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Mild Cognitive Impairment

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Protective effects of grape seed procyanidin on isoflurane-induced cognitive impairment in mice.

Xiangdan Gong, Lizhi Xu, Xin Fang, Xin Zhao, Ying Du, Hao Wu, Yue Qian, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu,

Context: Oxidative imbalance-induced cognitive impairment is among the most urgent clinical concerns. Isoflurane has been demonstrated to impair cognitive function via an increase in oxidative stress. GSP has strong antioxidant capacities, suggesting potential cognitive benefits.Objective: This study investigates whether GSP pre-treatment can alleviate isoflurane-induced cognitive dysfunction in mice.Materials and methods: ... Read more >>

Pharm Biol (Pharmaceutical Biology)
[2020, 58(1):200-207]

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"Sometimes it feels like thinking in syrup" - the experience of losing sense of self in those with young onset dementia.

Laila Mohrsen Busted, Dorthe S Nielsen, Regner Birkelund,

Purpose: To explore and describe the experience of people having young-onset dementia.Methods: This was a qualitative study that used semi-structured interviews to collect data from nine persons with young-onset dementia (aged 47-65; five men and four women). Data were collected in the spring of 2018. All interviews were conducted at ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1734277]

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An enigmatic case of cortical anopsia: Antemortem diagnosis of a 14-3-3 negative Heidenhain-variant MM1-sCJD.

Julius Obergassel, Lisa Lohmann, Sven G Meuth, Heinz Wiendl, Oliver Grauer, Christopher Nelke,

Sporadic Creutzfeldt-Jakob disease is the predominant type of human prion disease. While routine diagnostic in phenotypic cases has advanced considerably, the clinical heterogeneity and rarity of subtypes continue to constitute a major clinical and diagnostic challenge. Here, we report a peculiar case of the Heidenhain-variant of MM1 sporadic Creutzfeldt-Jakob disease ... Read more >>

Prion (Prion)
[2020, 14(1):24-28]

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Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities.

Lu-Lu Xue, Fang Wang, Rui-Ze Niu, Ya-Xin Tan, Jia Liu, Yuan Jin, Zheng Ma, Zi-Bin Zhang, Ya Jiang, Li Chen, Qing-Jie Xia, Jun-Jie Chen, Ting-Hua Wang, Liu-Lin Xiong,

Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease, often resulting in long-term neurodevelopmental disorders among surviving children. However, whether these neurodevelopmental issues can be passed to offspring remains unclear. The right common carotid artery of 7-day-old parental-generation rats was subjected to permanent ligation using a vessel electrocoagulator. Neonatal hypoxic-ischemic rat ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(9):1662-1670]

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Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer's disease.

Jun Mo, Tingkai Chen, Hongyu Yang, Yan Guo, Qi Li, Yuting Qiao, Hongzhi Lin, Feng Feng, Wenyuan Liu, Yao Chen, Zongliang Liu, Haopeng Sun,

Cholinesterase inhibitor plays an important role in the treatment of patients with Alzheimer's disease (AD). Herein, we report the medicinal chemistry efforts leading to a new series of 1,3-dimethylbenzimidazolinone derivatives. Among the synthesised compounds, 15b and 15j showed submicromolar IC50 values (15b, eeAChE IC50 = 0.39 ± 0.11 µM; 15j, eqBChE IC50 = 0.16 ± 0.04 µM) towards acetylcholinesterase (AChE) ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):330-343]

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Non-pharmacological interventions for Parkinson's disease mild cognitive impairment: future directions for research.

Davide Maria Cammisuli, Roberto Ceravolo, Ubaldo Bonuccelli,

Neural Regen Res (Neural regeneration research)
[2020, 15(9):1650-1651]

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Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes.

Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec,

Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer's disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal structure of previously described highly potent, reversible, and selective BChE inhibitors, we have developed ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):498-505]

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Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile.

Nabih Lolak, Mehmet Boga, Muhammed Tuneg, Gulcin Karakoc, Suleyman Akocak, Claudiu T Supuran,

A series of 16 novel benzenesulfonamides incorporating 1,3,5-triazine moieties substituted with aromatic amines, dimethylamine, morpholine and piperidine were investigated. These compounds were assayed for antioxidant properties by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, 2,2`-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical decolarisation assay and metal chelating methods. They were also investigated as inhibitors of ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):424-431]

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Mental well-being among the oldest old: revisiting the model of healthy ageing in a Finnish context.

Johanna Nordmyr, Johanna Creswell-Smith, Valeria Donisi, Elvira Lara, Natalia Martín-María, Linda Nyholm, Anna K Forsman,

Purpose: This study aimed to examine how participants aged 80 years old or over describe their mental well-being-exploring the suitability of the model of healthy ageing when outlining the mental well-being concept.Methods: Six structured focus group interviews with 28 participants were conducted in Western Finland in 2017. Qualitative content analysis was ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1734276]

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The level of tumour necrosis factor-alpha and its relationship to the cognitive function of Malayan-Mongoloid patients with schizophrenia.

Mustafa M Amin, Abdul Rasyid, Elmeida Effendy, Nurmiati Amir, Dwi Anita Suryandari,

Aim Schizophrenia is a mental disorder and one of the suspected causes is cytokines. One of them is tumour necrosis factor-alpha (TNF-α). Cytokines have the potential to affect cognitive function. The study aimed to find a correlation of TNF-α level with the Mini-Mental State Examination (MMSE) score in patients with ... Read more >>

Med Glas (Zenica) (Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina)
[2020, 17(2):]

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Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders.

Baruh Polis, Abraham O Samson,

Alzheimer's disease is an incurable chronic neurodegenerative disorder and the leading cause of dementia, imposing a growing economic burden upon society. The disease progression is associated with gradual deposition of amyloid plaques and the formation of neurofibrillary tangles within the brain parenchyma, yet severe dementia is the culminating phase of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1460-1470]

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Insights from human sleep research on neural mechanisms of Alzheimer's disease.

Susanna Cordone, Luigi De Gennaro,

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1251-1252]

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Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging.

Jie Zhang, Bin Xiao, Chen-Xu Li, Yi Wang,

Neurocognitive dysfunction is a common postoperative complication, especially in older adult patients. Fingolimod (FTY720) is a sphingosine-1-phosphate receptor modulator that has been found to be neuroprotective in several animal models of central nervous system disease. However, few reports have examined whether FTY720 could mitigate postoperative cognitive dysfunction. In this study, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1308-1315]

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Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation.

Shan-Shan Cui, Xiao-Bo Feng, Bing-Hong Zhang, Zhong-Yuan Xia, Li-Ying Zhan,

Glucagon-like peptide-1 receptor has anti-apoptotic, anti-inflammatory, and neuroprotective effects. It is now recognized that the occurrence and development of chronic pain are strongly associated with anti-inflammatory responses; however, it is not clear whether glucagon-like peptide-1 receptor regulates chronic pain via anti-inflammatory mechanisms. We explored the effects of glucagon-like peptide-1 receptor ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1333-1339]

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Jidong cognitive impairment cohort study: objectives, design, and baseline screening.

Dai-Yu Song, Xian-Wei Wang, Sa Wang, Si-Qi Ge, Guo-Yong Ding, Xue-Yu Chen, Yan-Ru Chen, Hua-Min Liu, Xiao-Mei Xie, Wei-Jia Xing, Dong Li, Yong Zhou,

The risk of dementia increases in patients with cognitive impairment. However, it is not clear what factors contribute to the onset of dementia in those with cognitive impairment. In this prospective cohort study, we will investigate the every-five-year incidence of cognitive impairment and prognostic factors for cognitive impairment. The Jidong ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1111-1119]

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Corrigendum: Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease.

[This corrects the article DOI: 10.4103/1673-5374.253535]. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1165]

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Evaluation of the relationship between cognitive impairment and suboptimal health status in a northern Chinese population: a cross-sectional study.

Guoyong Ding, Xuan Zhao, Youxin Wang, Daiyu Song, Dongzhen Chen, Yang Deng, Weijia Xing, Hualei Dong, Yong Zhou, Dong Li, Haifeng Hou,

Background:Suboptimal health status (SHS) is an intermediate health status between ideal health and illness. As a determinant of cardiovascular disease and stroke, SHS is hypothesized to be associated with the development of cognitive impairment and dementia. This study aimed to investigate whether individuals with SHS have poor cognitive ability based ... Read more >>

J Glob Health (Journal of global health)
[2020, 10(1):010804]

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The role of cofilin in age-related neuroinflammation.

Amsha S Alsegiani, Zahoor A Shah,

Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active "pro-inflammatory" state, causing chronic low-grade neuroinflammation. Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years, the underlying causes remain unclear. The identification of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1451-1459]

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Emotion recognition and inhibitory control in manifest and pre-manifest Huntington's disease: evidence from a new Stroop task.

Thomas Hunefeldt, Sabrina Maffi, Simone Migliore, Ferdinando Squitieri, Marta Olivetti Belardinelli,

Huntington's disease (HD) is a genetic neurodegenerative disorder that affects not only the motor but also the cognitive domain. In particular, cognitive symptoms such as impaired executive skills and deficits in recognizing other individuals' mental state may emerge many years before the motor symptoms. This study was aimed at testing ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1518-1525]

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Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance.

Fang Xing, Xin Fang, Xiang-Dan Gong, Xin Zhao, Ying Du, Zheng-Liang Ma, Xiao-Ping Gu, Tian-Jiao Xia,

Sleep-wake rhythm disturbances, which are characterized by abnormal sleep timing or duration, are associated with cognitive dysfunction. Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pattern experiments. In this study, we examined whether light ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1094-1101]

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Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction.

Dao-Xia Guo, Zheng-Bao Zhu, Chong-Ke Zhong, Xiao-Qing Bu, Li-Hua Chen, Tan Xu, Li-Bing Guo, Jin-Tao Zhang, Dong Li, Jian-Hui Zhang, Zhong Ju, Chung-Shiuan Chen, Jing Chen, Yong-Hong Zhang, Jiang He,

Stroke is the leading cause of death and long-term disability worldwide, and cognitive impairment and dementia are major complications of ischemic stroke. Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies. However, the relationship between CysC levels and cognitive dysfunction in previous studies has revealed ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):922-928]

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Abscisic acid, a promising therapeutic molecule to prevent Alzheimer's and neurodegenerative diseases.

Ana María Sanchez-Perez,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1035-1036]

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Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer's disease.

Jie Fu, Fengqi Bao, Min Gu, Jing Liu, Zhipeng Zhang, Jiaoli Ding, Sai-Sai Xie, Jinsong Ding,

A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment of AD. Most of these compounds exhibited strong and clearly selective inhibition to eeAChE. Among them, compound 4c was identified as the most potent inhibitor to both eeAChE and hAChE ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):118-128]

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Are Standard Follow-Up Parameters Sufficient to Protect Neurocognitive Functions in Patients with Diabetes Mellitus who Underwent Coronary Artery Bypass Grafting?

Hakan Sacli, Ibrahim Kara,

OBJECTIVE:We aimed to compare the effectiveness of cognitive function protection between the standard follow-up parameters and advanced neuromonitoring methods in diabetic patients who underwent coronary artery bypass grafting during cardiopulmonary bypass. METHODS:Study design was prospective and observational. Patients were separated into two groups, treated only with standard follow-up parameters (Group ... Read more >>

Braz J Cardiovasc Surg (Brazilian journal of cardiovascular surgery)
[2020, 35(1):75-81]

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Does Transcatheter Aortic Valve Implantation for Aortic Stenosis Impact on Cognitive Function?

Sophie Gu, Daniel Coakley, Danny Chan, Benjamin Beska, Fateh Singh, Richard Edwards, Vijay Kunadian,

Aortic stenosis (AS) is the most common valvular heart disease among elderly patients in developed countries. Surgical valve replacement is indicated for severe AS to relieve the obstructed outflow tract. Transcatheter aortic valve implantation (TAVI) has emerged as an alternative for patients with severe AS, particularly in those with high ... Read more >>

Cardiol Rev (Cardiology in review)
[2020, 28(3):135-139]

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