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Meniere Disease Idiopathic Endolymphatic Hydrops

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Menière's Disease and Disorders of the Carbohydrate Metabolism Involving the Inner Ear.

Pedro L Mangabeira Albernaz,

Introduction  Menière's disease was described in 1861, but there are still uncertainties regarding its pathophysiology and treatment. Endolymphatic hydrops is recognized as a fundamental pathological characteristic of the disease, as a result of an inadequate absorption of the endolymph. A milder type of endolymphatic hydrops results from an altered chemical ... Read more >>

Int Arch Otorhinolaryngol (International archives of otorhinolaryngology)
[2019, 23(2):218-220]

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A Nationwide, Population-based Cohort Study on Potential Autoimmune Association of Ménière Disease to Atopy and Vitiligo.

Hyung Jin Hahn, Sang Gyu Kwak, Dong-Kyu Kim, Jong-Yeup Kim,

Ménière disease (MD), an idiopathic disorder of sensorineural hearing loss and vertigo, shares many similarities with two common skin conditions, atopic dermatitis (AD) and vitiligo. Recent studies have suggested that MD may be related to or triggered by autoimmune conditions, notably Hashimoto thyroiditis and alopecia areata. These evidences led to ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):4406]

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Gadolinium-enhanced MRI reveals dynamic development of endolymphatic hydrops in Ménière's disease.

Xuanyi Li, Qianru Wu, Yan Sha, Chunfu Dai, Ru Zhang,

INTRODUCTION:Meniere's disease is associated with impaired hearing, tinnitus, vertigo, and aural fullness. Many anatomical studies have suggested idiopathic endolymphatic hydrops as the pathological basis of Meniere's disease, which now can be visualized by using gadolinium -enhanced magnetic resonance imaging of the inner ear. OBJECTIVE:To investigate the development of endolymphatic hydrops ... Read more >>

Braz J Otorhinolaryngol (Brazilian journal of otorhinolaryngology)
[2020, 86(2):165-173]

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Subcellular Abnormalities of Vestibular Nerve Morphology in Patients With Intractable Meniere's Disease.

Pengjun Wang, Huaming Zhu, Wen Lu, Qiang Song, Zhengnong Chen, Yaqin Wu, Hui Wang, Dongzhen Yu, Haibo Ye, Haibo Shi, Haibo Shi, Shankai Yin,

Objective: Few studies so far have focused on the retrocochlear lesions in Meniere's disease (MD). This study aims to investigate pathological alterations in the central portion of the vestibular nerve (VN) in patients with intractable Meniere's disease (MD) and to explore retrocochlear lesions and their relationship with disease severity. Methods: ... Read more >>

Front Neurol (Frontiers in Neurology)
[2019, 10:948]

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Restriction of salt, caffeine and alcohol intake for the treatment of Ménière's disease or syndrome.

Kiran Hussain, Louisa Murdin, Anne Gm Schilder,

BACKGROUND:Ménière's disease or syndrome is a chronic inner ear disorder that results in sporadic attacks of vertigo, sensorineural hearing loss, aural fullness and tinnitus.There is no definitive treatment for Ménière's disease and treatment options range from dietary modification through medication to surgery.Modification of diet, including restriction of salt, caffeine and ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2018, 12:CD012173]

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Recurrence of Non-Hydropic Sudden Sensorineural Hearing Loss (SSNHL): A Literature Review.

C Cassandro, P De Luca, M Ralli, F Gioacchini, F Di Berardino, A Albera, R Albera, E Cassandro, A Scarpa,

Transl Med UniSa (Translational medicine @ UniSa)
[2019, 20:22-27]

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Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment.

Laura Girasoli, Diego Cazzador, Roberto Padoan, Ennio Nardello, Mara Felicetti, Elisabetta Zanoletti, Franco Schiavon, Roberto Bovo,

The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. The association of vertigo ... Read more >>

J Immunol Res (Journal of immunology research)
[2018, 2018:5072582]

Cited: 1 time

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Inner ear pathologies impair sodium-regulated ion transport in Meniere's disease.

Andreas H Eckhard, MengYu Zhu, Jennifer T O'Malley, Gordon H Williams, Johannes Loffing, Steven D Rauch, Joe B Nadol, M Charles Liberman, Joe C Adams,

Meniere's disease (MD), a syndromal inner ear disease, is commonly associated with a pathological accumulation of endolymphatic fluid in the inner ear, termed "idiopathic" endolymphatic hydrops (iEH). Although numerous precipitating/exacerbating factors have been proposed for MD, its etiology remains elusive. Here, using immunohistochemistry and in situ protein-protein interaction detection assays, ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2019, 137(2):343-357]

Cited: 7 times

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European Position Statement on Diagnosis, and Treatment of Meniere's Disease.

Jacques Magnan, O Nuri Özgirgin, Franco Trabalzini, Michel Lacour, Antonio Lopez Escamez, Mans Magnusson, Enis Alpin Güneri, Jean Philippe Guyot, Daniele Nuti, Marco Mandalà,

Meniere Disease keeps challenges in its diagnosis and treatment since was defined by Prosper Meniere at the beginning of 19th Century. Several classifications and definition were made until now and speculations still exist on its etiology. As the etiology remains speculative the treatment models remain in discussion also. The European ... Read more >>

J Int Adv Otol (The journal of international advanced otology)
[2018, 14(2):317-321]

Cited: 1 time

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[Recurrent low frequency sensorineural deafness].

Ying Lin, Jin Ling Wang, Fei Sun, Jin Jin Shen, Zhao Xia Wang, Jian Hua Qiu, Ding Jun Zha,

Low frequency sensorineural deafness is a common subtype of idiopathic sudden deafness. Certain patients suffered recurrent attacks without vertigo, much alike Meniere's disease. Few of them developed into definite Meniere's disease during long-term follow-up in many clinical studies. Although the pathophysiology of recurrent low frequency deafness is yet unknown, the ... Read more >>

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery)
[2018, 32(6):474-476]

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Towards personalized medicine in Ménière's disease.

Jose Antonio Lopez-Escamez, Angel Batuecas-Caletrio, Alexandre Bisdorff,

Ménière's disease (MD) represents a heterogeneous group of relatively rare disorders with three core symptoms: episodic vertigo, tinnitus, and sensorineural hearing loss involving 125 to 2,000 Hz frequencies. The majority of cases are considered sporadic, although familial aggregation has been recognized in European and Korean populations, and the search for ... Read more >>

F1000Res (F1000Research)
[2018, 7:]

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Assessment Tools for Use in Patients with Ménière Disease: An Update.

Andrea Ciorba, Piotr Henryk Skarżyński, Virginia Corazzi, Chiara Bianchini, Claudia Aimoni, Stavros Hatzopoulos,

A number of electrophysiological tests have been proposed for the initial diagnostic assessment or for the follow-up phase of patients affected by Ménière disease. The most common are: (i) vestibular evoked myogenic potentials (VEMPs); (ii) electrocochleography (ECochG); and (iii) otoacoustic emissions (OAEs). This paper presents the latest clinical developments with ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2017, 23:6144-6149]

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Report from a Consensus Conference on the treatment of Ménière's disease with betahistine: rationale, methodology and results.

A P Casani, G Guidetti, R Schoenhuber, ,

Ménière's disease is a disorder of the inner ear that causes vertigo, tinnitus, fullness and hearing loss. Although several treatments are available, the success rate is reported to be around 70%, similar to placebo. Betahistine, a weak H1 receptor agonist and an effective H3 receptor antagonist, is frequently prescribed for ... Read more >>

Acta Otorhinolaryngol Ital (Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale)
[2018, 38(5):460-467]

Cited: 1 time

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Good Clinical Approach: Delphi Consensus for the Use of Betahistine in Menière's Disease.

Augusto Pietro Casani, Elena Navari, Giorgio Guidetti, Michel Lacour,

Menière's disease is a disorder of the inner ear that causes vertigo, tinnitus, fullness, and hearing loss. Several pharmacological treatments are available, but none of them has shown significant results. Betahistine has been largely used but its effect on the main symptoms of Menière's disease remains unclear. In order to ... Read more >>

Int J Otolaryngol (International journal of otolaryngology)
[2018, 2018:5359208]

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Association of Meniere's disease and retinal vascular calibre: a prospective observational study in China.

Yixu Wang, Tongxiang Diao, Lin Han, Ye Tao, Lisheng Yu,

OBJECTIVE:It is believed that Meniere's disease (MD) is associated with vascular disorders, but few studies have reported the relationship between retinal vascular disorders and MD. We evaluated and compared the retinal vascular calibres in patients with MD with healthy subjects matched for age, sex and vascular risk factors using retinal ... Read more >>

BMJ Open (BMJ open)
[2018, 8(10):e022069]

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Significance of Endolymphatic Hydrops in Ears With Unilateral Sensorineural Hearing Loss.

Yuriko Okazaki, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Ken Kato, Shinji Naganawa, Michihiko Sone,

The purpose of this study was to investigate the existence of endolymphatic hydrops (EH) in affected and unaffected ears in patients with unilateral sensorineural hearing loss (SNHL) using contrast-enhanced magnetic resonance imaging (MRI), and to evaluate the significance of EH in various otological diseases.Retrospective study.University hospital.One hundred eighty-two ears from ... Read more >>

Otol. Neurotol. (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2017, 38(8):1076-1080]

Cited: 3 times

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Betahistine for Ménière's disease or syndrome.

Babette van Esch, Hester J van der Zaag‐Loonen, Tjasse Bruintjes, Louisa Murdin, Adrian James, Peter Paul van Benthem,

AbstractThis is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To assess the effects of betahistine in patients with either Ménière's disease or Ménière's syndrome. ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2018, 2018(1):]

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Endolymphatic hydrops in idiopathic intracranial hypertension: prevalence and clinical outcome after lumbar puncture. Preliminary data.

Angelo Ranieri, Michele Cavaliere, Stefania Sicignano, Pietro Falco, Federico Cautiero, Roberto De Simone,

Idiopathic intracranial hypertension is characterized by raised intracranial pressure (ICP) without any underlying pathology, presenting with (IIH) or without papilledema (IIHWOP). Headache, often on daily basis, is the most frequent symptom. Among audiovestibular symptoms, tinnitus and dizziness are commonly reported, while vertigo and hearing impairment are infrequent reports. Endolymphatic hydrops ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2017, 38(Suppl 1):193-196]

Cited: 1 time

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Morphological correlation between caloric tests and vestibular hydrops in Ménière's disease using intravenous Gd enhanced inner ear MRI.

Ji Eun Choi, Yi-Kyung Kim, Young Sang Cho, Kieun Lee, Hyun Woo Park, Sung Hoon Yoon, Hyung-Jin Kim, Won-Ho Chung,

The purpose of this study was to prove the hypothesis that caloric response in Ménière's disease (MD) is reduced by hydropic expansion of the vestibular labyrinth, not by vestibular hypofunction, by evaluating the correlation morphologically using an intravenous Gadolinium (IV-Gd) inner ear MRI. In study I, the prevalence of abnormal ... Read more >>

PLoS ONE (PloS one)
[2017, 12(11):e0188301]

Cited: 2 times

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The Reliability and Validity of "Dokuz Eylül University Meniere's Disease Disability Scale".

Başak Mutlu, Günay Kırkım, Serpil Mungan Durankaya, Selhan Gürkan, Tahsin Oğuz Başokçu, Enis Alpin Güneri,

OBJECTIVE:Ménière's Disease (MD) is a chronic, non-life threatening inner ear disease, with attacks of disabling vertigo, progressive hearing loss, and tinnitus as the major symptoms. All three symptoms, separately or in combination, cause great distress and have a considerable impact on the quality of life of the patients. The aims ... Read more >>

J Int Adv Otol (The journal of international advanced otology)
[2018, 14(2):304-311]

Cited: 0 times

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Recent surgical options for vestibular vertigo.

Stefan Volkenstein, Stefan Dazert,

Vertigo is not a well-defined disease but a symptom that can occur in heterogeneous entities diagnosed and treated mainly by otolaryngologists, neurologists, internal medicine, and primary care physicians. Most vertigo syndromes have a good prognosis and management is predominantly conservative, whereas the need for surgical therapy is rare, but for ... Read more >>

GMS Curr Top Otorhinolaryngol Head Neck Surg (GMS current topics in otorhinolaryngology, head and neck surgery)
[2017, 16:Doc01]

Cited: 0 times

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Vertigo Induced During Coitus.

Sun-Uk Lee, Hyo-Jung Kim, Ja-Won Koo, Jeong-Yoon Choi, Ji-Soo Kim,

Objectives: The aim of this study was to describe the clinical features of vertigo developed during sexual intercourse. Methods: We retrospectively reviewed the clinical and laboratory findings of seven patients who reported recurrent vertigo during sexual intercourse. Results: All the patients reported spinning sensation for a few minutes to 1 ... Read more >>

Front Neurol (Frontiers in Neurology)
[2018, 9:1187]

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Clinical application of vestibular evoked myogenic potential (VEMP).

Toshihisa Murofushi,

The author reviewed clinical aspects of vestibular evoked myogenic potentials (VEMPs). Now two types of VEMPs are available. The first one is cervical VEMP, which is recorded in the sternocleidomastoid muscle and predominantly reflects sacculo-collic reflex. The other is ocular VEMP, which is usually recorded below the lower eye lid ... Read more >>

Auris Nasus Larynx (Auris, nasus, larynx)
[2016, 43(4):367-376]

Cited: 21 times

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Validity and Reliability of the Diagnostic Tests for Ménière's Disease.

Enis Alpin Güneri, Aslı Çakır, Başak Mutlu,

Ménière's disease is defined as an idiopathic syndrome characterized by endolymphatic hydrops. Various tests and measurement methods have been employed for the diagnosis of Ménière's disease. These include audiological, vestibular, radiological, clinical, and biochemical tests. However, the lack of a definitive or gold standard diagnostic test sometimes complicates the process ... Read more >>

Turk Arch Otorhinolaryngol (Turkish archives of otorhinolaryngology)
[2016, 54(3):124-130]

Cited: 3 times

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Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Ménière's Disease: Randomized Phase 2b Safety and Efficacy Trial.

Paul R Lambert, John Carey, Anthony A Mikulec, Carl LeBel, ,

To evaluate safety and efficacy of a single intratympanic injection of OTO-104, sustained-exposure dexamethasone, in patients with unilateral Ménière's disease.Randomized, double-blind, placebo-controlled, Phase 2b study over 5 months.Fifty-two academic and community otolaryngology centers.One hundred fifty four patients (77 per group) aged 18 to 85 years inclusive.Single intratympanic injection of OTO-104 ... Read more >>

Otol. Neurotol. (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2016, 37(10):1669-1676]

Cited: 9 times

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