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Balancing in a black box: Potential immunomodulatory roles for TGF-β signaling during blood-stage malaria.

Lisa L Drewry, John T Harty,

Malarial disease caused by Plasmodium parasites challenges the mammalian immune system with a delicate balancing act. Robust inflammatory responses are required to control parasite replication within red blood cells, which if unchecked, can lead to severe anemia and fatality. However, the same inflammatory response that controls parasite replication is also ... Read more >>

Virulence (Virulence)
[2020, 11(1):159-169]

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Coverage rates of the children vaccination programme in Greenland.

Nadja Albertsen, Anna Rask Lynge, Nils Skovgaard, Jesper Søndergaard Olesen, Michael Lynge Pedersen,

In order to estimate the current coverage rate among all children in Greenland, we conducted an observational cross-sectional study identifying all children in Greenland eligible for a vaccination between 1 March 2018 and 16 June 2019. we found an overall national coverage of 85.4%. The national coverage for the vaccinations ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1721983]

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Recurrent Herpes Simplex Virus 2 Lymphocytic Meningitis in Patient with IgG Subclass 2 Deficiency.

Tanvi Goyal, Imran Ali,

We report a case of a patient with a lifetime history of 8 episodes of recurrent lymphocytic meningitis. Our findings suggest that susceptibility to recurrent lymphocytic meningitis might be caused by low serum IgG subclass 2 immunodeficiency. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(4):748-750]

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The Origin of the Idea That Herpes Labialis Is of Prognostic Importance in Bacterial Meningitis.

Peter J Koehler,

OBJECTIVE:The aim of the work was to study the origin of the idea that herpes labialis (HL) in patients with pneumonia and meningitis was believed to be of prognostic importance. BACKGROUND:HL is caused by a primary infection or reactivation of herpes simplex type I. In the past, it has been ... Read more >>

Eur. Neurol. (European neurology)
[2020, :1-6]

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New Strategy Is Needed to Prevent Pneumococcal Meningitis.

Reshmi Mukerji, David E Briles,

BACKGROUND:Polysaccharide conjugate vaccines (PCVs) target the pneumococcal capsular types that most commonly cause fatal pneumonia and sepsis. Because these types were eliminated by the vaccines, it became apparent that in immunized populations, most invasive pneumococcal diseases, including bacteremia, sepsis and complicated pneumonia, were greatly reduced. However, the protective effects of ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, 39(4):298-304]

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Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management.

Katelyn A Pastick, Elizabeth Nalintya, Lillian Tugume, Kenneth Ssebambulidde, Nicole Stephens, Emily E Evans, Jane Frances Ndyetukira, Edwin Nuwagira, Caleb Skipper, Conrad Muzoora, David B Meya, Joshua Rhein, David R Boulware, Radha Rajasingham,

Cryptococcal meningitis causes 15% of AIDS-related deaths. Optimal management and clinical outcomes of pregnant women with cryptococcosis are limited to case reports, as pregnant women are often excluded from research. Amongst pregnant women with asymptomatic cryptococcosis, no treatment guidelines exist. We prospectively identified HIV-infected women who were pregnant or recently ... Read more >>

Med. Mycol. (Medical mycology)
[2020, 58(3):282-292]

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Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of Neisseria meningitidis, Haemophilus influenzae Type b, and Streptococcus pneumoniae during 2015 to 2018 in Turkey.

Mehmet Ceyhan, Yasemin Ozsurekci, Sevgen Tanır Basaranoglu, Nezahat Gurler, Enes Sali, Melike Keser Emiroglu, Fatma Nur Oz, Nursen Belet, Murat Duman, Emel Ulusoy, Zafer Kurugol, Hasan Tezer, Aslinur Ozkaya Parlakay, Ener Cagri Dinleyici, Umit Celik, Solmaz Celebi, Ahmet Faik Oner, Mehmet Ali Solmaz, Adem Karbuz, Nevin Hatipoglu, Ilker Devrim, Ilknur Caglar, Sefika Elmas Bozdemir, Emine Kocabas, Ozlem Ozgur Gundeslioglu, Murat Sutcu, Ozge Metin Akcan, Necdet Kuyucu, Fesih Aktar, Soner Sertan Kara, Havva Ozlem Altay Akisoglu, Nilden Tuygun, Zeynep Diyar Tamburaci Uslu, Eda Karadag Oncel, Cihangul Bayhan, Ali Bulent Cengiz,

The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) in the Turkish National Immunization Program (NIP). Administration of Hib vaccine and PCV-7 (7-valent pneumococcal conjugate vaccine) was implemented in NIP in 2006 and 2009, respectively. In ... Read more >>

mSphere (mSphere)
[2020, 5(2):]

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Efficacy of Cerebrospinal Fluid Beta-d-Glucan Diagnostic Testing for Fungal Meningitis: a Systematic Review.

Christian Davis, L Joseph Wheat, Thein Myint, David R Boulware, Nathan C Bahr,

Several case reports and cohort studies have examined the use of (1,3)-beta-d-glucan measurement with cerebrospinal fluid to diagnose fungal meningitis. This systematic review aims to characterize the evidence regarding cerebrospinal fluid (1,3)-beta-d-glucan measurement to detect fungal meningitis. We searched PubMed for (1,3)-beta-d-glucan and each of several distinct fungi, cerebrospinal fluid, ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2020, 58(4):]

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Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation.

Karina Barbosa de Queiroz, Vanessa Cavalcante-Silva, Flávia Lombardi Lopes, Gifone Aguiar Rocha, Vânia D'Almeida, Roney Santos Coimbra,

BACKGROUND:Bacterial meningitis (BM) causes apoptotic damage to the hippocampus and homocysteine (Hcy) accumulation to neurotoxic levels in the cerebrospinal fluid of children. The Hcy pathway controls bioavailability of methyl, and its homeostasis can be modulated by vitamin B12, a cofactor of the methionine synthase enzyme. Herein, the neuroprotective potential and ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2020, 17(1):96]

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Extended Continuous β-Lactam Infusion with Oral Acetaminophen in Childhood Bacterial Meningitis: A Randomized, Double-Blind Clinical Trial.

Okko Savonius, Emilie Rugemalira, Irmeli Roine, Manuel Leite Cruzeiro, Heikki Peltola, Tuula Pelkonen,

BACKGROUND:In our previous study in Luanda, Angola, initial continuous β-lactam infusion for 24 hours combined with oral acetaminophen for 48 hours showed promising results as a new treatment for childhood bacterial meningitis. We investigated whether extending this treatment regimen to 4 days would improve the outcomes further. METHODS:We conducted a ... Read more >>

Clin. Infect. Dis. (Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America)
[2020, :]

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Meningitis caused by Mycobacterium fortuitum mimicking tuberculous meningitis in an immunocompetent patient: a case report and literature review.

Lingyun Shao, Siran Lin, Qingluan Yang, Ting Wang, Wen Jia, Shu Chen, Wenhong Zhang,

<title>Abstract</title> <p> Background: Nontuberculous mycobacteria (NTM) are a large group of microorganisms that mainly affect persons who have immune deficiency. Mycobacterium fortuitum is one of them, which usually cause soft tissue or pulmonary disease. Meningitis caused by M. fortuitum is extremely rare and is often confused with tuberculous ... Read more >>

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Impact of Climate Factors in Modeling and Predicting the Transmission of Meningitis in Africa: The Case of Burkina Faso

Souleymane Sakande, Haoua Tall, Issaka Yaméogo, Ryan Novak, Lionel Ouedraogo, Ousmane Ouedraogo, Alima Essoh, Jennifer Moisi, Bazongo Baguinebie,

<title>Abstract</title> <p> Background: Meningitis is a major cause of morbidity in the world. Previous studies showed that climate factors influence the occurrence of meningitis. A multiple linear regression model was developed to forecast meningitis cases in Burkina Faso using climate factors. However, the multivariate linear regression model based ... Read more >>

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Meningitis (bacterial) and meningococcal septicaemia in under 16s: recognition, diagnosis and management

This guideline covers recognising, diagnosing and managing bacterial meningitis and meningococcal septicaemia (blood poisoning) in babies, children and young people under 16. It aims to reduce deaths and disability by promoting early recognition of symptoms and timely effective management.WHO IS IT FOR? Healthcare professionals. Under 16s with bacterial meningitis or ... Read more >>

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A correlation analysis between clinical manifestations, therapeutic strategies and prognosis of children with cryptococcal meningitis in China.

Haiyan Yang, Fei Yin, Ting Xiao, Siyi Gan, Zou Pan, Jing Peng, Liwen Wu,

OBJECTIVE:This study aims to analyze correlation between the clinical manifestations, treatment strategies and prognosis of cryptococcus meningitis (CM) in China. METHODS:Retrospective analysis of clinical data of CM patients from 2002 to 2019. We summarized the clinical features and supplementary examinations, treatment strategies and prognosis and then to do a correlation ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, :]

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Dynamic curve analysis of indicators related to lumbar cistern drainage for postoperative meningitis

Weining Ma, Lin Cong, Chun Li,

<title>Abstract</title> <p> Background Lumbar cisterna drainage (LCD) is widely used in neurosurgery as an effective treatment for postoperative meningitis, vasospasm of subarachnoid hemorrhage and ventricular system hemorrhage, and for reducing intracranial pressure in patients with severe craniocerebral trauma. The purpose of this work was two-fold: to analyze ... Read more >>

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Hypertrophic pachymeningitis in a southern Chinese population: a retrospective study

Li Feng, Xuewen Xiao, Dongni Fu,

<title>Abstract</title> <p> <bold>Background </bold>Hypertrophic pachymeningitis (HP) is a fibrotic disorder featuring a thickening of the dura matter. Most HP studies were from Caucasian population and only a few studies of HP are available in China. In this study, we investigated the causes, clinical and imaging features and therapeutic ... Read more >>

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MeningiSSS: A New Predictive Score to Support Decision on Invasive Procedures to Monitor or Manage the Intracerebral Pressure in Children with Bacterial Meningitis.

Urban Johansson Kostenniemi, Linda Karlsson, Sven-Arne Silfverdal, Christer Mehle,

BACKGROUND:Knowing the individual child's risk is highly useful when deciding on treatment strategies, especially when deciding on invasive procedures. In this study, we aimed to develop a new predictive score for children with bacterial meningitis and compare this with existing predictive scores and individual risk factors. METHODS:We developed the Meningitis ... Read more >>

Neurocrit Care (Neurocritical care)
[2020, 32(2):586-595]

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TRIM32 Drives Pathogenesis in Streptococcal Toxic Shock-Like Syndrome and Streptococcus suis Meningitis by Regulating Innate Immune Responses.

Xuan OuYang, Jie Guo, Qingyu Lv, Hua Jiang, Yuling Zheng, Peng Liu, Tongyan Zhao, Decong Kong, Huaijie Hao, Yongqiang Jiang,

Streptococcus suis is an emerging zoonotic agent that causes streptococcal toxic shock-like syndrome (STSLS) and meningitis in humans, with high mortality and morbidity. The pathogenesis of both STSLS and central nervous system (CNS) infections caused by S. suis is not well understood. TRIM32, a member of the tripartite motif (TRIM) ... Read more >>

Infect. Immun. (Infection and immunity)
[2020, 88(4):]

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Molecular diagnosis of polymicrobial brain abscesses with 16S rDNA-based next generation sequencing.

Alexander Stebner, Armin Ensser, Walter Geißdörfer, Yavor Bozhkov, Roland Lang,

OBJECTIVES:Brain abscesses lead to high mortality despite antibiotic and surgical treatment. Identification of causative bacteria is important to guide antibiotic therapy, but culture-based methods and molecular diagnostics by Sanger sequencing of 16S PCR products are hampered by antibiotic treatment and the often polymicrobial nature of brain abscesses. We have applied ... Read more >>

Clin. Microbiol. Infect. (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2020, :]

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Harrington WE, Mató S, Burroughs L, Carpenter PA, Gershon A, Schmid DS, Englund JA. Vaccine Oka Varicella Meningitis in Two Adolescents. Pediatrics. 2019;144(6):e20191522.

Pediatrics (Pediatrics)
[2020, :]

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Delirium in Meningitis and Encephalitis: Emergence and Prediction in a 6-Year Cohort.

Tolga Dittrich, Stephan Marsch, Stephan Rüegg, Gian Marco De Marchis, Sarah Tschudin-Sutter, Raoul Sutter,

BACKGROUND/OBJECTIVE:Data regarding delirium in patients presenting with infections of the central nervous system, such as meningitis and/or encephalitis (ME), are scarce. We aimed to determine the frequency and early predictors of delirium in the acute phase of ME. METHODS:We assessed clinical, radiologic, and laboratory data of patients with ME at ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2020, :885066620913004]

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Adult cochlear implant recipients and meningitis in New Zealand: are patients receiving the recommended immunisations?

Scott Mitchell, Lesina Nakhid-Schuster, Michel Neeff,

AIM:To investigate if adult cochlear implant (CI) recipients have received the recommended immunisations as compared to current guidelines and to report instances of meningitis within this population. METHODS:Telephone interview of CI recipient's general practitioner (GP) surgeries for details regarding immunisations received. Subsequent reporting of immunisation rates of adult patients, under ... Read more >>

N. Z. Med. J. (The New Zealand medical journal)
[2020, 133(1511):14-20]

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Metagenomic Next-Generation Sequencing for Diagnosis of Infectious Encephalitis and Meningitis: A Large, Prospective Case Series of 213 Patients.

Xiao-Wei Xing, Jia-Tang Zhang, Yu-Bao Ma, Mian-Wang He, Guo-En Yao, Wei Wang, Xiao-Kun Qi, Xiao-Yan Chen, Lei Wu, Xiao-Lin Wang, Yong-Hua Huang, Juan Du, Hong-Fen Wang, Rong-Fei Wang, Fei Yang, Sheng-Yuan Yu,

Purpose: We assessed the performance of metagenomic next-generation sequencing (mNGS) in the diagnosis of infectious encephalitis and meningitis. Methods: This was a prospective multicenter study. Cerebrospinal fluid samples from patients with viral encephalitis and/or meningitis, tuberculous meningitis, bacterial meningitis, fungal meningitis, and non-central nervous system (CNS) infections were subjected to ... Read more >>

Front Cell Infect Microbiol (Frontiers in Cellular and Infection Microbiology)
[2020, 10:88]

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Impact of decreasing cerebrospinal fluid enterovirus PCR turnaround time on costs and management of children with suspected enterovirus meningitis.

Mohammad Alghounaim, Chelsea Caya, MinGi Cho, Marc Beltempo, Cedric P. Yansouni, Nandini Dendukuri, Jesse Papenburg,

To estimate the impact of implementing in-hospital enterovirus (EV) polymerase chain reaction (PCR) testing of cerebrospinal fluid (CSF) with same-day turn-around-time (TAT) on length-of-stay (LOS), antibiotic use and on cost per patient with suspected EV meningitis, compared with testing at an outside reference laboratory. A model-based analysis using a retrospective ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[0, :1-10]

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