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Macular Corneal Dystrophy

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Long-Term Outcomes of Descemet Membrane Endothelial Keratoplasty in Postvitrectomized Eyes With the Use of Pars Plana Infusion.

Zale Mednick, Nir Sorkin, Adi Einan-Lifshitz, Gisella Santaella, Tanya Trinh, Clara C Chan, David S Rootman,

PURPOSE:To evaluate the use of pars plana infusion as part of Descemet membrane endothelial keratoplasty (DMEK) in eyes of patients who underwent vitrectomy. METHODS:A retrospective chart review was conducted of patients at Toronto Western Hospital (Toronto, Canada) who had undergone DMEK with pars plana infusion, with a minimum follow-up of ... Read more >>

Cornea (Cornea)
[2020, 39(4):457-460]

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Effect of Iris Color on the Outcome of Descemet Membrane Endothelial Keratoplasty.

Takahiko Hayashi, Deniz Hos, Silvia Schrittenlocher, Sebastian Siebelmann, Mario Matthaei, Jeremy Franklin, Thomas Clahsen, Felix Bock, Björn Bachmann, Claus Cursiefen,

PURPOSE:To explore the impact of iris color on the outcome of Descemet membrane endothelial keratoplasty (DMEK). METHODS:Consecutive cases of Fuchs endothelial dystrophy after DMEK were retrospectively analyzed from the prospective Cologne DMEK database between 2011 and 2017 at the University of Cologne, Germany. Iris pictures were graded by color into ... Read more >>

Cornea (Cornea)
[2020, :]

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Fingolimod-associated macular edema controlled with nepafenac non-steroidal anti-inflammatory opthalmologic applications.

Rachel Husmann, John B Davies, Malik Ghannam, Brent Berry, Praful Kelkar,

Background:Fingolimod, an immunomodulatory agent, is used for the treatment of relapsing-remitting multiple sclerosis (RRMS). Fingolimod-associated macular edema (FAME) is a known complication with an incidence of 0.4%. The current recommendation for treatment of FAME is cessation of fingolimod. There are few case reports with management of FAME with steroid eye ... Read more >>

Clin Mol Allergy (Clinical and Molecular Allergy : CMA)
[2020, 18:3]

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Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren's ulcer.

Marta Jerez-Peña, Borja Salvador-Culla, María F de la Paz, Rafael I Barraquer,

INTRODUCTION:Mooren's ulcer is a painful, inflammatory chronic keratitis that affects corneal periphery, progressing centripetally, ultimately ending in perforation. The first line of treatment includes systemic immunomodulators, with surgery being the last option. We present a case of bilateral Boston keratoprosthesis implantation for severe Mooren's ulcer that responded differently in each ... Read more >>

Eur J Ophthalmol (European journal of ophthalmology)
[2020, :1120672120909768]

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Characterization of in vivo biomechanical properties in macular corneal dystrophy.

Sepehr Feizi, Zahra Karjou, Hamed Abbasi, Mohammad Ali Javadi, Amir A Azari,

PURPOSE:To measure and compare corneal biomechanics in patients with macular corneal dystrophy (MCD), those who underwent penetrating keratoplasty (PK) for MCD, and normal subjects. DESIGN:Cross-sectional study. METHODS:This study enrolled 24 eyes with MCD, 25 PK eyes with preoperative diagnosis of MCD, and 28 normal eyes. The ocular response analyzer was ... Read more >>

Am. J. Ophthalmol. (American journal of ophthalmology)
[2020, :]

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Effect of 0.1% Bromfenac for Preventing Macular Edema after Cataract Surgery in Patients with Diabetes.

Seok Hyeon Song, Seung Kook Baek, Min Woo Lee, Young Hoon Lee,

PURPOSE:To investigate the effect of 0.1% bromfenac sodium hydrate ophthalmic solution for prevention of macular edema after cataract surgery in patients with diabetes. METHODS:A retrospective analysis of 75 patients with diabetes who underwent cataract surgery was performed. Thirty-eight patients (52 eyes) were instilled with 0.1% bromfenac solution (bromfenac group) and ... Read more >>

Korean J Ophthalmol (Korean journal of ophthalmology : KJO)
[2020, 34(1):46-55]

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A very short version of the Visual Function Questionnaire (VFQ-3oo7) for use as a routinely applied Patient-Reported Outcome Measure.

Martijn S Visser, Reinier Timman, Karlijn J Nijmeijer, Hans G Lemij, Emine Kilic, Jan J V Busschbach,

BACKGROUND:Patient-reported outcome measures (PROMs) are valuable supplements in regular care to facilitate routine monitoring of quality of life from the patient's perspective. The 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) is a widely used PROM in ophthalmology. However, the NEI-VFQ-25 is too time-consuming and cumbersome for routine evaluations in ... Read more >>

Acta Ophthalmol (Acta ophthalmologica)
[2020, :]

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Ab interno implantation of glaucoma drainage devices tubes in the posterior chamber.

Javier Moreno-Montañés, Concepción Guirao-Navarro, Francisco Argüeso,

BACKGROUND:Glaucoma drainage device (GDD) implantation in the anterior chamber are associated with corneal complications. We describe a novel technique to implant GDD tubes in the posterior chamber of pseudophakic eyes. METHODS:Ten patients with glaucoma who required GDD tube implantation were included. RESULTS:The new technique begins with the passage of one ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2020, 20(1):66]

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Placoid choroidopathy after bilateral uncomplicated descemet's membrane endothelial keratoplasty.

Thomas H Dohlman, Neepa Shah, Colin Prensky, Mrinali P Gupta, Donald J D'Amico, Szilard Kiss, Christopher S Sales,

Purpose:To describe a case of bilateral, sequential placoid choroidopathy following uncomplicated Descemet's membrane endothelial keratoplasty (DMEK). Observations:A 49-year old woman presented with flashing lights and central visual field scotomas after undergoing uncomplicated DMEK combined with cataract surgery for Fuch's endothelial dystrophy in the right eye. She was found to have ... Read more >>

Am J Ophthalmol Case Rep (American journal of ophthalmology case reports)
[2020, 17:100610]

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Lightning Injury to Eye: Brief Review of the Literature and Case Series.

Eli Pradhan, Anadi Khatri, Akwasi Agyeman Ahmed, Ang Jangmu Lama, Roshija Khanal, Leena Bajracharya, Srijana Adhikari,

Purpose:In ophthalmology, injuries due to lightning strikes have been documented as various entities ranging from keratitis, cataracts, uveitis in the anterior segments to retinal detachments, papillitis, and macular hole formation in the posterior segment. We report the largest case series so far with a total of seven cases of lightning injuries ... Read more >>

Clin Ophthalmol (Clinical Ophthalmology (Auckland, N.Z.))
[2020, 14:597-607]

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Hole-in-one: simple non-surgical technique for the management of anterior chamber migrated Ozurdex® implant.

Pablo Rivera-Pérez de Rada, Pedro Fernández-Avellaneda, Lucía Teresa Barturen Herraiz, Iker Henares Fernández, Estibaliz Ispizua Mendivil, Maria Ángeles Castellanos Relloso, Javier Hidalgo-Santamaría, Jesús Alfonso Grijalvo López,

Introduction: The migration of a dexamethasone implant to the anterior chamber is a vision-threatening complication which can happen in non-compartmentalized eyes treated with this device. Previous literature suggests that the solution to this complication is almost always surgical and in most cases cannot be delayed. Case description: We present the ... Read more >>

GMS Ophthalmol Cases (GMS Ophthalmology Cases)
[2020, 10:]

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Clinical diagnosis and treatment recommendations for ocular toxicities of targeted therapy and immune checkpoint inhibitor therapy.

Xiaowei Liu, Zheng Wang, Chan Zhao, Hanping Wang, Xiaoxiao Guo, Jiaxin Zhou, Lian Duan, Xiaoyan Si, Li Zhang, Yue Li, Mengzhao Wang, Meifen Zhang, Li Zhang,

The increased use of targeted therapy and immune checkpoint inhibitors in cancers has brought new hope of survival to patients with advanced tumors. However, increasing numbers of immune-related adverse events (irAEs) of these medications have been reported, affecting almost all human organs including the eye. These adverse effects may affect ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, 11(3):810-818]

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Efficacy of Topical Brinzolamide Treatment in Posterior Microphthalmos-Related Macular Cystoid Lesions: A Case Series

Ceren Durmaz Engin, Umut Baran Ekinci, Alper Selver, Ali Osman Saatci,

The aim of this study was to report the outcome of topical brinzolamide 1% treatment on macular cystoid lesions resembling retinoschisis in 4 patients diagnosed with posterior microphthalmia. The medical records of 4 patients with a clinical diagnosis of posterior microphthalmia who had started topical brinzolamide 1% treatment were reviewed. ... Read more >>

Turk J Ophthalmol (Turkish journal of ophthalmology)
[2020, 50(1):44-49]

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Anomalous retinal artery associated with branch retinal artery occlusion and neovascular glaucoma: A case report.

Wan-Ju Yang, Yan-Ning Yang, Ming-Gao Cai, Yi-Qiao Xing,

BACKGROUND:Congenital anomalous retinal artery is rare and does not typically affect visual acuity. However, an abnormal artery that passes through and supplies blood to the macular area complicated with branch retinal artery occlusion may negatively impact visual acuity. This study reports an unusual case of anomalous retinal artery combined with ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2020, 8(5):980-985]

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Dexamethasone Implant Migration through an Iris Coloboma.

Yoav Glidai, Shulamit Schwartz, Eyal Cohen,

Ozurdex® 0.7 mg (dexamethasone 0.7 mg implant, Allergan, Dublin, Ireland), an intravitreal biodegradable implant, is indicated for cystoid macular edema due to various causes. One of its known and uncommon complications is implant migration to the anterior chamber, causing corneal edema that, in some cases, is irreversible. Reported risk factors ... Read more >>

Case Rep Ophthalmol (Case reports in ophthalmology)
[2020, 11(1):73-78]

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Hole-in-one: simple non-surgical technique for the management of anterior chamber migrated Ozurdex® implant.

Pablo Rivera-Pérez de Rada, Pedro Fernández-Avellaneda, Lucía Teresa Barturen Herraiz, Iker Henares Fernández, Estibaliz Ispizua Mendivil, Maria Ángeles Castellanos Relloso, Javier Hidalgo-Santamaría, Jesús Alfonso Grijalvo López,

Introduction: The migration of a dexamethasone implant to the anterior chamber is a vision-threatening complication which can happen in non-compartmentalized eyes treated with this device. Previous literature suggests that the solution to this complication is almost always surgical and in most cases cannot be delayed. Case description: We present the ... Read more >>

GMS Ophthalmol Cases (GMS Ophthalmology Cases)
[2020, 10:Doc05]

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Multimodal Chorioretinal Imaging in Erdheim-Chester Disease.

Riccardo Sacconi, Corrado Campochiaro, Alessandro Rabiolo, Alessandro Marchese, Alessandro Tomelleri, Livia Tomasso, Maria Vittoria Cicinelli, Lea Querques, Francesco Bandello, Lorenzo Dagna, Giuseppe Querques,

Purpose:To analyze the subclinical intraocular involvement using multimodal imaging approach in patients affected by Erdheim-Chester disease (ECD) without ocular symptoms. Patients and Methods:In this prospective cross-sectional study, 18 eyes of 9 consecutive patients with ECD were enrolled. Each patient underwent comprehensive ocular examination and extensive multimodal chorioretinal imaging. Results:None of ... Read more >>

Clin Ophthalmol (Clinical Ophthalmology (Auckland, N.Z.))
[2020, 14:581-588]

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Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort.

Jasmin Rezapour, Alexander K Schuster, Stefan Nickels, Christina A Korb, Hisham Elbaz, Tunde Peto, Matthias Michal, Thomas Münzel, Philipp S Wild, Jochem König, Karl Lackner, Andreas Schulz, Norbert Pfeiffer, Manfred E Beutel,

To investigate the prevalence and new onset of depression and anxiety among subjects with age-related macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4816]

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A Novel Technique for Recurrent Tube Exposure Repair.

J Minjy Kang, Yen Cheng Hsia, Ying Han,

Purpose:Tube exposure can lead to vision-threatening consequences and requires prompt surgical attention. Posterior repositioning of the tube to the pars plana has previously been reported as a successful technique. However, this method requires a pars plana vitrectomy (PPV). Here, we describe a novel technique of repositioning the tube into the ... Read more >>

Case Rep Ophthalmol Med (Case reports in ophthalmological medicine)
[2020, 2020:6878025]

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Atorvastatin-loaded solid lipid nanoparticles as eye drops: proposed treatment option for age-related macular degeneration (AMD).

Monika Yadav, Nicola Schiavone, Ana Isabel Guzman Aranguez, Fabrizio Giansanti, Laura Papucci, Maria J Perez de Lara, Mandeep Singh, Indu Pal Kaur,

Statins, widely prescribed for cardiovascular diseases, are also being eyed for management of age-related macular degeneration (AMD). Poor bioavailability and blood-aqueous barrier may however limit significant ocular concentration of statins following oral administration. We for the first time propose and investigate local application of atorvastatin (ATS; representative statin) loaded into ... Read more >>

Drug Deliv Transl Res (Drug delivery and translational research)
[2020, :]

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Efficacy and safety of ultrasonic circular cyclocoagulation with second-generation probe in glaucoma: A retrospective study.

Chloé Chamard, Vincent Daien, Hyosun Han, David S Greenfield, Max Villain,

BACKGROUND:To assess the efficacy and safety of the second-generation probe of ultrasonic circular cyclocoagulation (UC3) in naive or refractory glaucoma, with a 6-month follow-up. METHODS:A retrospective consecutive case-series study included patients having a UC3 procedure with the second-generation probe of the EyeOP1 device, intraocular pressure (IOP) ≥ 21 mmHg and ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0227389]

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Inherited Eye Diseases with Retinal Manifestations through the Eyes of Homeobox Genes.

Yuliya Markitantova, Vladimir Simirskii,

Retinal development is under the coordinated control of overlapping networks of signaling pathways and transcription factors. The paper was conceived as a review of the data and ideas that have been formed to date on homeobox genes mutations that lead to the disruption of eye organogenesis and result in inherited ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(5):]

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Long-term effects of pattern scan laser pan-retinal photocoagulation on diabetic retinopathy in Chinese patients: a retrospective study.

Chuang-Xin Huang, Kun-Bei Lai, Li-Jun Zhou, Zhen Tian, Xiao-Jing Zhong, Fa-Bao Xu, Ya-Jun Gong, Lin Lu, Chen-Jin Jin,

AIM:To evaluate the long-term effects of pattern scan laser (PASCAL) pan-retinal photocoagulation (PRP) on diabetic retinopathy (DR) in Chinese patients. METHODS:In this retrospective study, we evaluated clinical data of 29 patients (53 eyes) with severe non-proliferative DR (SNPDR) or proliferative DR (PDR) who received PRP and follow-up at our hospital ... Read more >>

Int J Ophthalmol (International journal of ophthalmology)
[2020, 13(2):239-245]

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Systematic review and Meta-analysis of treating open angle glaucoma with gonioscopy-assisted transluminal trabeculotomy.

Chun-Yan Guo, Xiao-Hui Qi, Jian-Ming Qi,

AIM:To systematically review and Meta-analyze studies of managing open angle glaucoma (OAG) with gonioscopy-assisted transluminal trabeculotomy (GATT) and to evaluate its effectiveness and safety. METHODS:Eligible studies were retrieved and screened from five main electronic databases. Mean difference (MD) was hired to show the pooled effectiveness of intraocular pressure (IOP) and ... Read more >>

Int J Ophthalmol (International journal of ophthalmology)
[2020, 13(2):317-324]

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One-year natural course of corneal densitometry in high myopic patients after implantation of an implantable collamer lens (model V4c).

Xun Chen, Yang Shen, Haipeng Xu, Xiaoying Wang, Xingtao Zhou,

BACKGROUND:Corneal densitometry, which is also known as corneal backscattering, is a surrogate measure of corneal clarity. The purpose of the study was to investigate the changes in corneal densitometry (CD) after implanting an implantable collamer lens (ICL-V4c). METHOD:Twenty-six high myopic patients (aged 29.3 ± 6.6 years, 6 males and 20 females) who underwent ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2020, 20(1):50]

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