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Mesothelioma

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Epidemiology and outcome of peritoneal and pleural mesothelioma subtypes in Norway. A 20 year nation-wide study.

Odd Terje Brustugun, Yngvar Nilssen, Inger Johanne Zwicky Eide,

<h4>Background</h4>Mesothelioma of the pleural or peritoneal cavities is one of the deadliest cancer types. The incidence of pleural subtypes has decreased over time due to decrease in asbestos exposure, and the current treatment landscape is changing due to introduction of novel therapies. In this study we have analysed contemporary epidemiological ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2021, :1-7]

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Primary Pericardial Mesothelioma: A Population-Based Propensity Score-Matched Analysis.

Hilliard Brydges, Kanhua Yin, Ramkumar Balasubramaniyan, Kyle W Lawrence, Rongkui Luo, Karl J Karlson, David B McAneny, Niloo M Edwards, Michael J Reardon, Nikola Dobrilovic,

Primary pericardial mesothelioma is a rare malignancy of the mesothelial lining of the pericardium. This study aimed to evaluate the clinical characteristics and survival outcomes of these patients using a US population-based cancer database. We queried the Surveillance, Epidemiology, and End Results program (1973-2015). Primary pericardial mesothelioma patients with complete ... Read more >>

Semin Thorac Cardiovasc Surg (Seminars in thoracic and cardiovascular surgery)
[2021, :]

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Unusual case of malignant pleural mesothelioma.

Timothy Johanan Rajaratnam, Jurgen Herre,

We present the case of a 65-year-old woman who presented with progressive dysphagia and was diagnosed with achalasia. She subsequently developed bilateral chylous pleural effusions, with no cause identified despite extensive investigations (including computed tomography (CT) scans, gastroscopy and medical thoracoscopy (MT)) and review at a dedicated pleural multidisciplinary team ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(7):]

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Evaluation of prognostic histological parameters proposed for pleural mesothelioma in diffuse malignant peritoneal mesothelioma. A short report.

Federica Pezzuto, Luigi Vimercati, Francesco Fortarezza, Andrea Marzullo, Antonio Pennella, Domenica Cavone, Alessandra Punzi, Concetta Caporusso, Antonio d'Amati, Teresa Lettini, Gabriella Serio,

<h4>Introduction</h4>Diffuse malignant peritoneal mesothelioma (DMPM) is a rare malignant neoplasm with poor survival that shares some similarities with the best-known pleural variant, pleural mesothelioma. The recent European Reference Network on Rare Adult Cancers (EURACAN)/International Association for the Study of Lung Cancer (IASLC) proposals attempted to improve the histological diagnosis and ... Read more >>

Diagn Pathol (Diagnostic pathology)
[2021, 16(1):64]

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Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma.

Meilin Chan, Licun Wu, Zhihong Yun, Trevor D McKee, Michael Cabanero, Yidan Zhao, Mikihiro Kohno, Junichi Murakami, Marc de Perrot,

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm originating from the pleura. Non-epithelioid (biphasic and sarcomatoid) MPM are particularly resistant to therapy. We investigated the role of the GITR-GITRL pathway in mediating the resistance to therapy. We found that GITR and GITRL expressions were higher in the sarcomatoid cell line ... Read more >>

Commun Biol (Communications biology)
[2021, 4(1):914]

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Survival Outcomes for Malignant Peritoneal Mesothelioma at Academic Versus Community Hospitals.

Vanessa M Welten, Adam C Fields, Robert A Malizia, James Yoo, Jennifer L Irani, Joel E Goldberg, Ronald Bleday, Nelya Melnitchouk,

<h4>Background</h4>Malignant peritoneal mesothelioma is a rare disease with poor outcomes. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is the cornerstone of therapy. We aim to compare outcomes of malignant peritoneal mesothelioma treated at academic versus community hospitals.<h4>Methods</h4>This was a retrospective cohort study using the National Cancer Database to identify patients with ... Read more >>

J Gastrointest Surg (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2021, :]

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Thoracic Benign Cystic Mesothelioma.

M Furkan Sahin, Alkin Yazicioglu, Neslihan Inci Zengin, Erdal Yekeler,

<h4>Background</h4>Benign cystic mesotheliomas (BCMs), also known as multilocular mesothelial inclusion cysts, inflammatory inclusion cysts or multicystic mesothelial proliferation, are frequently observed in females and are localised localised in the pelvic peritoneum. They are rarely present in the thoracic and mediastinal areas; however, these locations have been reported in a few ... Read more >>

Acta Chir Belg (Acta chirurgica Belgica)
[2021, :1-6]

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A Case of Pulmonary Embolism with Sarcomatoid Malignant Pleural Mesothelioma with Long-Term Pleural Effusion.

Rumeng Gu, Luxi Jiang, Ting Duan, Chun Chen, Shengchang Wu, Deguang Mu,

<h4>Background</h4>Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that originates from pleural mesothelial cells. In recent years, with the development of asbestos-related industries and the increase in air pollution, its incidence has been increased. The incidence of pulmonary embolism combined with sarcomatoid MPM is very low and the prognosis ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2021, 14:4231-4237]

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Diagnostic accuracy of the cancer ratio for the prediction of malignant pleural effusion: evidence from a validation study and meta-analysis.

Ying Zhang, Xiaoou Li, Junhui Liu, Xueru Hu, Chun Wan, Rui Zhang, Yongchun Shen,

<h4>Objective</h4>This study aimed to assess the diagnostic accuracy of serum LDH to pleural ADA ratio (cancer ratio, CR)for malignant pleural effusion (MPE) through an original study and meta-analysis.<h4>Methods</h4>We retrospectively collected data from 145 patients with MPE and 117 cases of benign pleural effusions (BPE). The diagnostic performance of CR and ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):558-566]

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Up-regulation of Mitotic Nuclear Division-related Genes and Down-regulation of TGF-β-related Genes Correlate with Survival in Malignant Pleural Mesothelioma

Lili Su, Yonggang Wang, Daowei Li, Xingguang Wang, Bin Liang, Weixia Ma, Honglin Guo, Wenjie You, Shujuan Jiang,

Malignant pleural mesothelioma (MPM) is a highly aggressive and lethal malignancy; however, its molecular origins remain largely unknown. The purpose of this study was to use transcriptomics to explore the molecular mechanisms of MPM tumorigenesis toward gaining a better understanding of disease development. The transcriptomes from MPM tissues and paired ... Read more >>

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Underreporting of mesothelioma, asbestosis and pleural plaques in Brazil.

V S Santana, L Salvi, F Cavalcante, F Campos, E Algranti,

<h4>Background</h4>Brazil has a long history of heavy asbestos consumption. However, the number of asbestos-related diseases (ARDs) falls far below the one expected compared with other asbestos consumer countries.<h4>Aims</h4>To examine underreporting of ARDs, that is mesothelioma, asbestosis and pleural plaques, in Brazil's Mortality Information System (SIM).<h4>Methods</h4>Health information systems (HIS) were mapped, ... Read more >>

Occup Med (Lond) (Occupational medicine (Oxford, England))
[2021, :]

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Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma.

Koichi Hata, Chikara Sakaguchi, Michiko Tsuchiya, Yukio Nagasaka,

Used for a wide range of cancers, nivolumab has been reported to cause immune-related adverse events, including isolated adrenocorticotropic hormone deficiency (IAD). We report an 81-year-old woman with malignant mesothelioma who presented with abdominal pain after eight courses of nivolumab therapy, leading to the diagnosis of nivolumab-induced IAD. We should ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(7):]

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A Trial of Intra-Pleural BacteriaL ImmunoTherapy In Malignant Pleural Mesothelioma (TILT) – A Randomised Feasibility Study Using The Trial Within A Cohort (TwiC) Methodology

Anna Bibby, Natalie Zahan-Evans, Emma Keenan, Charles Comins, John Harvey, Helen Day, Najib Rahman, Janet Fallon, Rachael Gooberman-Hill, Nick Maskell,

<h4>Background: </h4> Malignant pleural mesothelioma (MPM) is an aggressive thoracic malignancy with a poor prognosis. Systemic immunotherapy is an effective front-line treatment for MPM, and there is a scientific rationale supporting the possible efficacy of local i.e. intra-pleural immune modulators. TILT investigated the feasibility of performing a randomised trial of ... Read more >>

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Systemic characterization of alternative splicing related to prognosis and immune infiltration in malignant mesothelioma.

Jinzhi Lai, Hainan Yang, Tianwen Xu,

<h4>Background</h4>Malignant mesothelioma (MM) is a relatively rare and highly lethal tumor with few treatment options. Thus, it is important to identify prognostic markers that can help clinicians diagnose mesothelioma earlier and assess disease activity more accurately. Alternative splicing (AS) events have been recognized as critical signatures for tumor diagnosis and ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):848]

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Mesothelioma Risk Score: A New Prognostic Pretreatment, Clinical-Molecular Algorithm for Malignant Pleural Mesothelioma.

Beow Y Yeap, Assunta De Rienzo, Ritu R Gill, Michela E Oster, Mary N Dao, Nhien T Dao, Rachel D Levy, Kimberly Vermilya, Corinne E Gustafson, Gavin Ovsak, William G Richards, Raphael Bueno,

<h4>Introduction</h4>Prognostic models for malignant pleural mesothelioma have been limited to demographics, symptoms, and laboratory values. We hypothesize higher accuracy using both tumor and patient characteristics. The mesothelioma prognostic test (MPT) and molecular subtype based on claudin-15-to-vimentin expression ratio are molecular signatures associated with survival. Tumor volume (TV) has improved performance ... Read more >>

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2021, :]

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Cerebral air embolism after indwelling pleural catheter insertion in a chronic hydropneumothorax secondary to epithelioid mesothelioma.

Dissanayake Mudiyanselage Chanaka Jayawardena, Rakesh K Panchal, Sanjay Agrawal, Indrajeet Das,

A 75-year-old man with a history of epithelioid mesothelioma and a right-sided indwelling pleural catheter (IPC) presented with a history of a purulent fluid drainage via the IPC. The pleural fluid cultured <i>Klebsiella oxytoca</i> and <i>Enterococcus faecalis</i> He was treated with a course of oral fluoroquinolone followed by uneventful IPC ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(7):]

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Risk of asbestosis, mesothelioma, other lung disease or death among motor vehicle mechanics: a 45-year Danish cohort study.

Reimar Wernich Thomsen, Anders Hammerich Riis, Esben Meulengracht Flachs, David H Garabrant, Jens Peter Ellekilde Bonde, Henrik Toft Sørensen,

<h4>Introduction</h4>The risk of asbestosis, malignant mesothelioma and lung cancer among motor vehicle mechanics is of concern because of potential exposure to chrysotile asbestos during brake, clutch and gasket repair and maintenance. Asbestos has also been used in insulation and exhaust systems.<h4>Methods</h4>We examined the long-term risk of incident mesothelioma, lung cancer, ... Read more >>

Thorax (Thorax)
[2021, :]

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Hyperthermic Intrathoracic Chemoperfusion for Malignant Pleural Mesothelioma: Systematic Review and Meta-Analysis.

Tommi Järvinen, Juuso Paajanen, Ilkka Ilonen, Jari Räsänen,

Malignant pleural mesothelioma (MPM) is an aggressive malignancy of the pleural lining with exceptionally poor survival. Hyperthermic intrathoracic chemoperfusion (HITHOC) is commonly used with surgery in limited disease. However, data on its effect on survival are limited. In this systematic review and meta-analysis, we analyzed a total of 11 observational ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(14):]

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Recent Patent based perspective on diagnostic and therapeutic interventions in Malignant Mesothelioma: Is Drug Repositioning knocking the door?

Vikas Yadav, Roghaiyeh Safari,

<h4>Background</h4>Malignant Mesothelioma (MM), an orphan but aggressive malignancy of the mesothelial membrane, is a fatal tumor. Global epidemic related to malignant pleural mesothelioma is on the rise, so there is a need to explore novel biomarkers and ingenious therapeutic approaches to stalk this silent killer.<h4>Objective</h4>The main aim of the present ... Read more >>

Recent Pat Anticancer Drug Discov (Recent patents on anti-cancer drug discovery)
[2021, :]

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Mesothelioma in immigrants from Turkey: Genes have a minor role.

Selma Metintas, Muzaffer Metintas, Guntulu Ak, Gunnar Hillerdal, Hirsh Koyi,

<h4>Objective</h4>To examine the incidence and epidemiology of malignant mesothelioma in immigrants from Karain where there is an extraordinarily high incidence of mesothelioma, Cappadocia, Turkey, to Stockholm, Sweden, and their children over 20 years of age born in Stockholm, i.e. two genetically similar populations with and without erionite exposure.<h4>Methods</h4>This survey was ... Read more >>

Respir Med (Respiratory medicine)
[2021, 186:106527]

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Preclinical Evaluation of Podoplanin-Targeted Alpha-Radioimmunotherapy with The Novel Antibody NZ-16 for Malignant Mesothelioma

Hitomi Sudo, Atsushi Tsuji, Aya Sugyo, Mika Kaneko, Yukinari Kato, Kotaro Nagatsu, Hisashi Suzuki, Tatsuya Higashi,

<h4>Purpose: </h4> This study aimed to evaluate the potential of podoplanin (PDPN)-targeted alpharadiotherapy (RIT) for treating malignant mesothelioma. <h4>Methods: </h4> A newly developed anti-PDPN antibody, NZ-16, and a previous anti-PDPN antibody, NZ-12, were assessed. The in vitro properties of radiolabeled antibodies were evaluated by cell binding and competitive inhibition assays ... Read more >>

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Membranous HEG1 expression is a useful marker in the differential diagnosis of epithelioid and biphasic malignant mesothelioma versus carcinomas.

Kenzo Hiroshima, Di Wu, Eitetsu Koh, Yasuo Sekine, Daisuke Ozaki, Toshikazu Yusa, Tadao Nakazawa, Shoutaro Tsuji, Yohei Miyagi, Ann E Walts, Alberto M Marchevsky, Aliya N Husain, Kohzoh Imai,

Sialylated HEG1 has been reported as a highly specific and sensitive mesothelioma marker but a comprehensive evaluation of its expression in carcinomas in different organs, various sarcomas and reactive mesothelial proliferations has not been reported. The aim of this study was to evaluate the clinical applicability of HEG1 as a ... Read more >>

Pathol Int (Pathology international)
[2021, :]

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Malignant Peritoneal Mesothelioma Interactome with 417 Novel Protein-Protein Interactions

Kalyani Karunakaran, Madhavi Ganapathiraju,

Malignant peritoneal mesothelioma (MPeM) is an aggressive cancer affecting the peritoneal lining of the abdominal cavity and intra-abdominal organs, with a median survival of ~2.5 years. We constructed an ‘MPeM interactome’ with over 400 computationally predicted protein-protein interactions (PPIs) and over 4,700 known PPIs of 59 literature-curated genes whose activity ... Read more >>

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Biological basis for novel mesothelioma therapies.

Joanna Obacz, Henry Yung, Marie Shamseddin, Emily Linnane, Xiewen Liu, Arsalan A Azad, Doris M Rassl, David Fairen-Jimenez, Robert C Rintoul, Marko Z Nikolić, Stefan J Marciniak,

Mesothelioma is an aggressive cancer that is associated with exposure to asbestos. Although asbestos is banned in several countries, including the UK, an epidemic of mesothelioma is predicted to affect middle-income countries during this century owing to their heavy consumption of asbestos. The prognosis for patients with mesothelioma is poor, ... Read more >>

Br J Cancer (British journal of cancer)
[2021, :]

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Molecular Signatures Associated With the Development of Pulmonary Toxicities in Mesothelioma Patients Treated With Radical Hemithoracic Radiation Therapy

Sergio Crovella, Alberto Relevant, Elena Muraro, Ronald Moura, Lucas Brandão, Marco Trovò, Agostino Steffan, Paola Zacchi, Giuliano Zabucchi, Emilio Minatel, Violetta Borelli,

<h4>Background: </h4> Radical Hemithoracic Radiotherapy (RHR), after lung-sparing surgery, has recently become a concrete therapeutic option for malignant pleural mesothelioma (MPM), an asbestos-related, highly aggressive tumor with increasing incidence and poor prognosis. Although the toxicity associated to this treatment has been reduced, it is still not negligible and must be ... Read more >>

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