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Meningococcemia

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Neisseria meningitidis Induced Fatal Waterhouse-Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure.

Meng-Yu Wu, Chien-Sheng Chen, Chih-Yi Tsay, Giou-Teng Yiang, Jian-Yu Ke, Po-Chen Lin,

Neisseria meningitidis-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse-Friderichsen syndrome (WFS). Here, ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(3):]

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The Inflammatory and Hemostatic Response in Sepsis and Meningococcemia.

Navin P Boeddha, Thomas Bycroft, Simon Nadel, Jan A Hazelzet,

Meningococcemia is notorious for evasion of the host immune system and its rapid progression to fulminant disease, and serves as a unique model for pediatric sepsis. Illness severity is determined by complex interplays among host, pathogen, and environment. The inflammatory host response, including proinflammatory and anti-inflammatory responses in innate and ... Read more >>

Crit Care Clin (Critical care clinics)
[2020, 36(2):391-399]

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[Meningococcemia: Different Serotypes in the Same Region].

Nükhet Aladağ Çiftdemir, Rıdvan Duran, Ülfet Vatansever Özbek, Selda Hançerli Törün, Betül Acunaş, Nuriye Ünal Şahin,

Meningococcal infections are important health problems causing high morbidity and mortality. Neisseria meningitidis have 13 serogroups. A, B, C, Y and W135 are the most common causes of invasive disease among those serogroups. The distribution of the serogroups differs according to the geographical regions and the age groups. In this ... Read more >>

Mikrobiyol Bul (Mikrobiyoloji bulteni)
[2020, 54(1):163-170]

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First case report of fulminant septic shock from meningococcemia associated with Cryptococcus neoformans coinfection in an immunocompetent patient.

Guilherme Dienstmann, Karina Tolfo Avi, Luiz Arthur Calheiros Leite, Joaquim Squizatto Alano, Matheus Leite Ramos de Souza, Marcelo da Silva Mulazani, Paula Cristina Gern Mendivil,

The meningococcal disease manifestation associated with the presence of Cryptococcus neoformans is rare. There are no reports in the literature about these simultaneous infections in immunocompetent patients. The aim of the present study is to describe the first case of fulminant septic shock by Neisseira meningitidis associated with Cryptococcus neoformans ... Read more >>

Med Mycol Case Rep (Medical mycology case reports)
[2019, 26:44-46]

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Acute abdominal pain as the initial manifestation of meningococcemia in adult patient.

Carolina Contero, Coral Martín, Angie Gómez, Philip Erick Wikman-Jorgensen,

Enferm. Infecc. Microbiol. Clin. (Enfermedades infecciosas y microbiologia clinica)
[2019, :]

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Does the Plague Still Threaten Us?

Alzira Maria Paiva de Almeida, Marise Sobreira, Nilma Cintra Leal, Celso Tavares,

Rev. Soc. Bras. Med. Trop. (Revista da Sociedade Brasileira de Medicina Tropical)
[2020, 53:e20190136]

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Atypical presentation of invasive meningococcal disease caused by serogroup W meningococci.

C Stinson, C Burman, J Presa, M Abalos,

Neisseria meningitidis, a gram-negative diplococcus, is typically an asymptomatic coloniser of the oropharynx and nasopharynx. Passage of N. meningitidis into the bloodstream can cause invasive meningococcal disease (IMD), a potentially life-threatening illness with rapid onset that generally presents as meningitis, septicemia or both. Serogroup W IMD has been increasing in ... Read more >>

Epidemiol. Infect. (Epidemiology and infection)
[2020, 148:e12]

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50 Years Ago in TheJournal ofPediatrics: Heparin Therapy in Fulminant Meningococcemia.

Elizabeth Dorn, Philip Toltzis,

J. Pediatr. (The Journal of pediatrics)
[2019, 212:207]

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A case report of multiple cerebral abscess formation complicating serogroup B Neisseria meningitidis meningitis.

Ciara O'Connor, Aedin Collins, Eilish Twomey, Conor Hensey, John Caird, Patrick J Gavin,

BACKGROUND:Invasive meningococcal disease (IMD) presenting with meningitis causes significant mortality and morbidity. Suppurative complications of serogroup B meningococcal sepsis are rare and necessitate urgent multidisciplinary management to mitigate long-term morbidity or mortality. CASE PRESENTATION:We present a rare case of invasive meningococcal disease in a 28-month old boy complicated by multiple ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2019, 19(1):863]

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Myocarditis in fulminant meningococcemia.

Hanyu Qin, Wei Jiang,

Intensive Care Med (Intensive care medicine)
[2019, 45(11):1655-1656]

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Chronic meningococcemia.

Beatriz Prista-Leão, Francisco Almeida, Ana Cláudia Carvalho, Susana Silva, António Sarmento,

The spectrum of Neisseria meningitidis-associated clinical entities involves mild forms of disease, without neurological involvement or sepsis, and asymptomatic carrier states. Rarely, N. meningitidis bacteremia can be associated with a prolonged fever with or without arthritis, which we designate as chronic meningococcemia. Chronic meningococcemia is an uncommon entity, usually associated ... Read more >>

IDCases (IDCases)
[2019, 15:e00502]

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Pustular Vasculitis: Different Names for Same Entity?

Shivani B Kaushik, Animesh A Upadhyay, Ethan Routt, Robert Phelps,

Indian Dermatol Online J (Indian Dermatology Online Journal)
[2019, 10(6):721-723]

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Purpura in the Emergency Room: Two Cases of Sepsis with Cutaneous Manifestations.

Kenneth L Frye, Brian C McMaster, Kevin J Tomecsek,

Purpura fulminans is a seldom seen manifestation of sepsis in the emergency department (ED). The morbidity and mortality of sepsis have been widely studied and reported; the hallmark of treatment is early recognition and intervention. In extreme cases, sepsis can cause widespread activation of the coagulation cascade further complicating the treatment ... Read more >>

Cureus (Cureus)
[2019, 11(6):e4976]

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Pediatric Cutaneous Emergencies and their Outcome: Study from a Tertiary Care Center in South India.

Dharshini Sathishkumar, Parthiban Udhayakumar, Debasis Das Adhikari, Renu George,

Background:Skin problems are commonly encountered in the pediatric emergency department (PED). Although there are a few studies on the prevalence and spectrum of skin conditions in children attending the PED, only limited information is available on the outcome of the children with skin-related ailments requiring hospitalization. Aim:To study the clinical ... Read more >>

Indian Dermatol Online J (Indian Dermatology Online Journal)
[2019, 10(6):650-656]

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The Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old.

Linda E Brostowski, Erin H Graf,

J. Clin. Microbiol. (Journal of clinical microbiology)
[2019, 57(2):]

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Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) - a dramatic presentation for a benign disease.

Elena Carboni, Maria Scavone, Ettore Stefanelli, Valentina Talarico, Stefania Zampogna, Maria Concetta Galati, Giuseppe Raiola,

We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, but after some ... Read more >>

F1000Res (F1000Research)
[2019, 8:1771]

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Eculizumab Safety: Five-Year Experience From the Global Atypical Hemolytic Uremic Syndrome Registry.

Eric Rondeau, Spero R Cataland, Imad Al-Dakkak, Benjamin Miller, Nicholas J A Webb, Daniel Landau,

Introduction:Eculizumab has transformed outcomes for patients with atypical hemolytic uremic syndrome (aHUS). Its efficacy and safety profile was well characterized in the clinical trial program. The long-term safety profile was not previously assessed or compared against nontreated patients in an observational registry setting. Methods:The Global aHUS Registry recruits patients with ... Read more >>

Kidney Int Rep (Kidney international reports)
[2019, 4(11):1568-1576]

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Closing the Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old.

Linda E Brostowski, Erin H Graf,

J. Clin. Microbiol. (Journal of clinical microbiology)
[2019, 57(2):]

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Meningococcemia Masquerading as a Nonspecific Flu-Like Syndrome.

Paula J Watts, Natasha Fazel, Dmitriy Scherbak,

Neisseria meningitidis is a cause of bacterial meningitis and meningococcemia worldwide. Rarely, it causes invasive disease with significant lifelong sequela if survived. Early clinical recognition is key as meningococcemia is an easily treatable disease, yet mortality is 50% if it is left untreated. In this case review, we present a ... Read more >>

Case Rep Crit Care (Case reports in critical care)
[2018, 2018:2097824]

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Chronic meningococcemia: a report of 26 cases and literature review.

Benjamin Lefèvre, Yves Poinsignon, Caroline Piau, François-Charles Javaugue, Jean-Philippe Talarmin, Maeva Lefebvre, Nicolas Varache, Hélène Drouin, Pierre Tattevin, ,

Chronic meningococcemia is defined by blood culture(s) positive for Neisseria meningitidis, symptoms duration > 7 days, and neither meningitis nor shock on admission. This series of 26 consecutive cases illustrates that this is a rare disease (< 5% of meningococcemia, < 0.05 cases per 100,000 inhabitants per year), mostly affecting young adults, males, with ... Read more >>

Infection (Infection)
[2019, 47(2):285-288]

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Images of the month 2: Disseminated gonococcal infection presenting as the arthritis-dermatitis syndrome.

Chi-Hui Wang, Chun-Wei Lu,

Clin Med (Lond) (Clinical medicine (London, England))
[2019, 19(4):340-341]

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First Report of a Disease by Rhazes 10 Centuries Ago.

Rouzbeh R Ghafouri, Mostafa Araj-Khodaei, Somaiyeh T Targhi, Mojtaba Varshochi, Zahra Parsian, Reza Yarani, Samad E J Golzari,

Introduction:Abu Bakr Mohammad Ibn Zakariya Al-Razi (865-925 CE), who was known as "Rhazes" in the west, was a famous scientist of medieval ages. He has more than 200 books and treatises. His masterpiece on medicine "Kitab Al-Hawi Fi Al-Tibb" contains around 900 case reports. Some of the diseases which seem ... Read more >>

Int J Prev Med (International journal of preventive medicine)
[2019, 10:6]

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1985. Atypical Symptoms and High Mortality Associated With Serogroup B Meningococcal Disease in Cartagena Colombia 2012–2016.

Wilfrido Coronell-Rodríguez, Cindy Arteta-Acosta,

AbstractBackgroundMeningococcal disease occurs in an endemic or epidemic form, such as meningitis or meningococcemia, the latter being a fast and high disease, mainly in children. Atypical symptoms have been described by the serogroup W. The aim of this study was to determine the clinical and epidemiological characteristics of invasive meningococcal ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S577-S577]

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Symptomatic Vaginal Infection by Neisseria meningitidis Resulting in Meningitis with Septic Shock.

Ryan Offman, Elissa Boggs, Adam Gwizdala,

The most common infectious etiologies of vaginitis include Gardnerella bacterial vaginosis, candidiasis, and trichomoniasis. A few case reports describe symptomatic infection with Neisseria (N) meningitidis, an organism with potential for causing systemic disease with a high rate of morbidity and mortality. We describe a patient who presented with fulminant meningitis ... Read more >>

Clin Pract Cases Emerg Med (Clinical practice and cases in emergency medicine)
[2019, 3(2):153-155]

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A Case of Pulmonary Syphilis Resulting in Multi-organ Dysfunction and Consequential Demise of a 19-Year-old Male.

Sonam Sharma, Aditya Mehta,

This case presents a young male, with a history of high-risk sexual behavior and immunosuppression, admitted with multi-organ dysfunction and pronounced dead within 24 hours of admission. After an extensive investigation, to include post-mortem studies, his symptoms were attributed to secondary syphilis, which was confirmed with high rapid plasma reagin (RPR) ... Read more >>

Cureus (Cureus)
[2019, 11(9):e5560]

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