, 2021:]

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Differential effects on neuromuscular physiology between Sod1 loss-of-function mutation and paraquat-induced oxidative stress in Drosophila.

Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu,

Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of <i>Superoxide dismutase 1</i> (<i>Sod1</i>) and by paraquat (PQ) feeding in <i>Drosophila</i>. We demonstrated alterations in <i>Sod1</i> mutants; the larval neuromuscular junction displayed supernumerary discharges and the ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Subcellular localization of the voltage-gated K+ channel EGL-36 , a member of the KV3 subfamily, in the ciliated sensory neurons in C. elegans.

Sebiha Cevik, Oktay I Kaplan,

Delineated as the first cellular organelle in 1675 by Antonie van Leeuwenhoek, cilia did not receive much attention until the 2000s, when it became apparent that cilia played a key role in the development of embryos, a variety of signaling pathways. Therefore, collective efforts by many scientists have led to ... Read more >>

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[2021, 2021:]

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sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress.

Veronica H Ryan, Anne C Hart,

Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between <i>sym-2</i>, the gene encoding an ortholog of hnRNPF and hnRNPH, and <i>hrpa-1</i>, the ortholog of of the gene encoding hnRNPA2, which when mutated ... Read more >>

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[2021, 2021:]

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Estimation of C. elegans cell- and tissue volumes.

Jonathan J Froehlich, Nikolaus Rajewsky, Collin Y Ewald,

Although <i>C. elegans</i> is one of the best-studied model organisms, an estimate of its cell sizes and tissues is missing. Here we used the Virtual Worm that is based on electron microscopy images to calculate a zeroth-order approximation of cell and tissue sizes of <i>C. elegans</i>. We conclude that the ... Read more >>

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[2021, 2021:]

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A histamine-gated channel is an efficient negative selection marker for C. elegans transgenesis.

Sonia El Mouridi, Sarah AlHarbi, Christian Frøkjær-Jensen,

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Genetic analysis of the interaction between the N- and C-terminal halves of UNC-112 (kindlin).

Hiroshi Qadota, Yating Luo, Andres F Oberhauser, Guy M Benian,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos.

Fan-Suo Geng, Elisa de la Calle-Mustienes, José Luis Gómez-Skarmeta, Ryan Lister, Ozren Bogdanovic,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Minimum number of synaptic vesicles for the initiation of a single action potential at C. elegans neuromuscular junction.

Lili Chen, Ya Wang, Shangbang Gao,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Lipopolysaccharide stimulates egg laying in Caenorhabditis elegans.

Angela Ching-Yee Leung, Catherine Hughes, Jakob Gunderson, Myeongwoo Lee,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Zebrafish Trak proteins 1a and 2 localize to the mitochondria.

Kelsey A Oonk, Lauren B Bienvenu, Paxton S Sickler, Christine Martin, Emily Nickoloff-Bybel, Albert Matthew Volk, Douglas C Weiser, Susan Walsh,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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The cadmium-responsive gene, cdr-6, does not influence Caenorhabditis elegans responses to exogenous zinc.

Kathryn S Evans, Erik C Andersen,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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