Full Text Journal Articles about
Multiple System Atrophy

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RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.

Jung-Youn Han, Hyung-Sup Jang, Alison J E Green, Young Pyo Choi,

RT-QuIC is a shaking-based cyclic amplification technique originally developed in the prion field to detect minute amounts of scrapie prion protein (PrPSc). In this study, we applied the RT-QuIC assay to investigate a-synuclein (a-syn) seeding activity in brains of Dementia with Lewy Body (DLB) patients and in brains of G2-3 ... Read more >>

Prion (Prion)
[2020, 14(1):88-94]

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Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis.

Yihui Ma, Jinlin Song, Huthayfa N S Almassri, Dan Zhang, Ting Zhang, Yuting Cheng, Xiaohong Wu,

Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lactic-co-glycolic acid) (MINO-PLGA) electrospun membranes and to evaluate their ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):151-160]

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Genome-wide transcriptional analysis of Aristolochia manshuriensis induced gastric carcinoma.

Lianmei Wang, Chunying Li, Jingzhuo Tian, Jing Liu, Yong Zhao, Yan Yi, Yushi Zhang, Jiayin Han, Chen Pan, Suyan Liu, Nuo Deng, Zhong Xian, Guiqin Li, Xin Zhang, Aihua Liang,

Context: Aristolochia manshuriensis Kom (Aristolochiaceae) (AMK) is known for toxicity and mutagenicity.Objective: The tumorigenic role of AMK has yet to be understood.Materials and methods: AMK extracts were extracted from root crude drug. SD (Sprague Dawley) rats underwent gavage with AMK (0.92 g/kg) every other day for 10 (AMK-10) or 20 (AMK-20) ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):98-106]

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Impact of depressive symptoms on self-perceived severity of autonomic dysfunction in multiple system atrophy: relevance for patient-reported outcomes in clinical trials.

Jose Martinez, Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Amir Garakani, Horacio Kaufmann,

PURPOSE:To assess the relationship between depressive symptoms and self-perceived severity of autonomic dysfunction in patients with multiple system atrophy (MSA). METHODS:Cross-sectional evaluation of patients with MSA who underwent autonomic testing, Unified MSA Rating Scale (UMSARS)-1 and -2, rating of the presence and severity of depressive symptoms (Zung scale), quality of ... Read more >>

Clin. Auton. Res. (Clinical autonomic research : official journal of the Clinical Autonomic Research Society)
[2020, :]

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Theory of Mind in multiple system atrophy: comparison with Parkinson's disease and healthy subjects.

Gabriella Santangelo, Sofia Cuoco, Marina Picillo, Roberto Erro, Massimo Squillante, Giampiero Volpe, Autilia Cozzolino, Giulio Cicarelli, Paolo Barone, Maria Teresa Pellecchia,

Theory of Mind is defined as the ability to attribute mental state and emotions to other people and is relevant to social relationships. The cortical and subcortical regions involved in Theory of Mind are damaged by neurodegenerative processes of Parkinsonian syndromes, so the aim of the present study was to ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2020, :]

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Progression and prognosis in multiple system atrophy presenting with REM behavior disorder.

Giulia Giannini, Vincenzo Mastrangelo, Federica Provini, Andrea Droghini, Annagrazia Cecere, Giorgio Barletta, Francesco Mignani, Pietro Guaraldi, Pietro Cortelli, Giovanna Calandra-Buonaura,

OBJECTIVES:To investigate (1) the prevalence of REM sleep behavior disorder (RBD) as mode of disease onset in a cohort of patients with multiple system atrophy (MSA) and (2) disease progression and prognosis in patients with MSA with RBD predating (pre-RBD) and following (post-RBD) disease onset. METHODS:We retrospectively identified all patients ... Read more >>

Neurology (Neurology)
[2020, :]

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Association of orthostatic blood pressure with the symptoms of orthostatic hypotension and cognitive impairment in patients with multiple system atrophy.

Miki Ueda, Tomohiko Nakamura, Masashi Suzuki, Eriko Imai, Yumiko Harada, Kazuhiro Hara, Masaaki Hirayama, Masahisa Katsuno,

The degree and frequency of orthostatic hypotension (OH) are high in patients with multiple system atrophy (MSA); however, the association of orthostatic blood pressure (BP) with the symptoms of OH and cognitive impairment in these patients remains unclear. The aim of this study was to clarify whether absolute BP and/or ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, :]

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Diagnosing multiple system atrophy at the prodromal stage.

Chenjie Xia, Ronald B Postuma,

Identifying individuals at the earliest disease stage becomes crucial as we aim to develop disease-modifying treatments for neurodegenerative disorders. Prodromal diagnostic criteria were recently developed for Parkinson's disease (PD) and are forthcoming for dementia with Lewy bodies (DLB). The latest 2008 version of diagnostic criteria for multiple system atrophy (MSA) ... Read more >>

Clin. Auton. Res. (Clinical autonomic research : official journal of the Clinical Autonomic Research Society)
[2020, :]

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Exercise promotes recovery after motoneuron injury via hormonal mechanisms.

Cory Chew, Dale R Sengelaub,

Injuries to spinal motoneurons manifest in a variety of forms, including damage to peripheral axons, neurodegenerative disease, or direct insult centrally. Such injuries produce a variety of negative structural and functional changes in both the directly affected and neighboring motoneurons. Exercise is a relatively simple behavioral intervention that has been ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1373-1376]

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Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease.

Shunsuke Koga, Fuyao Li, Na Zhao, Shanu F Roemer, Tanis J Ferman, Anna I Wernick, Ronald L Walton, Ayman H Faroqi, Neill R Graff-Radford, William P Cheshire, Owen A Ross, Dennis W Dickson,

BACKGROUND:Abnormal aggregates of α-synuclein are pathologic hallmarks of multiple system atrophy (MSA) and Lewy body disease (LBD). LBD sometimes coexists with MSA, but the impact of co-pathology, particularly diffuse LBD, on presentation of MSA has not been studied. We aimed to determine the frequency and clinicopathologic features of MSA with ... Read more >>

Brain Pathol. (Brain pathology (Zurich, Switzerland))
[2020, :]

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Repeat expansion scanning of the NOTCH2NLC gene in patients with multiple system atrophy.

Pu Fang, Yanyan Yu, Sheng Yao, Shuyun Chen, Min Zhu, Yunqing Chen, Keji Zou, Lulu Wang, Huan Wang, Ling Xin, Tao Hong, Daojun Hong,

OBJECTIVE:Trinucleotide GGC repeat expansion in the 5'UTR of the NOTCH2NLC gene has been recognized as the pathogenesis of neuronal intranuclear inclusion disease (NIID). Previous studies have described that some NIID patients showed clinical and pathological similarities with multiple system atrophy (MSA). This study aimed to address the possibility that GGC ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, :]

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Recurrent laryngospasm as the only presenting feature of multiple system atrophy.

Federica Terenzi, Luca Giovanni Locatello, Alessio Novelli, Oreste Gallo, Silvia Ramat,

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Selective Cerebellar Atrophy Associates with Depression and Fatigue in the Early Phases of Relapse-Onset Multiple Sclerosis.

Andrea Lazzarotto, Monica Margoni, Silvia Franciotta, Sofia Zywicki, Alice Riccardi, Davide Poggiali, Mariagiulia Anglani, Paolo Gallo,

Cerebellar dysfunctions have been associated to depressive disorders and cognitive impairment in neurodegenerative diseases. The objective is to analyze the associations between cerebellar atrophy, depression, and fatigue in the early phases of relapse-onset multiple sclerosis (RRMS). Sixty-one RRMS patients and 50 healthy controls (HC) were enrolled and clinically evaluated by ... Read more >>

Cerebellum (Cerebellum (London, England))
[2020, 19(2):192-200]

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Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans.

Sergio Bagnato, Cristina Boccagni,

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1247-1248]

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α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species.

Sophie A Morgan, Isabelle Lavenir, Juan Fan, Masami Masuda-Suzukake, Daniela Passarella, Michael A DeTure, Dennis W Dickson, Bernardino Ghetti, Michel Goedert,

Assembled a-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of a-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of a-synuclein from the brains of ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2020, :]

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Cerebrospinal fluid neurogranin as a new player in prion disease diagnosis and prognosis.

Anna Villar-Pique, Inga Zerr, Franc Llorens,

Neural Regen Res (Neural regeneration research)
[2020, 15(5):861-862]

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Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.

Jorge A Trejo-Lopez, Zachary A Sorrentino, Cara J Riffe, Stefan Prokop, Dennis W Dickson, Anthony T Yachnis, Benoit I Giasson,

Human neurodegenerative diseases can be characterized as disorders of protein aggregation. As a key player in cellular autophagy and the ubiquitin proteasome system, p62 may represent an effective immunohistochemical target, as well as mechanistic operator, across neurodegenerative proteinopathies. In this study, 2 novel mouse-derived monoclonal antibodies 5G3 and 2A5 raised ... Read more >>

J. Neuropathol. Exp. Neurol. (Journal of neuropathology and experimental neurology)
[2020, 79(4):407-418]

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[Autonomic dysfunction in the patient with neurodegenerative disease].

R Roa-Chamorro, L Torres-Quintero, P González-Bustos,

Autonomic dysfunction is a common condition in the alpha-synucleinopathies (Parkinson's disease, dementia with Lewy bodies, multiple system atrophy). Cardiovascular symptoms may include orthostatic hypotension, supine hypertension or decreased heart rate response. A clinical suspicion and physical examination are essential for diagnosis, taking blood pressure in supine and standing positions. The ... Read more >>

Hipertens Riesgo Vasc (Hipertension y riesgo vascular)
[2020, :]

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Effects of gender on cognitive and behavioral manifestations in multiple system atrophy.

Sofia Cuoco, Marina Picillo, Arianna Cappiello, Immacolata Carotenuto, Roberto Erro, Maria Claudia Russillo, Filomena Abate, Giampiero Volpe, Massimo Squillante, Autilia Cozzolino, Giulio Cicarelli, Gabriella Santangelo, Paolo Barone, Maria Teresa Pellecchia,

Gender differences have been described in several neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The effects of gender on cognitive and behavioral manifestations in multiple system atrophy and the changes of cognitive functions over time according to gender have not been investigated so far. Fifty-five patients with a ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2020, :]

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The clinical application of nigrosome 1 detection on high-resolution susceptibility-weighted imaging in the evaluation of suspected Parkinsonism: The real-world performance and pitfalls.

Jungbin Lee, A Leum Lee, Jeong-Ho Park, Ji Eun Moon, Jung-Mi Park, Sang Joon Kim, Kee-Hyun Chang,

PURPOSE:To evaluate the real-world diagnostic performance of high-resolution susceptibility-weighted imaging (HR-SWI) and investigate whether the reader's predictions can be used to find cases where HR-SWI finding and final clinical diagnosis matched. METHODS:This retrospective study enrolled patients with suspected Parkinsonism (n = 48) or volunteers with other intracranial pathologies (n = ... Read more >>

PLoS ONE (PloS one)
[2020, 15(4):e0231010]

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Sympathetic outflow to skin predicts central autonomic dysfunction in multiple system atrophy.

Kazumasa Shindo, Toko Fukao, Naofumi Kurita, Akane Satake, Mai Tsuchiya, Yuta Ichinose, Takanori Hata, Kishin Koh, Takamura Nagasaka, Yoshihisa Takiyama,

BACKGROUND:To find out the physiological method for evaluating the severity of central autonomic dysfunction, we performed detailed evaluation of cutaneous vasomotor neural function in a comparatively large sample of multiple system atrophy (MSA). METHODS:We evaluated cutaneous vasomotor neural function in 24 MSA patients. Skin sympathetic nerve activity (SSNA) and sympathetic ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Dysarthria enhancement mechanism under external clear speech instruction in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy.

Dominik Skrabal, Tereza Tykalova, Jiri Klempir, Evzen Ruzicka, Jan Rusz,

Clear speech refers to intentionally modifying conversational speech to maximise intelligibility. This study aimed to compare the speech behaviour of patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and Parkinson's disease (PD) under conversational and clear speech conditions to gain greater pathophysiological insight. A total of 68 participants ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2020, :]

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Response to: Conjugal multiple system atrophy: Computing chance or investigating real patients?

Elizabeth A Coon, Phillip A Low, Wolfgang Singer,

Parkinsonism Relat. Disord. (Parkinsonism & related disorders)
[2020, 73:44]

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Disease-Specific Strains of α-Synuclein in Multiple System Atrophy and Parkinson's Disease: But Why?

Conor Fearon, Michael A Farrell,

Mov. Disord. (Movement disorders : official journal of the Movement Disorder Society)
[2020, :]

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Diagnostic utility of fluid biomarkers in multiple system atrophy: a systematic review and meta-analysis.

Shengri Cong, Chunchen Xiang, Hailong Wang, Shuyan Cong,

BACKGROUND:Multiple system atrophy (MSA) is an adult onset, fatal neurodegenerative disease. However, no reliable biomarker is currently available to guide clinical diagnosis and help to determine the prognosis. Thus, a comprehensive meta-analysis is warranted to determine effective biomarkers for MSA and provide useful guidance for clinical diagnosis. METHODS:A comprehensive literature ... Read more >>

J. Neurol. (Journal of Neurology)
[2020, :]

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