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Migraine Headache

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Regional volume changes of the brain in migraine chronification.

Xiao-Yan Chen, Zhi-Ye Chen, Zhao Dong, Meng-Qi Liu, Sheng-Yuan Yu,

The pathophysiology of migraine is complex. Neuroimaging studies reveal functional and structural changes in the brains of migraine patients. We sought to explore regional volume differences in intracranial structures in patients with episodic and chronic migraine. Sixteen episodic migraine patients, 16 chronic migraine patients, and 24 normal controls were recruited ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(9):1701-1708]

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Pattern of triptans use: a retrospective prescription study in Calabria, Italy.

Damiana Scuteri, Annagrazia Adornetto, Laura Rombolà, Maria Diana Naturale, Adele Emanuela De Francesco, Stefania Esposito, Mariacristina Zito, Luigi Antonio Morrone, Giacinto Bagetta, Paolo Tonin, Maria Tiziana Corasaniti,

Triptans are 5-hydroxytryptamine 1B/1D receptor agonists used in moderate to severe migraine attacks as first line when non-specific, symptomatic, nonsteroidal anti-inflammatory drugs are not effective. To gain insight in the treatment of migraine in the regional context, this retrospective (from January to August of the years 2017 and 2018) study ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1340-1343]

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Migraine, headache, and mortality in women: a cohort study.

Jessica L Rohmann, Pamela M Rist, Julie E Buring, Tobias Kurth,

BACKGROUND:Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased risk of cardiovascular mortality. However, published evidence on relationships between migraine or non-migraine headache and all-cause mortality is inconclusive. Therefore, we ... Read more >>

J Headache Pain (The journal of headache and pain)
[2020, 21(1):27]

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An Evidence-Based Review of Fremanezumab for the Treatment of Migraine.

Ivan Urits, Gavin Clark, Daniel An, Bredan Wesp, Rebecca Zhou, Ariunzaya Amgalan, Amnon A Berger, Hisham Kassem, Anh L Ngo, Alan D Kaye, Rachel J Kaye, Elyse M Cornett, Omar Viswanath,

Migraine headache is a common, chronic, debilitating disease with a complex etiology. Current therapy for migraine headache comprises either treatments targeting acute migraine pain or prophylactic therapy aimed at increasing the length of time between migraine episodes. Recent evidence suggests that calcium gene-related peptide (CGRP) is a critical component in ... Read more >>

Pain Ther (Pain and therapy)
[2020, :]

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Rapid referral for headache management from emergency department to headache centre: four years data.

Andrea Negro, Valerio Spuntarelli, Paolo Sciattella, Paolo Martelletti,

BACKGROUND:Headache is one of the most common reason for medical consultation to emergency department (ED). The inappropriate use of ED for non-emergency conditions is a problem in terms of overcrowding of emergency facilities, unnecessary testing and treatment, increased medical costs, burden on medical service providers and weaker relationships between patient ... Read more >>

J Headache Pain (The journal of headache and pain)
[2020, 21(1):25]

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Behavioral Therapy Preferences in People With Migraine.

Mia T Minen, Adama Jalloh, Olivia Begasse de Dhaem, Elizabeth K Seng,

BACKGROUND:There are safe and well-tolerated level A evidence-based behavioral therapies for the prevention of migraine. They are biofeedback, cognitive behavioral therapy, and relaxation. However, the behavioral therapies for the prevention of migraine are underutilized. OBJECTIVES:We sought to examine whether people with migraine with 4 or more headache days a month ... Read more >>

Headache (Headache)
[2020, :]

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Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study.

Kristen M George, Aaron R Folsom, A Richey Sharrett, Thomas H Mosley, Rebecca F Gottesman, Ali G Hamedani, Pamela L Lutsey,

OBJECTIVE:We aimed to assess the association between migraine headache and incident dementia. BACKGROUND:Migraine is a risk factor for white matter hyperintensities and ischemic stroke, which are both associated with increased risk of dementia. However, it is unknown whether migraine is independently associated with dementia. METHODS:History of migraine was ascertained via ... Read more >>

Headache (Headache)
[2020, :]

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A Comprehensive Review of Over-the-counter Treatment for Chronic Migraine Headaches.

Jacquelin Peck, Ivan Urits, Justin Zeien, Shelby Hoebee, Mohammad Mousa, Hamed Alattar, Alan D Kaye, Omar Viswanath,

PURPOSE OF REVIEW:Migraine headaches are a neurologic disorder characterized by attacks of moderate to severe throbbing headache that are typically unilateral, exacerbated by physical activity, and associated with phonophobia, photophobia, nausea, and vomiting. In the USA, the overall age-adjusted prevalence of migraine in female and male adults is 22.3% and ... Read more >>

Curr Pain Headache Rep (Current pain and headache reports)
[2020, 24(5):19]

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The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine.

Hung-Yu Liu, Pei-Lin Lee, Kun-Hsien Chou, Kuan-Lin Lai, Yen-Feng Wang, Shih-Pin Chen, Wei-Ta Chen, Shuu-Jiun Wang,

BACKGROUND:The increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, or remission is elusive. The purpose of this study is to identify the brain signatures that are predictive of the long-term outcomes ... Read more >>

J Headache Pain (The journal of headache and pain)
[2020, 21(1):29]

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Psychosocial repercussion of migraine: is it a stigmatized disease?

A Martínez-Fernández, M Rueda Vega, S Quintas, M de Toledo Heras, J Díaz de Terán, G Latorre González, O Trabajos García, J Vivancos Mora, A B Gago-Veiga,

INTRODUCTION:Stigma manifests both in prejudices and rejection from society towards patients who suffer from a specific pathology, and by patient's internalization of this discrimination, with the consequent repercussions on their state of mind and quality of life. The aim of the study was to quantify the stigma associated with migraine ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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A Study of Clinical Features and Risk Factors of Self-Referring Emergency Department Headache Patients: A Comparison with Headache Center Outpatients.

Alessandro Viganò, Ersilia Savastano, Barbara Petolicchio, Massimiliano Toscano, Rita De Sanctis, Ilaria Maestrini, Vittorio Di Piero,

BACKGROUND:Nonlife-threatening headaches account for 3% of emergency department (ED) admissions, with social and economic negative consequences. We aim to investigate clinical features and risk factors of nonlife-threatening headache patients referring to ED versus those referring to headache outpatient clinics. METHODS:During 6 months, we promptly reevaluated in our headache unit (HU) ... Read more >>

Eur. Neurol. (European neurology)
[2020, :1-7]

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Altered local and distant functional connectivity density relate to headache frequency in migraine without aura

Lingling Dai, Jun Ke, Yang Yu, Xiaodong Zhang, Yunyan Su, Ximing Wang, Su Hu, Hui Dai, Chunhong Hu, Hongru Zhao,

<title>Abstract</title> <p> Background Episodic migraine (EM) is associated with alterations in functional connectivity of several regions or resting-state networks, but it is not well known how large-scale functional connectivity pattern of the whole brain is affected in chronic migraine (CM). Methods Fifty-six migraineurs without aura (39 with EM, ... Read more >>

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Migraine Care in the Era of COVID-19: Clinical Pearls and Plea to Insurers.

Christina L Szperka, Jessica Ailani, Rebecca Barmherzig, Brad C Klein, Mia T Minen, Rashmi B Halker Singh, Robert E Shapiro,

OBJECTIVE:To outline strategies for the treatment of migraine which do not require in-person visits to clinic or the emergency department, and to describe ways that health insurance companies can remove barriers to quality care for migraine. BACKGROUND:COVID-19 is a global pandemic causing wide-spread infections and death. To control the spread ... Read more >>

Headache (Headache)
[2020, :]

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Onabotulinumtoxin A improves psychological aspects in chronic migraine patients

Jasem Al-Hashel, Hasan Ashkanani, Ohood Almutairi, Fajer Bokubar, Shahad Mubarak, Sawsan Alwazzan, Raed Alroughani, Doaa Youssry, Samar Ahmed,

<title>Abstract</title> <p> Background: Chronic migraine (CM) affects 5.4% of the Kuwaiti population. It is associated with significant headache-related disability, psychiatric comorbidity and reduces quality of life. The aim of this study is to assess the efficacy of OnabotulinumtoxinA on psychological aspects of chronic migraine patients.Methods: 113 chronic migraineurs ... Read more >>

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Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the migraine in America symptoms and treatment (MAST) study.

Dawn C Buse, Michael L Reed, Kristina M Fanning, Ryan Bostic, David W Dodick, Todd J Schwedt, Sagar Munjal, Preeti Singh, Richard B Lipton,

BACKGROUND:Migraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between headache pain intensity and monthly headache day (MHD) frequency with migraine comorbidities is novel and adds to our understanding of migraine comorbidity. METHODS:The MAST Study is a prospective, web-based survey ... Read more >>

J Headache Pain (The journal of headache and pain)
[2020, 21(1):23]

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Sustained Response To Onabotulinumtoxin A In Patients With Chronic Migraine: Real-Life Data

Simona Sacco, Raffaele Ornello, Simona Guerzoni, Carlo Baraldi, Luana Evangelista, Ilaria Frattale, Carmine Marini, Cindy Tiseo, Francesca Pistoia,

<title>Abstract</title> <p> Background Treatment with onabotulinumtoxin A (BT-A) is safe and effective for chronic migraine (CM). Several studies assessed possible predictors of response to treatment with BT-A, but there is little knowledge on the frequency and predictors of sustained response. The aim of this study was to evaluate ... Read more >>

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Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache.

Noemi Meylakh, Kasia K Marciszewski, Flavia Di Pietro, Vaughan G Macefield, Paul M Macey, Luke A Henderson,

BACKGROUND:There is evidence of altered resting hypothalamic activity patterns and connectivity prior to a migraine, however it remains unknown if these changes are driven by changes in overall hypothalamic activity levels. If they are, it would corroborate the idea that changes in hypothalamic function result in alteration in brainstem pain ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2020, :333102420911623]

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A Markov chain method for counting and modelling migraine attacks.

Mathias Barra, Fredrik A Dahl, Kjersti Grøtta Vetvik, E Anne MacGregor,

To ensure reproducibility in research quantifying episodic migraine attacks, and identifying attack onset, a sound theoretical model of a migraine attack, paired with a uniform standard for counting them, is necessary. Many studies report on migraine frequencies-e.g. the fraction of migraine-days of the observed days-without paying attention to the number ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3631]

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The Effects of the Rome IV Criteria on Pediatric Gastrointestinal Practice.

Desiree F Baaleman, Carlo Di Lorenzo, Marc A Benninga, Miguel Saps,

PURPOSE OF REVIEW:To evaluate the impact of the implementation of the Rome IV criteria on pediatric gastrointestinal practice. RECENT FINDINGS:In 2016, the Rome IV criteria were published, providing an update of symptom-based criteria to diagnose children with functional gastrointestinal disorders (FGIDs). For neonates and toddlers, Wessel's criteria for diagnosing infant ... Read more >>

Curr Gastroenterol Rep (Current gastroenterology reports)
[2020, 22(5):21]

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Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura

Xiaoxia Du, Zhaoxia Qin, Jingjing Su, Xin-Wei He, Shiyu Ban, Qian Zhu, Yangyang Cui, Jilei Zhang, Yue Hu, Yi-Sheng Liu, Rong Zhao, Yuan Qiao, Jianqi Li, Jian-Ren Liu,

<title>Abstract</title> <p> Background: Migraine is a severe and disabling brain disorder, and the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, and headache attacks disrupt their sensory information processing and sensorimotor integration. The altered functional connectivity (FC) of sub-regions of sensorimotor brain areas with other brain ... Read more >>

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Sensory Processing Patterns affect Headache Severity among Adolescents with Migraine

Jacob Genizi, Ayelet Halevy, Mitchell Schertz, Khaled Osman, Nurit Assaf, Idan Segal, Isaac Sr, Aharon Kessel, Batya Engel-Yeger,

<title>Abstract</title> <p> Objective : To evaluate the relationship between pain catastrophizing level, sensory processing patterns, and headache severity among adolescents with episodic migraine. Background : Catastrophizing about pain is a critical variable in how we understand adjustment to pain and has a unique contribution in predicting pain intensity. ... Read more >>

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Headache and non-headache symptoms provoked by nitroglycerin in migraineurs: A human pharmacological triggering study.

Nazia Karsan, Pyari R Bose, Charlotte Thompson, Jayde Newman, Peter J Goadsby,

BACKGROUND:Studying a spontaneous migraine attack is challenging, particularly the earliest components. Nitroglycerin is a potent, reliable and reproducible migraine trigger of the entirety of the migraine attack, making its use experimentally attractive. METHODS:Fifty-three subjects with migraine with a history of spontaneous premonitory symptoms were exposed to a 0.5 mcg/kg/min nitroglycerin infusion. ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2020, :333102420910114]

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Prolonged Migraine Stuttering Aura: Structural, Functional, and Video Neuroimaging Study of an Atypical Migraine Aura. A Case Report.

Emilio Rodríguez-Castro, Ariela N Lagorio, Alejandro Bejarano-García, Pablo Aguiar, Julia Cortés, Rogelio Leira,

BACKGROUND:Stuttering is a disorder in the rhythm of speech characterized by an involuntary repetition, prolongation, and cessation of sounds. Neurogenic acquired stuttering is a very rare disorder which could result from different conditions with the involvement of several brain locations. CASE REPORT:A 16-year-old male presented to our Hospital with headache ... Read more >>

Headache (Headache)
[2020, 60(4):776-780]

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Population pharmacokinetic and exposure-response analysis of eptinezumab in the treatment of episodic and chronic migraine.

Brian Baker, Barbara Schaeffler, Martin Beliveau, Igor Rubets, Susan Pederson, MyMy Trinh, Jeff Smith, John Latham,

Eptinezumab is a humanized mAb that targets calcitonin gene-related peptide and is under regulatory review for the prevention of episodic and chronic migraine (EM, CM). It is important to determine whether exposures achieved with intravenous (IV) administration of eptinezumab achieve desired pharmacologic effects. Population pharmacokinetics, including dose- and exposure-response analyses, ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2020, 8(2):e00567]

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Migraine With Aura as Early Disease Marker in Hereditary Dutch-Type Cerebral Amyloid Angiopathy.

Emma A Koemans, Sabine Voigt, Ingeborg Rasing, Ellis S van Etten, Erik W van Zwet, Marianne A A van Walderveen, Marieke J H Wermer, Gisela M Terwindt,

Background and Purpose- To determine whether migraine, which has often been described as an inaugural manifestation in monogenic cerebrovascular syndromes, is associated with cerebral amyloid pathology, we assessed migraine and its correlation with magnetic resonance imaging markers in Hereditary Dutch-Type Cerebral Amyloid Angiopathy (D-CAA or Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch ... Read more >>

Stroke (Stroke)
[2020, 51(4):1094-1099]

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