Full Text Journal Articles about
Multiple Sclerosis

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MicroRNAs as disease progression biomarkers and therapeutic targets in experimental autoimmune encephalomyelitis model of multiple sclerosis.

Bridget Martinez, Philip V Peplow,

Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination. Focal demyelination is associated with relapsing-remitting multiple sclerosis, while progressive forms of the disease show axonal degeneration and neuronal loss. The tests ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(10):1831-1837]

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Myelin positron emission tomography (PET) imaging in multiple sclerosis.

Daniele de Paula Faria,

Neural Regen Res (Neural regeneration research)
[2020, 15(10):1842-1843]

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Environmental enrichment as a promising strategy for aiding multiple sclerosis treatment.

Berenice Anabel Silva, Carina Cintia Ferrari,

Neural Regen Res (Neural regeneration research)
[2020, 15(9):1660-1661]

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Carbonic anhydrase IX as a novel candidate in liquid biopsy.

Ozen Ozensoy Guler, Claudiu T Supuran, Clemente Capasso,

Among the diagnostic techniques for the identification of tumour biomarkers, the liquid biopsy is considered one that offers future research on precision diagnosis and treatment of tumours in a non-invasive manner. The approach consists of isolating tumor-derived components, such as circulating tumour cells (CTC), tumour cell-free DNA (ctDNA), and extracellular ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):255-260]

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Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.

Bridget Martinez, Philip V Peplow,

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. The disability caused by inflammatory demyelination clinically dominates the early stages of relapsing-remitting MS and is reversible. Once there is considerable loss of axons, MS patients enter a secondary progressive stage. Disease-modifying drugs currently in use for ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1220-1234]

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Novel small molecule TRVA242 targets neuromuscular junction in amyotrophic lateral sclerosis.

Poulomee Bose,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1041-1042]

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CNS-localized myeloid cells capture living invading T cells during neuroinflammation.

Beatrice Wasser, Dirk Luchtman, Julian Löffel, Kerstin Robohm, Katharina Birkner, Albrecht Stroh, Christina Francisca Vogelaar, Frauke Zipp, Stefan Bittner,

To study the role of myeloid cells in the central nervous system (CNS) in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), we used intravital microscopy, assessing local cellular interactions in vivo in EAE animals and ex vivo in organotypic hippocampal slice cultures. We ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2020, 217(6):]

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Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis.

Jean Pierre Pallais, Catherine M Kotz, Milos Stanojlovic,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1039-1040]

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Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging.

Jie Zhang, Bin Xiao, Chen-Xu Li, Yi Wang,

Neurocognitive dysfunction is a common postoperative complication, especially in older adult patients. Fingolimod (FTY720) is a sphingosine-1-phosphate receptor modulator that has been found to be neuroprotective in several animal models of central nervous system disease. However, few reports have examined whether FTY720 could mitigate postoperative cognitive dysfunction. In this study, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1308-1315]

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Adrenomedullin: an important participant in neurological diseases.

Feng-Jiao Li, Si-Ru Zheng, Dong-Mei Wang,

Adrenomedullin, a peptide with multiple physiological functions in nervous system injury and disease, has aroused the interest of researchers. This review summarizes the role of adrenomedullin in neuropathological disorders, including pathological pain, brain injury and nerve regeneration, and their treatment. As a newly characterized pronociceptive mediator, adrenomedullin has been shown ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1199-1207]

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Deep-Learning Generated Synthetic Double Inversion Recovery Images Improve Multiple Sclerosis Lesion Detection.

Tom Finck, Hongwei Li, Lioba Grundl, Paul Eichinger, Matthias Bussas, Mark Mühlau, Bjoern Menze, Benedikt Wiestler,

OBJECTIVES:The aim of the study was to implement a deep-learning tool to produce synthetic double inversion recovery (synthDIR) images and compare their diagnostic performance to conventional sequences in patients with multiple sclerosis (MS). MATERIALS AND METHODS:For this retrospective analysis, 100 MS patients (65 female, 37 [22-68] years) were randomly selected ... Read more >>

Invest Radiol (Investigative radiology)
[2020, 55(5):318-323]

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Image Domain Transfer by Deep Learning is Feasible in Multiple Sclerosis Clinical Practice.

Akifumi Hagiwara, Koji Kamagata, Shigeki Aoki,

Invest Radiol (Investigative radiology)
[2020, 55(5):324-325]

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Associations of antiretroviral therapy and comorbidities with neurocognitive outcomes in HIV-1-infected patients.

Uma Siangphoe, Kellie J Archer, Christopher Nguyen, Kwan R Lee,

OBJECTIVE:The aim of this study was to evaluate associations of antiretroviral therapy (ART) and comorbidities with neurocognitive impairments (NCIs) in ART-naive HIV-1-infected patients in clinical practice. DESIGN:A retrospective study was conducted in ART-naive patients with HIV-1 diagnosis between January 2009 and December 2013 in the United States. METHODS:The primary outcome ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(6):893-902]

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The window of opportunity for treatment of progressive multiple sclerosis.

Per Soelberg Sorensen, Robert J Fox, Giancarlo Comi,

PURPOSE OF REVIEW:Based on the knowledge of disease mechanisms in the progressive course of multiple sclerosis and the experience from randomized clinical trials, we assessed the timing of disease-modifying therapy in patients with progressive multiple sclerosis to define the optimal window of opportunity for treatment of progressive multiple sclerosis. RECENT ... Read more >>

Curr. Opin. Neurol. (Current opinion in neurology)
[2020, :]

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The effects of modified anti-inflammatory diet on fatigue, quality of life,and inflammatory biomarkers in relapsing-remitting multiple sclerosis patients: A randomized clinical trial.

Zahra Mousavi-Shirazi-Fard, Zohreh Mazloom, Sadegh Izadi, Mohammad Fararouei,

Background:The role of dietary interventions in improving the symptoms of Multiple Sclerosis (MS) has always been considered, but few studies have been conducted in this area. This study aimed to investigate the effects of modified anti-inflammatory diet on fatigue, quality of life, and inflammatory markers among patients withRelapsing-Remitting Multiple Sclerosis ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-12]

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Evaluation of cardiovascular autonomic dysfunction according to heart rate turbulence and variability in patients with relapsing remitting multiple sclerosis

Serkan Gökaslan, Hayri Demirbaş, Çiğdem Özer Gökaslan,

Background/aim:Multiple sclerosis (MS) is an autoimmune disease characterized by neurodegeneration or demyelination; the relapsing–remitting phase of MS is characterized by acute exacerbation of disease activity. ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(2):442-447]

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Evidence of an Increased Prevalence of Multiple Sclerosis: A Population-Based Study of Tehran Registry during 1999–2018

Sharareh Eskandarieh, Amir Almasi-Hashiani, Mohammad Ali Sahraian,

<title>Abstract</title> <p> Background: The epidemiological characteristics of multiple sclerosis (MS) have been investigated in various studies, which have revealed that the prevalence of MS varies across countries. The present study was conducted to investigate the longitudinal prevalence of MS in Tehran, Iran. Methods: The present population-based study was ... Read more >>

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Effect of Eccentric Strength Training on Elbow Flexor Spasticity and Muscle Weakness in People With Multiple Sclerosis: Proof-of-Concept Single-System Case Series.

Andrea Manca, Gianluca Martinez, Elena Aiello, Lucia Ventura, Franca Deriu,

OBJECTIVE:To date, no attention has been devoted to the employment of eccentric contractions to manage spasticity in multiple sclerosis. This single-system case series aimed to explore the effects of eccentric training on spasticity-related resistance to passive motion in people with multiple sclerosis with elbow flexor spasticity. METHODS:Six people with multiple ... Read more >>

Phys Ther (Physical therapy)
[2020, :]

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Are White Matter Tract Integrities Different in Multiple Sclerosis Women With Voiding Dysfunction?

Khue Tran, Christof Karmonik, Timothy B Boone, Rose Khavari,

OBJECTIVES:Two white matter tracts (WMTs) are proposed to be involved in bladder function: anterior thalamic radiation and superior longitudinal fasciculus. Multiple sclerosis (MS) patients with voiding dysfunction (VD) may have distinct changes in these 2 WMTs. This study aims to compare the fractional anisotropy (FA) and mean diffusivity (MD) from ... Read more >>

Female Pelvic Med Reconstr Surg (Female pelvic medicine & reconstructive surgery)
[2020, :]

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Multiple Sclerosis and Smoking.

Dr Borros Arneth,

Multiple sclerosis (MS) is a common, severe neurological disease that affects millions of people worldwide. Nevertheless, the actual cause of MS remains unknown. Smoking has been studied with respect to MS development and progression. The objectives of this review were to examine the relationship between smoking and MS and to ... Read more >>

Am. J. Med. (The American journal of medicine)
[2020, :]

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Validity and Reliability of the World Health Organization Disability Assessment Schedule 2.0 36-Item Persian Version for Persons with Multiple Sclerosis.

Reza Salehi, Hossein Negahban, Farzad Faraji Khiavi, Shiva Saboor, Nastaran Majdinasab, Kamal Shakhi,

Background:No previous studies have assessed the psychometric properties of the 36-item version of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in the Persian language of Iran. This study was designed and conducted to evaluate the validity and reliability of the Persian version using a sample of persons ... Read more >>

Korean J Fam Med (Korean journal of family medicine)
[2020, :]

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The impact of vitamin D3 intake on inflammatory markers in multiple sclerosis patients and their first-degree relatives.

Reza Hashemi, Seyed Saeed Hosseini-Asl, Seyed Rafie Arefhosseini, Mohammad Morshedi,

BACKGROUND & AIMS:In our previous study, a Seesaw model was proposed for the fluctuation of crucial anti- (IL-10) and pro-inflammatory (Il-6 & IL-17A) cytokines through vitamin D3. In this paper, however, it is intended to extend the mentioned model by assessing the expression mRNA levels of IL-27 and TGF-β1 as ... Read more >>

PLoS ONE (PloS one)
[2020, 15(4):e0231145]

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An investigation of genetic polymorphisms in Heparan Sulfate Proteoglycan core proteins and key modification enzymes in an Australian Caucasian multiple sclerosis population

Larisa Haupt, Rachel Okolicsanyi, Julia Bluhm, Cassandra Miller, Lyn Griffiths,

<title>Abstract</title> <p> Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system in young adults. Heparan sulfate proteoglycans (HSPGs) are ubiquitous to the cell surface and the extracellular matrix. HSPG biosynthesis is a complex process involving enzymatic attachment of heparan sulfate (HS) chains to ... Read more >>

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The Role of B Cells in the Immunopathogenesis of Multiple Sclerosis.

Tohid Gharibi, Zohreh Babaloo, Arezoo Hosseini, Faroogh Marofi, Abbas Ebrahimi-Kalan, Saeed Jahandideh, Behzad Baradaran,

Over the last years, there has been an ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis (MS). The success of B cell targeting therapies in MS highlighted the role of B cells particularly the antibody-independent functions of these cells such as antigen presentation to T ... Read more >>

Immunology (Immunology)
[2020, :]

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Oral therapies for treatment of relapsing-remitting multiple sclerosis in Austria: a 2-year comparison using an inverse probability weighting method.

Michael Guger, Christian Enzinger, Fritz Leutmezer, Jörg Kraus, Stefan Kalcher, Erich Kvas, Thomas Berger, ,

OBJECTIVES:To compare the efficacies, frequencies and reasons for treatment interruption of fingolimod (FTY), dimethyl fumarate (DMF) or teriflunomide (TERI) in a nationwide observational cohort. MATERIALS AND METHODS:Two cohorts of patients with relapsing-remitting multiple sclerosis (RRMS) having started treatment with FTY, DMF or TERI documented in the Austrian MS Treatment Registry ... Read more >>

J. Neurol. (Journal of neurology)
[2020, :]

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