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Methylglyoxal

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In-solution derivatization and detection of glyoxal and methylglyoxal in alcoholic beverages and fermented foods by headspace solid-phase microextraction and gas chromatography–mass spectrometry

Hyun-Hee Lim, Ho-Sang Shin,

A simple and sensitive method for the simultaneous determination of glyoxal and methylglyoxal in alcoholic beverages and fermented foods was developed. This method involved simultaneous derivatization in solution with 2,2,2-trifluoroethyl hydrazine (TFEH) and headspace solid phase microextraction, followed by detection via gas chromatography-mass spectrometry (GC–MS). The method established herein can ... Read more >>

J Food Compost Anal (Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems)
[2021, 92:Not Available]

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Sulfated polysaccharides from red seaweed Gelidium amansii: Structural characteristics, anti-oxidant and anti-glycation properties, and development of bioactive films

Gang Yu, Qiaozhi Zhang, Yanbo Wang, Qing Yang, Hejun Yu, Huan Li, Jian Chen, Linglin Fu,

Marine red algae are rich sources of sulfated polysaccharides as bioactive ingredients and hydrocolloid molecules. In this study, sulfated polysaccharides (YGAP, EGAP, and NGAP) were extracted from Gelidium amansiis that were harvested from three different sea areas of China. Characterization of these polysaccharides shows that they contain 3.7–4.0% sulfate and ... Read more >>

(Food hydrocolloids.)
[2021, 119:Not Available]

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A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway.

Huong Nguyen, Jia Yi Koh, Hainan Li, Argel Islas-Robles, Sai Pranathi Meda Venkata, Jie-Mei Wang, Terrence J Monks,

Peripheral arterial disease (PAD) is one of the major complications of diabetes due to an impairment in angiogenesis. Since there is currently no drug with satisfactory efficacy to enhance blood vessel formation, discovering therapies to improve angiogenesis is critical. An imidazolinone metabolite of the metformin-methylglyoxal scavenging reaction, (E)-1,1-dimethyl-2-(5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl) guanidine (IMZ), ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21645]

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Dietary Quercetin Reduces Plasma and Tissue Methylglyoxal and Advanced Glycation End Products in Healthy Mice Treated with Methylglyoxal.

Yantao Zhao, Yao Tang, Shengmin Sang,

<h4>Background</h4>Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), has been linked to AGEs-associated diseases.<h4>Objectives</h4>This study investigated the efficacy and mechanisms of dietary quercetin in decreasing plasma and tissue concentrations of MGO and AGEs in MGO-administered mice.<h4>Methods</h4>Male, 6-wk-old CD-1 mice were administered AIN-93G diet and water (Con) or 0.12% MGO ... Read more >>

J Nutr (The Journal of nutrition)
[2021, :]

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Protective effects of sciadopitysin against methylglyoxal-induced degeneration in neuronal SK-N-MC cells.

Kwang Sik Suh, Suk Chon, Woon Won Jung, Eun Mi Choi,

The accumulation of advanced glycation end products (AGEs) causes metabolic dysfunction and neuronal cell damage. Methylglyoxal (MG) is a major glycating agent that reacts with basic residues present in proteins and promotes the formation of AGEs. Sciadopitysin, a type of biflavonoid, exerts protective effects against neuronal cell damage; however, the ... Read more >>

J Appl Toxicol (Journal of applied toxicology : JAT)
[2021, :]

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Carbonylation of skin collagen induced by reaction with methylglyoxal.

Ko Sugiura, Shin Koike, Toshihiro Suzuki, Yuki Ogasawara,

Our previous studies have shown that glycerin, which is present at high concentrations in moisturizers and skin lotions, gradually oxidizes to produce methylglyoxal (MGO). In this study, we observed that MGO-treated porcine dermis type-I collagen was carbonylated in an MGO concentration- and time-dependent manner. Furthermore, we examined the structure of ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 562:100-104]

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The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and neuronal network activity changes

Ryan Griggs, Duc V.M. Nguyen, Leonid Yermakov, Jeneane Jaber, Jennae Shelby, Josef Steinbrunner, John Miller, Carlos Gonzalez-Islas, Peter Wenner, Keiichiro Susuki,

Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or position along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is shorter in the prefrontal cortex of type 2 diabetic mice with cognitive impairment. The key type 2 diabetes-related factor that ... Read more >>

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Genistein Inhibits Protein Glycation in Healthy and Pre-Obese Mice Treated With High-Fat Diet via Trapping and Activating the Detoxification Pathways of Methylglyoxal

Yantao Zhao, Yantao Zhao, Pei Wang, Shengming Sang,

Abstract <h4>Objectives</h4> High levels of methylglyoxal (MGO) and advanced glycation end products (AGEs) play important roles in the pathogenesis of diabetes and other chronic diseases. This study aimed to investigate the underlying mechanisms that dietary genistein inhibits the accumulations of MGO and AGEs in healthy and pre-obese mice treated with ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2021, 5(Suppl 2):387-387]

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Methylglyoxal augments uridine diphosphate-induced contraction via activation of p38 mitogen-activated protein kinase in rat carotid artery.

Takayuki Matsumoto, Tomoki Katome, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi,

The methylglyoxal elicits diverse adverse effects on the body. Uridine diphosphate, an extracellular nucleotide, plays an important role as a signaling molecule controlling vascular tone. This study aimed to evaluate the relationship between methylglyoxal and uridine diphosphate-induced carotid arterial contraction in rats. Additionally, we examined whether p38 mitogen-activated protein kinase ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2021, 904:174155]

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Bacterial Immobilization and Toxicity Induced by a Bean Plant Immune System.

Bret Cooper, Hunter S Beard, Ronghui Yang, Wesley M Garrett, Kimberly B Campbell,

<i>Pseudomonas savastanoi</i> pv. <i>phaseolicola</i> causes halo blight disease in the common bean <i>Phaseolus vulgaris</i>. The bacterium invades the leaf apoplast and uses a type III secretion system to inject effector proteins into a bean cell to interfere with the bean immune system. Beans counter with resistance proteins that can detect ... Read more >>

J Proteome Res (Journal of proteome research)
[2021, :]

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Methylglyoxal influences development of Caenorhabditis elegans via lin-41-dependent pathway.

Yiren Yue, Jiaying Wang, Peiyi Shen, Kee-Hong Kim, Yeonhwa Park,

Methylglyoxal is a highly reactive dicarbonyl compound. It can be obtained either endogenously through biological enzymatic/non-enzymatic pathways or exogenously via the uptake of certain foods and beverages, such as Manuka honey. Studies about its biological properties are quite controversial, though the majority reported a positive association between methylglyoxal and certain ... Read more >>

Food Chem Toxicol (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2021, 152:112238]

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Discovery of Diagnostic and Therapeutic Targets For Vascular Injury Induced By Methylglyoxal Using Proteomics

Ming-Zhang Xie, Yan-Ting Liu, Min Zhang, Meng-Meng Zhao, Ke-Tao Sun, Yu-Chao Zhang, Yu-Jing Zhang, Xiao-Chun Zhou, Lei Wang, De-Ying Bo, Shi-Yan Wang, Guo-An Zhao, Yan-Xuan Liu,

<h4>Background: </h4> Methylglyoxal, a byproduct of diabetes or the consumption of a high-carbohydrate diet, is associated with vascular injury; however, its molecular mechanisms remain unclear. We aimed to systematically characterize molecular profiles and offer unique insights into new disease pathways, thereby contributing to understanding the mechanisms and pathogenesis of vascular ... Read more >>

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Glycemic, insulinemic and methylglyoxal postprandial responses to starches alone or in whole diets in dogs versus cats: Relating the concept of glycemic index to metabolic responses and gene expression.

Jennifer M Briens, Marina Subramaniam, Alyssa Kilgour, Matthew E Loewen, Kaushik M Desai, Jennifer L Adolphe, Kyla M Zatti, Murray D Drew, Lynn P Weber,

Species differences between domestic cats (Felis catus) and dogs (Canis familiaris) has led to differences in their ability to digest, absorb and metabolize carbohydrates through poorly characterized mechanisms. The current study aimed to first examine biopsied small intestine, pancreas, liver and skeletal muscle from laboratory beagles and domestic cats for ... Read more >>

Comp Biochem Physiol A Mol Integr Physiol (Comparative biochemistry and physiology. Part A, Molecular & integrative physiology)
[2021, 257:110973]

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Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats.

Lulu Chen, Zixiang Chen, Zhuqiu Xu, Weifeng Feng, Xiaonan Yang, Zuoliang Qi,

Oxidative stress plays the main role in the pathogenesis of diabetes mellitus and peripheral neuropathy. Polydatin (PD) has been shown to exhibit strong antioxidative and antiinflammatory effects. At present, no research has focused on the possible effects of PD on Schwann cells and impaired peripheral nerves in diabetic models. Here, ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Interaction pattern of histidine, carnosine and histamine with methylglyoxal and other carbonyl compounds.

Raheleh Ghassem Zadeh, Varoujan Yaylayan,

The ability of histidine to scavenge sugar-derived 1,2-dicarbonyl compounds was investigated using aqueous methanolic model systems containing histidine or histamine in the presence of glucose, methylglyoxal, or glyoxal. The samples were prepared either at room temperature (RT) or at 150 °C and analyzed using ESI-qTOF-MS/MS and isotope labeling technique. Replacing glucose ... Read more >>

Food Chem (Food chemistry)
[2021, 358:129884]

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Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide.

Sih Min Tan, Runa S J Lindblom, Mark Ziemann, Adrienne Laskowski, Cesare Granata, Matthew Snelson, Vicki Thallas-Bonke, Assam El-Osta, Carlos D Baeza-Garza, Stuart T Caldwell, Richard C Hartley, Thomas Krieg, Mark E Cooper, Michael P Murphy, Melinda T Coughlan,

Diabetic kidney disease (DKD) remains the number one cause of end-stage renal disease in the western world. In experimental diabetes, mitochondrial dysfunction in the kidney precedes the development of DKD. Reactive 1,2-dicarbonyl compounds, such as methylglyoxal, are generated from sugars both endogenously during diabetes and exogenously during food processing. Methylglyoxal ... Read more >>

Nutrients (Nutrients)
[2021, 13(5):]

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Carbonyl stress in diabetics with acute coronary syndrome.

Sushmita Bora, Prashant Shankarrao Adole,

The prevalence and incidence of diabetes mellitus (DM) are increasing worldwide bringing with it a significantly higher rate of complications. Various mechanisms such as carbonyl stress, polyol pathway, oxidative stress, hexosamine pathways, diacylglycerol/protein kinase-C activation, etc., are responsible for the pathogenesis of DM and its complications. Persistent hyperglycaemia and inhibition ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2021, 520:78-86]

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Pterostilbene prevents methylglyoxal-induced cytotoxicity in endothelial cells by regulating glyoxalase, oxidative stress and apoptosis.

Dan Tang, Wei Xiao, Wen-Ting Gu, Zhi-Tong Zhang, Shu-Hong Xu, Zhi-Quan Chen, You-Hua Xu, Lu-Yong Zhang, Shu-Mei Wang, Hong Nie,

Methylglyoxal (MGO), a cytotoxic byproduct of glycolysis in biological systems, can induce endothelial cells dysfunction, implicated in diabetic vascular complications. Pterostilbene (PTS), a naturally occurring resveratrol derivative, is involved in various pharmacological activities. This study aimed to explore the effects of PTS on MGO induced cytotoxicity in human umbilical vein ... Read more >>

Food Chem Toxicol (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2021, 153:112244]

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Methylglyoxal stimulates endoplasmic reticulum stress in vascular smooth muscle cells.

Mustafa Kırça, Akın Yeşilkaya,

Methylglyoxal (MGO) is considered responsible for the detrimental effects of high blood glucose. MGO is produced as a by-product of the glycolysis pathway. While the glyoxalase system removes it, the system fails in people with diabetes. MGO concentration is detected as elevated in these patients. Endoplasmic reticulum (ER) stress may ... Read more >>

J Recept Signal Transduct Res (Journal of receptor and signal transduction research)
[2021, :1-6]

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Methylglyoxal Drives a Distinct, Nonclassical Macrophage Activation Status.

Foivos-Filippos Tsokanos, Carolin Muley, Sajjad Khani, Daniela Hass, Thomas Fleming, Gretchen Wolff, Alexander Bartelt, Peter Nawroth, Stephan Herzig,

Metabolic complications in diabetic patients are driven by a combination of increased levels of nutrients and the presence of a proinflammatory environment. Methylglyoxal (MG) is a toxic byproduct of catabolism and has been strongly associated with the development of such complications. Macrophages are key mediators of inflammatory processes and their ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2021, :]

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Methylglyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Inflammation via Interaction with RAGE in Mesangial Cells.

Hee-Weon Lee, Min Ji Gu, Jee-Young Lee, Seungju Lee, Yoonsook Kim, Sang Keun Ha,

<h4>Introduction</h4>Advanced glycation end products (AGEs) and receptor of advanced glycation end products (RAGE) mediate renal function during diabetic and non-diabetic nephropathy development. Methylglyoxal-lysine dimer (MOLD), a typical toxic advanced glycation end product (TAGE), contributes to inflammatory responses during renal diseases. This study determines the effect of MOLD on inflammatory responses ... Read more >>

Mol Nutr Food Res (Molecular nutrition & food research)
[2021, :e2000799]

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Hepatocyte growth factor ameliorates methylglyoxal-induced peritoneal inflammation and fibrosis in mouse model.

Haruhito Yoshimine, Shiroh Tanoue, Yutaro Ibi, Masato Minami, Mai Nakahara, Koki Tokunaga, Shuji Kanmura, Akio Ido,

<h4>Background</h4>Peritoneal dialysis (PD) is essential for patients with end-stage renal disease. Peritoneal fibrosis (PF) is a complex inflammatory, fibrogenic process. No effective treatments are available to prevent these processes. Hepatocyte growth factor (HGF) possesses anti-inflammatory and anti-fibrotic properties. The aim of this study was to analyze whether HGF suppresses MGO-induced ... Read more >>

Clin Exp Nephrol (Clinical and experimental nephrology)
[2021, :]

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Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium.

Derek R Case, Jon Zubieta, Ren Gonzalez, Robert P Doyle,

Magnesium (Mg<sup>2+</sup>) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully characterized, highly bioavailable, and substantially water-soluble ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(9):]

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Effect of Methionine on the Thermal Degradation of N-(1-Deoxy-d-fructos-1-yl)-methionine Affecting Browning Formation.

Shibin Deng, Heping Cui, Khizar Hayat, Shahzad Hussain, Muhammad Usman Tahir, Yun Zhai, Qiang Zhang, Xiaoming Zhang, Chi-Tang Ho,

The effect of additional dl-methionine (Met) on the thermal degradation of a methionine-glucose-derived Amadori rearrangement product (MG-ARP) was investigated under different reaction conditions. The resulting color formation and changes in the concentrations of MG-ARP, Met, and α-dicarbonyl compounds were investigated. Additional Met did not affect the degradation rate of MG-ARP ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2021, 69(17):5167-5177]

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High-Performance affinity chromatographic studies of repaglinide and nateglinide interactions with normal and glyoxal- or methylglyoxal-modified human albumin serum.

Susan T Ovbude, Pingyang Tao, Zhao Li, David S Hage,

During diabetes human serum albumin (HSA), an important drug transport protein, can be modified by agents such as glyoxal (Go) and methylglyoxal (MGo) to form advanced glycation end-products. High-performance affinity microcolumns and zonal elution competition studies were used to compare interactions by the anti-diabetic drugs repaglinide and nateglinide with normal ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 201:114097]

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