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One-hour post-load glucose improves the prediction of cardiovascular events in the OPERA study.

Anni Saunajoki, Juha Auvinen, Aini Bloigu, Olavi Ukkola, Sirkka Keinänen-Kiukaanniemi, Markku Timonen,

<h4>Background</h4>To estimate the ability of fasting, 1-h, and 2-h post-load glucose to predict cardiovascular outcomes.<h4>Methods</h4>We examined a population-based study consisting of 977 middle-aged subjects who underwent an oral glucose tolerance test with glucose values measured at 0, 60, and 120 min. Participants were followed up to 24 years, and cardiovascular outcomes were ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):478-484]

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Uterine dehiscence in pregnant with previous caesarean delivery.

Zhengfeng Zhu, HeZhou Li, JunQing Zhang,

<h4>Background</h4>The main risk factor for uterine scar dehiscence is a previous caesarean section. Better characterisation of the ultrasonographic features of uterine scar dehiscence may improve preoperative diagnostic accuracy in pregnant women with a caesarean scar. This study aimed to evaluate the ultrasonographic features of uterine scar dehiscence in pregnant women ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1265-1269]

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Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013-2017: a retrospective study at Thailand's largest national tertiary referral center.

Pakpoom Phoompoung, Nantaporn Pirogard, Amornrut Leelaporn, Nasikarn Angkasekwinai,

<h4>Objectives</h4>To determine the incidence of invasive Group B streptococcal (iGBS) diseases and the factors significantly associated with iGBS mortality in adult patients.<h4>Material and methods</h4>This retrospective study included adults with a positive culture for GBS isolated from a sterile site at Siriraj Hospital - Thailand's largest tertiary care hospital - during ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):715-721]

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Rate control strategies for atrial fibrillation.

Muath Alobaida, Abdullah Alrumayh,

Atrial fibrillation (AF) is one of the main cardiac arrhythmias associated with higher risk of cardiovascular morbidity and mortality. AF can cause adverse symptoms and reduced quality of life. One of the strategies for the management of AF is rate control, which can modulate ventricle rate, alleviate adverse associated symptoms ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):682-692]

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Infections in hematopoietic stem cell transplant patients admitted to Hematology intensive care unit: a single-center study.

Tuğba Barlas, Kamil İnci, Gulbin Aygencel, Melda Türkoğlu, Özlem Güzel Tunçcan, Ferda Can, Lale Aydın Kaynar, Zübeyde Nur Özkurt, Zeynep Arzu Yeğin, Münci Yağcı,

<h4>Objective</h4>The aim of this study was to investigate the data of HSCT patients who were admitted to our Hematology ICU due to infections or infectious complications.<h4>Materials and methods</h4>HSCT patients who were admitted to our Hematology ICU between 01 January 2014 and 01 September 2017 were analyzed retrospectively.<h4>Results</h4>62 HSCT patients were ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):328-339]

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Catheter ablation superiority over the pharmacological treatments in atrial fibrillation: a dedicated review.

Abdullah Alrumayh, Muath Alobaida,

Atrial fibrillation globally affects roughly 33.5 million people, making it the most common heart rhythm disorder. It is a crucial arrhythmia, as it is linked with a variety of negative outcomes such as strokes, heart failure and cardiovascular mortality. Atrial fibrillation can reduce quality of life because of the potential ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):551-557]

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lncRNA PROX1-AS1 mediates the migration and invasion of placental trophoblast cells via the miR-211-5p/caspase-9 axis.

Dan Tang, Li Geng, Jing Ma,

Preeclampsia (PE) is a potentially fatal pregnancy complication; however, its pathogenesis remains unclear. Long non-coding RNAs (lncRNAs) are associated with occurrence and progression of PE. Therefore, this study aimed to explore the function of the lncRNA prospero homeobox 1-antisense RNA 1 (PROX1-AS1) and elucidate its underlying molecular mechanism of action. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4100-4110]

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Baicalin suppresses lung cancer growth phenotypes via miR-340-5p/NET1 axis.

Fucheng Zhao, Zhenxia Zhao, Yanru Han, Sujuan Li, Caili Liu, Kui Jia,

As a malignant disease, lung cancer has a high morbidity and mortality rate. Baicalin is derived from Radix Scutellariae and has anti-tumor effects, however, its role in lung cancer remains unknown. Here, functional assays suggested baicalin suppressed in vitro lung cancer phenotypes. We used micro (mi)RNA array analysis to explore ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1699-1707]

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Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome.

Javier Toro-Pérez, Ramón Rodrigo,

<h4>Background</h4>The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key pathophysiological role. Moreover, oxidative stress ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):35-44]

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Non-random relations in drug use expressed as patterns comprising prescription and over-the-counter drugs in multimorbid elderly patients in primary care: Data of the exploratory analysis of the multicentre, observational cohort study MultiCare.

Caroline Krüger, Ingmar Schäfer, Hendrik van den Bussche, Michael Baehr, Horst Bickel, Angela Fuchs, Jochen Gensichen, Wolfgang Maier, Steffi G Riedel-Heller, Hans-Helmut König, Anne Dahlhaus, Gerhard Schön, Siegfried Weyerer, Birgitt Wiese, Wolfgang von Renteln-Kruse, Claudia Langebrake, Martin Scherer,

<h4>Background</h4>The elderly population deals with multimorbidity (three chronic conditions) and increasinged drug use with age. A comprehensive characterisation of the medication - including prescription and over-the-counter (OTC) drugs - of elderly patients in primary care is still insufficient.<h4>Objectives</h4>This study aims to characterise the medication (prescription and OTC) of multimorbid elderly ... Read more >>

Eur J Gen Pract (The European journal of general practice)
[2021, 27(1):119-129]

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Abortion hotlines around the world: a mixed-methods systematic and descriptive review.

Roopan K Gill, Amanda Cleeve, Antonella F Lavelanet,

Barriers to access abortion services globally have led to the development of alternative methods to assist and support women who seek an abortion. One such method is the use of hotlines, currently utilised globally for abortion care. This review aimed to understand (1) how abortion hotlines facilitate access to abortion; ... Read more >>

Sex Reprod Health Matters (Sexual and reproductive health matters)
[2021, 29(1):1907027]

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Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer.

Hongjun Guan, Changpeng Sun, Yinfeng Gu, Jinjin Li, Jie Ji, Yongxian Zhu,

Non-small cell lung cancer (NSCLC) is a common malignant tumor, with high morbidity and mortality. Circular RNA (circRNA) circ_0003028 was reported to be upregulated in NSCLC. This study is designed to explore the role and mechanism of circ_0003028 on NSCLC progression. In this work, circ_0003028, microRNA-1298-5p (miR-1298-5p), and glutamic oxaloacetic ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2326-2340]

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Long non-coding RNA DDX11-AS1 promotes esophageal carcinoma cell proliferation and migration through regulating the miR-514b-3p/RBX1 axis.

Chao Wu, Zhibin Wang, Xuetao Tian, Jianqiang Wang, Yuesong Zhang, Biao Wu,

Esophageal carcinoma (ESCA) is one of the most aggressive malignancies with extremely high morbidity and mortality. At present, limited advancement in ESCA treatment has achieved. Therefore, it is urgent to explore the pathogenesis and progression mechanism of ESCA to provide the basis for the formulation of novel therapeutic strategies. Previous ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3772-3786]

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Identification of potential biomarkers and immune cell infiltration in acute myocardial infarction (AMI) using bioinformatics strategy.

Yun Xie, Yi Wang, Linjun Zhao, Fang Wang, Jinyan Fang,

Acute myocardial infarction (AMI) was considered a fatal disease resulting in high morbidity and mortality; platelet activation or aggregation plays a critical role in participating in the pathogenesis of AMI. The current study aimed to reveal the underlying mechanisms of platelets in the confrontation of AMI and potential biomarkers that ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2890-2905]

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The association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis.

Chongyang Ma, Kai Yan, Zisong Wang, Qiuyun Zhang, Lianyin Gao, Tian Xu, Jiayang Sai, Fafeng Cheng, Yuqiong Du,

Nonalcoholic fatty liver disease (NAFLD) has become a major public health issue as its progression increases risks of multisystem morbidity and mortality. Recent evidence indicates a more complex relationship between hypertension and NAFLD than previously thought. In this study, a comprehensive literature search was used to gather information supporting the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2187-2202]

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Streptococcus Pneumoniae septic arthritis in adults in Bristol and Bath, United Kingdom, 2006-2018: a 13-year retrospective observational cohort study.

Catherine Hyams, Zahin Amin-Chowdhury, Norman K Fry, Paul North, Adam Finn, Andrew Judge, Shamez N Ladhani, O Martin Williams,

Few studies on adult pneumococcal septic arthritis are sufficiently large enough to assess both epidemiological trends following routine pneumococcal immunization and clinical disease. With major shifts in serotypes causing invasive pneumococcal disease (IPD), we wanted to determine the clinical phenotype of adult septic arthritis caused by <i>Streptococcus pneumoniae</i>. We conducted ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1369-1377]

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An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment.

Linda Eklund, Filip Schagatay, Ellen Tufvesson, Rita Sjöström, Lars Söderström, Helen G Hanstock, Thomas Sandström, Nikolai Stenfors,

Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals.Thirty-one healthy ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1897213]

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Isolation, identification, and phylogenetic analysis of subgroup III strain of bovine respiratory syncytial virus contributed to outbreak of acute respiratory disease among cattle in Northeast China.

Shuo Jia, Xin Yao, Yaqi Yang, Chao Niu, Yi Zhao, Xiaomei Zhang, Ronghui Pan, Xiaoxia Jiang, Sun Xiaobo, Xinyuan Qiao, Xueting Guan, Yigang Xu,

Bovine respiratory syncytial virus (BRSV) is a clinically important causative agent of acute respiratory diseases in postweaning calves and feedlot cattle and causes numerous economic losses to the cattle industry. In June 2018, an outbreak of an acute respiratory disease occurred among 4- to 10-month-old calves on three intensive beef ... Read more >>

Virulence (Virulence)
[2021, 12(1):404-414]

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Assessment of Lebanese healthcare professionals' awareness on acquired haemophilia: a cross-sectional study.

Ali Taher, Layal Al Mahmasani, Abdallah Aadra, Patricia Yazbeck, Georges Abi Saad, Fadi Nasr, Rita Habib, Amal Chalfoun, Fadi Haddad,

<h4>Background</h4>Acquired haemophilia A (AHA) is a rare immune-mediated disorder characterised by the development of autoantibodies against factor VIII. Morbidity and mortality are in general high due to multiple factors including the age of the patient, underlying diseases, toxic effects of available treatments and bleeding itself.<h4>Objective</h4>To assess the awareness about AHA ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):83-87]

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Detection of occult atrial fibrillation with 24-hour ECG after cryptogenic acute stroke or transient ischaemic attack: A retrospective cross-sectional study in a primary care database in Israel.

Ori Liran, Tamar Banon, Alon Grossman,

<h4>Background</h4>Ischaemic stroke or cerebrovascular accident (CVA) due to occult atrial fibrillation (AF) may cause severe morbidity and mortality. Diagnosing occult AF can be challenging and there is no consensus regarding the optimal duration of screening. A 24-hour Holter electrocardiogram (ECG) is frequently employed to detect occult AF following ischaemic CVA.<h4>Objectives</h4>Demonstration ... Read more >>

Eur J Gen Pract (The European journal of general practice)
[2021, 27(1):152-157]

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Risk factors and predictive model for abdominal wound dehiscence in neonates: a retrospective cohort study.

Shouxing Duan, Xuan Zhang, Xuewu Jiang, Wenhui Ou, Maxian Fu, Kaihong Chen, Xinquan Xie, Wenfeng Xiao, Lian Zheng, Shuhua Ma, Jianhong Li,

<h4>Background</h4>Abdominal wound dehiscence (AWD) is a major complication of abdominal surgery, and neonates are a group with a high risk of AWD, which has serious consequences or can even result in death. The purpose of this study is to explore the risk factors for neonatal AWD and construct a predictive ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):900-907]

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The Effect of Smoking on Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease Patients with Preserved Renal Function.

Cuma Bulent Gul, Abdulmecit Yildiz, Saim Sag, Aysegul Oruc, Alparslan Ersoy, Sumeyye Gullulu,

<h4>Background</h4>In autosomal dominant polycystic kidney disease (ADPKD), endothelial dysfunction (ED) is common and occurs much earlier than kidney function impairment. The impact of smoking on ED in ADPKD patients has not been previously studied. The aim of this study was to investigate the potential contribution of smoking habits to ED ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):1124-1129]

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Research priorities to support evidence-informed policies and advocacy for access to safe abortion care in sub-Saharan Africa.

Anthony Idowu Ajayi, Ramatou Ouedraogo, Kenneth Juma, Grace Kibunja, Collins Cheruiyot, Meggie Mwoka, Emmy Kageha Igonya, Winnie Opondo, Emmanuel Otukpa, Caroline W Kabiru, Boniface Ayanbekongshie Ushie,

A key obstacle to advocacy efforts to promote legal and policy reforms that ensure women's and girls' access to comprehensive abortion care (CAC) is the lack of relevant and timely evidence. This commentary outlines a research agenda-setting initiative that identified research priorities to support evidence-informed policy and advocacy for CAC ... Read more >>

Sex Reprod Health Matters (Sexual and reproductive health matters)
[2021, 29(1):1881207]

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Human challenge trials to assess the efficacy of currently approved COVID-19 vaccines against SARS-CoV-2 variants.

Shan Su, Yiming Shao, Shibo Jiang,

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):439-441]

Cited: 2 times

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Alarmins, COVID-19 and comorbidities.

Eleonora Di Salvo, Mario Di Gioacchino, Alessandro Tonacci, Marco Casciaro, Sebastiano Gangemi,

The coronavirus SARS-CoV-2, the aetiological agent of COVID-19 disease, is representing a worldwide threat for the medical community and the society at large so that it is being defined as "the twenty-first-century disease". Often associated with a severe cytokine storm, leading to more severe cases, it is mandatory to block ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):777-785]

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