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Medical Informatics in Neurology

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Clinical risk factors and outcomes of massive ascites accumulation after discontinuation of peritoneal dialysis.

Ming-Shan Chang, Nai-Ching Chen, Chih-Yang Hsu, Chien-Wei Huang, Po-Tsang Lee, Kang-Ju Chou, Hua-Chang Fang, Chien-Liang Chen,

Background: Encapsulating peritoneal sclerosis (EPS) is a serious complication of peritoneal dialysis (PD), with high morbidity and mortality that requires an early diagnosis for effective treatment. PD withdrawal and bacterial peritonitis are important triggers for the onset of EPS. However, few studies have focused on cases of PD withdrawal without ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):1-9]

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Evolving roles of clerkship directors: have expectations changed?

Gary L Beck Dallaghan, Cynthia H Ledford, Douglas Ander, John Spollen, Sherilyn Smith, Scott Graziano, Susan M Cox,

BACKGROUND:Physician educators directing medical student programs face increasingly more complex challenges to ensure students receive appropriate preparation to care for patients. The Alliance for Clinical Education (ACE) defined expectations of and for clerkship directors in 2003. Since then, much has changed in medical education and health care. METHODS:ACE conducted a ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1714201]

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Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study.

Henrik Heitmann, Bernhard Haller, Laura Tiemann, Mark Mühlau, Achim Berthele, Thomas R Tölle, Anke Salmen, Björn Ambrosius, Antonios Bayas, Susanna Asseyer, Hans-Peter Hartung, Christoph Heesen, Martin Stangel, Brigitte Wildemann, Sarah Haars, Sergiu Groppa, Felix Luessi, Tania Kümpfel, Sandra Nischwitz, Sven G Meuth, Luisa Klotz, Ralf A Linker, Uwe K Zettl, Ulf Ziemann, Hayrettin Tumani, Björn Tackenberg, Frauke Zipp, Heinz Wiendl, Ralf Gold, Bernhard Hemmer, Markus Ploner,

Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal relationships between pain and biopsychosocial factors in MS are largely unknown. Longitudinal studies might help to clarify the prevalence and determinants ... Read more >>

Pain (Pain)
[2020, 161(4):787-796]

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Second-line treatments in benzodiazepine-resistant convulsive status epilepticus: An updated network meta-analysis including the ESET Trial - What did change?

Francesco Brigo, Cinzia Del Giovane, Raffaele Nardone, Eugen Trinka, Simona Lattanzi,

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:107035]

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Simple MRI score aids prediction of dementia in cerebral small vessel disease.

Ali Amin Al Olama, James M S Wason, Anil M Tuladhar, Esther M C van Leijsen, Marisa Koini, Edith Hofer, Robin G Morris, Reinhold Schmidt, Frank-Erik de Leeuw, Hugh S Markus,

OBJECTIVE:To determine whether a simple small vessel disease (SVD) score, which uses information available on rapid visual assessment of clinical MRI scans, predicts risk of cognitive decline and dementia, above that provided by simple clinical measures. METHODS:Three prospective longitudinal cohort studies (SCANS [St George's Cognition and Neuroimaging in Stroke], RUN ... Read more >>

Neurology (Neurology)
[2020, 94(12):e1294-e1302]

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Nusinersen in adults with 5q spinal muscular atrophy: a non-interventional, multicentre, observational cohort study.

Tim Hagenacker, Claudia D Wurster, René Günther, Olivia Schreiber-Katz, Alma Osmanovic, Susanne Petri, Markus Weiler, Andreas Ziegler, Josua Kuttler, Jan C Koch, Ilka Schneider, Gilbert Wunderlich, Natalie Schloss, Helmar C Lehmann, Isabell Cordts, Marcus Deschauer, Paul Lingor, Christoph Kamm, Benjamin Stolte, Lena Pietruck, Andreas Totzeck, Kathrin Kizina, Christoph Mönninghoff, Otgonzul von Velsen, Claudia Ose, Heinz Reichmann, Michael Forsting, Astrid Pechmann, Janbernd Kirschner, Albert C Ludolph, Andreas Hermann, Christoph Kleinschnitz,

BACKGROUND:Nusinersen is approved for the treatment of 5q spinal muscular atrophy of all types and stages in patients of all ages. Although clinical trials have shown improvements in motor function in infants and children treated with the drug, data for adults are scarce. We aimed to assess the safety and ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(4):317-325]

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Comparing Different Methods for Named Entity Recognition in Portuguese Neurology Text.

Fábio Lopes, César Teixeira, Hugo Gonçalo Oliveira,

Electronic Medical Records (EMRs) are written in an unstructured way, often using natural language. Information Extraction (IE) may be used for acquiring knowledge from such texts, including the automatic recognition of meaningful entities, through models for Named Entity Recognition (NER). However, while most work on the previous was made for English, ... Read more >>

J Med Syst (Journal of medical systems)
[2020, 44(4):77]

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Incidence and prevalence of amyotrophic lateral sclerosis in urban China: a national population-based study.

Lu Xu, Lu Chen, Shengfeng Wang, Jingnan Feng, Lili Liu, Guozhen Liu, Jinxi Wang, Siyan Zhan, Pei Gao, Dongsheng Fan,

OBJECTIVE:Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease and information on disease burden of ALS in mainland China was limited. We aimed to estimate the prevalence and incidence of ALS in China. METHODS:We used 2012-2016 data from China's Urban Employee Basic Medical Insurance and Urban Residence Basic Medical Insurance, ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, :]

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Multiple Vowels Repair Based on Pitch Extraction and Line Spectrum Pair Feature for Voice Disorder.

Tao Zhang, Yangyang Shao, Yaqin Wu, Zhibo Pang, Ganjun Liu,

Individuals, such as voice-related professionals, elderly people and smokers, are increasingly suffering from voice disorder, which implies the importance of pathological voice repair. Previous work on pathological voice repair only concerned about sustained vowel /a/, but multiple vowels repair is still challenging due to the unstable extraction of pitch and ... Read more >>

IEEE J Biomed Health Inform (IEEE journal of biomedical and health informatics)
[2020, :]

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Prevalence of acute neurology: a 2-week snapshot in a district general hospital.

Meneka Kanagaratnam, Ajay Boodhoo, Bridget K MacDonald, Arani Nitkunan,

Neurological illnesses are a common cause of hospital admissions, yet most patients are not primarily managed by neurologists. Acute neurology service provision varies across the UK. This study aimed to establish the number of neurological admissions during a 2-week period in a district general hospital, as well as the proportion ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2020, 20(2):169-173]

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A Retrospective Study of Neurological Complications in Pediatric Patients With Moyamoya Disease Undergoing General Anesthesia.

Shih-Shan Lang, Emma Vollmer, Lezhou Wu, Abhijith Bathini, Bhavya Kanuga, Annie Ma, Karyn Barrett, Jorge A Galvez, Phillip B Storm, Jimmy Huh, Allan F Simpao,

BACKGROUND:Moyamoya disease is a condition with potentially devastating and permanent neurological sequelae. Adequate volume status and blood pressure, tight control of carbon dioxide to achieve normocarbia, and providing postoperative analgesia to prevent hyperventilation are typical goals that are used during anesthetic care in these patients. The purpose of this study ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2020, :]

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A longitudinal study of CMT1A using Rasch analysis based CMT neuropathy and examination scores.

Vera Fridman, Stefan Sillau, Gyula Acsadi, Chelsea Bacon, Kimberly Dooley, Joshua Burns, John Day, Shawna Feely, Richard S Finkel, Tiffany Grider, Laurie Gutmann, David N Herrmann, Callyn A Kirk, Sarrah A Knause, Matilde Laurá, Richard A Lewis, Jun Li, Thomas E Lloyd, Isabella Moroni, Francesco Muntoni, Emanuela Pagliano, Chiara Pisciotta, Giuseppe Piscosquito, Sindhu Ramchandren, Mario Saporta, Reza Sadjadi, Rosemary R Shy, Carly E Siskind, Charlotte J Sumner, David Walk, Janel Wilcox, Sabrina W Yum, Stephan Züchner, Steven S Scherer, Davide Pareyson, Mary M Reilly, Michael E Shy, ,

OBJECTIVE:To evaluate the sensitivity of Rasch analysis-based, weighted Charcot-Marie-Tooth Neuropathy and Examination Scores (CMTNS-R and CMTES-R) to clinical progression in patients with Charcot-Marie-Tooth disease type 1A (CMT1A). METHODS:Patients with CMT1A from 18 sites of the Inherited Neuropathies Consortium were evaluated between 2009 and 2018. Weighted CMTNS and CMTES modified category ... Read more >>

Neurology (Neurology)
[2020, 94(9):e884-e896]

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Disinhibition of sensory cortex in patients with amyotrophic lateral sclerosis.

Raffaele Nardone, Stefan Golaszewski, Aljoscha Thomschewski, Luca Sebastianelli, Viviana Versace, Francesco Brigo, Andrea Orioli, Leopold Saltuari, Yvonne Höller, Eugen Trinka,

In patients with amyotrophic lateral sclerosis (ALS) a motor cortical hyperexcitability has been reported in transcranial magnetic stimulation studies, but little is known about the neuronal excitability in other cortical areas. The aim of the present study was the functional evaluation of the sensory cortex in subjects with ALS by ... Read more >>

Neurosci. Lett. (Neuroscience letters)
[2020, 722:134860]

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A Neuro-ontology for the neurological examination.

Daniel B Hier, Steven U Brint,

BACKGROUND:The use of clinical data in electronic health records for machine-learning or data analytics depends on the conversion of free text into machine-readable codes. We have examined the feasibility of capturing the neurological examination as machine-readable codes based on UMLS Metathesaurus concepts. METHODS:We created a target ontology for capturing the ... Read more >>

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2020, 20(1):47]

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Neuro R2 score: Predicting high-risk neurologic readmissions within 30 days.

Sarah H Peacock, Ami A Grek, Emily R Rogers, William D Freeman, Launia J White, Zhuo Li, Tonja Hartjes, James M Naessens,

OBJECTIVE:To evaluate clinical and demographic factors of patients with neurologic disorders to determine which patient characteristics are significant for predicting 30-day hospital readmissions to develop a readmission risk predictor specific to patients with neurologic disorders. METHODS:We performed a retrospective single-center chart review for all patients admitted to the Department of ... Read more >>

Neurology (Neurology)
[2020, :]

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Biological characteristics of dynamic expression of nerve regeneration related growth factors in dorsal root ganglia after peripheral nerve injury.

Yin-Ying Shen, Xiao-Kun Gu, Rui-Rui Zhang, Tian-Mei Qian, Shi-Ying Li, Sheng Yi,

The regenerative capacity of peripheral nerves is limited after nerve injury. A number of growth factors modulate many cellular behaviors, such as proliferation and migration, and may contribute to nerve repair and regeneration. Our previous study observed the dynamic changes of genes in L4-6 dorsal root ganglion after rat sciatic ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1502-1509]

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Effects of repetitive transcranial magnetic stimulation in subjects with sleep disorders.

Raffaele Nardone, Luca Sebastianelli, Viviana Versace, Francesco Brigo, Stefan Golaszewski, Elke Pucks-Faes, Leopold Saltuari, Eugen Trinka,

In this review, we aimed at identifying the studies that have employed repetitive transcranial magnetic stimulation (rTMS) in patients with sleep disorders. Low-frequency (LF) rTMS stimulating the right dorsolateral prefrontal cortex (DLPFC) or the posterior parietal cortex (PPC) was found to be effective to reduce cortical hyperexcitability and improve the ... Read more >>

Sleep Med. (Sleep medicine)
[2020, :]

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Association of social relationships with incident cardiovascular events and all-cause mortality.

Janine Gronewold, Rene Kropp, Nils Lehmann, Börge Schmidt, Simone Weyers, Johanne Siegrist, Nico Dragano, Karl-Heinz Jöckel, Raimund Erbel, Dirk M Hermann, ,

OBJECTIVE:To examine how different aspects of social relationships are associated with incident cardiovascular events and all-cause mortality. METHODS:In 4139 participants from the population-based Heinz Nixdorf Recall study without previous cardiovascular disease (mean (SD) age 59.1 (7.7) years, 46.7% men), the association of self-reported instrumental, emotional and financial support and social ... Read more >>

Heart (Heart (British Cardiac Society))
[2020, :]

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Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.

Alexander Duscha, Barbara Gisevius, Sarah Hirschberg, Nissan Yissachar, Gabriele I Stangl, Eva Eilers, Verian Bader, Stefanie Haase, Johannes Kaisler, Christina David, Ruth Schneider, Riccardo Troisi, Daniel Zent, Tobias Hegelmaier, Nikolaos Dokalis, Sara Gerstein, Sara Del Mare-Roumani, Sivan Amidror, Ori Staszewski, Gereon Poschmann, Kai Stühler, Frank Hirche, Andras Balogh, Stefan Kempa, Pascal Träger, Mario M Zaiss, Jacob Bak Holm, Megan G Massa, Henrik Bjørn Nielsen, Andreas Faissner, Carsten Lukas, Sören G Gatermann, Markus Scholz, Horst Przuntek, Marco Prinz, Sofia K Forslund, Konstanze F Winklhofer, Dominik N Müller, Ralf A Linker, Ralf Gold, Aiden Haghikia,

Short-chain fatty acids are processed from indigestible dietary fibers by gut bacteria and have immunomodulatory properties. Here, we investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease. Serum and feces of subjects with MS exhibited significantly reduced PA amounts compared with controls, particularly after the first ... Read more >>

Cell (Cell)
[2020, 180(6):1067-1080.e16]

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Reply to: MIDN locus structural variants and Parkinson's disease risk.

Yutaro Obara, Hidenori Sato, Takahiro Nakayama, Takeo Kato, Kuniaki Ishii,

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, :]

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Chronic demyelination exacerbates neuroaxonal loss in patients with MS with unilateral optic neuritis.

Yuyi You, Michael H Barnett, Con Yiannikas, John Parratt, Jim Matthews, Stuart L Graham, Alexander Klistorner,

OBJECTIVE:To examine the effect of chronic demyelination in the optic nerve of patients with MS on progressive loss of retinal ganglion cell (RGC) axons. METHODS:Progressive retinal nerve fiber layer (RNFL) loss, as measured by optical coherence tomography, was longitudinally examined in 51 patients with MS with a history of unilateral ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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Effect of Age on Longitudinal Changes in Symptoms, Function, and Outcome in the First Year After Mild-Moderate Traumatic Brain Injury.

Hilaire J Thompson, Frederick P Rivara, Jin Wang,

OBJECTIVE:The aim of this study was to describe and compare the recovery and disability trajectory at 1 year post injury for younger and older adults with traumatic brain injury (TBI). METHODS:This was a prospective longitudinal cohort study. Individuals 21 years and older with mild to moderate TBI were recruited from ... Read more >>

J Neurosci Nurs (The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses)
[2020, 52(2):46-52]

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Neural circuits of idiopathic Normal Pressure Hydrocephalus: A perspective review of brain connectivity and symptoms meta-analysis.

Alessandra Griffa, Dimitri Van De Ville, François R Herrmann, Gilles Allali,

Idiopathic normal pressure hydrocephalus (iNPH) is a prevalent reversible neurological disorder characterized by impaired locomotion, cognition and urinary control with ventriculomegaly. Symptoms can be relieved with cerebrospinal fluid drainage, which makes iNPH the leading cause of reversible dementia. Because of a limited understanding of pathophysiological mechanisms, unspecific symptoms and the ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2020, 112:452-471]

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Impact of a Structured Response and Evidence-Based Checklist on In-hospital Stroke Outcomes.

Joshua Snavely, Hilaire Thompson, Elizabeth Bridges, Joelle Fathi,

BACKGROUND:In-hospital stroke events account for 2% to 17% of all ischemic strokes in the United States. Current stroke guidelines do not provide guidance on how to care for in-hospital stroke. Use of checklists during high-acuity events reduces error and provides clarity for responding staff. We sought to determine whether the ... Read more >>

J Neurosci Nurs (The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses)
[2020, :]

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Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.

Jean Shin, Shaojie Ma, Edith Hofer, Yash Patel, Daniel E Vosberg, Steven Tilley, Gennady V Roshchupkin, André M M Sousa, Xueqiu Jian, Rebecca Gottesman, Thomas H Mosley, Myriam Fornage, Yasaman Saba, Lukas Pirpamer, Reinhold Schmidt, Helena Schmidt, Amaia Carrion-Castillo, Fabrice Crivello, Bernard Mazoyer, Joshua C Bis, Shuo Li, Qiong Yang, Michelle Luciano, Sherif Karama, Lindsay Lewis, Mark E Bastin, Mathew A Harris, Joanna M Wardlaw, Ian E Deary, Markus Scholz, Markus Loeffler, A Veronica Witte, Frauke Beyer, Arno Villringer, Nicola J Armstrong, Karen A Mather, David Ames, Jiyang Jiang, John B Kwok, Peter R Schofield, Anbupalam Thalamuthu, Julian N Trollor, Margaret J Wright, Henry Brodaty, Wei Wen, Perminder S Sachdev, Natalie Terzikhan, Tavia E Evans, Hieab H H H Adams, M Arfan Ikram, Stefan Frenzel, Sandra van der Auwera-Palitschka, Katharina Wittfeld, Robin Bülow, Hans Jörgen Grabe, Christophe Tzourio, Aniket Mishra, Sophie Maingault, Stephanie Debette, Nathan A Gillespie, Carol E Franz, William S Kremen, Linda Ding, Neda Jahanshad, , Nenad Sestan, Zdenka Pausova, Sudha Seshadri, Tomas Paus, ,

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We ... Read more >>

Cereb. Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, :]

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